The Mediation of Circulating Inflammatory Proteins in the Causal Pathway from Immune Cells to COPD by Yan K, Wang Y, Xin P

“…The causal relationships between immune cells, inflammatory proteins and COPD were sequentially analysed by multivariate Mendelian randomisation and validated using Bayesian weighted Mendelian randomisation. Subsequently, sensitivity analyses were conducted, employing Cochran’s Q test to assess heterogeneity, MR-PRESSO and MR-Egger tests to assess pleiotropy, and reverse MR and Steiger directionality tests to rule out reverse causality. …”
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Chronic lung lesions in COVID-19 survivors: predictive clinical model by Paulo A Lotufo, Juliana C Ferreira, Eloisa Bonfa, Anna S Levin, Rodrigo Caruso Chate, Marta Imamura, Esper G Kallas, Roger Chammas, Thais Mauad, Izabel Marcilio, Nelson Gouveia, Ricardo Nitrini, José Eduardo Krieger, Marcio Valente Yamada Sawamura, Michelle Louvaes Garcia, Cristiano Gomes, Guilherme Fonseca, Jorge Hallak, Luis Yu, Marcio Mancini, Maria Elizabeth Rossi, Thiago Avelino-Silva, Edivaldo M Utiyama, Aluisio C Segurado, Beatriz Perondi, Anna Miethke-Morais, Amanda C Montal, Leila Harima, Marjorie F Silva, Marcelo C Rocha, Maria Amélia de Jesus, Carolina Carmo, Clarice Tanaka, Julio F M Marchini, Thaís Guimarães, Ester Sabino, Carlos Roberto Ribeiro Carvalho, Celina Almeida Lamas, Diego Armando Cardona Cardenas, Daniel Mario Lima, Paula Gobi Scudeller, João Marcos Salge, Cesar Higa Nomura, Marco Antonio Gutierrez, Adriana L Araújo, Bruno F Guedes, Carolina S Lázari, Cassiano C Antonio, Claudia C Leite, Emmanuel A Burdmann, Euripedes C Miguel, Fabio R Pinna, Fabiane Y O Kawano, Geraldo F Busatto, Giovanni G Cerri, Heraldo P Souza, Izabel C Rios, Larissa S Oliveira, Linamara R Batisttella, Luiz Henrique M Castro, Marcello M C Magri, Maria Cassia J M Corrêa, Maria Cristina P B Francisco, Maura S Oliveira, Orestes V Forlenza, Ricardo F Bento, Rodolfo F Damiano, Rossana P Francisco, Solange R G Fusco, Tarcisio E P Barros-Filho, Wilson J Filho

“…The machine learning model, including the results of 257 patients with complete data on mMRC, SpO2, FVC, CXR and CT, accurately detected pulmonary lesions by the joint data of CXR, mMRC scale, SpO2 and FVC (sensitivity, 0.85±0.08; specificity, 0.70±0.06; F1-score, 0.79±0.06 and area under the curve, 0.80±0.07).Conclusion A predictive clinical model based on CXR, mMRC, oximetry and spirometry data can accurately screen patients with lung lesions after SARS-CoV-2 infection. …”
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Correlation of Serum Albumin Level to Lung Ultrasound Score and Its Role as Predictors of Outcome in Acute Respiratory Distress Syndrome Patients: A Prospective Observational Study by Souvik Chaudhuri, Sagar S. Maddani, Shwethapriya Rao, Sirish Gauni, N. R. Arjun, Pratibha Todur, Nitin Gupta

“…The cut-off value of albumin for predicting a prolonged length of ICU stay (≥10 days) in ARDS patients was <3.25 g/dL with AUC 0.623, p<0.05, sensitivity of 86.67%, specificity of 45.45%, and 95% confidence interval (CI) [0.513–0.732], and on multivariate analysis it increased the odds of prolonged ICU stay by 8.9 times (Hosmer and Lemeshow p value 0.810, 95% CI [2.760–28.72]). …”
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Factors enhancing implementation of occupational safety and health management systems in manufacturing industry of Mutare, Zimbabwe by Johanes Mandowa, Mark Matsa, Steven Jerie

