Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia by Sabrina Grundtner, Julia R. Sondermann, Feng Xian, Daniel Malzl, Daniel Segelcke, Esther M. Pogatzki-Zahn, Jörg Menche, David Gómez-Varela, Manuela Schmidt

“…We quantified over 12,000 proteins, including notable ion channels involved in pain, highlighting the sensitivity of our approach. Differential expression revealed sex- and age-dependent proteome changes upon nerve injury. …”
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Effect of Intervention of Vaccination and Treatment on the Transmission Dynamics of HBV Disease: A Mathematical Model Analysis by Firaol Asfaw Wodajo, Temesgen Tibebu Mekonnen

“…Both local and global asymptotic stability conditions for disease-free and endemic equilibria are determined. The sensitivity index shows that the transfer rate from exposed class to acute infective class and transfer rate from exposed class to chronic infective class are the most dominant parameters contributing to the transmission of HBV. …”
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The Study on Blockchain Adoption Strategies for Pharmaceutical Regulatory Products Under Dual-Channel Competition by Jianan Chen, You Xiao, Nianxing Yuan, Yong Wang, Jiamin Zhang, Lihui Wang

“…Additionally, numerical analysis is conducted using hypothetical parameter values to evaluate the influence of factors like market potential demand, price sensitivity, and the negative impact of non-adoption. …”
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Machine learning and SHAP value interpretation for predicting comorbidity of cardiovascular disease and cancer with dietary antioxidants by Xiangjun Qi, Shujing Wang, Caishan Fang, Jie Jia, Lizhu Lin, Tianhui Yuan

“…LightGBM also demonstrated balanced sensitivity and specificity, both close to 88 %. SHAP analysis indicated that naringenin, magnesium, theaflavin, kaempferol, hesperetin, selenium, malvidin, and vitamin C were the most influential contributors. …”
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A modeling of budget optimization for the strategic plan of universities by different faculties: a case study in Allameh Tabataba'i University by Hassan Rashidi, Morteza Khorsandi, Fatemeh Shams

“…These nine activities include 1) publishing a book, 2) publishing an internal article, 3) publishing an external article, 4) holding a theory session, 5) holding a meeting to solve problems and a promotional session, 6) implementing educational plans, 7) holding internal and external conferences, 8) holding internal and external workshops and meetings, and 9) other activities.Originality/Value: Implementing this model and performing sensitivity analysis on its important parameters will bring acceptable and effective results for the support of faculty officials as well as managers of the university's strategic plan.…”
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Association of Visceral Adipose Tissue With Hypertension: Results From the NHANES 2011–2018 and Mendelian Randomization Analyses by Jia Liao, Miaohan Qiu, Jing Li, Yi Li, Yaling Han

“…The primary analysis employed the random‐effects inverse‐variance weighted (IVW) method, with MR‐Egger, weighted median, simple mode, and weighted mode as sensitivity analyses. A total of 7661 participants were included. …”
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Assessing the effects of diabetes mellitus on the monocyte-to-lymphocyte ratio and the QuantiFERON-TB gold plus assays for tuberculosis treatment monitoring: a prospective cohort s... by Paulo Ranaivomanana, Arimanitra Razafimahefa, Mame Ndiaye, Crisca Razafimahatratra, Haja Ramamonjisoa, Perlinot Herindrainy, Mamy Raherison, Antso Hasina Raherinandrasana, Julio Rakotonirina, Jonathan Hoffmann, Rila Ratovoson, Niaina Rakotosamimanana

“…The aim of this study was to assess the influence of DM on the respective performances of QFT-P and WBC assays in their capacities to monitor the treatment of drug-sensitive pulmonary TB (TBP). The QFT-P and WBC were prospectively compared between TB patients with and without DM at inclusion (D0), at the end of treatment (M6) and two months after the end of treatment (M8). …”
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Prevalence of direct antiglobulin test positive in whole blood donors: Study at a tertiary blood center Northern India by Jyoti Bharti, Archana Solanki, Ashutosh Singh, Mallika Agarwal, Tulika Chandra

“…BACKGROUND: The direct antiglobulin test (DAT) detects red blood cell (RBC) sensitivity to complement or IgG in vivo. The clinical disorders of hemolytic disease of the newborn, hemolytic transfusion reaction, and autoimmune and drug-induced hemolytic anemia are some examples of those that can cause in vivo coating of RBCs with antibodies or complement autoimmune hemolytic anemia (AIHA). …”
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Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels by Zhikui Zhou, Baiyun Fan, Qiang Chen, Xuezhong Li, Xianjin Ke

“…Serum NfL levels were measured using a highly sensitive immunoassay. Bayesian kernel machine regression (BKMR) models were used to estimate the combined effects of vitamin mixtures on cognitive function.ResultsIn both single- and multiple-vitamin models, individuals with a higher intake of dietary vitamin K exhibited greater global cognitive function, compared to those with a lower vitamin intake. …”
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DOCK4 Is a Platinum-Chemosensitive and Prognostic-Related Biomarker in Ovarian Cancer by Qianqian Zhao, Jie Zhong, Ping Lu, Xiao Feng, Ying Han, Chenqi Ling, Wenke Guo, Weijin Zhou, Fudong Yu

