Cryptolepine, the Main Alkaloid of the Antimalarial Cryptolepis sanguinolenta (Lindl.) Schlechter, Induces Malformations in Zebrafish Embryos by Kwesi Boadu Mensah, Charles Benneh, Arnold Donkor Forkuo, Charles Ansah

“…Lower cryptolepine concentration (<100 μM) caused mortality, approximately 15–18%, only after the 48 hours postfertilization. The most sensitive period of embryo lethality corresponded well with the pharyngula (24 to 48 hours) and hatching (48 to 72 hours) stages of embryonic development. …”
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Association of reported sleep disturbances with objectively assessed mild cognitive impairment among adults in the United States by Chan Shen, Hao Wang, Arthur Nguimatsa Djiotsop, R. Constance Wiener, Mona Pathak, Sophie Mitra, Patricia A Findley, Usha Sambamoorthi

“…Our findings demonstrate a positive association between sleep disturbances and mild cognitive impairment, although these associations were sensitive to covariate adjustments. These findings suggest multifaceted pathways for reducing the risk of mild cognitive impairment.…”
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Transcriptome profiling revealed multiple circadian rhythm-related genes associated with common gynecological cancers by Lan Peng, Meiping Jiang, Kangming Li, Shuhui Yu, Chunfang Zhao, Lan Zhang, Lan Li

“…It is notable that multiple immune-related signaling pathways were associated with the clinical risk of CC, and the immunotherapy sensitivity was worse in the high-risk group. In addition, we found that most of biomarkers had the prognostic values in other common gynecologic cancers. …”
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Comparing Clean Water Act Section 316(b) Policy Options by John Kadvany

“…Three simplified policy options are considered, each with a different implicit or explicit AEI approach: (1) a technology-driven rule based on a strict reading of the 316(b) regulatory text, and for which any impingement and entrainment count as AEI, (2) a complementary, open-ended risk-assessment process for estimating population effects with AEI characterized on a site-specific basis, and (3) an intermediate position based on proxy measures such as specially constructed definitions of littoral zone, sensitive habitat, or water body type. The first two proposals correspond roughly to responses provided, respectively, by the Riverkeeper environmental organization and the Utility Water Act Group to the U.S. …”
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The effect of blood glucose levels on serum triglyceride clearance in patients with hyperlipidemic acute pancreatitis by Yuxin Liu, Shuqi Qin, Si Dai, Jing Zhou, Zhendan Wang, Guojian Yin

“…And patients with TG slow-clearance (day 2 TG ≥ 7.335 mmol/L) were more likely to develop MSAP & SAP (sensitivity 0.932, specificity 0.898), severe pancreatic necrosis, and death. …”
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The Prediction Model of High-Frequency Ultrasound Combined with Artificial Intelligence-Assisted Scoring System Improved the Diagnosis of Sclerosing Adenosis and Early Breast Cance... by Ma B, Wu G, Zhu H, Liu Y, Hu W, Zhao J, Liu Y, Liu Q

“…In the training group, the AUC of the sonographer and AI in differential diagnosis was 0.67(95% CI, 0.62– 0.71) and 0.89(95% CI, 0.84– 0.93), respectively, and the sonographer’s assessment showed better sensitivity (1.00 VS 0.73), but AI showed a higher accuracy rate (0.66 VS 0.80).Conclusion: Age, lesion size, burr, blood flow, and AI risk score are independent predictors of sclerosing adenosis and early breast cancer. …”
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Microiontophoretic Application of Dynorphin in Dental Pain: Excitatory or Inhibitory Effects by Choi SH, Kim YM, Son JY, Ahn DK

