Effect of Sechium edule extract on blood sugar levels and pancreatic histopathology in male Rats with type II diabetes mellitus by Marti Silfia, Gusbakti Rusip, Linda Chiuma, Ade Indra Mukti, Lia Restumulia

“…The etiology of diabetes varies depending on its type, including Type 1 diabetes, which is caused by autoimmune destruction of pancreatic beta cells responsible for insulin production; Type 2 diabetes, resulting from insulin resistance; and gestational diabetes, triggered by hormonal changes during pregnancy affecting insulin sensitivity. Insulin plays a crucial role in glucose metabolism by converting glucose into glycogen for storage. …”
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Incidence and influencing factors related to social isolation among HIV/AIDS patients: Protocol for a systematic review and meta-analysis. by Qiao Wu, Jiarong Tan, Shu Chen, Jiayi Wang, Xiaogang Liao, Lingling Jiang

“…Sources of heterogeneity will be accounted for by subgroup and sensitivity analyses.<h4>Results</h4>The results may reveal the prevalence of social isolation among PLWH and provide data support for understanding its etiology and prevention.…”
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GENDER-SPECIFIC INFLUENCE OF Aу MUTATION ON PROGENY METABOLIC PHENOTYPE, FETAL GROWTH AND PLACENTAL GENE EXPRESSION IN MICE by E. N. Makarova, E. I. Denisova, V. V. Kozhevnikova, A. E. Kuleshova

“…Aim: to study the influence of Ау mutation on sensitivity to diet-induced obesity in male and female offspring, on fetal and placental weight and on the expression of genes in the placentas of the fetuses of different sexes. …”
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Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis by Wenwen Zhu, Jiali Fang, Chenbo Ji, Hong Zhong, Tianying Zhong, Xianwei Cui

“…Exposure to mixed NEOs during gestation resulted in elevated glucose levels and impaired insulin sensitivity in normal pregnant and GDM mice models. …”
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Performance of current tools used for on-the-day assessment and diagnosis of mild traumatic brain injury in sport: a systematic review by Phoebe Haste, Leonardo de Almeida e Bueno, Antoine Jérusalem, Jeroen Bergmann

“…Area under the curve (AUC), sensitivity and specificity were the most frequent outcome metrics provided. …”
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Creep Energy Evolution of Red-Bed Soft Rocks in South China under Chemical-Stress-Seepage Coupling by Shuguang Zhang, Fanyao Peng, Yingbo Li, Zhifeng Liu, Wenbo Liu

“…The instantaneous strain is more sensitive to the acidity of the chemical solution, and the proportion of creep strain increases gradually with the increase of seepage pressure. …”
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Exercise-induced methylation of the Serhl2 promoter and implication for lipid metabolism in rat skeletal muscle by Mutsumi Katayama, Kazuhiro Nomura, Jonathan M. Mudry, Alexander V. Chibalin, Anna Krook, Juleen R. Zierath

“…A Nr4a binding motif in the Serhl2 promoter, when deleted, reduced promoter activity and sensitivity to methylation in L6 myotubes. Silencing Serhl2 in L6 myotubes reduced intracellular lipid oxidation and triacylglycerol synthesis in response to EPS. …”
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Chronic kidney disease among people living with HIV on TDF based regimen: A systematic review and meta-analysis. by Taklo Simeneh Yazie, Wondimeneh Shibabaw Shiferaw, Asaye Alamneh Gebeyehu, Assefa Agegnehu Teshome, Zenaw Debasu Addisu, Abebe Muche Belete

“…All statistical analysis including sensitivity analysis were made using Stata 17 software.…”
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Reverse-Phase Chromatographic Determination and Intrinsic Stability Behavior of 5-[(4-Chlorophenoxy)Methyl]-1,3,4-Oxadiazole-2-Thiol by Shehzadi Naureen, Hussain Khalid, Islam Muhammad, Bukhari Nadeem Irfan, Khan Muhammad Tanveer, Salman Muhammad, Siddiqui Sabahat Zahra, Rehman Aziz-Ur, Abbasi Muhammad Athar

“…The results of the study indicate that the method is selective, sensitive and suitable to be used for determination of OXCPM in bulk and under stress conditions.…”
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Prevalence and Characterization of Streptococcus pyogenes Clinical Isolates from Different Hospitals and Clinics in Mansoura by Zeinab M. Helal, Dina E. Rizk, Mohamed M. Adel El-Sokkary, Ramadan Hassan

“…S. pyogenes isolates were identified by their bacitracin sensitivity, positive spy1258 detection, and positive GAS latex agglutination. …”
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Innovative applications and future trends of multiparametric PET in the assessment of immunotherapy efficacy by Tingting Qiao, Tingting Qiao, Zhaoping Cheng, Yanhua Duan

“…The integration of multi-omics data (including genomics and proteomics) with PET imaging enhanced the sensitivity and accuracy of efficacy prediction. Through integrated analysis, PET metabolic parameters demonstrated potential in predicting immune therapy response patterns, such as pseudo-progression and hyper-progression.ConclusionThe integration of multiparametric PET imaging and multi-omics data holds broad potential for predicting the efficacy of immunotherapies and may support the development of personalized treatment strategies. …”
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Polysomnographic features of children with obesity: body mass index predict severe obstructive sleep apnea in obese children? by Rungrat Sukharom, Prakarn Tovichien, Kanokporn Udomittipong, Pinyapach Tiamduangtawan, Wattanachai Chotinaiwattarakul

