Lipidomics-based investigation of its impact on the pathogenesis of coronary atherosclerosis: a Mendelian randomization study by Qun Wang, Yuan Cao, Lianqun Jia

“…Random-effects inverse variance weighted (IVW) MR analyses were performed by a series of sensitivity assessments to measure the robustness of our findings and to detect any violations of MR assumptions. …”
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PIVKA-II as a surrogate biomarker for therapeutic response in Non-AFP-secreting hepatocellular carcinoma by San-Chi Chen, Hsiang-Ling Ho, Chien-An Liu, Yi‑Ping Hung, Nai-Jung Chiang, Ming‑Huang Chen, Yee Chao, Muh-Hwa Yang

“…Prothrombin induced by vitamin K absence II (PIVKA-II) is more sensitive for HCC detection, though its role in systemic therapy remains underexplored. …”
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Inter- and Intra-observer Reproducibility of Thyroid Fine Needle Aspiration Cytology: An investigation of Bethesda 2023 Using Immunohistochemical BRAFV600E Antibody by Erdogan Bahattin, Dündar Emine, Çetin Kısmet Çivi, Yılmaz Fatih

“…Results: For the applied RM8 antibody, sensitivity was 64.71% and specificity was 87.27%. In terms of diagnostic categories, inter-observer agreement was good for Bethesda II (K = 0.606) and moderate for Bethesda III (K = 0.429), Bethesda IV (K = 0.523), Bethesda V (K = 0,464), and Bethesda VI (K = 0.544), respectively. …”
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The Quebec Association of Gastroenterology Position Paper on Colorectal Cancer Screening - 2003 by AN Barkun, G Jobin, G Cousineau, S Dubé, R Lahaie, P Paré, B Stein, R Wassef

“…Colonoscopy is the best strategy to both detect and remove polyps and to diagnose colorectal cancer, with double contrast barium enema also being a sensitive detection method. The Task Force recommended the establishment, in Quebec, of a screening program with five- to 10-yearly double contrast barium enema or 10-yearly colonoscopy for individuals aged 50 years or older at low risk. …”
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A lignin-based controlled/sustained release hydrogel by integrating mechanical strengthening and bioactivities of lignin by Bowei Wang, Dingkun Qiu, Yihui Gu, Zhu Shan, Ruonan Shi, Jing Luo, Shuang Qi, Yilin Wang, Bo Jiang, Yongcan Jin

“…The construction of electrostatic interaction could not only slow down the sudden release of lignin but also make the hydrogel exhibit a good pH-sensitive behavior of controlled-release lignin. Also, the developed hydrogel had good biocompatibility and the released lignin had reactive oxygen species scavenging as well as inhibitory activity against Staphylococcus aureus. …”
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Drivers of innovation value: simulation for new drug pricing evaluation based on system dynamics modelling by Qian Xing, Wendi Cheng, Wei Wang, Chunlin Jin, Haiyin Wang

“…The most substantial growth in value occurs in medications for rare diseases and niche markets, with effects varying in the short to medium term and stabilizing over the long term. Sensitivity analysis highlights that factors like combination therapies, faster mechanisms of action, and novel therapeutic parts notably influence the value dimension. …”
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Functional assessment of cancer therapy – head & neck (FACT-HN) translation and validation in Serbian by Masa Petrovic, Bojana Salovic, Ana Tomic, Tanja Jesic-Petrovic, Aleksandar Matejic, Ivana Radovic, Silvana Babic, Aleksa Korugic, Drago Jelovac, Nikola Mikovic, Sasa Jakovljevic, Svetislav Pelemis, Milovan Dimitrijevic, Jovica Milovanovic, Ana Jotic, Aleksandar Trivic, Ana Dimitrijevic, Sulin Bulatovic, Zoran Dudvarski, Ivan Soldatovic, Jelena Ilic-Zivojinovic

“…Further research is needed to assess its sensitivity to longitudinal treatment-related changes.…”
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Appendiceal Intraluminal Gas: A CT Marker for Gangrenous Appendicitis by Chantelle Ip, Edward H. Wang, Michael Croft, Wanyin Lim

“…Images were independently assessed by 3 radiologists for intraluminal gas, and the results were then correlated with reference standards obtained from surgical and histopathology reports for the diagnosis of nongangrenous versus gangrenous appendicitis. The sensitivity, specificity, and predictive values of CT intraluminal gas in gangrenous appendicitis were calculated. …”
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The Association between the Pulmonary Arterial Obstruction Index and Atrial Size in Patients with Acute Pulmonary Embolism by Taraneh Faghihi Langroudi, Maryam Sheikh, Mohammadreza Naderian, Morteza Sanei Taheri, Amir Ashraf-ganjouei, Isa Khaheshi

“…Atrial measurements are correlated with POAI, and they could be used as sensitive parameters in predicting heart failure in patients with PE.…”
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Integrative pan-cancer analysis and experiment validation identified GLS as a biomarker in tumor progression, prognosis, immune microenvironment, and immunotherapy by Dongming Li, Donghui Cao, Yangyu Zhang, Xinyi Yu, Yanhua Wu, Zhifang Jia, Jing Jiang, Xueyuan Cao

