Association of geriatric nutritional risk index with renal prognosis and all-cause mortality among older patients with chronic kidney disease: a secondary analysis of CKD-ROUTE stu... by Lei Chen, Mengyao Yan, Jie Li, Xue Zhao, Lu Zeng, Zhumei Gao, Hongli Jiang, Limin Wei

“…Moreover, the associations were generally consistent across several subgroup and sensitivity analyses.Conclusions The lower GNRI is significantly associated with higher risks of renal prognosis and all-cause mortality in elderly patients with CKD.…”
Get full text

Mechanistic insights into epithelial-mesenchymal transition mediated cisplatin resistance in ovarian cancer by Taha Umair Wani, Hyun-Yi Kim, Geum-Hwa Lee, Young Je Lim, Han-Jung Chae, Ji-Ye Kim, Hyonok Yoon

“…In our previous study we established that cisplatin resistance in ovarian cancer (OC) is associated with EMT using sensitive OV90 cells and its resistant counterparts OV90CisR1 and OV90CisR2. …”
Get full text

Evaluating NfL and NTproBNP as predictive biomarkers of intracranial injuries after mild traumatic brain injury in children presenting to emergency departments by Anne-Cécile Chiollaz, Virginie Pouillard, Michelle Seiler, Céline Habre, Fabrizio Romano, Céline Ritter Schenck, Fabian Spigariol, Christian Korff, Fabienne Maréchal, Verena Wyss, Lyssia Gruaz, Joan Montaner, Jean-Charles Sanchez, Sergio Manzano

“…NfL and NTproBNP were increased in the CT+ group and their performances to safely rule-out patient without ICI reached up to 30% specificity with 100% sensitivity. Equivalent performances were observed whether selecting patients with blood collection within 6 h or 24 h post-trauma.ConclusionNfL and NTproBNP were described for the first time in children suffering mTBI. …”
Get full text

Association of CHA2DS2-VASC Score with in-Hospital Cardiovascular Adverse Events in Patients with Acute ST-Segment Elevation Myocardial Infarction by Caoyang Fang, Zhenfei Chen, Jing Zhang, Xiaoqin Jin, Mengsi Yang

“…The CHA2DS2-VASc score was higher in the MACE group than in the non-MACE group (P<0.05), and multivariate logistic regression analysis showed that the CHA2DS2-VASc score was an independent risk factor for MACE events during hospitalization in STEMI patients (OR = 1.391, 95%CI 1.044–1.853, P=0.024); ROC curve analysis showed that the area under the curve (AUC) of the CHA2DS2-VASc score was 0.744, the sensitivity was 0.64, the specificity was 0.694, and the optimal cutoff value was 3.5 in predicting the risk of MACE events during hospitalization in STEMI patients. …”
Get full text

The Antibacterial Property of Nigella sativa (Black seed) Oil Against Gram-positive and Gramnegative Bacteria by Sakar Ahmed Abdullah, Tara Faeq M. Salih, Abdullah Ahmed Hama, Salar Ibrahim Ali, Hassan Hussein Hamaamin

“…Bacillus subtilis was more sensitive than other strains, and the significant antibacterial effect of the extracted was observed against Escherichia coil, while it has no significant effect on Pseudomonas aeruginosa and Salmonella enterica.? …”
Get full text

Voluntary Forelimbs Exercise Reduces Immobilization-Induced Mechanical Hyperalgesia in the Rat Hind Paw by Kumiko Ishikawa, Satoshi Oga, Kyo Goto, Junya Sakamoto, Ryo Sasaki, Yuichiro Honda, Hideki Kataoka, Minoru Okita

“…To investigate the abnormality of primary sensory neurons and central sensitization, the number of calcitonin gene-related peptide-positive cells in the dorsal root ganglion and the expression level of calcitonin gene-related peptide in the spinal dorsal horn were analyzed by immunohistochemical staining. …”
Get full text

