MSCs with upregulated lipid metabolism block hematopoietic stem cell differentiation via exosomal CTP-1A in MDS by Chunlai Yin, Xue Yan, Jinyi Ren, Cheng Zhang, Jiaqing Liu, Zilong Wang, Jing Liu, Weiping Li, Xia Li

“…Notably, we observed an upregulation of lipid metabolism in these MSCs, which appears to contribute to their dysfunction. Intriguingly, the aberrant lipid metabolic profile can be effectively reversed by the administration of etomoxir (ETO), an inhibitor of carnitine palmitoyltransferase 1A (CPT-1A). …”
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An animal model of severe acute respiratory distress syndrome for translational research by Kuo-An Chu, Chia-Yu Lai, Yu-Hui Chen, Fu-Hsien Kuo, I.-Yuan Chen, You-Cheng Jiang, Ya-Ling Liu, Tsui-Ling Ko, Yu-Show Fu

“…Morphologically, the surface of the left lung appeared uneven on Day 1, the alveoli of the left lung disappeared on Day 2, and the left lung shrank on Day 7. …”
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Impact of COVID-19 pandemic restrictions and relaxation on pediatric respiratory virus hospitalizations in Southwest China: a retrospective study by Ting Gong, Fengqi He, Yongle Zhao, Shuya Lu, Daiyin Tian, Daiyin Tian

“…The peak in the first half of 2024 returned to its normal timing. ADV appeared to be unaffected, with increased detection in 2022, and decreased in 2023 and 2024.ConclusionEpidemiological patterns of respiratory viruses have been altered by multiple influencing factors. …”
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Air Quality, Atmospheric Variables and Spread of COVID-19 in Delhi (India): An Analysis by Abhishek Dutta, Wanida Jinsart

“…Abstract Based on a time series analysis of the criteria pollutants, meteorological parameters, and COVID-19 positive cases, this paper explores the impact of epidemic prevention and control actions on air quality for five different periods of COVID-19 outbreak in Delhi, India. …”
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Scaling Arctic landscape and permafrost features improves active layer depth modeling by Wouter Hantson, Daryl Yang, Shawn P Serbin, Joshua B Fisher, Daniel J Hayes

“…Consequently, this could limit our ability to model and anticipate how ALD will respond to climate change and disturbances across tundra ecosystems. In this paper, we studied the fine-scale heterogeneity of ALD and its connections with land surface characteristics across spatial and spectral scales using a combination of ground, unoccupied aerial system, airborne, and satellite observations. …”
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High-resolution spatiotemporal analysis of chikungunya epidemics between 2019 and 2020 in Salvador, Brazil: a municipality-level transmission dynamics studyResearch in context by Hernan D. Argibay, Cristiane W. Cardoso, William M. de Souza, Raquel L. Souza, Maysa Pellizzaro, Geraldo M. Cunha, Julie Clennon, Scott C. Weaver, Mitermayer G. Reis, Uriel Kitron, Guilherme S. Ribeiro

“…Interpretation: These findings suggest that CHIKV transmission is localized, even during what appeared to be a citywide epidemic, creating high-risk pockets within the city. …”
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The challenges of using Escherichia coli as a host in recombinant insulin production by Muhammad Taher

“…The most common diabetes is type 2 which usually happened in adults when the body becomes resistant to insulin, or the body does not produce enough insulin. …”
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Evaluation of ior ® Leukocim efficacy on patients with Neutropenia. by Ana María Ramos Cedeño, Leslie Pérez Ruiz, Julio Dámaso Fernández Águila, Tamara Guerra, Maritza Cabrera Zamora, Hailen Bobillo López

“…Gustavo Aldereguía Lima¨ in Cienfuegos and happened during one year (2005-2006). It was analyzed: demographic data, absolute neutrophils count values, number of administered doses, treatment regime and possible treatment interruptions <strong>Results:</strong> 50, 5% received treatment in an ambulatory way. …”
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Differentiation between glioblastoma and solitary brain metastases using perfusion and amide proton transfer weighted MRI by Malte Knutsson, Tim Salomonsson, Faris Durmo, Emelie Ryd Johansson, Anina Seidemo, Jimmy Lätt, Anna Rydelius, Sara Kinhult, Elisabet Englund, Johan Bengzon, Peter C. M. van Zijl, Peter C. M. van Zijl, Linda Knutsson, Linda Knutsson, Linda Knutsson, Pia C. Sundgren, Pia C. Sundgren, Pia C. Sundgren

“…Quantitative parameter maps were calculated, and regions-of-interest (ROIs) were placed in whole tumor, contrast-enhanced tumor (ET), edema, necrosis and normal-appearing white matter (NAWM). The mean and max of the APTw signal, CBF, leakage-corrected CBV and K2 were obtained from each ROI. …”
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Effect of drug interactions with apixaban on clinical outcomes in cancer patients with venous thromboembolism by Marte Svalastoga, Trine-Lise Larsen, Trine-Lise Larsen, Jorunn Brekke, Tone Enden, Hege Frøen, Herish Garresori, Eva Marie Jacobsen, Alina Carmen Porojnicu, Anne Hansen Ree, Anne Hansen Ree, Dag Torfoss, Elin Osvik Velle, Hilde Skuterud Wik, Waleed Ghanima, Waleed Ghanima, Per Morten Sandset, Per Morten Sandset, Anders Erik Astrup Dahm, Anders Erik Astrup Dahm

“…The use of fluconazole appeared associated with CRNMB (OR 3.6, 95% confidence interval (CI) 0.99-13), but not with major bleeding (OR 0.56, 95% CI 0.06 - 4.8). …”
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“I lock myself in my room and cry in frustration”: an analysis of adolescent behaviors of child-to-parent violence by Shirley Arias-Rivera, Barbara Lorence, Barbara Lorence, Jesus Maya

