The peak efficiency of initial antihypertensive therapy of primary open-angle glaucoma considering the factors that reduce adherence to the ther by N.G. Glazko, T.M. Volobueva, E.A. Egorov

“…However, continuous drug instillation leads to several side effects (such as dryness, hyperemia, burning sensation, itching, and blurred vision after the drug instillation) induced by exposure of preservatives (i. e., an ingredient of antihypertensive drops) to the eye surface. …”
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Temperate phage-antibiotic synergy is widespread—extending to Pseudomonas—but varies by phage, host strain, and antibiotic pairing by Rabia Fatima, Alexander P. Hynes

“…Screening across multiple clinical strains reveals that temperate phages can reduce the antibiotic minimum inhibitory concentration up to 32-fold, even in a resistant isolate, functionally re-sensitizing the bacterium to the antibiotic. Meropenem and tobramycin did not reduce the frequency of lysogens, suggesting a mechanism of action independent of the temperate nature of the phages. …”
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TLR7: A Key Prognostic Biomarker and Immunotherapeutic Target in Lung Adenocarcinoma by Feiming Hu, Chenchen Hu, Yuanli He, Yuanjie Sun, Chenying Han, Xiyang Zhang, Lingying Yu, Daimei Shi, Yubo Sun, Junqi Zhang, Dongbo Jiang, Shuya Yang, Kun Yang

“…The response of the TLR7 subgroup to immunotherapy and drug sensitivity was observed. <b>Results:</b> We found significant associations between the immune and stromal components of LUAD TME and clinical features and prognosis. …”
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Circulating Stress Hormones, Brain Health, and Cognition in Healthy Older Adults: Cross-Sectional Findings and Sex Differences in Age-Well by Maxie Liebscher, Silke White, Simon Hass, Anne Chocat, Florence Mezenge, Brigitte Landeau, Marion Delarue, Oriane Hébert, Anne-Laure Turpin, Natalie L. Marchant, Gaël Chételat, Olga Klimecki, Géraldine Poisnel, Miranka Wirth, Claire André, Pierre Champetier, Léa Chauveau, Fabienne Collette, Sophie Dautricourt, Robin de Flores, Vincent De La Sayette, Harriet Demnitz-King, Séverine Fauvel, Francesca Felisatti, Victor Ferment, Eglantine Ferrand-Devouge, Julie Gonneaud, Antoine Garnier-Crussard, Anaïs Hamel, Sacha Haudry, Pierre Krolak-Salmon, Elizabeth Kuhn, Valérie Lefranc, Antoine Lutz, Valentin Ourry, Cassandre Palix, Anne Quillard, Géraldine Rauchs, Eric Salmon, Edelweiss Touron, Patrik Vuilleumier, Tim Whitfield

“…Stress hormone levels were measured in overnight fasting blood serum (cortisol, dehydroepiandrosterone sulfate) and blood plasma (epinephrine, norepinephrine) samples. AD-sensitive measures of brain health, including glucose metabolism (n = 89), cerebral perfusion, gray matter volume, amyloid deposition in a priori regions of interest, and cognitive markers were evaluated. …”
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Association of Serum Gamma-Glutamyltransferase with In-hospital Heart Failure in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary I... by An-Cheng Hou, Jian-Tong Hou, Wei-Ning Zhou, Yan-Jin Wei, Zhi-Hong Ou, Cun-Fei Liu

“…The area under the curve was 0.607 (95% CI, 0.558–0.654; p = 0.007) when GGT was used to predict in-hospital HF, with a sensitivity of 57.14% and a specificity of 64.04%. Moreover, the incidence of HF significantly increased in-hospital death risk (OR, 7.75; 95% CI, 1.87–32.12; p = 0.005). …”
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Hippocampal dendritic spines store-operated calcium entry and endoplasmic reticulum content is dynamic microtubule dependent by Anastasiya Rakovskaya, Ekaterina Volkova, Ilya Bezprozvanny, Ekaterina Pchitskaya

