Crizanlizumab and comparators for adults with sickle cell disease: a systematic review and network meta-analysis by George Joseph, Howard Thom, Jeroen Jansen, Hung-Yuan Cheng, Jason Shafrin, Lauren Zhao, Subhajit Gupta, Nirmish Shah

“…The HR for reduction in VOC for crizanlizumab relative to L-glutamine was (0.67 (0.50, 0.88); >0.99). These results were sensitive to assumptions regarding whether patient age is an effect modifier.Conclusions This NMA provides preliminary evidence comparing the efficacy of crizanlizumab with other treatments for VOC prevention.…”
Get full text

Pharmacokinetic Properties of Baitouweng Decoction in Bama Miniature Pigs: Implications for Clinical Application in Humans by Qianqian Xu, Huilan Gao, Fuqiang Zhu, Wenliang Xu, Yubo Wang, Jinwen Xie, Guangjun Guo, Limei Yang, Li Ma, Zhiqiang Shen, Jichang Li

“…To facilitate this research, a rapid and sensitive UPLC-MS/MS method has been developed for the simultaneous quantification of eleven active ingredients of BTWD in plasma. …”
Get full text

Le « lâcher-prise » : mutations numériques des gestes architecturaux by Sébastien Bourbonnais

“…This decreased attention is certainly one of the major problems showing the limits of the sensitivity of “let go-grasp”.  As “the marks of a letting go”, an expression used by Jean-Luc Nancy in his works on the initial moment of painting in the cave, this “let go-grasp” describes one of the singular and original connection offered by the digital mutations of architectural gestures and architectural environments.…”
Get full text

Deep Learning and Recurrence Information Analysis for the Automatic Detection of Obstructive Sleep Apnea by Daniele Padovano, Arturo Martinez-Rodrigo, José M. Pastor, José J. Rieta, Raul Alcaraz

“…Under the challenging context of external validation (MIT-BIH and UCD for training, and Apnea-ECG for testing), the results obtained were comparable to those presented in the state of the art, achieving a peak accuracy of 75%, while maintaining balanced sensitivity and specificity at 74% and 75%, respectively. …”
Get full text

Variations of the ulnar nerve within the ulnar tunnel and palm in a select South African population by Lutho Daza, Julia Fernandes, Geney Gunston, Jeshika Luckrajh-Williams

“…UTS is characterised by sensory deficits and muscular weakness, impaired sensation of the volar fingertips, and weakness in grasping with intrinsic hand muscles. …”
Get full text

Application of sustainability indicators for the evaluation and selection of robust organic-rich wastewater treatment technology for resource recovery by Chrisogoni Paschal, Mwemezi J. Rwiza, Karoli N. Njau

“…The composite sustainability indicator (CSI) for AFP-CW was 42.14% and for WSPs was 39.27%, with the global sustainability indicator (GSi) reaching 21.54% for AFP-CW and 18.88% for WSPs. A sensitivity analysis revealed that the maximum global sustainability indicator was 22.34% for AFP-CW and 19.54% for WSPs. …”
Get full text

The solvent effect, preferential solvation of metformin hydrochloride in binary mixed solvents of methanol/ethanol + water mixtures from 278.15 K to 323.15 K by Adel Noubigh, Abdalazeem A. Omar, Manef Abderrabba

“…The findings reveal that MET.HCl is sensitive to solvation effects, with the values of δx1,MET-HCl exhibiting a non-linear relationship with the proportion of solvent (1) in the two solvent mixtures. …”
Get full text

Carboxylated Graphene: An Innovative Approach to Enhanced IgA-SARS-CoV-2 Electrochemical Biosensing by Luciana de Souza Freire, Ariamna María Dip Gandarilla, Yonny Romaguera Barcelay, Camila Macena Ruzo, Barbara Batista Salgado, Ana P. M. Tavares, Francisco Xavier Nobre, Julio Nino de Souza Neto, Spartaco Astolfi-Filho, Ștefan Țălu, Pritesh Lalwani, Niranjan Patra, Walter Ricardo Brito

“…This device shows considerable potential because of its fast response time, miniaturized design facilitated by SPCEs, reduced sample volume requirements, high sensitivity and specificity, low detection limits, and signal enhancement achieved through nanomaterial integration.…”
Get full text

The Study of Cooperative Obstacle Avoidance Method for MWSN Based on Flocking Control by Zuo Chen, Lei Ding, Kai Chen, Renfa Li

“…Compared with the space fixed feature of traditional wireless sensor network (WSN), mobile WSN has better robustness and adaptability in unknown environment, so that it is always applied in the research of target tracking. …”
Get full text

Fault Identification of UHVDC Transmission Based on DF-AD and Ensemble Learning by Qingsheng Zhao, Xinyu Yang, Xiaoqing Han, Dingkang Liang, Xuping Wang

“…High-resistance ground faults are difficult to detect with existing ultrahigh voltage direct current (UHVDC) transmission fault detection systems because of their low sensitivity. To address this challenge, a straightforward mathematical method has been proposed for fault detection in UHVDC system based on the downsampling factor (DF) and approximation derivatives (AD). …”
Get full text

