Different Responses to Drug Safety Screening Targets between Human Neonatal and Infantile Heart Tissue and Cardiac Bodies Derived from Human-Induced Pluripotent Stem Cells by Jan Trieschmann, Moritz Haustein, Annette Köster, Jürgen Hescheler, Konrad Brockmeier, Gerardus Bennink, Tobias Hannes

“…If used for cardiotoxicity screening, caution is warranted as hiPS-CBs might be less sensitive to pharmacologic targets compared to the native myocardium of neonates and infants.…”
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Changing of expression actinbinding proteins in the kidney under dehydration by I. I. Khegay

“…The most probable molecular mechanism of changing the expression of the genes for alpha-actinin and tropomyosin is transduction of the V2-mediated vasopressin hormonal signal to protein kinase A, phosphorylation of the cAMPresponsible transcriptional factor CREB, and nuclear CREB interaction with gene CRE sites sensitive to it.…”
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Workflow for Conflict and Reinforcement Identification Based on STPA and STRIDE by Andrei Carniel, Juliana de Melo Bezerra, Celso Massaki Hirata

“…CPSs involve processing and storage units, mechanical and electrical components, sensors, actuators, and communication networks, having software as the dominant part of this integration. …”
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Adaptation and combination of two scales to measure dispositional gratitude in health sciences faculty: a psychometric analysis by Jesus Alfonso Beltran-Sanchez, José Moral de la Rubia, Adrian Valle de la O, Josue Omar Nava-Manzo, Angeles Dominguez

“…Gratitude has proven to be sensitive to different cultures. This research aims to determine the psychometric properties using a combined scale to measure dispositional gratitude in health sciences faculty. …”
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Incidence Density Rate of Neonatal Mortality and Predictors in Sub-Saharan Africa: A Systematic Review and Meta-Analysis by Zebenay Workneh Bitew, Ayinalem Alemu, Ermias Getaneh Ayele, Desalegn Abebaw Jember, Michael Tamene Haile, Teshager Worku

“…Fixed and random effect models were used to compute pooled estimates. Subgroup and sensitivity analyses were performed. Results. Neonates were followed for a total of 1,095,611 neonate-days; 67142 neonate-days for neonates treated in neonatal intensive care units and 1,028,469 neonate-days for community-based studies. …”
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Aberrant SNHG expression predicts poor prognosis in esophageal cancer using meta-analysis and bioinformatics analysis by Ke Shi, Li-De Huang, Dan Li, Wei-Min Luo, Hua-Song Liu, Dong-Xiao Ding, Qiang Guo, Yue-Feng Liu

“…Odds ratio (OR) with 95%CI were extracted to assess the association between SNHG expression and other clinicopathological parameters. Sensitivity analysis and publication bias were performed to explore the reliability and robustness of the results. …”
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Soil total carbon as a key factor affects soil biota attributes in plant mixtures over time: A meta-analysis by Huiling Zhang, Jinshan Cai, Xu Yang, Jing Huang, Xuan Zhou, Dima Chen

“…The responses of soil microbial attributes were more sensitive than soil fauna abundances under plant mixture over time. …”
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Development and validation of a Non-INvaSive Pregnancy RIsk ScoRE (INSPIRE) for the screening of high-risk pregnant women for gestational diabetes mellitus in Pakistan by Romaina Iqbal, Iqbal Azam, Subhash Chandir, Rahat Qureshi, Ali Jaffar, Neelofur Babar, Sabahat Naz, Samreen Jamal, Aisha Syed Wali

“…INSPIRE achieved a good calibration (Pearson’s χ2=29.55, p=0.08) and acceptable discrimination with an AUC of 0.721 (95% CI 0.61 to 0.83) with a sensitivity of 74.1% and specificity of 59.4% in the validation dataset.Conclusion We developed and validated an INSPIRE that efficiently differentiates Pakistani pregnant women at high risk of GDM from those at low risk, thus reducing the unnecessary burden of the OGTT test.…”
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Healing potentiality of blood clot, S-PRF and A-PRF as scaffold in treatment of non-vital mature single rooted teeth with chronic peri-apical periodontitis following regenerative e... by Omnia Badawy Darwish, Said Mohamed Abdel Aziz, Hany Samy Sadek

“…Incidence of the gaining sensitivity after 12 and 18 months was 29.4% with A-PRF group and 41.2% within the S-PRF group, 17.6% with BC group. …”
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Epidemiological Dynamics of Extended-Spectrum β-Lactamase- or AmpC β-Lactamase-Producing Escherichia coli Screened in Apparently Healthy Chickens in Uganda by Steven Kakooza, Damien Munyiirwa, Paul Ssajjakambwe, Edrine Kayaga, Dickson Stuart Tayebwa, Dickson Ndoboli, Loreen Basemera, Esther Nabatta, Maria Agnes Tumwebaze, John Baligwamunsi Kaneene

“…Consequently, injudicious antimicrobial use should be replaced with an accurate diagnosis by bacterial culture and sensitivity testing so as to circumvent AMR emergence, spread, and associated losses.…”
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Affective-sexual and gender diversity in Spanish education: a systematic literature review by Delfín Ortega-Sánchez, Esther Sanz de la Cal, Jaime Ibáñez Quintana, Eduardo Encabo-Fernández

