The Pathology of Orthopedic Implant Failure Is Mediated by Innate Immune System Cytokines by Stefan Landgraeber, Marcus Jäger, Joshua J. Jacobs, Nadim James Hallab

“…In some people implant debris (particles and ions from metals) can influence the adaptive immune system as well, giving rise to the concept of metal sensitivity. However, a consensus of studies agrees that the dominant form of this response is due to innate reactivity by macrophages to implant debris where both danger (DAMP) and pathogen (PAMP) signalling elicit cytokine-based inflammatory responses. …”
Get full text

Investigation of non-alcoholic steatohepatitis in labidochromis caeruleus and xiphophorus hellerii by Mustafa Ünal Boyraz, Muhammet Yaşar Dörtbudak, Muhammet Bahıttin Dörtbudak

“…<p> <b>Conclusion:</b> The histopathological changes in the liver were investigated and under optimum conditions and standard feding conditions, and the sensitivities of these commercially important aquarium ornamental fishes were determined against market baits. …”
Get full text

A GIS-based on application of Monte Carlo and multi-criteria decision-making approach for site suitability analysis of solar-hydrogen production: Case of Cameroon by Fotsing Metegam Isabelle Flora

“…The findings are validated through a case study in Guider and Maroua, highlighting the importance of socio-economic and environmental criteria in decision-making. A sensitivity analysis reveals that economic and social criteria significantly influence land suitability, underscoring the importance of criteria selection in decision-making.…”
Get full text

Early Detection of Pancreatic Cancer: Opportunities Provided by Cancer-induced Paraneoplastic Phenomena and Artificial Intelligence by Wei-Chih Liao

“…Novel computer-aided detection tools based on AI technologies, including deep learning and radiomic analysis with machine learning, have achieved accurate detection and might supplement human interpretation to improve the sensitivity for early PDAC on CT images. Conclusion: Novel blood-based biomarkers and AI-augmented image analysis may be complementary and hold promise for the early detection of PDAC.…”
Get full text

Paradoxical and Retrograde Air Embolism from Pressurized Peripheral Bolus by Joshua Santucci, Naresh Mullaguri, Anusha Battineni, Raviteja R. Guddeti, Christopher R. Newey

“…Her medical history was significant for intravenous heroin and cocaine abuse, methicillin-sensitive Staphylococcus aureus tricuspid valve infective endocarditis on vancomycin, patent foramen ovale, septic pulmonary embolism with cavitation, tracheostomy with chronic ventilator dependence, multifocal cerebral infarction, hepatitis C, nephrolithiasis, anxiety, and depression. …”
Get full text

Orienting attention to auditory and visual working memory in older adults with cochlear implants. by Amisha Ojha, Andrew Dimitrijevic, Claude Alain

“…Cochlear implantation is a well-established method for restoring hearing sensation in individuals with severe to profound hearing loss. …”
Get full text

High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes by Jer-Chuan Li, Du-An Wu, Jia-Sian Hou, Yi-Maun Subeq, Hsin-Dean Chen, Bang-Gee Hsu

“…Multivariate forward stepwise linear regression analysis revealed that body fat mass (P<0.001), logarithmically transformed creatinine (log-creatinine; P<0.001), female DM patients (P<0.001), and logarithmically transformed high sensitive C-reactive protein (log-hs-CRP; P=0.013) were positively correlated, while albumin (P=0.004) and glomerular filtration rate (GFR; P=0.043) were negatively correlated with serum A-FABP levels in type 2 DM patients. …”
Get full text

Anti-Apoptosis Effects of Green Tea in Diagnostic and Therapeutic Doses of Ionizing Radiation by Najmeh Anbiaee, Mohammad Taghi Bahreyni Toossi, Hosein Azimian, Zoha Sahebnasagh, Sepideh Abdollahi Dehkordi, Majid Kianmehr, samaneh soudmand salarabadi, Maryam Najafi Amiri

“…The protective effects of the green tea polyphenol on Bcl-2 and Bax genes expression levels were evaluated in cultured lymphocytes obtained from treated cells (24 h and 1 h before and 1 h after exposure to ionizing radiation) and non-treated cells (Receiving X-radiation and non-receiving green tea).Results: The results of this investigation demonstrated Bax/Bcl-2 ratio, as an index of the radiation sensitivity, was significantly decreased in groups which had been received dose of 2 Gy in treated cells groups of 1 h before and 1 h after X-radiation (p<0.05).Conclusion: The results indicated different effects of green tea on low and high doses of X-radiation. …”
Get full text

Application of Factorial and Doehlert Designs for the Optimization of the Simultaneous Separation and Determination of Antimigraine Drugs in Pharmaceutical Formulations by RP-HPLC-... by Sami Jebali, Chaouki Belgacem, Mohamed Radhouen Louhaichi, Senda Bahri, Latifa Latrous El Atarche

“…A sensitive, precise, accurate, and specific isocratic reversed-phase high-performance liquid chromatographic (RP-HPLC) method for the simultaneous separation and determination of zolmitriptan, naratriptan, dihydroergotamine, ketotifen, and pizotifen in pharmaceutical formulations has been developed and validated. …”
Get full text

Serum Concentration and Chemotactic Activity of E-selectin (CD62E) in Inflammatory Bowel Disease by B. Vainerc, O. H. Nielsen

