Proteomic and serologic assessments of responses to mRNA-1273 and BNT162b2 vaccines in human recipient sera by Thomas E. Hickey, Uma Mudunuri, Heidi A. Hempel, Troy J. Kemp, Nancy V. Roche, Keyur Talsania, Brian A. Sellers, James M. Cherry, Ligia A. Pinto

“…In this proof-of-concept study, sera from male and female vaccine recipients were evaluated for proteomic and immunologic responses 1-month and 6-months following homologous third vaccination.MethodsAn aptamer-based (7,289 marker) proteomic assay coupled with traditional serology was leveraged to generate a comprehensive evaluation of systemic responsiveness in 64 and 68 healthy recipients of mRNA-1273 and BNT162b2 vaccines, respectively.ResultsSera from female recipients of mRNA-1273 showed upregulated indicators of inflammatory and immunological responses at 1-month post-third vaccination, and sera from female recipients of BNT162b2 demonstrated upregulated negative regulators of RNA sensors at 1-month. Sera from male recipients of mRNA-1273 showed no significant upregulation of pathways at 1-month post-third vaccination, though there were multiple significantly upregulated proteomic markers. …”
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Comparison of Decadal Trends among Total Solar Irradiance Composites of Satellite Observations by Nicola Scafetta, Richard C. Willson

“…The ERBE results have a sensor degradation caused downward gap trend, contrary to the SMFS/TSI paradigm, that biased the PMOD composite decadal trend downward during solar cycles 21 and 22. …”
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Involvement of Neuropeptide Y within Paraventricular Nucleus in Electroacupuncture Inhibiting Sympathetic Activities in Hypertensive Rats by Qi Zhang, Yingying Tan, Xin Wen, Fangfang Li

“…The results showed that the enhanced arterial BP and sympathetic activities were effectively reduced by 30 days of EA treatment, and baroreflex sensitivity was improved in 2K1C hypertensive rats. …”
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Computer-aided diagnosis of hepatic cystic echinococcosis based on deep transfer learning features from ultrasound images by Miao Wu, Chuanbo Yan, Gan Sen

“…Other performance measures used in the study are specificity, sensitivity, precision, F1-score, and area under the curve (AUC). …”
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Salvia deserti Decne., an endemic and rare subshrub from Arabian desert: antidiabetic and antihyperlipidemic effects of leaf hydroethanolic extracts by Arbi Guetat, Slimen Selmi, Abdelrhman T. Abdelwahab, Marwa A. Abdelfattah, Abd Ealrhman M. Elhaj, Roaa T. Mogharbel, M. J. A. Abualreish, Abdullah F. Alanazi, Karim Hosni, Naceur Mejri, Abdennacer Boulila

“…The presence of several phenolic compounds (derivatives of ferulic, coumaric, and caffeic acids, among other derivatives) could at least in part explain the obtained data and empower the use of S. deserti as a source of bioactive ingredients with antioxidant, antidiabetic and antihyperlipidemic properties.DiscussionOur research has unveiled S. deserti as a source of potential to effectively manage diabetes and its associated dyslipidemia by improving antioxidant status, recovery of the liver and kidney functions and presumably by increasing insulin secretion and sensitivity of peripheral tissues to insulin.…”
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Early risk assessment in paediatric and adult household contacts of confirmed tuberculosis cases by novel diagnostic tests (ERASE-TB): protocol for a prospective, non-interventiona... by Ursula Panzner, Katharina Kranzer, Tsitsi Bandason, Kuda Mutasa, Sandra Rukobo, Charles Sandy, Bariki Mtafya, Andrea Rachow, Norbert Heinrich, Michael Hoelscher, Judith Bruchfeld, Olena Ivanova, Nyanda Elias Ntinginya, Doreen Pamba, Laura Olbrich, Issa Sabi, Simeon Mwanyonga, Elmar Saathoff, Willyhelmina Olomi, Junior Mutsvangwa, Hazel M Dockrell, Edson Tawanda Marambire, Denise Banze, Alfred Mfinanga, Theodora D Mbunda, Khosa Celso, Gunilla Kallenius, Claire J Calderwood, Christof Geldmacher, Kathrin Held, Tejaswi Appalarowthu, Friedrich Rieß, Anna Shepherd, Christopher Sundling, Mishelle Mugava, Martha Chipinduro, Lwitiho Sudi, Antelmo Haule, Emmanuel Sichone, Paschal Qwaray, Harrieth Mwambola, Lilian Minja, Peter Edwin, Dogo Ngalison, Stella Luswema, Celina Nhamuave, António Machiana, Carla Madeira, Emelva Manhiça, Nádia Sitoe, Jorge Ribeiro