“…Several reports point out that PPARs can also have an effect on the sensitivity of tumor cells to platinum-based chemotherapy drugs. …”
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A Nationwide Exploration of Social Inequalities in Cancer Mortality Amidst the COVID‐19 Pandemic in Belgium by Yasmine Khan, Laura Van den Borre, Delphine De Smedt, Nick Verhaeghe, Brecht Devleesschauwer, Patrick Deboosere, Katrien Vanthomme, Sylvie Gadeyne

“…Relative inequalities in cancer mortality by social groups were calculated for both time frames using Poisson regression. Sensitivity analysis considered any mention of specified cancer groups on the Belgian death certificate. …”
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Design and pilot evaluation of a brief intervention to reduce transphobia and improve attitudes of government officials to address legal gender affirmation needs of transgender peo... by Sari L. Reisner, Amaya Perez-Brumer, Ximena Salazar, Alfonso Silva-Santisteban

“…This project, in partnership with Registro Nacional de Identificación y Estado Civil (RENIEC) and transgender communities, designed and piloted a group-based intervention to sensitize government officers to the importance of gender-concordant identity documents. …”
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Lyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysis by Ganesh Bushi, Ashok Kumar Balaraman, Shilpa Gaidhane, Suhas Ballal, Sanjay Kumar, Mahakshit Bhat, Shilpa Sharma, M Ravi Kumar, Aashna Sinha, Mahalaqua Nazli Khatib, Nishant Rai, Sanjit Sah, Ambanna Yappalparvi, Shailesh Kumar Samal, Doddolla Lingamaiah, Muhammed Shabil

“…Although heterogeneity across the studies was high, sensitivity analysis confirmed the consistency of our findings. …”
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X-ray pulsed light curves of highly compact neutron stars as probes of scalar–tensor theories of gravity by Tulio Ottoni, Jaziel G. Coelho, Rafael C. R. de Lima, Jonas P. Pereira, Jorge A. Rueda

“…Our investigation is motivated by the increased sensitivity of the pulse to the scalar charge of the spacetime in such high compactness regimes, making these systems exceptionally suitable for scrutinizing deviations from GR, notably phenomena such as spontaneous scalarization, as predicted by STT. …”
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Evaluation of Antimicrobial Resistance in Staphylococcus aureus Isolates by Years by Cennet Rağbetli, Mehmet Parlak, Yasemin Bayram, Huseyin Guducuoglu, Nesrin Ceylan

“…According to the results of susceptibility tests of all isolates of S. aureus, they have been identified as sensitive to vancomycin, daptomycin, linezolid, and levofloxacin. …”
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Serum VEGF: Diagnostic Value of Acute Coronary Syndrome from Stable Angina Pectoris and Prognostic Value of Coronary Artery Disease by Anan Huang, Xin Qi, Yameng Cui, Yulin Wu, Shiqi Zhou, Mingyin Zhang

“…VEGF serum concentrations were higher in the ACS subgroup than in the SAP subgroup (P<0.001) with diagnostic accuracy of ACS from SAP (AUC: 0.667, sensitivity: 68.5%, specificity: 60.1%, P<0.001). Patients with high risk of Gensini score showed reduced VEGF levels (P<0.001) accompanied by a negative correlation (r = −0.396, P<0.001). …”
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Hyperthermia and cisplatin combination therapy promotes caspase-8 accumulation and activation to enhance apoptosis and pyroptosis in cancer cells by Guanghui Zi, Jin Chen, Yatu Peng, Yue Wang, Baowei Peng

“…Knockdown of caspase-8 by CRISPR/Cas9 based gene editing reduced the sensitivity of tumor cells to apoptosis and pyroptosis.Conclusions Our study presented a novel mechanism in which hyperthermia synergized with chemotherapy in promoting apoptosis and pyroptosis in a caspase-8 dependent manner.…”
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A two-sample bidirectional Mendelian randomization analysis between telomere length and hyperthyroidism by Shiben Zhu, Ziyu Hao, Qihang Chen, Xiaoliu Liu, Wenyan Wu, Fang Zhang

“…Reverse MR analysis suggested no causal association between TL and hyperthyroidism (p &gt; 0.05). Sensitivity analyses confirmed the robustness of these results, suggesting minimal susceptibility to confounding factors and bias.ConclusionThe finding that longer telomeres reduce hyperthyroidism risk highlights the need to validate hyperthyroidism’s impact on telomere length, offering valuable insights for prevention and treatment.…”
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Serum chemokine IL-8 acts as a biomarker for identifying COVID-19-associated persistent severe acute kidney injury by Zhi He, Jing-jing Liu, Shao-lei Ma

“…Moreover, plasma IL-8 levels of >32.2 pg/ml on admission could predict PS-AKI risk (sensitivity = 92.6%, specificity = 51.1%). Additionally, the IL-8 level was associated with total protein and IL-6 levels.Conclusion Plasma IL-8 is a promising marker for the early identification of PS-AKI among COVID-19 patients. …”
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An exploration of distinguishing subjective cognitive decline and mild cognitive impairment based on resting-state prefrontal functional connectivity assessed by functional near-in... by Zhengping Pu, Zhengping Pu, Hongna Huang, Man Li, Hongyan Li, Xiaoyan Shen, Qingfeng Wu, Qin Ni, Yong Lin, Donghong Cui

“…Model performance was assessed based on accuracy, specificity, sensitivity, and area under the curve (AUC) with 95% confidence interval (CI) values.ResultsStatistical analysis revealed a trend toward compensatory enhanced prefrontal FC in SCD and MCI individuals. …”
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