Auditory evoked-potential abnormalities in a mouse model of 22q11.2 Deletion Syndrome and their interactions with hearing impairment by Chen Lu, Jennifer F. Linden

“…After identifying one of the simplest and best-validated methods for AEP measurement in mice from the diversity of previous approaches, we measured peripheral hearing sensitivity and cortical AEPs in Df1/+ mice and their WT littermates. …”
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Bacterial Culture of Tear Duct Infections Secondary to Congenital Nasolacrimal Duct Obstructions by Weiming Yang, Li Shen, Anken Wang, Meiyan Li, Chenhao Yang

“…Antibiotic susceptibility test results suggested that both Gram-positive and Gram-negative bacteria were highly sensitive to most of the tested antibiotics. Conclusions. …”
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Administration of PDE4 Inhibitors Suppressed the Pannus-Like Inflammation by Inhibition of Cytokine Production by Macrophages and Synovial Fibroblast Proliferation by Katsuya Kobayashi, Toshio Suda, Haruhiko Manabe, Ichiro Miki

“…The purpose of this study is to elucidate the effects of phosphodiesterase 4 (PDE4) inhibitors in a new animal model for the evaluation of pannus formation and cytokine production in the pannus. Mice sensitized with methylated bovine serum albumin (mBSA) were challenged by subcutaneous implantation of a membrane filter soaked in mBSA solution in the back of the mice. …”
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Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats by Pei-Ran Lv, Yang-Shuai Su, Wei He, Xiao-Yu Wang, Hong Shi, Xiao-Ning Zhang, Bing Zhu, Yu Kan, Li-Zhen Chen, Qiao-Feng Wu, Shu-Guang Yu, Xiang-Hong Jing

“…Rats in the colitis group (induced by colonic infusion of 2,4,6-trinitrobenzenesulfonic acid, TNBS), instead of the control and vehicle groups, displayed evident focal inflammatory destruction of the distal colon accompanied not only with the sensitized visceromotor response (VMR) to noxious colorectal distension (CRD) but also with referral hindpaw hyperalgesia indicated by reduced mechanical and thermal withdrawal latencies. …”
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Interconnections between BDH1-plasma protein-type 2 diabetes Mellitus: a mediated mendelian randomization analysis using plasma proteomics by Yi-Ying Liu, Yue-Yang Zhang, Qin Wan

“…Finally, we conducted bidirectional MR analyses along with various sensitivity analyses to ensure the robustness and reliability of the study findings. …”
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Optimization of microprobe analysis of cementitious materials incorporating glass powder under electron beam to avoid alkali migration by Wena de Nazaré do Rosário Martel, Josée Duchesne, Benoît Fournier

“…The results show that alkali migration is highly sensitive to material composition and irradiation conditions. …”
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Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis by Virginie Carrière, Muhammad Imran Arshad, Jacques Le Seyec, Benjamin Lefevre, Muhammad Farooq, Aurélien Jan, Christelle Manuel, Laurence Touami-Bernard, Catherine Lucas-Clerc, Valentine Genet, Hugues Gascan, Jean-Philippe Girard, Frédéric Chalmel, Lucie Lamontagne, Claire Piquet-Pellorce, Michel Samson

“…The IL-33 KO mice were more sensitive to L2-MHV3 infection exhibiting higher levels of AST/ALT, higher tissue damage, significant weight loss, and earlier death. …”
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Quantifying Joystick Interactions and Movement Patterns of Toddlers With Disabilities Using Powered Mobility With an Instrumented Explorer Mini by Kimberly A. Ingraham, Nicole L. Zaino, Claire Feddema, Mia E. Hoffman, Liesbeth Gijbels, Alexis Sinclair, Andrew N. Meltzoff, Patricia K. Kuhl, Heather A. Feldner, Katherine M. Steele

“…For this work, we developed a custom-instrumented Explorer Mini with embedded sensors to measure joystick interactions and wheel rotations. …”
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Annotation-free deep learning algorithm trained on hematoxylin & eosin images predicts epithelial-to-mesenchymal transition phenotype and endocrine response in estrogen receptor-po... by Kaimin Hu, Yinan Wu, Yajing Huang, Meiqi Zhou, Yanyan Wang, Xingru Huang

“…Our classifier achieved a predicting accuracy of 81.25%, and 88.7% slides labeled as endocrine resistant were predicted as the mesenchymal-phenotype, while 75.6% slides labeled as sensitive were predicted as the epithelial-phenotype. …”
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Epigenetic and Neurological Impairments Associated with Early Life Exposure to Persistent Organic Pollutants by Nathalie Grova, Henri Schroeder, Jean-Luc Olivier, Jonathan D. Turner

“…Although the aetiology remains uncertain, evidence is now growing that exposure to persistent organic pollutants during sensitive neurodevelopmental periods such as early life may be a strong risk factor, predisposing the individual to disease development later in life. …”
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Evaluating the impact of smoking on the risk of dry eye disease: a two-sample Mendelian randomization study by Kuiliang Yang, Han Zhang, Yujin Wang, Yulin Yan, Zixian Yang, Shanshan Wan, Wanju Yang, Yanning Yang