“…It is concluded that sE-selectin in contrast to sICAM-1 does not act as a sensitive indicator of local immune activation in IBD. …”
Get full text

Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin by Kazuaki Tokodai, Noritoshi Amada, Izumi Haga, Atsushi Nakamura, Toshiaki Kashiwadate, Naoki Kawagishi, Noriaki Ohuchi

“…Receiver-operating characteristic analysis revealed a cut-off value of 5.2% with an optimal sensitivity of 64% and specificity of 78% for predicting NODAT. …”
Get full text

Bacteriological valuations of some powdered infant milk and antibiotic resistance estimation by Sameira S. Swilaiman, Lawin A. Omer, Suhaila N. Darogha

“…A region of 16S rRNA gene were amplified by PCR to allow species identification, and the sensitivity of isolates to eight antibiotics was studied by using standard disc diffusion method Results: Eight samples of infant powdered milk (N = 12) were contaminated with (62.5%) Staphylococcus sp and (37.5%) Lactobacillus sp . …”
Get full text

Genomic characterization of foodborne Salmonella enterica and Escherichia coli isolates from Saboba district and Bolgatanga Municipality Ghana. by Gabriel Temitope Sunmonu, Frederick Adzitey, Erkison Ewomazino Odih, Boniface Awini Tibile, Rejoice Ekli, Martin Aduah, Anderson O Oaikhena, Olabisi C Akinlabi, Akebe Luther King Abia, Daniel Gyamfi Amoako, Iruka N Okeke

“…Most Salmonella isolates were pan-sensitive, but genes conferring resistance to fosfomycin (fosA7.2) and tetracycline (tet(A)) were detected in one and three isolates, respectively. …”
Get full text

Performance of Shear Connector in Composite Slab and Steel Beam with Reentrant and Open Trough Profiled Steel Sheeting by Alemu Feyissa, Goshu Kenea

“…Similarly, when the concrete grade increased from C-40 to C-60, the capacity of the shear connector also increased by 70.128% and 48.301% with open and reentrant profiled steel sheeting, respectively. Furthermore, sensitivity analysis is done to see how much each input parameters affect the output parameter.…”
Get full text

The enigma of cancer polyploidy as deciphered by evolutionary cancer cell biology (ECCB) by Vladimir F. Niculescu, Eugenia R. Niculescu

“…These cancer stem cell hallmarks share deep homology with the oxygen-sensitive non-gametogenic (NG) Urgermline, which evolved from the common ancestor of amoebozoan, metazoan, and fungi (AMF). …”
Get full text

Evaluation of Antibiotic Resistance and Biofilm Production among Clinical Strain Isolated from Medical Devices by Veronica Folliero, Gianluigi Franci, Federica Dell’Annunziata, Rosa Giugliano, Francesco Foglia, Rossella Sperlongano, Anna De Filippis, Emiliana Finamore, Massimiliano Galdiero

“…All biofilm producing isolates were sensitive to a limited spectrum of antibiotic classes. …”
Get full text

Naringin prevents heart mitochondria dysfunction during diabetic cardiomyopathy in rats by Ilya Zavodnik, Tatsiana A. Kavalenia, Siarhei N. Kirko, Elena B. Belonovskaya, Irina A. Kuzmitskaya, Yulia V. Eroshenko, Elena A. Lapshina, Vyacheslav U. Buko

“…The present study evaluated the effects of flavonoid glycoside naringin treatment on the interconnection between changes in cardiac mitochondria oxygen consumption, membrane potential and mitochondrial Ca2+ sensitivity during type 1 diabetes. Experimental approach: Type 1 diabetes was induced by an intraperitoneal injection of streptozotocin (40 mg/kg) in rats and islet morphology, glucose and insulin levels, changes in heart mitochondria respiration, membrane potential, spontaneous and Ca2+ - induced mitochondrial permeability transition (MPT) pore opening were evaluated. …”
Get full text

Refined methodology for quantifying Pseudomonas aeruginosa virulence using Galleria mellonella by Christopher M. R. Axline, Travis J. Kochan, Sophie Nozick, Timothy Ward, Tania Afzal, Issay Niki, Sumitra D. Mitra, Ethan VanGosen, Julia Nelson, Aliki Valdes, David Hynes, William Cheng, Joanne Lee, Prarthana Prashanth, Timothy L. Turner, Nathan B. Pincus, Marc H. Scheetz, Kelly E. R. Bachta, Alan R. Hauser

“…The use of G. mellonella to study Pseudomonas aeruginosa pathogenesis, however, is challenging because of the extreme sensitivity of larvae to this bacterium. For some P. aeruginosa strains, as few as 1–5 colony-forming units are sufficient to kill G. mellonella, which poses challenges for determining LD50 values. …”
Get full text

Models of technological development: The influence of investment structure by Vilhelmina V. Glazunova, Oleg S. Sukharev

“…The result is the identification of a model of technological modernisation in the Russian economy according to the structure of investments in “old – new” technologies and the sensitivity of the general technological intensity to investments. …”
Get full text

Mathematical Analysis of the Transmission Dynamics of Skin Cancer Caused by UV Radiation by Tahera Parvin, Md. Haider Ali Biswas, Bimal Kumar Datta

“…We also have observed the sensitivity of the model parameters. After this, we have investigated the different scenarios of bifurcations of the model’s parameters. …”
Get full text