“…This recommendation places a demand on researchers and OSH stakeholders globally to rethink the current global order for OSHMSs implementation in order to advance an approach to OSHMSs implementation in the SMMCs that is sensitive to contextual compounding factors. The study develops a framework that is key in creating a “preventive safety culture” at workplaces which is an epitome for sustainability in OSHMSs implementation.…”
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High perioperative lactate levels as a potential predictor for severe acute kidney injury following aortic arch surgery by Dongxu Wang, Chen Yang, Han Wang, Mengmeng Ye, Chao Xue, Weiguang Wang, Bo Yu, Kai Ren, Zhenxiao Jin, Shiqiang Yu, Shiqiang Yu, Weixun Duan

“…Multivariate stepwise backward logistic regression analysis identified lactate levels at 12 h postoperatively ([Lacpo12h], cutoff value: 3.3 mmol/L; sensitivity: 63.2%; specificity: 72.3%) as an independent predictor of severe AKI. …”
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Role of Subsurface Geo-Energy Pilot and Demonstration Sites in Delivering Net Zero by M. H. Stephenson, D. A. C. Manning, M. J. Spence, L. Stalker, Z. K. Shipton, A. A. Monaghan

“…Gaps were identified in two areas: 1) test facilities to aid the design of low cost, high resolution, unobtrusive seismic and other monitoring for a seismically noisy urban environment with a sensitive human population, for example for ATES in urban areas; and 2) a dedicated through-fault zone test site to understand fault transmissivity and reactivation. …”
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Fire return intervals and recruitment affect population growth rate of canopy trees in tall open forest in humid savanna by Patricia A. Werner, Stephanie J. Peacock

“…We also explore the sensitivity of λ to two key life history parameters: recruitment and seedling survival. …”
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Comparison of Transcutaneous Electric Nerve Stimulation (TENS) and Microcurrent Nerve Stimulation (MENS) in the Management of Masticatory Muscle Pain: A Comparative Study by B. Saranya, Junaid Ahmed, Nandita Shenoy, Ravikiran Ongole, Nanditha Sujir, Srikant Natarajan

“…Microcurrent also has the advantage of being subthreshold, and hence the side effects such as tingling sensation and paresthesia seen to occur in some patients following TENS are absent. …”
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Construction of an Index System of the Biosafety Incident Response Capability for Nursing Staff: A Delphi Study by Chao Wu, Mengyi Hu, Xinyan Zhang, Mimi Fu, Lu Li, Qiang Xu, Xiaolan Guo, Hongjuan Lang

“…ABSTRACT Aim This study was to establish a scientific and sensitive index system of the biosafety incident response competence for clinical nursing staff to provide a reference for the evaluation of nurses' biosafety incident response competence. …”
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Construction and evaluation of a triage assessment model for patients with acute non-traumatic chest pain: mixed retrospective and prospective observational study by Xuan Zhou, Gangren Jian, Yuefang He, Yating Huang, Jie Zhang, Shengfang Wang, Yunxian Wang, Ruofei Zheng

“…Moreover, our model demonstrated better outcomes in terms of accuracy/sensitivity in both cohorts (81.9%/85.2% and 94.8%/78.5%). …”
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Spatiotemporal Response of MODIS Derived Vegetation index to climatic condition Case study: Kohgiloyeh O Boirahmad Province of Iran by Mohammad Hossein Nasserzadeh, zahra Hejazizadeh, Zahra Gholampour, Bohloul Alijani

“…The plant community in an area is the most sensitive indicator of climate. A visual comparison of climate and vegetation on a global scale immediately reveals a strong correlation between climatic and vegetation zones and this relationship, of course, are not co-incidental.  …”
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Parameter Uncertainty Analysis for Streamflow Simulation Using SWAT Model in Nashe Watershed, Blue Nile River Basin, Ethiopia by Megersa Kebede Leta, Dessalegn Geleta Ebsa, Motuma Shiferaw Regasa

“…The results show that CN_2, GW_DELAY, ALPHA_BNK, CH_N2, and SOL_AWC were the most sensitive parameter for the monthly period and had a great impact on the streamflow simulation. …”
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Synthetic inhibition of SREBP2 and the mevalonate pathway blocks rhabdomyosarcoma tumor growth in vitro and in vivo and promotes chemosensitization by Silvia Codenotti, Michela Asperti, Maura Poli, Luisa Lorenzi, Alberto Pietrantoni, Matteo Cassandri, Francesco Marampon, Alessandro Fanzani