“…Statistical analyses will include assessment of diagnostic accuracy by constructing receiver operating curves and calculation of sensitivity and specificity.Ethics and dissemination ERASE-TB has been approved by regulatory and ethical committees in each African country and by each partner organisation. …”
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Cost–utility and budget impact analysis of tocilizumab for the treatment of refractory systemic juvenile idiopathic arthritis in Thailand by Nitichen Kittiratchakool, Disorn Kulpokin, Chonticha Chanjam, Soamarat Vilaiyuk, Sirirat Charuvanij, Gun Phongsamart, Parichat Khaosut, Manasita Tanya, Ratanavadee Nanagara, Sira Nantapaisarn, Pattara Leelahavarong

“…One-way and probabilistic sensitivity analysis were conducted to investigate parameter uncertainty. …”
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Oral Findings, Salivary Copper, Magnesium, and Leptin in Type II Diabetic Patients in Relation to Oral Candida Species by Mohammed Jasim Mohammed, Abbas S. Al-mizraqchi, Salah M. Ibrahim

“…Oral examination is done for the symptoms including burning sensation, candidiasis, and a reduction in the production of saliva. …”
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Study of regulated deficit irrigation regime based on individual fruit weight and quality response to water deficit duration: A case study in tomato by Xianbo Zhang, Hui Yang, Taisheng Du

“…However, for tomato, which has prolonged flowering period and whose yield and quality are both sensitive to water deficit and salt stress, RDI regime for stabilizing yield and improving quality needs to be further explored, especially for salinized soils. …”
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Antimicrobials profiling, biofilm formation, and clonal lineage of methicillin-resistant Staphylococcus aureus isolated from cockroaches by Yasin Saberi, Mehrdad Halaji, Mohsen Karami, Jalal Jafarzadeh, Kasra Javadi, Hoda Shirafkan, Abazar Pournajaf

“…This study examined 386 cockroaches, including 230 American and 156 German cockroaches. Antibiotic sensitivity, inducible resistance, and biofilm formation were evaluated. …”
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Microbes on the Mobile Phones of Healthcare Workers in Palestine: Identification, Characterization, and Comparison by Mohammad Qadi, Rasha Khayyat, Mohammed A. AlHajhamad, Yazan I. Naji, Beesan Maraqa, Kais Abuzaitoun, Ahmed Mousa, Maysa Daqqa

“…Coagulase-negative staphylococci (CoNS; 67.3%), methicillin-sensitive Staphylococcus aureus (MSSA; 17.5%), Gram-positive bacilli (4.1%), methicillin-resistant Staphylococcus aureus (MRSA; 1.6%), and Gram-negative species (1.6%) were the most predominant bacterial isolates. …”
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Análise multitemporal do uso e cobertura da terra em nove municípios do Sul do Tocantins, utilizando imagens Landsat by Leovigildo Aparecido Costa Santos, Antonio Carlos Batista, Cinthia Ohana Marques Neves, Edmar Vinicius de Carvalho, Micael Moreira Santos, Marcos Giongo

“…Os dados de 1990, 2000 e 2007 foram provenientes da base de dados da Secretaria de Planejamento e Orçamento do estado do Tocantins, e os dados de 2015 foram obtidos por meio do processamento digital das imagens do sensor OLI (Landsat-8). A classe de uso de solo agropecuária apresentou maior avanço de área, sendo o aumento de 1990 a 2015 mais expressivo nos municípios de Gurupi, Peixe e São Valério. …”
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Inversion Methods of Soil Hydraulic Parameters Based on Hyperspectral Characteristics by WU Yanmei, ZHU Han, LI Ji, LI Zixin, HE Jianliang, LIN Kairong, DONG Chunyu, ZHUANG Luwen