Identification of Industrial Occupational Safety Risks and Selection of Optimum Intervention Strategies: Fuzzy MCDM Approach by Gülay Demir, Mouhamed Bayane Bouraima, Ibrahim Badi, Željko Stević, Dillip Kumar Das

“…While the primary risks identified under the main criteria and sub-criteria are occupational diseases and noise-induced diseases, with weights of 0.4737 and 0.1313, respectively, the intervention strategy deemed most effective for enhancing occupational safety is behavioral safety programs, which hold a weight of 11.0341. The sensitivity test of the analysis results reveals that although the criteria weights and the parameters used in the analysis vary under various scenarios, the ranking of the alternatives remains consistent. …”
Get full text

Prevalence of Squamous and Basal Cell Carcinomas in African Albino Skin Cancer Lesions: A Systematic Review and Meta-Analysis of Proportion by Nnaemeka T. Onyishi, Samuel R. Ohayi

“…African albinos have hypomelanized sensitive skin that is quite susceptible to photocarcinogenesis. …”
Get full text

Association Between SHBG Levels and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta‐Analysis by Ajay Malvi, Muhammed Shabil, Mahalaqua Nazli Khatib, Roopashree R, Mandeep Kaur, Manish Srivastava, Amit Barwal, G. V. Siva Prasad, Pranchal Rajput, Rukshar Syed, Kamal Kundra, Vinamra Mittal, Amit Kumar, Pancham Cajla, Ganesh Bushi, Rachana Mehta, Zaid Khan, Prakasini Satapathy, Shilpa Gaidhane, Renu Sah

“…The association between SHBG levels and the risk of any HDP showed a pooled OR of 0.875 (95% CI: 0.772–0.993), for PE 0.890 (95% CI: 0.767–1.032), and for GH 0.729 (95% CI: 0.442–1.205), suggesting significant association between SHBG and HDP. Sensitivity analysis validated the robustness of the findings. …”
Get full text

Duodenal Eosinophilia in Functional Dyspepsia by A. S. Silaeva, E. L. Bueverova, Yu. O. Shulpekova

“…The patient suffers from pollinosis; sensitization to birch pollen was diagnosed by a skin prick test. …”
Get full text

RNA editing-based biomarker blood test for the diagnosis of bipolar disorder: protocol of the EDIT-B study by Andrea Miranda-Mendizabal, Diana Vetter, Juan Zambrano, Jeff Zarp, Victor Chavarría, Anna Giménez-Palomo, Meritxell Gonzalez-Campos, Marc Valenti, Lara Walczer Baldinazzo, Sara Siddi, Maurizio Ferrari, Dinah Weissmann, Chantal Henry, Josep Maria Haro, Lars Vedel Kessing, Eduard Vieta

“…The clinical validation performance of the EDIT-B will be evaluated using the area under the curve, sensitivity, specificity, positive and negative predictive values, and likelihood ratios. …”
Get full text

Cohort profile: the Halland osteoarthritis (HALLOA) cohort–from knee pain to osteoarthritis: a longitudinal observational study in Sweden by Ann Bremander, Maria L E Andersson, S Bergman, Katarina Aili, Emma Haglund

“…We also found that modifiable factors as increased visceral fat and total body fat were associated with increased pain sensitivity among individuals with knee pain.Future plans By studying possible pathophysiological mechanisms of OA over time, we aim to provide new insights on OA progression, identify usable preventive measures helping the clinicians in the management of the disease and improve health for the patients. …”
Get full text

Impacts of Climatic Change on Reference Crop Evapotranspiration across Different Climatic Zones of Ningxia at Multi-Time Scales from 1957 to 2018 by Ziyang Zhao, Hongrui Wang, Cheng Wang, Wangcheng Li, Hao Chen, Shuxin Gong

“…RH and Tmax were the most sensitive climatic factors at the annual and seasonal scales, while the largest contribution rates were Tmax and SD. …”
Get full text

