Characteristic external genitalia in male neonates with 5α-reductase deficiency by Takeshi Munenaga, Yosuke Ichihashi, Satsuki Nakano, Hironori Shibata, Takeshi Sato, Hiroshi Asanuma, Keiko Homma, Tomonobu Hasegawa, Tomohiro Ishii

“…An SPL cut-off value of <15 mm yielded a sensitivity of 50% (95% confidence interval [CI]; 7–93%) and specificity of 100% (95% CI, 72–100%) for discriminating between the groups. …”
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The preference for surprise in reinforcement learning underlies the differences in developmental changes in risk preference between autistic and neurotypical youth by Motofumi Sumiya, Kentaro Katahira, Hironori Akechi, Atsushi Senju

“…Method We ran a game-like risk-sensitive reinforcement learning task on 75 participants aged 6–30 years (AUT group, n = 31; NTP group, n = 44). …”
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Associations between changes in the gut microbiota and liver cirrhosis: a systematic review and meta-analysis by Ye Liu, Ziwei Chen, Chang Li, Tianhan Sun, Xuanmei Luo, Boyue Jiang, Meilan Liu, Qing Wang, Tong Li, Jianfu Cao, Yayu Li, Yuan Chen, Lu Kuai, Fei Xiao, Hongtao Xu, Hongyuan Cui

“…We subsequently performed subgroup, sensitivity, and publication bias analyses. cirrhosis dysbiosis ratio. …”
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Brassica rapa selenium transporter NPF2.20 (BrNPF2.20) accounts for Se-enrichment in Chinese cabbage by Xiaoting Hu, Yucheng Chen, Weihong Xu

“…Heterologous expression of BrNPF2.20 increased the sensitivity of yeast to Se. The overexpression of BrNPF2.20 significantly increased the Se content in Arabidopsis plants, whereas silencing BrNPF2.20 in Chinese cabbage leaves reduced the Se content. …”
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Seroprevalence and Risk Factors of Brucellosis in Ruminants in Dhofar Province in Southern Oman by Waleed Al-Marzooqi, Elshafie I. Elshafie, AlGhalya Al-Toobi, Abeer Al-Hamrashdi, Kaadhia Al-Kharousi, Hatim El-Tahir, Maryne Jay, Yannick Corde, Yasmin ElTahir

“…Parameters such as the positive predictive value (PPV) and the negative predictive value (NPV) showed that the sensitivity of I-ELISA and CFT based on the RBT test was 61.9% and 57.1%, respectively, whereas the specificity of I-ELISA (94.6%) was less than that of CFT (97.33%). …”
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Electrochemical properties of hydroxyapatite immobilization material for potential cytosensor fabrication by Dennis Adusei, Bernard O. Asimeng, Francis D. Krampa, Elvis K. Tiburu

“…Unique materials that enhance immobilisation of biorecognition molecules and improve electrochemical signal transduction are important in overcoming challenges based on the sensitivity of biosensors. In this regard, the electrochemical properties (EPs) of hydroxyapatite (HAp) material for the direct immobilisation of cells was investigated. …”
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Correlation between mitral annular plane systolic excursion (MAPSE) at different degrees of ejection fraction in patients with diabetes mellitus by Muhammad Rido, Khalid Saleh, A. Makbul Aman, Syakib Bakri, Haerani Rasyid, Andi Alfian Zainuddin

“…The purpose of this study is to determine how mitral annular plane systolic excursion (MAPSE) is a sensitive marker of early cardiac dysfunction in patients with diabetes mellitus by examining the relationship between MAPSE values and different levels of ejection fraction. …”
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Development and experimental validation of a machine learning model for the prediction of new antimalarials by Mukul Kore, Dimple Acharya, Lakshya Sharma, Shruthi Sridhar Vembar, Sandeep Sundriyal

“…RF-1 displayed 91.7% accuracy, 93.5% precision, 88.4% sensitivity and 97.3% area under the Receiver operating characteristic (AUROC) for the remaining 20% test set. …”
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Intelligent Turning Tool Monitoring with Neural Network Adaptive Learning by Maohua Du, Peixin Wang, Junhua Wang, Zheng Cheng, Shensong Wang

“…This tool monitoring system has neural network adaptive learning ability with the change of the experimental sample signals which are collected simultaneously by selected vibration and acoustic emission (AE) sensors in all factors turning experiments. Based on LabVIEW and MATLAB hybrid programming, the waveforms of signals are observed and the significant characteristics of signals are extracted through the time-frequency domain analysis and then the calculation of the energy proportion of each frequency band obtained using 4 levels of wavelet packet decompositions of the vibration signal as well as 8 levels of wavelet multiresolution decompositions of the AE signal; the ensuing Relief-F algorithm is used to further reextract the features that are most relevant to the tool state as input of neural network pattern recognition. …”
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Fracture properties of porcine versus human thoracic aortas from tricuspid/bicuspid aortic valve patients via symmetry-constraint Compact Tension testing by Marta Alloisio, Antti Siika, David Freiholtz, Anders Franco-Cereceda, Joy Roy, Hanna M. Björck, T. Christian Gasser