“…To ensure the robustness of the MR results, sensitivity analyses were conducted. In MR analyses, it was observed that both lifetime smoking and regular smoking were associated with a significant increase in the risk of DED (IVW method: P < 0.05). …”
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Aplicación electrónica para el ahorro de agua en una vivienda familiar by Juan Carlos Cruz-Ardila, Diego Fernando Gómez-Etayo, Luz Karime Sánchez-Mina, Juan Carlos Cuervo-Ballestero

“…Así mismo se hace una descripción de los dispositivos empleados, como son el sensor de nivel, el sistema de control de potencia y el circuito de procesamiento. …”
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Tumour heterogeneity and personalized treatment screening based on single-cell transcriptomics by Xinying Zhang, Jiajie Xie, Zixin Yang, Carisa Kwok Wai Yu, Yaohua Hu, Jing Qin

“…Despite advancements in anticancer drugs and optimised chemotherapy regimens that have improved cure rates for malignant tumours, the presence of tumour heterogeneity has resulted in substantial variations among patients in terms of disease progression, clinical response, sensitivity to therapy, and prognosis, posing significant challenges in attaining optimal therapeutic outcomes for each patient. …”
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CircRNF13 enhances IGF2BP1 phase separation-mediated ITGB1 mRNA stabilization in an m6A-dependent manner to promote oral cancer cisplatin chemoresistance by Xuemeng Xu, Qiu Peng, Zongyao Ren, Yaqian Han, Xianjie Jiang, Zhu Wu, Shiming Tan, Wenjuan Yang, Linda Oyang, Xia Luo, Jinguan Lin, Longzheng Xia, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Hao Tian, Yujuan Zhou, Qianjin Liao

“…Results from both in vitro and in vivo experiments indicated that circRNF13 enhances cancer cell proliferation and tumor growth, while concurrently diminishing tumor sensitivity to cisplatin. Mechanistically, circRNF13 interacts with the m6A “reader” protein IGF2BP1, inhibiting its ubiquitin-mediated degradation and promoting its phase separation formation. …”
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Female Consumers’ Involvement in Intentional Non-Sustainable and Unintentional Sustainable Apparel Decisions: An Emerging Market Perspective by Elizabeth Kempen, Rejoice Tobias-Mamina, Mariette Strydom, Lorna Christi, Mirriam Makopo

“…Unintentional sustainable apparel behaviour is characterised by (1) in-store apparel purchases: signifying quality clothing, observed in the material and stitching, resulting in clothing items worn for longer and handed down from generation to generation, sensitivity to the origin of the garment and (2) apparel disposal behaviour such as (a) keeping apparel as cleaning material and repurposing into wearable apparel; (b) permanent disposal through handing down items and (c) temporary disposal through exchanged items. …”
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Using a region-specific ice-nucleating particle parameterization improves the representation of Arctic clouds in a global climate model by A. B. Gjelsvik, R. O. David, T. Carlsen, F. Hellmuth, S. Hofer, Z. McGraw, Z. McGraw, H. Sodemann, H. Sodemann, T. Storelvmo, T. Storelvmo

“…<p>Projections of global climate change and Arctic amplification are sensitive to the representation of low-level cloud phase in climate models. …”
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Natural Killer Cell-Secreted IFN-γ and TNF-α Mediated Differentiation in Lung Stem-like Tumors, Leading to the Susceptibility of the Tumors to Chemotherapeutic Drugs by Kawaljit Kaur, Angie Perez Celis, Anahid Jewett

“…Differentiated lung cancer cell line (H292) and NK cells differentiated hA549 expressed reduced NK cell-mediated cytotoxicity but expressed higher sensitivity to chemotherapeutic drugs. This finding validated our previous reports demonstrating that the levels of tumor killing by NK cells and by chemotherapeutic drugs correlate directly and indirectly, respectively, with the stage and levels of tumor differentiation. …”
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Gluten Detection by Real-Time PCR: an Alternative for Tracking Processed Foods by Wemerson de Castro Oliveira, Hans Fröder, Eléia Righi

“…The results highlight the potential of the real-time PCR technique in detecting gluten and/or allergens in foods with a complex matrix, such as chocolate and cereal bars tested in this study, proving to be sensitive and robust to detect the presence of potentially high gluten concentrations. harmful for celiac consumers.…”
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All-Cause Mortality Prediction in Subjects with Diabetes Mellitus Using a Machine Learning Model and Shapley Values by Oana Mirea, Mostafa Ghelich Oghli, Oana Neagoe, Mihaela Berceanu, Eugen Țieranu, Liviu Moraru, Victor Raicea, Ionuț Donoiu

“…The ML model achieved 90% sensitivity and 87% specificity with an AUC of 0.88 and an accuracy of 88% for predicting all-cause mortality. …”
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Exploring RNA-Seq Data Analysis Through Visualization Techniques and Tools: A Systematic Review of Opportunities and Limitations for Clinical Applications by Farhana Manzoor, Cyruss A. Tsurgeon, Vibhuti Gupta

“…RNA sequencing (RNA-seq) has emerged as a prominent resource for transcriptomic analysis due to its ability to measure gene expression in a highly sensitive and accurate manner. With the increasing availability of RNA-seq data analysis from clinical studies and patient samples, the development of effective visualization tools for RNA-seq analysis has become increasingly important to help clinicians and biomedical researchers better understand the complex patterns of gene expression associated with health and disease. …”
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