Application of ursodeoxycholic acid at non-alcoholic and alcohol-induced steatohepatitis by Ye. A. Fedos’ina, M. V. Mayevskaya

“…Disorders of carbohydrate metabolism (including insulin resistance) serve as the indication for prescription of drugs, that sensitize peripheral tissues to insulin. At alcohol-induced steatohepatitis abstinence is categorical. …”
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P-glycoprotein and/or Histone Deacetylase 2 Regulates Steroid Responsiveness in Childhood Nephrotic Syndrome by Harshit Singh, Narayan Prasad, Durga Prasanna Misra, Akhilesh Kumar Jaiswal, Vikas Agarwal

“…Materials and Methods: Thirty-one patients were recruited at baseline (n = 31) (before initiating steroid therapy); after 6 weeks of steroid therapy, 24 patients achieved remission (steroid-sensitive NS [SSNS] n = 24 mean age, 7.96 ± 3.90), whereas seven patients were resistant to steroids (SRNS, n = 7, mean age 10.00 ± 3.55). mRNA expression of HDAC2 and P-gp and functional analysis of P-gp and enzymatic activity of HDAC2 were analyzed at baseline, and at 6 weeks of steroid treatment and at the time of relapse. …”
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Development of a diagnostic multivariable prediction model of a positive SARS-CoV-2 RT-PCR result in healthcare workers with suspected SARS-CoV-2 infection in hospital settings. by Sandra Liliana Valderrama-Beltrán, Juliana Cuervo-Rojas, Martín Rondón, Juan Sebastián Montealegre-Diaz, Juan David Vera, Samuel Martinez-Vernaza, Alejandra Bonilla, Camilo Molineros, Viviana Fierro, Atilio Moreno, Leidy Villalobos, Beatriz Ariza, Carlos Álvarez-Moreno

“…The model achieved an AUC of 0.79 (95% CI 0.77-0.81), with 93% specificity, 36% sensitivity, and satisfactory calibration.<h4>Conclusions</h4>We present an innovative diagnostic prediction model that as a special feature includes a variable that represents SARS-CoV-2 epidemiological situation. …”
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Genetic differentiation and historical dynamics of the endemic species Rheum pumilum on the Qinghai-Tibetan Plateau inferred from phylogeography implications by Shuliang Liu, Jianxin Gao, Bo Xiao, Wenjie Guo, Qiushi Yu, Ailan Wang, Weiwei Li

“…Ecological Niche Modeling (ENM) indicates sensitivity of Rh. pumilum to humidity, temperature and altitude, aligning with a historical distribution resembling a “displacement refugia” model during the Quaternary ice ages. …”
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Predictive Factors and Clinical Prediction Score for Serious Intracranial Causes in Acute Nontraumatic Headache at an Emergency Department by Siriwimon Tantarattanapong, Lalita Chalongkulasak

“…A score ≥3 out of 10 points of the clinical prediction score was likely to identify a serious intracranial cause of acute NTH with a sensitivity and specificity of 87.50% (95% CI 78.73–93.59%) and 87.70% (95% CI 83.90–90.89%), respectively. …”
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The sporophytic type of fertility restoration in the A3 CMS-inducing cytoplasm of sorghum and its modification by plant water availability conditions by L. A. Elkonin, V. V. Kozhemyakin, M. I. Tsvetova

“…The A3 type of CMS in sorghum is one of the most difficult to restore fertility because of the low frequency of fertilityrestoring genes among sorghum accessions, the complex mechanism of fertility restoration that occurs with the complementary interaction of two gametophytic genes Rf3 and Rf4, and the sensitivity of their expression to air and soil drought. …”
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Associations of carbohydrate quality and cardiovascular risk factors vary among diabetes subtypes by Katharina S. Weber, Sabrina Schlesinger, Janina Goletzke, Klaus Straßburger, Oana-Patricia Zaharia, Sandra Trenkamp, Robert Wagner, Wolfgang Lieb, Anette E. Buyken, Michael Roden, Christian Herder, for the GDS group