The value of susceptibility weighted imaging for immediate assessing the hyperacute outcome of MRgFUS ablation for uterine fibroids: a preliminary study by Yaoqu Huang, Shouguo Zhou, Yinghua Su, Zhuochao Pang, Shihua Cai

“…When using the complete hypointense peripheral rim as a diagnostic criterion to identify NPV ratio ≥ 90%, readers 1 and 2 showed diagnostic sensitivity, specificity, and accuracy of 85.7%, 76.9%, 81.5%, and 78.6%, 76.9%, 77.8%, respectively.Conclusion Identifying a complete hypointense peripheral rim on SWI may be a potential imaging marker for assessing the hyperacute outcome of uterine fibroids ablation by MRgFUS, specifically in determining whether the NPV ratio is ≥90%.…”
Get full text

Ultrasound-detected osteophytes predict the development of radiographic and clinical features of hand osteoarthritis in the same finger joints 5 years later by Tore K Kvien, Hilde Berner Hammer, Ida K Haugen, Barbara Slatkowsky-Christensen, Alexander Mathiessen

“…Background Structural pathology may be present in joints without radiographic evidence of osteoarthritis (OA). Ultrasound is a sensitive tool for early detection of osteophytes. …”
Get full text

Experimental Study of the Flow Mechanism of Deep Lacustrine Carbonate Reservoirs in the Yingxi Area of the Qaidam Basin by Xiangrong Luo, Yongxian Zheng, Penggang Huang, Li’an Yang, Xiaodong Chen, Xiaojuan Ren, Guo Wang, Yanzhi Wang, Zhiguo Wang, Xiaoxiao Li

“…The experimental results demonstrate that the cores, especially the fractured cores, have a strong stress sensitivity. The oil phase flow in the core has the characteristics of non-Darcy flow, and the threshold pressure gradient is 0.01–0.003 MPa/m. …”
Get full text

DIAGNOSIS AND PREDICTION OF CHOLECYSTITIS DEVELOPMENT ON THE BASIS OF NEURAL NETWORK ANALYSIS OF RISK FACTORS by V. A. Lazarenko, A. E. Antonov

“…The proposed new approach to the diagnosis and prognosis of cholecystitis has demonstrated its effectiveness, which is confirmed in clinical approbation by the levels of sensitivity (94.44%, m = 2.26) and specificity (80.6%, m = 3.9).2. …”
Get full text

Possible biocontrol of bacterial blight in pomegranate using native endophytic Bacillus spp. under field conditions by N. Manjunatha, Somnath S. Pokhare, Ruchi Agarrwal, Nripendra V. Singh, Jyotsana Sharma, Mallikarjun M. Harsur, Rajiv A. Marathe

“…In addition, these endophytes also exhibited reduced sensitivity to this immune modulator; thus, the current study advocates the use of B. haynesii, B. subtilis, and B. tequilensis as biocontrol agents for bacterial blight of pomegranate either alone or as a part of integrated disease management.…”
Get full text

Unraveling the Molecular Nexus between GPCRs, ERS, and EMT by Niti Kumari, Somrudee Reabroi, Brian J. North

“…Many GPCRs modulate ERS and UPR signaling via ERS sensors, IRE1α, PERK, and ATF6, to support cancer cell survival and inhibit cell death. …”
Get full text

Genome sequence and metabolic analysis of Pseudomonas fragi unveil the meat spoilage and CO2-antibacterial mechanism under high-oxygen modified atmosphere packaging by Jun Yang, Yikun Xu, Yimin Zhang, Rongrong Liang, Lixian Zhu, Yanwei Mao, Xin Luo, Xiaoyin Yang

“…Pseudomonas fragi is a predominant meat-borne spoilage bacterium that is sensitive to CO2 under high-oxygen modified atmosphere packaging (HiOx-MAP). …”
Get full text