“…Seung-Ho Choi,&ast; Yu-Mi Kim,&ast; Jo-Young Son, Dong-Kuk Ahn Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea&ast;These authors contributed equally to this workCorrespondence: Dong-Kuk Ahn, Department of Oral Physiology, School of Dentistry, Kyungpook National University, 2177, Dalgubeol-Daero, Jung-Gu, Daegu, 41940, Korea, Tel +82-53-660-6840, Email dkahn@knu.ac.krBackground: The tooth exhibits increased sensitivity to noxious stimuli due to the dense innervation of thin myelinated Aδ fibers and unmyelinated C fibers within the dental pulp. …”
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Analysis of the Concentration of Heavy Metals in Khat Grown in Meru County and the Assessment of Their Associated Health Risks by Albert M. Oyugi, Joshua K. Kibet, John O. Adongo

“…Accordingly, the Meru khat farmers should be sensitized on alternative farming practices that do not potentially cause heavy metal contamination in khat.…”
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Effects of physical exercise on anxiety depression and emotion regulation in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis by Yagang Song, Shuqi Jia, Xing Wang, Aiwei Wang, Tao Ma, Shufan Li, Jiwei Chen, Zhaohui Guo, Feng Ding, Yuxi Ren, Man Qin

“…The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) profiler method was utilized to further assess the quality of evidence. Meta-analysis, sensitivity analysis, and publication bias testing were performed using Stata 18.0 software. …”
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Identification of major hemorrhage in trauma patients in the prehospital setting: diagnostic accuracy and impact on outcome by Nigel R M Tai, Evangelia Kyrimi, Jared M Wohlgemut, Zane B Perkins, William Marsh, Michael Christian, Erhan Pisirir, Rebecca S Stoner, Thomas Hurst

“…MH was correctly diagnosed in 97 of 138 patients (sensitivity 70%) and correctly excluded in 764 of 809 patients (specificity 94%). …”
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PD-L1 and IFN-γ modulate Non-Small Cell Lung Cancer (NSCLC) cell plasticity associated to immune checkpoint inhibitor (ICI)-mediated hyperprogressive disease (HPD) by Stefania Angelicola, Francesca Giunchi, Francesca Ruzzi, Mariateresa Frascino, Mary Pitzalis, Laura Scalambra, Maria Sofia Semprini, Olga Maria Pittino, Chiara Cappello, Irene Siracusa, Ilaria Candida Chillico, Martina Di Noia, Cristian Turato, Silvia De Siervi, Francesco Lescai, Teresa Ciavattini, Giulia Lopatriello, Luca Bertoli, Hugo De Jonge, Luisa Iamele, Annalisa Altimari, Elisa Gruppioni, Andrea Ardizzoni, Marzia Rossato, Francesco Gelsomino, Pier-Luigi Lollini, Arianna Palladini

“…In vitro investigations, including the evaluation of cell sensitivity to interferon-gamma (IFN-γ) and cell response to PD-L1 modulation, were conducted to explore the influence of these factors on cell plasticity regulation. …”
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Introduction to deep learning methods for multi‐species predictions by Yuqing Hu, Sara Si‐Moussi, Wilfried Thuiller

“…Popular species distribution models use statistical and machine learning methods but face limitations with multi‐species predictions at the community level, hindered by scalability and data imbalance sensitivity. This paper explores the potential of deep learning methods to overcome these challenges and provide more accurate multi‐species predictions. …”
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Red blood cell indices in different hemoglobinopathies: A cross-sectional study in Eastern India by Ayandip Nandi, Manas Talukdar, Saikat Bhattacharya, Susruta Sen, Supratik Biswas, Kuntal Roy

“…A value of MCV at ≤73.8 fl and MCH at ≤21.9 pg may be a clue of diagnosis for BTT rather than E-trait with >90% sensitivity and >80% specificity. Conclusion: RBC indices vary significantly between BTT and other HbE-related hemoglobinopathies. …”
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The impact of primary health care on AIDS incidence and mortality: A cohort study of 3.4 million Brazilians. by Priscila F P S Pinto, James Macinko, Andréa F Silva, Iracema Lua, Gabriela Jesus, Laio Magno, Carlos A S Teles Santos, Maria Yury Ichihara, Mauricio L Barreto, Corrina Moucheraud, Luis E Souza, Inês Dourado, Davide Rasella