“…Patients with bicuspid aortic valves were more sensitive to age, had stronger aortas and required more $$D$$ than tricuspid valves individuals (peak load: axial loading 4.42 $$\pm$$ 1.56 N vs 2.51 $$\pm$$ 1.60 N; circumferential loading 5.76 $$\pm$$ 2.43 N vs 4.82 $$\pm$$ 1.49 N. …”
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Funding the New Biologics – A Health Economic Critique of the CCOHTA Report: Infliximab for the Treatment of Crohn’s Disease by Craig R Mitton

“…The QALYs that were derived might not have been sensitive to small changes in health outcomes. Moreover, the indirect costs of Crohn’s disease and its complications were ignored. …”
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Spectral Investigation and In Vitro Antibacterial Evaluation of NiII and CuII Complexes of Schiff Base Derived from Amoxicillin and α-Formylthiophene (αft) by Narendra Kumar Chaudhary, Parashuram Mishra

“…Particle size calculation by Scherrer’s formula indicates nanocrystalline nature of the complexes. The antibacterial sensitivity study suggests promising activities of Haαft (Ligand) and M(Haαft)2 complexes against four clinical pathogenic bacteria, namely, E. coli, P. vulgaris, P. aeruginosa, and S. aureus, though being less active than the standard drug amikacin.…”
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The molecular view of mechanical stress of brain cells, local translation, and neurodegenerative diseases by T. M. Khlebodarova

“…Evidence is provided that chronic mechanical stress may result in aberrant activation of mTOR signaling and the WAVE regulatory complex via the YAP/TAZ system, the key sensor of mechanical signals, and influence the associated pathways regulating the formation of F actin filaments and the dendritic spine structure. …”
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Dog alerting and/or responding to epileptic seizures: A scoping review. by Amélie Catala, Hugo Cousillas, Martine Hausberger, Marine Grandgeorge

“…Dogs have been reported as being sensitive to epileptic episodes in their owners, alerting before and/or responding during or after a seizure, with or without specific training. …”
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The association between physical activity, low-grade inflammation, and labour market attachment among people with multimorbidity: A cross-sectional study from the Lolland-Falster H... by Vivian Rueskov Poulsen, Linda Kjær Fischer, Mette Aadahl, Ole Steen Mortensen, Søren T Skou, Lars Bo Jørgensen, Randi Jepsen, Anne Møller, Therese Lockenwitz Petersen, Jan Christian Brønd, Lars Tang, Mette Korshøj

“…Degree of inflammation was determined by high sensitive C-reactive protein (hsCRP) level. Associations were investigated using multiple logistic regression analyses, stratified by labour market attachment. …”
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Indoor Particulate Matters Measured in Residential Homes in the Southeastern United States: Effects of Pandemic Lockdown and Holiday Cooking by Sierra Laltrello, Azita Amiri, Shan-Hu Lee

“…Particle size distributions between 0.25–35 µm were measured with a low-cost sensor, which does not utilize hazardous chemicals and radiation sources and is ideal for indoor air monitoring in real households without disruption of residents’ living conditions. …”
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Real-world cost-effectiveness of nirmatrelvir-ritonavir as treatment for SARS-CoV-2 infection in the Belgian setting with omicron variant by Sophie Marbaix, Sophie Marbaix, Steven Simoens, Philippe Clevenbergh, Pascal Van Bleyenbergh, Keliane Liberman, Dimitri Dehenau

“…Costs were calculated for the year 2023 from the healthcare payer’s perspective. Extensive sensitivity analyses were conducted to test the robustness of the cost-effectiveness results.ResultsIn a cohort of 1,000 patients, treatment with nirmatrelvir-ritonavir is projected to save 95 QALYs and €82,658 compared to no anti-SARS-CoV-2 treatment over a lifetime horizon. …”
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The emerging role of blood-based biomarkers in early detection of colorectal cancer: A systematic review by Faris Shweikeh, Yuhao Zeng, Abdur Rahman Jabir, Erica Whittenberger, Saurav P. Kadatane, Yuting Huang, Mohamad Mouchli, Dani Ran Castillo

“…The comprehensive search strategy centered on sensitivity, specificity, and AUC-ROC of multiple types of molecular blood biomarkers. …”
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Impact of finasteride on modulating the risk and clinical outcomes of bladder cancer: insights from a comprehensive meta-analysis by Ailing Yu, Ailing Yu, Ailing Yu, Ailing Yu, Ailing Yu, Zian Bai, Zian Bai, Zian Bai, Zian Bai, Yijie Wang, Yijie Wang, Yijie Wang, Yijie Wang, Zhen Luo, Zhen Luo, Zhen Luo, Zhen Luo, Xiaochen Du, Mengxin Chen, Shuang Wen, Honglong Wang, Xiaoying Yuan, Chunyu Yang, Shanshan Bai, Bo Fan, Bo Fan, Bo Fan, Bo Fan

“…Subgroup analyses and leave-one-out sensitivity analyses, were applied to mitigate the potential confounding factors associated with heterogeneity.ResultsOur investigation revealed that finasteride markedly decreased the likelihood of developing BCa (hazard ratio [HR]: 0.75, 95% confidence interval [CI]: 0.63–0.88). …”
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Exploring the effects of cannabidiol encapsulation in liposomes on their physicochemical properties and biocompatibility by Inga Jurgelane, Karina Egle, Andra Grava, Dana Galkina, Margarita Brante, Maksims Melnichuks, Marite Skrinda-Melne, Girts Salms, Arita Dubnika

“…However, CBD’s limited water solubility and sensitivity to environmental stresses hinder its efficacy and bioavailability. …”
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