“…In conclusion, GLS is an underlying biomarker for oncological progression, prognosis, TME, antitumor drug sensitivity, and immunotherapy response. Targeting GLS can facilitate the implementation of individualized and combined treatment strategies.…”
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Social Risk Early Warning of Environmental Damage of Large-Scale Construction Projects in China Based on Network Governance and LSTM Model by Junmin Fang, Dechun Huang, Jingrong Xu

“…Compared with other classical models, the long short-term memory model has the advantages of strong processing capability and high early warning accuracy for time-sensitive data and will have broad application prospects in the field of risk control research. …”
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Screening and selection of drought-tolerant rainfed lowland rice seedlings based on early seedling vigor under Polyethylene Glycol-Induced Stress by Minerva L. Gaurana-Nuñez

“…AL52 and NSIC Rc82 were markedly affected at the highest PEG level (-1MPa) and hence considered as drought-sensitive.…”
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Suppressing GDF15 enhances the chemotherapeutic effect of 5 FU on MSI-H CRC by regulating the ferroptosis pathway SLC7A11/GSH/GPX4 by Zhi min Huang Fu, Ming Xiao, Hailun Xie, Shuxian Zhang, Tang Yi, Qingshu Li, Ming Li, Yalan Wang

“…Furthermore, suppressing GDF15 can increase the sensitivity of MSI-H CRC cells to 5-fluorouracil (5-FU), which decreases cell viability and increases the apoptosis rate. …”
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Positive real-time PCR in pneumococcal meningitis 12 hours after initiation of antibiotic therapy – case report by Cem Thunstedt, Carla Palleis, Johannes Wischmann, Suzette Heck, Konstantinos Dimitriadis, Matthias Klein

“…However, PCR cannot replace cultures when it comes to adapting therapy based on the antibiotic sensitivity of the causative pathogen. Awareness of Austrian syndrome’s diverse manifestations is crucial for timely recognition and appropriate management.…”
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Clinical and Economic Evaluation of Transdermal Oxybutynin in the Treatment of Overactive Bladder in Spain by Carlos Crespo, Pedro Blasco, Marcelo Guigini, Jordi Galván

“…The robustness of the results was validated with a deterministic and probabilistic sensitivity analysis. **Results:** After a year, transdermal oxybutynin was seen to have greater persistence deriving from its better risk/benefit balance compared to muscarinic antagonists and mirabegron (55% transdermal oxybutynin, 33% mirabegron, 25% tolterodine, 27% fesoterodine, 25% solifenacin, 23% trospium chloride and 17% oxybutynin). …”
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A comparative template-switching cDNA approach for HTS-based multiplex detection of three viruses and one viroid commonly found in apple trees by Francisco Mosquera-Yuqui, Daniel Ramos-Lopez, Xiaojun Hu, Yu Yang, Joshua L. Mendoza, Emmanuel Asare, Joshua Habiger, Oscar P. Hurtado-Gonzales, Andres S. Espindola

“…A framework of considerations for expanding this sensitive approach to other targets and crops is discussed.…”
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A compressive damage model for a rock considering the microcrack mechanical behavior by Cui LIU, Zhong LI, Feiya XU, Mo ZHANG, Xiaowei CAO, Heng LEI

“…Finally, the parametric sensitivity analysis was adopted to study the effects of the microcrack length, friction coefficient, and rock fracture toughness on the rock mechanical properties. …”
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Pain and the perception of space in fibromyalgia by Michele Scandola, Maddalena Beccherle, Enrico Polati, Giorgia Pietroni, Elena Rossato, Vittorio Schweiger, Valentina Moro

“…The estimation of distances and slopes in navigation space (i.e. the space reachable by locomotion) is influenced by sensations relating to body condition and the metabolic cost of the actions. …”
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Development and validation of a LAMP-based method for rapid and reliable detection of Xanthomonas albilineans, the causal agent of sugarcane leaf scald by Moutoshi Chakraborty, Moutoshi Chakraborty, Shamsul Arafin Bhuiyan, Shamsul Arafin Bhuiyan, Simon Strachan, Simon Strachan, Muhammad J. A. Shiddiky, Nam-Trung Nguyen, Rebecca Ford, Rebecca Ford

“…Sugarcane samples from infected plants were subjected to heat lysis, followed by loop-mediated isothermal amplification (LAMP)-based fluorescence and colorimetric quantification within a single microcentrifuge tube.ResultsThe method exhibited exceptional detection sensitivity (detecting as low as 1 cell/μL), reproducibility [with a standard deviation (SD) of <5% for n = 3], and a broad linear dynamic range (10 pM to 1 aM or 107–100 copies/μL, r = 0.99). …”
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Membuka potensi karyawan melalui leader-member exchange, kepuasan kerja, dan dukungan persepsi dari supervisor dengan identifikasi organisasi sebagai mediator by Deasy Aseanty, Tsamarah Afnan As’ad

“…Penelitian ini menggunakan responden yang didapat sesuai kriteria dengan metode pengambilan sampel sensus sebanyak 320 karyawan dari 2 perusahaan farmasi yaitu PT Kalbe Farma dan anak perusahaannya PT Bifarma Adiluhung. …”
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