“…Abstract One of the mechanisms of calcium signalling in neurons is store-operated calcium entry (SOCE), which is activated when the calcium concentration in the smooth endoplasmic reticulum (ER) decreases and its protein-calcium sensor STIM (stromal interacting molecule) relocate to the endoplasmic reticulum and plasma membrane junctions, forms clusters and induces calcium entry. …”
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Parodontgel® on Wound Healing and Patient-Reported Outcome Measures (PROMs) after Tunneled Coronally Advanced Flap (TCAF) by Leonardo Mancini, Vincenzo Mancini

“…A 33-year-old male patient with a central lower incisor class RT1 recession sought treatment due to sensitivity and dissatisfaction with the appearance of his smile. …”
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Leucine-rich alpha-2 glycoprotein in combination with C-reactive protein for predicting endoscopic activity in Crohn’s disease: a single-centre, cross-sectional study by Yoshiaki Takada, Hiroki Kiyohara, Yohei Mikami, Masataka Taguri, Ryoya Sakakibara, Yasuhiro Aoki, Kosaku Nanki, Takaaki Kawaguchi, Yusuke Yoshimatsu, Shinya Sugimoto, Tomohisa Sujino, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Motohiko Kato, Yasushi Iwao, Nobuhiro Nakamoto, Takanori Kanai

“…LRG and CRP concentrations were considered positive when they were above these cut-off values, and the sensitivity and specificity for an SES-CD > 6 were 58.3% and 93.8%, respectively. …”
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Salivary Lactate Dehydrogenase in Relationship to the Severity of Hypoxic-Ischemic Encephalopathy among Newborn Infants by Hend Elmoursi, Mohamed Abdalla, Bader Eldin Mesbah, Abdelmoneim Khashana

“…The best cutoff value was 1420 IU/L or more which showed the best results in predicting the occurrence of HIE with 98.3% and 97.6% sensitivity and specificity, respectively. Conclusion. …”
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Associations between HEXACO personality traits, substance use disorders, and behavioral addictions: a protocol for a comprehensive systematic review and meta-analysis by Farangis Sharifibastan, Eilin Kristine Erevik, Katharina Teresa Enehaug Morken, Ståle Pallesen

“…Subgroup analyses and meta-regression will be performed to investigate potential sources of heterogeneity. Sensitivity analyses will examine the robustness of the results. …”
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Detection of Circulating Tumor DNA in Patients with Thyroid Nodules by Krupal B. Patel, Nicholas Cormier, James Fowler, Allison Partridge, Julie Theurer, Morgan Black, Nicole Pinto, John Yoo, Kevin Fung, Danielle MacNeil, William Stecho, Christopher Howlett, Muriel Brackstone, John W. Barrett, Anthony Nichols

“…Detection of circulating tumor DNA (ctDNA) in cancer patients can potentially serve as a noninvasive, sensitive test of disease status. The purpose of this study was to determine the ability to detect BRAF (V600E) mutations in the plasma of patients with thyroid nodules, with the goal of distinguishing between benign and malignant nodules. …”
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Correlation of GLUT4, LEPR , and TNF-a with endometrial receptivity in women with polycystic ovarian syndrome-induced infertility by Yan Dong, Kong Wei, Yifei Li, Yan Liu, Lin Li, Yan Li

“…Results: GLUT4 was lower in the research group compared with the control and normal groups, while LEPR and TNFa were higher (P<0.05); the control group showed lower GLUT4 and higher LEPR and TNF-a levels than the normal group (P<0.05). The diagnostic sensitivity and specificity of GLUT4, LEPR, and TNF-a combined assay for PCOSinduced infertility in PCOS women were 88.57% and 75.00%, respectively, and those for PCOS in healthy women were 78.57% and 60.00%, respectively (P<0.05). …”
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Anomaly Detection Using Explainable Random Forest for the Prediction of Undesirable Events in Oil Wells by Nida Aslam, Irfan Ullah Khan, Aisha Alansari, Marah Alrammah, Atheer Alghwairy, Rahaf Alqahtani, Razan Alqahtani, Maryam Almushikes, Mohammed AL Hashim