“…While previous research has largely focused on classifying CPV behaviors and examining their causes, there is limited investigation into what happens immediately after CPV episodes. This study aims to describe the behaviors of adolescents following violent actions in both mild and severe cases of CPV. …”
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Protocol for a meta-review of interventions to prevent and manage ICU delirium by Andrew Booth, Maria Pufulete, Ben Gibbison, Burak Kundakci, Katherine Louise Jones

“…Patients who develop ICU delirium cannot think clearly, have trouble paying attention, do not understand what is happening around them and may see or hear things that are not there. …”
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From Dickens’s Theatrical Performance to Contemporary post Dickensian Narrative and Artistic Performance (Acker, Ackroyd, Waters and Rushdie) by Georges Letissier

“…Kathy Acker’s Great Expectations, by juxtaposing disjointed jump-cut sequences incorporating fantasy, personal statements and plagiarism transforms Dickensian theatrical performance into “narrative happenings”. As for Rushdie, the few pages he dedicates to Our Mutual Friend in his Satanic Verses capitalize on Dickens’s histrionic exuberance to stun the reader through verbal fireworks.…”
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Borrelia burgdorferi sensu lato inhibits CIITA transcription through pSTAT3 activation and enhanced SOCS1 and SOCS3 expression leading to limited IFN-γ production by Michelle A.E. Brouwer, Zara Karami, Samuel T. Keating, Hedwig Vrijmoeth, Heidi L.M. Lemmers, Helga Dijkstra, Frank L. van de Veerdonk, Mihaela Lupse, Hadewych J.M. ter Hofstede, Mihai G. Netea, Leo A.B. Joosten

“…Throughout initial Borrelia burgdorferi sensu lato (B. burgdorferi s.l.) infection in vitro, inadequate IFN-γ production results in the absence of a strong T-helper 1 cell response, potentially hampering the development of an effective antibody responses in Lyme borreliosis (LB) patients. …”
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THE ATTITUDE OF STUDENT YOUTH TO FAMILY VALUES (CASE STUDY OF THE SVERDLOVSK REGION) by Yu. R. Vishnevsky, M. V. Yachmeneva

“…It is concluded that the greatest changes have happened in marital status of students over the past two decades. …”
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Comparison of demographic, clinical and laboratory characteristics between first and second COVID-19 waves in a secondary care hospital in Qatar: a retrospective study by Prem Chandra, Vamanjore A Naushad, Nishan K Purayil, Abazar Ahmad M Saeed, Pradeep Radhakrishnan, Irfan Varikkodan, Joe V Mathew, Jaseem Sirajudeen, Riyadh A Hammamy, Ahmad M Badi, Aasir M Suliman, Mohamed N Badawi, Saket Arya, Maryam AlMotawa, Aisha Al-Baker, Rania Alatom, Anand Kartha

“…The second wave had a shorter length of stay (14.58±7.75 vs 12.61±6.16, p&lt;0.001) and more patients were discharged home (22% vs 10%, p&lt;0.001).Conclusions Patients who presented during the second wave of COVID-19 pandemic appeared to be more ill clinically and based on their laboratory parameters. …”
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Exploring the impact of aging on motor imagery abilities: a systematic review with meta-analysis by José Fierro-Marrero, José Fierro-Marrero, José Fierro-Marrero, Mario González-Iglesias, Alberto Melis-Romeu, Javier Andrés López-Vidal, Alba Paris-Alemany, Alba Paris-Alemany, Alba Paris-Alemany, Roy La Touche, Roy La Touche, Roy La Touche

“…Hand recognition in hand laterality judgment task visual analysis revealed a poorer accuracy, greater response time and lower efficiency in older adults.ConclusionVividness of MI in kinesthetic and visual modalities appears to be preserved in older adults. Tendencies for greater time in mental chronometry were observed in older adults in TUG, linear walk and upper limb tasks. …”
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Integrative Omics Analysis Reveals Mechanisms of Anthocyanin Biosynthesis in Djulis Spikes by Chunmei Zheng, Wenxuan Ge, Xueying Li, Xiuzhang Wang, Yanxia Sun, Xiaoyong Wu

“….), a member of the <i>Amaranthaceae</i> family plant, is noted for its vibrant appearance and significant ornamental value. However, the mechanisms underlying color variation in its spikes remain unexplored. …”
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The state of combined thoracoabdominal triple-organ transplantation in the United States by Emily G. Dunbar, BS, Ye In Christopher Kwon, BA, Matthew Ambrosio, MS, Inna F. Tchoukina, MD, Keyur B. Shah, MD, David A. Bruno, MD, Walker A. Julliard, MD, Josue Chery, MD, Vigneshwar Kasirajan, MD, Zubair A. Hashmi, MD

“…While overall survival between TOTs appears similar, adding a liver to a heart-lung transplant may be associated with a poorer prognosis compared to adding a kidney. …”
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The efficacy of neoadjuvant immunotherapy and lymphocyte subset predictors in locally advanced esophageal squamous cell carcinoma: A retrospective study by Ruotong Wang, Shaodi Wen, Xiaoyue Du, Jingwei Xia, Bowen Hu, Yihan Zhang, Guoren Zhou, Feng Jiang, Xiaomin Lu, Miaolin Zhu, Xinyu Xu, Bo Shen

“…Conclusion The combination of PD‐1 inhibitors and chemotherapy appears promising for locally advanced ESCC. Evaluating the differentiation status and dynamic changes of peripheral blood immune cells may provide valuable predictive insights into treatment efficacy and prognosis.…”
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