“…These findings suggest a cutoff BMI for predicting severe OSA of greater than 29.2 kg/m2 with 81.3% sensitivity and 48.5% specificity. Conclusion Severe OSA is common in children with obesity; thus, we recommend screening children with obesity and a BMI greater than 29.2 kg/m2 for severe OSA.…”
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Dietary inflammatory index and disability among older adults in Guangzhou: a cross-sectional analysis by Junbin Liao, Junbin Liao, Wenfeng Cai, Danrong Lin, Yuanyun Xiao, Yanxi Liu, Yahui Wang, Yuquan Zhong, Fan Xiao, Heng Fang, Yilu Yao, Yunfeng Lin, Jiewen Su, Siyu Sun, Bo Zhang, Yan Wang, Wei Zhu, Wei Zhu

“…Restricted cubic spline and sensitivity analyses were used to assess the association between DII and the degree of disability of the older adult population.ResultsInactivity (never exercising, OR = 8.48, 95% CI = 2.30–31.31) and reduced activity (formerly exercising, OR = 4.85, 95% CI = 1.39–16.96), stroke (OR = 2.78, 95% CI = 1.61–4.80), and dementia (OR = 2.69, 95% CI = 1.26–5.78) were significantly associated with increased disability. …”
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Mutation yellow in agouti loci prevents age-related increase of skeletal muscle genes regulating free fatty acids oxidation by Y. V. Piskunova, A. Y. Kazantceva, A. V. Baklanov, N. M. Bazhan

“…The relative mRNA level of genes was measured by real-time PCR in skeletal muscles (uncoupling protein 3 (Ucp3) and carnitine palmitoyl transferase 1b (Cpt1b) (free fatty acids oxidation), solute carrier family 2 (facilitated glucose transporter), member 4 (Slc2a4) (glucose uptake)), in WAT lipoprotein lipase (Lpl) (triglyceride deposition), hormone-sensitive lipase (Lipe) (lipid mobilization), and Slc2a4 (glucose uptake)), and in BAT: uncoupling protein 1 (Ucp1) (energy expenditure). …”
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Data-Oriented Analysis of Uplink Transmission in Massive IoT System With Limited Channel Information by Jyri Hamalainen, Rui Dinis, Mehmet C. Ilter

“…Also, it is shown that the channel side-information based cooperation is robust against changes in the radio environment but sensitive to possible errors in the channel side-information. …”
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A Novel Approach for Monitoring the Ecoenvironment of Alpine Wetlands using Big Geospatial Data and Cloud Computing by Haijun Wang, Xiangdong Kong, Ji Luo, Pengju Li, Tianhui Xie, Xiaobo Yi, Fang Wang, Jie Xiao

“…Alpine wetlands in western Sichuan plateau (WSCP) are located on the eastern edge of the Qinghai-Tibet Plateau (QTP), where the ecological environment is very sensitive to global climate change. Being naturally driven coupled with unreasonable human development activities, alpine wetlands have experienced serious ecological and environmental issues such as drought, inversion, and desertification. …”
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Clinical characteristics of EGFR-ctDNA shedders in EGFR-mutant NSCLC patients by Martina Ruglioni, Iacopo Petrini, Stefania Crucitta, Andrea Sbrana, Giovanna Irene Luculli, Leila Sadeghi Gol, Carola Forte, Antonio Chella, Christian Rolfo, Romano Danesi, Marzia Del Re

“…Background: Circulating tumor DNA (ctDNA) revolutionized the molecular diagnostics of lung cancer by enabling non-invasive, sensitive identification of actionable mutations. However, ctDNA analysis may be challenging due to tumor shedding variability, leading to false negative results. …”
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Addressing genome scale design tradeoffs in Pseudomonas putida for bioconversion of an aromatic carbon source by Deepanwita Banerjee, Javier Menasalvas, Yan Chen, Jennifer W. Gin, Edward E. K. Baidoo, Christopher J. Petzold, Thomas Eng, Aindrila Mukhopadhyay

“…Through proteomics, promoter-variation, and growth characterization of a fully implemented gene deletion design, we provide evidence that aromatic catabolism in the completed design is rate-limited by fumarase hydratase (FUM) enzyme activity in the citrate cycle and requires careful optimization of another fumarate hydratase protein (PP_0897) expression to achieve growth and production. A double sensitivity analysis also confirmed a strict requirement for fumarate hydratase activity in the strain where all genes in the growth coupling design have been implemented. …”
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Liquid Chromatographic–Mass Spectrometric Determination of Ezetimibe in Human Plasma With Validation Approach by Ahmed A. Alobaida

“…Materials and Methods: The quantification of free and total EZ in human plasma was achieved by the creation of a straightforward, quick, and highly sensitive mass detection method by applying the liquid chromatographic technique. …”
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Benchmarking passive-microwave-satellite-derived freeze–thaw datasets by A. Bartsch, X. Muri, M. Hetzenecker, K. Rautiainen, H. Bergstedt, J. Wuite, T. Nagler, D. Nicolsky

“…Frozen versus unfrozen conditions are operationally mostly derived using passive microwave (PMW) measurements from various sensors and different frequencies. Products differ thematically, as well as in terms of spatial and temporal characteristics. …”
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