“…An offshore oil well is an oil well type where a wellbore is drilled underneath the ocean bed to obtain oil to the surface that demands more stability than other oil wells. The sensors of oil wells generate massive amounts of multivariate time-series data for surveillance engineers to analyze manually and have continuous insight into drilling operations. …”
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The Role of Phosphatidylethanolamine-N-methyltransferase (PEMT) Gene rs12449964 Polymorphism in the Development of Acute Pancreatitis and its Complications by T. A. Samgina, Yu. E. Azarova, Yu. V. Kanishchev, V. A. Lazarenko, P. M. Nazarenko, A. V. Polonikov

“…The disruption of phosphatidylethanolamine methylation processes increases the sensitivity of cells to oxidative stress, which can lead to the development of acute pancreatitis.…”
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Optimal Embryo Selection: The Irreplaceable Role of the Embryologist in an Age of Advancing Technology by Lauren Kendall Rauchfuss, Yulian Zhao, David Walker, Terri Galantis, Jolene Fredrickson, Kathrynne Barud, Chandra Shenoy

“…Using the ROC-determined cutoff that optimised both sensitivity and specificity, a binary outcome for each test was analysed using agreement statistics to determine if one method of embryo evaluation was superior to the other. …”
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Assessing the Logistics Efficiency of Baltic Region Seaports Through DEA-BCC and Spatial Analysis by Vilma Locaitienė, Kristina Čižiūnienė

“…The spatial autocorrelation analysis examined the relationships among the Baltic Sea ports, container volumes, and logistic efficiency values derived from the DEA model. Recognizing the sensitivity of the weight matrix in previous studies, this paper introduced an enhanced two-factor weighting matrix that incorporated geographical distance and the port connectivity index, calculated by the United Nations Conference on Trade and Development (UNCTAD). …”
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Changes and Diurnal Variation of Visual Quality after Orthokeratology in Myopic Children by Hao-Chen Guo, Wan-Qing Jin, An-Peng Pan, Qin-Mei Wang, Jia Qu, A-Yong Yu

“…Parameters including corneal curvature, ocular objective scatter index (OSI), the modulation transfer function (MTF), root mean square of ocular and corneal wavefront aberrations, and contrast sensitivity function (CSF) were measured before and at two time points during the same day after 1 month of orthokeratology. …”
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Demographic influences on Lithuanian physicians’ attitudes toward medical assistance in dying: a cross-sectional study by Benedikt Bachmetjev, Artur Airapetian, Marija Jakubauskienė, Rolandas Zablockis, Asta Čekanauskaitė

“…Significantly lower acceptance for psychiatric patients indicates higher sensitivity regarding mental competency and the ethics of E/PAS in such cases. …”
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Positive Pneumocystis jirovecii Sputum PCR Results with Negative Bronchoscopic PCR Results in Suspected Pneumocystis Pneumonia by Kelly Pennington, John Wilson, Andrew H. Limper, Patricio Escalante

“…The diagnostic standard for Pneumocystis jirovecii pneumonia (PCP) is direct microscopic identification; however, in recent years, polymerase chain reaction (PCR) from bronchoalveolar lavage (BAL) samples to detect Pneumocystis nucleic acids has proven to be more sensitive and specific. Sputum samples have been presumed inferior to bronchoscopic samples secondary to variability and adequacy of sample collection. …”
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Investigation of The Effect of Smoking on Some Blood Parameters and Respiratory Functions in Wrestlers by Kürşat Hazar

“…For this reason, it is necessary to emphasize the importance of smoking in the wrestlers to ensure that both athletes and coaches demonstrate the required sensitivity.…”
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