“…Similarly, the visibility of diverse identities, social inclusion, and plurality are associated with the necessity for education geared toward democratic citizenship. The sensitivity of the content and its curricular invisibility, along with training deficiencies, lack of academic recognition, and the absence of specific protocols for preventing LGBTIQphobia are identified as the most prominent limitations or hurdles for the comprehensive promotion of education pertaining to affective-sexual and gender diversity across distinct educational stages.DiscussionInstances of discrimination, harassment, and both physical and symbolic violence against non-heteronormative groups, grounded in the sex-gender system and cis-heteronormativity, continue to be recognized by educators. …”
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Analysis of vulnerability, its drivers, and strategies applied towards reducing the pastoral and agro-pastoral livelihood vulnerability to climatic shocks by Daniel Assefa Tofu, Tegegn Dilbato, Chalchisa Fana, Niguse Bekele Dirbaba, Gutu Tesso

“…Arid and semi-arid ecosystems are sensitive to changes in climate variability, including the Borana zone. …”
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Metabolism features and milk microbiota of cows with mastitis in the Amur Oblast by M. E. Ostyakova, I. S. Shulga, V. K. Irkhina, K. S. Kositsyna, N. S. Golaydo

“…The aim of the work was to study the microbiological profile of milk, the sensitivity of isolated microorganisms to antibiotics and metabolism features of cows with mastitis in the Amur Oblast. …”
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Pelnac® artificial dermis assisted by vacuum sealing drainage for treatment of severe avulsion injuries of the fingers by Zhenmu Lv, Yujie Wang, Jingliang Chen, Qingfu Zhang, Haitao Zhao

“…Ten patients reported normal or near-normal sensation, while 2 patients experienced slight sensory loss. …”
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Effects of biochar on soil respiration mediated by rainfall events: evidence from one-year field experiment in an urban forest by Haoran Zu, Zijun Deng, Xin Liu, Junyi Luo, Ying Chen, Meiling Yi, Xiao Wang, Xiaocui Liang, Xiang Zhang, Wende Yan

“…The significant correlation between soil moisture and the temperature sensitivity of soil respiration (Q 10) was eliminated by biochar application, both during one day after rainfall events and more than eight days after rainfall events. …”
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Point-of-care lung ultrasonography for early identification of mild COVID-19: a prospective cohort of outpatients in a Swiss screening center by Olivier Hugli, Jean-Yves Meuwly, Noémie Boillat-Blanco, Pierre-Nicolas Carron, Siméon Schaad, Thomas Brahier, Mary-Anne Hartley, Jean-Baptiste Cordonnier, Luca Bosso, Tanguy Espejo, Olivier Pantet

“…However, LUS has an insufficient sensitivity and is not an appropriate screening tool in outpatients. …”
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Effects of nitrogen deposition on soil nitrogen fractions and enzyme activities in wet meadow of the Qinghai-Tibet Plateau by Jiangqi Wu, Haiyan Wang, Guang Li, Nan Chen

“…The nitrogen component content within the surface soil (0–10 cm) under four treatments is more sensitive to N addition, whereas the nitrogen component in the deep soil is relatively stable. …”
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Factores de riesgo que influyen en la recaída de consumo de drogas lícitas e ilícitas en adolescentes atendidos en el Instituto sobre Alcoholismo y Farmacodependencia / Risk Factor... by Tatiana Blanco-Álvarez, Silvia Jiménez-Morales

“…Conclusions: intrapersonal variables such as emotional regulation (goal-directed behavior), attentional control (focused attention), negative emotional states, and seeking positive sensations are risk factors that determine drug consumption relapse. …”
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Association between Circulating B-Type Natriuretic Peptide and Diabetic Peripheral Neuropathy: A Cross-Sectional Study of a Chinese Type 2 Diabetic Population by Pijun Yan, Qin Wan, Zhihong Zhang, Yong Xu, Ying Miao, Pan Chen, Chenlin Gao

“…Last but most importantly, the analysis of receiver operating characteristic curves revealed that the best cutoff value for circulating levels of BNP to predict DPN was 15.18 pg/mL (sensitivity 78.7% and specificity 48.2%). These findings suggest that high circulating physiological levels of BNP may be associated with the development of DPN and may be a potential biomarker for DPN in patients with T2DM.…”
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Development and internal validation of the Edmonton Obesity Staging System-2 Risk screening Tool (EOSS-2 Risk Tool) for weight-related health complications: a case-control study in... by Evan Atlantis, P Fahey, Kathryn Williams, Paul Dugdale, James Rufus John, SL Hocking, Kath Peters

“…The final model was chosen based on the area under the receiver operating characteristic curve and the Hosmer-Lemeshow statistic; and validated using sensitivity, specificity and positive predictive value.Setting and participants We analysed cross-sectional data from the Australian Health Survey 2011–2013 sample aged between 18 and 65 years (n=7518) with at least overweight and obesity.Results An EOSS≥2 classification was present in 78% of the sample. …”
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