“…Among MARD, a higher dietary GL and higher-GI carbohydrate intake were associated with higher serum triglycerides (10.9% (2.4; 20.1), 12.4% (3.9; 21.5)) and fatty liver index (absolute change: 0.18 (0.06; 0.31), 0.17 (0.05; 0.28)) and lower HDL-cholesterol (− 4.1% (− 7.6; − 0.4), − 4.4% (− 7.8; − 0.8)), whilst higher intake of low-GI carbohydrates and dietary fiber were associated with lower high-sensitivity C-reactive protein (− 16.0% (− 25.7; − 5.1), − 13.9% (− 24.2; − 2.2)). …”
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Organ Donation Conversations on X and Development of the OrgReach Social Media Marketing Strategy: Social Network Analysis by Wasim Ahmed, Mariann Hardey, Josep Vidal-Alaball

“…ResultsThis analysis reveals an “elite tier” shaping the conversation, with themes reflecting existing societal sensitivities around organ donation. We demonstrate how prominent social media profiles act as information intermediaries, navigating the tension between open dialogue and negative perceptions. …”
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Balancing environmental impact: A sustainability index analysis of sorghum production for food and feed by A. Prabowo, R.N. Hayati, S. Minarsih, B. Haryanto, D.D. Ludfiani, A. Supriyo, S. Subiharta, E. Nurwahyuni, Y. Hindarwati, M.N. Setiapermas, S. Sudarto, S. Samijan, B. Utomo, E. Winarn, N.D. Suretno, W. Wibawa, S. Agustini, A. Prasetyo, F.R.P. Hantoro, W. Hariyanto, V.E. Aristya

“…These included land availability, the efficiency of water used, the prevention of natural resource exploitation, motivation level, minimal interference with primary agricultural activities, community acceptance, productivity, sales profit level, ease of sale and cultivation, tools availability, and technological sensitivity.CONCLUSION: Sustainability index of sorghum for food and feed was categorized as very sustainable with a value of 79.67. …”
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Use of Texture Analysis on Noncontrast MRI in Classification of Early Stage of Liver Fibrosis by Ru Zhao, Xi-Jun Gong, Ya-Qiong Ge, Hong Zhao, Long-Sheng Wang, Hong-Zhen Yu, Bin Liu

“…Cross-validation results reported the following values of mean accuracy, specificity, and sensitivity: 0.98 each for out-of-phase T1W; 0.90, 0.89, and 0.90 for in-phase T1W; and 0.86, 0.88, 0.84 for T2W in the training set, and 0.76, 0.81, and 0.72 for out-of-phase T1W; 0.74, 0.72, and 0.75 for in-phase T1W; and 0.63, 0.64, and 0.63 for T2W for the test group, respectively. …”
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Position-based assessment of head impact frequency, severity, type, and location in high school American football by Amirhossein Bagherian, Alireza Abbasi Ghiri, Mohammadreza Ramzanpour, James Wallace, Sammy Elashy, Morteza Seidi, Marzieh Memar

“…Validated mouthguard sensors measured head impact kinematics, including linear acceleration, angular acceleration, and angular velocity across ten games, and were used to identify impact locations on the head. …”
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Serum and plasma as a good candidates of body fluids for detection lung cancer by FTIR liquid biopsy by Jolanta Smok-Kalwat, Stanisław Góźdź, Paweł Macek, Zuzanna Kalwat, Maryna Khalavka, Wioletta Rzad, Andrzej Stepulak, Joanna Depciuch

“…Principal component analysis (PCA) of FTIR spectra showed plasma and serum samples collected from lung cancer patients and individuals without lung cancer symptoms were better differentiated in fingerprinting region (from 800 to 1800 cm− 1) when compared to lipid region (2800–3000 cm− 1). Moreover, also sensitivity specificity and accuracy calculated by logistic regression (LR) and receive operating characteristic (ROC) showed higher values for fingerprint range (800–1800 cm− 1) in comparison with lipids (2800–3000 cm− 1) one for both, serum and plasma. …”
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The Antiobesity Effect of GLP-1 Receptor Agonists Alone or in Combination with Metformin in Overweight /Obese Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Ana... by Xiaorui Lyu, Taibiao Lyu, Xue Wang, Huijuan Zhu, Hui Pan, Linjie Wang, Hongbo Yang, Fengying Gong