“…We also estimated the FHS impact by sex and age and performed a wide range of sensitivity and triangulation analyses; 100% FHS coverage was associated with lower AIDS incidence (rate ratio [RR]: 0.76, 95% CI: 0.68 to 0.84) and mortality (RR: 0.68, 95%CI: 0.56 to 0.82). …”
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Causal Inference for Hypertension Prediction With Wearable E lectrocardiogram and P hotoplethysmogram Signa... by Ke Gon g, Yifan Chen, Xinyue Song, Zhizhong Fu, Xiaorong Ding

“…Hypertension can be detected in a timely manner with cardiac signals, such as through an electrocardiogram (ECG) and photoplethysmogram (PPG) , which can be observed via wearable sensors. Most previous studies predicted hypertension from ECG and PPG signals with extracted features that are correlated with hypertension. …”
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Development of the RP-HPLC Method for Simultaneous Determination and Quantification of Artemether and Lumefantrine in Fixed-Dose Combination Pharmaceutical Dosage Forms by Simon Nyarko, Kwabena Ofori-Kwakye, Raphael Johnson, Noble Kuntworbe, Desmond Asamoah Bruce Otu, Denis Dekugmen Yar, Yaa Asantewaa Osei

“…The current study developed a novel, simple, sensitive, precise, accurate, and cost-effective RP-HPLC method for the simultaneous determination and quantification of artemether and lumefantrine in pharmaceutical dosage forms. …”
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Identification of Plasma Absorbed Components of Qingxin Zishen Prescription by UPLC-Q-TOF MS by Yu HU, Juan SHANG, Xue-jiao LI, Yun-hua FENG, Kai-cheng XIE, Wei-feng YAO, Jian-dong ZOU, Yun CHEN, Su LU, Mei-juan XU

“…Intelligent dynamic background deduction, information dependent acquisition and highly sensitive mode were used to collect the data. According to the accurate m/z values of MS and MS2 information, data from reference substance and related literature, the absorbed components in plasma were identified. …”
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Helping people with psychosis with a low-cost intervention DIALOG+: protocol for the economic evaluation in a randomised control trial in India and Pakistan by Victoria Jane Bird, Sara Evans-Lacko, Lakshmi Venkatraman, Padmavati Ramachandran, Ashar Muhammad Malik, Renata Peppl, Sana Zehra Zehra Sajun, Onaiza Qureshi, Krishna Priya, Hufsa Sarwar

“…Incremental cost, incremental effectiveness and incremental cost-effectiveness ratios will be calculated using linear regression models with a hierarchical data structure. A probabilistic sensitivity analysis will be carried out to test for the uncertainty surrounding the estimates of cost-effectiveness.Discussion This study will provide evidence of a patient-centred approach to improve the quality of community-based care for people with psychosis in India and Pakistan. …”
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Application possibility of ophthalmic heparin ointment as an artificial tear (preliminary report) by V.D. Yartsev

“…<br> <b>Patients and Methods:</b> clinical research included 11 patients (21 eyes) with a previously diagnosed DES and with complains on ocular discomfort, sandy-gritty sensation, eyelid itching. All patients underwent a lacrimal meniscometry based on optical coherence tomography with determination of the depth and height of the tear meniscus. …”
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Trade-Off Between Enzymatic Antioxidant Defense and Accumulation of Organic Metabolite Affects Salt Tolerance of White Clover Associated with Redox, Water, and Metabolic Homeostase... by Min Zhou, Yuting Wu, Yuchen Yang, Yan Yuan, Junnan Lin, Long Lin, Zhou Li

“…This study aims to investigate the difference in the mechanism of salt tolerance in relation to osmotic adjustment, enzymatic and nonenzymatic antioxidant defenses, and organic metabolites remodeling between salt-tolerant PI237292 (Trp004) and salt-sensitive Korla (KL). Results demonstrated that salt stress significantly induced chlorophyll loss, water imbalance, and accumulations of malondialdehyde (MDA), hydrogen peroxide (H₂O₂), and superoxide anion (O₂<sup>.…”
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