“…Methods: In silico analyses of RNA datasets were performed to correlate MVP with RMS patient survival. The sensitivity of RMS cell lines to MVP inhibitors was assessed in vitro by analysis of cell growth (crystal violet and clonogenic assays), cell migration (wound healing assay), cell survival (neutral red assay), and oxidative stress (ROS assay). …”
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Comparative thoracic radiography in healthy and tuberculosis-positive sun bears (Helarctos malayanus) by Kirsty Officer, Kirsty Officer, Natalie Webster, Alana J. Rosenblatt, Phorn Sorphea, Kris Warren, Kris Warren, Bethany Jackson, Bethany Jackson

“…Interstitial, interstitial-to-alveolar, alveolar and nodular lung patterns, along with radiographic signs of lymphadenomegaly and pleural fluid, were almost exclusively found in TB cases, however the sensitivity of the presence of any of these changes for detecting TB was below 70%. …”
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A Novel Pyroptosis-Based Prognostic Model Correlated with the Parainflammatory Immune Microenvironment of Pancreatic Cancer by Kong-kong Wei, Zhi-xing Du, Jun-ge Deng, Jin-wei Yang, Hao Chen

“…Spearman correlation analyses revealed that the parainflammatory response in PC might be implicated in GSDMC-mediated pyroptosis via cytosolic DNA-sensing pathways under hypoxic conditions. Furthermore, the risk scores were significantly and positively related to the expression of HNRNPC, RBM15, YTHDF1, and YTHDF2, as well as sensitivity to gemcitabine, cisplatin, and erlotinib. …”
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Three-Dimensional Inversion of Borehole-Surface Resistivity Method Based on the Unstructured Finite Element by Zhi Wang, Sinan Fang

“…The quasi-Newton method with limited memory (L_BFGS) is used to optimize the objective function in the inversion calculation, and a double-loop recursive method is used to solve the normal equation obtained at each iteration in order to avoid computing and storing the sensitivity matrix explicitly and reduce the amount of calculation. …”
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Environmental vulnerability characteristics in an active swarm region by A.V.H. Simanjuntak, U Muksin, A. Arifullah, K. Lythgoe, Y. Asnawi, M. Sinambela, S. Rizal, S. Wei

“…The seismic spectral ratio of horizontal-over-vertical components was applied to calculate the spectrum in the active swarm region from all newly installed seismic sensors. The root mean square was applied to average the amplitude of the horizontal components. …”
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Evaluating ChatGPT’s diagnostic potential for pathology images by Liya Ding, Lei Fan, Lei Fan, Miao Shen, Miao Shen, Yawen Wang, Kaiqin Sheng, Zijuan Zou, Huimin An, Zhinong Jiang

“…The model achieved 0.88 accuracy in distinguishing low-grade from high-grade dysplasia and 0.75 in distinguishing high-grade dysplasia from adenocarcinoma, with a high sensitivity in detecting adenocarcinoma. Consistency between initial and follow-up evaluations showed slight to moderate agreement, with Kappa values ranging from 0.204 to 0.375.ConclusionGPT-4 demonstrates the ability to diagnose pathological images, showing improved performance over earlier versions. …”
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The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases by Aleksandra Pogoda-Wesołowska, Nina Sługocka, Agnieszka Synowiec, Klaudia Brodaczewska, Marcin Mejer-Zahorowski, Maciej Ziękiewicz, Wojciech Szypowski, Piotr Szymański, Adam Stępień

“…Nonetheless, to date, no sensitive or specific marker has been identified for the detection of the disease at its initial stage. …”
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Transauricular vagus nerve stimulation in preventing post-traumatic stress disorder in emergency trauma surgery patients in China: a study protocol for a multicenter, double-blind,... by Jun Zhang, Xin Yu, Gang Chen, Yu Li, Qi-Hong Shen, Xinru Lin, Tieshuai Liu, Yunyun Yu, Jingwen Liang

“…The intensity will start at 0.4 V, increasing in 0.4 V increments until a tingling sensation is detected, and will be adjusted to the highest tolerable level without causing pain. …”
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