“…The results showed that GLP-1RAs alone or combined with MET was associated with a greater weight loss (N = 318, WMD = −2.61, 95% CI: −3.51 to −1.72, P≤0.001, I2 = 77.5%), more obvious reduction of waist circumference (N = 276, WMD = −3.46, 95% CI: −4.36 to −2.56, P≤0.001, I2 = 0.0%), and body mass index (BMI) (N = 318, WMD = −0.93, 95% CI: −1.60 to −0.26, P=0.007, I2 = 84.9%) in overweight/obese PCOS patients when compared with MET alone. Further sensitivity analysis demonstrated that the meta-analysis results of the efficacy differences in terms of body weight, waist circumference, and BMI were relatively stable and reliable. …”
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Valine potentiates cefoperazone-sulbactam to kill methicillin-resistant Staphylococcus aureus by Shao-hua Li, Yuan Tao, Zhi-cheng Yang, Huan-zhe Fu, Hui-yin Lin, Xuan-xian Peng, Hui Li

“…Metabolomics comparison between MRSA and methicillin-sensitive Staphylococcus aureus showed a depressed metabolic state in MRSA. …”
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The efficacy and safety of qiwei baizhu san in the treatment of type 2 diabetes mellitus: a systematic review and meta-analysis by Quan Zhang, Hongyan Liu, Jiahong Zhang, Yujie Ouyang, Xiaoxu Fu, Xiaoxu Fu, Xiaoxu Fu, Chunguang Xie, Chunguang Xie, Chunguang Xie

“…Heterogeneity sources were examined via subgroup analyses, the robustness of the results was determined by sensitivity analyses, publication bias was evaluated using funnel plots and Egger’s test, evidence quality was appraised with GRADEpro, and possible mechanisms of QWBZS for T2DM were categorized and summarized.ResultsThis analysis encompassed 14 qualifying trials with a total of 1,169 subjects. …”
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Right ventricular function in athletes engaged in endurance exercise using speckle tracking echocardiography: a meta-analysis by Chenzan Guo, Hebin Zhang, Cunxin Yang, Peipei Hu, Hui Ma, Ying Ma, Feng Gao

“…Meta regression was employed to identify sources of heterogeneity and publication bias was evaluated by Egger’s test and funnel plots. Sensitivity analysis was performed by removing sources of significant change from the results of a single publication to evaluate the stability of the results. …”
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Immune regulatory genes impact the hot/cold tumor microenvironment, affecting cancer treatment and patient outcomes by Mengmeng Sang, Jia Ge, Juan Ge, Juan Ge, Gu Tang, Qiwen Wang, Jiarun Wu, Liming Mao, Liming Mao, Xiaoling Ding, Xiaorong Zhou

“…Additionally, hub genes that regulate the tumor microenvironment were identified, and their expression patterns were analyzed using single-cell RNA sequencing. Furthermore, drug sensitivity and molecular docking analyses were performed to identify potential drug candidates capable of transforming cold tumors into hot tumors. …”
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Effects of bronchoscopic alveolar lavage–assisted mechanical ventilation on postoperative pulmonary infection and inflammatory factors in patients undergoing lung cancer surgery by Hui Zhu, Haiyang Lu

“…The levels of inflammatory markers (high-sensitivity C-reactive protein, procalcitonin, tumor necrosis factor α, high-mobility group box 1, interleukin 6, and macrophage inflammatory protein 1α) in peripheral blood were decreased regardless of the treatment method (all P <⁠0.05). …”
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The validation and cross-cultural adaptation of the PainDETECT questionnaire in osteoarthritis-related pain by Xiaofeng Chang, Shuxin Yao, Jie Wei, Lei Shang, Chao Xu, Jianbing Ma

“…A cohort of 241 knee osteoarthritis (KOA) patients completed the PDQ-CV, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), EuroQol-5 Dimensions-5 Levels (EQ-5D-5 L), and Central Sensitization Inventory Chinese Version (CSI-CV). We assessed internal consistency using Cronbach’s alpha and test-retest reliability via intraclass correlation coefficient (ICC). …”
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Introducing an index on prediction of post-revascularization cerebral infarction using preoperative CT perfusion parameters in moyamoya disease by Xiaojun Hao, Chao Zhang, Chen Yang, Xintong Zhao, Yunfeng Zhou, Juan Wang

“…The preoperative mean Tmax produced the largest area under the curve (0.955, 95% CI: 0.914–0.997) with a cutoff of 3.590 s (sensitivity, 100%; specificity, 87.7%). Conclusions Adults with MMD are at risk of post-CI when the preoperative mean Tmax is > 3.590 s. …”
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