“…The results are as follows. ① The spectral curves exhibit clear linearity in three bands: 700–750 nm, 830–1 100 nm, and 1 520–1 620 nm, with the mean values of coefficient of determination for the linear fitting <italic>R²</italic>all over 0.94. ② Among gradient boosting regression (GBR), partial least squares regression (PLSR), and random forest (RF), GBR performs the best and shows high sensitivity to the linear fitting parameter lg<italic>a</italic>₂ (the logarithm of the slope) in the 830-1100 nm band. …”
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Economic evaluation of Maternal Depression Treatment in HIV (M-DEPTH) for perinatal depression among women living with HIV in Uganda: a cost-effectiveness analysis by Ryan McBain, Adeyemi Okunogbe, Rhoda K Wanyenze, Violet Gwokyalya, Glenn Wagner

“…This yielded an ICER of $397 per DALY averted, when limiting benefits to those accrued over the study period. Sensitivity analyses generated estimates ranging from $162 to $418 per DALY averted.Conclusions M-DEPTH represents a financially feasible task-shifted model of evidence-based perinatal depression screening and treatment. …”
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ITGA4 as a potential prognostic and immunotherapeutic biomarker in human cancer and its clinical significance in gastric cancer: an integrated analysis and validation by Jiaxing Zhang, Jiaxing Zhang, Gang Wang, Jie Liu, Futian Tang, Song Wang, Yumin Li, Yumin Li

“…It could also predict immunotherapy efficacy and chemotherapy sensitivity. In GC, high ITGA4 expression was related to poor prognosis, promoted tumor proliferation and migration, and enhanced immune cell infiltration. …”
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A Panel of Three MicroRNA Signatures as a Potential Biomarker for CRC Screening Based on Stages and Functional Prediction Using Bioinformatic Analysis by Syarah Syamimi Mohamed, Azmir Ahmad, Nurul Syakima Ab Mutalib, Tengku Ahmad Damitri Al-Astani Tengku Din, Md Salzihan Md Salleh, Andee Dzulkarnaen Zakaria, Zaidi Zakaria

“…ROC curve analysis was used to evaluate miRNAs’ diagnostic performance in the early and advanced stages. (3) Results: Collectively, hsa-miR-20a-5p showed the highest discriminative value (AUC= 0.82, sensitivity = 86%, and specificity= 88%) in discriminating early CRC, while both hsa-miR-21-5p and hsa-miR-210-3p give a perfect performance for advance CRC. …”
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Cloud-edge hybrid deep learning framework for scalable IoT resource optimization by Umesh Kumar Lilhore, Sarita Simaiya, Yogesh Kumar Sharma, Anjani Kumar Rai, S. M. Padmaja, Khan Vajid Nabilal, Vimal Kumar, Roobaea Alroobaea, Hamed Alsufyani

“…The hybrid DQN-PPO-GNN-RL model addresses bottlenecks by dynamically managing computing and network resources, allowing for efficient operations in low-latency, high-demand environments such as autonomous systems, sensor networks, and real-time monitoring. The use of Graph Neural Networks (GNNs) improves the accuracy of resource representation, while reinforcement learning-based scheduling allows for seamless adaptation to changing workloads. …”
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Scoping review and interpretation of myofascial pain/fibromyalgia syndrome: An attempt to assemble a medical puzzle. by Shiloh Plaut

“…Many studies focus on central sensitization. Therefore, the purpose of this scoping review is to systematically search cross-disciplinary empirical studies of MPS, focusing on mechanical aspects, and suggest an organic mechanism explaining how it might evolve into fibromyalgia. …”
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Patients with detectable KIT p.D816V in peripheral blood are at high risk for adverse systemic events during venom immunotherapy and treatment failure by Ajda Demšar Luzar, Jakob Otorepec, Mitja Košnik, Peter Kopač, Julij Šelb, Peter Korošec, Matija Rijavec

“…The KIT p.D816V variant was assayed with a highly sensitive, allele‐specific, quantitative PCR. Results KIT p.D816V was detected in the PBL of 125 (15%) of 839 VIT patients. …”
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Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy by Miaomiao Mao, Nikola Jancovski, Yafit Kushner, Lucas Teasdale, Phan Truong, Kun Zhou, Samuel Reid, Linghan Jia, Ye Htet Aung, Melody Li, Christopher A. Reid, Sean Byars, Ingrid Scheffer, Steven Petrou, Snezana Maljevic

“…Electrophysiology recordings in brain slices revealed a hyperexcitable phenotype for cortical layer 2/3 pyramidal neurons with retigabine (KV7 channel opener) able to rescue both the increased sensitivity to chemically-induced seizures in vivo and neuronal excitability ex vivo. …”
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