Resistance of Echinochloa crus-galli Populations to Acetolactate Synthase-Inhibiting Herbicides by Dilpreet S. Riar, Jason K. Norsworthy, Jason A. Bond, Mohammad T. Bararpour, Michael J. Wilson, Robert C. Scott

“…The AR1 and MS1 populations were cross-resistant to bispyribac-sodium; however, AR2 was sensitive to bispyribac-sodium. The AR1, AR2, and MS1 populations were >94, >94, and 3.3 times, respectively, more resistant to imazamox; >94, 30, and 9.4 times, respectively, more resistant to penoxsulam; and 15, 0.9, and 7.2 times, respectively, more resistant to bispyribac-sodium compared to a susceptible population. …”
Get full text

Evaluation of VP4-VP2 sequencing for molecular typing of human enteroviruses. by Kouichi Kitamura, Minetaro Arita

“…The VP4-pVP2 region is particularly sensitive to RT-PCR detection, making it efficient for clinical specimen analysis. …”
Get full text

Pyrrocidines A and B demonstrate synergistic inhibition of Fusarium verticillioides growth by Lily W. Lofton, Lily W. Lofton, Quentin D. Read, Hailey L. Hamilton, Anthony E. Glenn, Jaci A. Hawkins, Trevor R. Mitchell, Scott E. Gold

“…Additionally, we showed that the FvABC3 (FVEG_11089) mutant, earlier described as hypersensitive to pyrrocidine, is particularly sensitive to pyrrocidine B. Thus, pyrrocidine A and B show different target specificity (FvZBD1 or FvABC3) and synergistic action. …”
Get full text

Impact of virtual agent facial emotions and attention on N170 ERP amplitude: comparative study by Luisa Kirasirova, Olga Maslova, Vasiliy Pyatin, Vasiliy Pyatin

“…IntroductionIt is known from the literature that face perception of virtual agents affects the amplitude and latency of the ERP components. However, sensitivity of the N170 component to virtual agent facial emotions, and level of attention to facial emotional expressions were not investigated in the virtual reality environment by now, which was the aim of our study.MethodsEEG recording, 2D and 3D visual testing of the neutral, happy and disgusted facial emotions of virtual agents were used. …”
Get full text

Screening for retinopathy of prematurity in China: a five-year cohort study in seven screening centers by Yusheng Zhong, Xiacheng Lin, Yating Yang, Liying He, Na Li, Jun Lu, Yu Zhou, Rong Zhang, Yacong Wang, Zhongyu Zhang, Mochi Yang, Hong Yin, Mingwei Zhao, Xiaoxin Li, Jianhong Liang, Yong Cheng

“…This study proposed the optimization of guidelines to be ≤ 30 weeks of GA and ≤ 1600 g of BW, achieving a sensitivity of 99.4%, as high as the current standard, with an 18.0% reduction in screening requirements. …”
Get full text

Adaptive compensation for multi-axial real-time hybrid simulation via nonlinear parameter estimation by Santiago Ruiz, Wei Song

“…Extensive simulations on the maRTHS incorporating various earthquake inputs, sensor noise, and model uncertainties, demonstrated an excellent tracking performance and strong robustness across four parameter estimation cases (EKF-TF, UKF-TF, EKF-SS, and UKF-SS). …”
Get full text

On the Assessment of Daily Equatorial Plasma Bubble Occurrence Modeling and Forecasting by B. A. Carter, J. L. Currie, T. Dao, E. Yizengaw, J. Retterer, M. Terkildsen, K. Groves, R. Caton

“…Various assessment metrics are explored, including the use of significance testing on skill scores for threshold selection. The sensitivity of these skill scores to data set type (i.e., GPS versus UHF) and data set size (30, 50, 60, and 90 days/events) is also investigated. …”
Get full text

Candida albicans Fungaemia following Traumatic Urethral Catheterisation in a Paraplegic Patient with Diabetes Mellitus and Candiduria Treated by Caspofungin by Subramanian Vaidyanathan, Bakul Soni, Peter Hughes, Gordon Ramage, Leighann Sherry, Gurpreet Singh, Paul Mansour

“…Urine and blood culture yielded Candida albicans. Identical sensitivity pattern of both isolates suggested that the source of the bloodstream infection was most likely urine. …”
Get full text

The Data Heterogeneity Issue Regarding COVID-19 Lung Imaging in Federated Learning: An Experimental Study by Fatimah Alhafiz, Abdullah Basuhail

“…In the context of making a COVID-19 diagnosis using lung imaging, FL enables institutions to collaboratively train a global model without sharing sensitive patient data. A central manager aggregates local model updates to compute global updates, ensuring secure and effective integration. …”
Get full text

Social Strata Differentials in Reproductive Behavior among Agricultural Families in the Krummhörn Region (East Frisia, 1720-1874) by Kai P. Willführ, Charlotte Störmer

“…We believe this period-sensitive response to changes in the crop price was the result of a social transition that took place during our study period, in which relations between the classes went from being based on communal “table fellowships” (Tischgemeinschaft) to being based on capitalist employer/employee arrangements.…”
Get full text