Drought Analysis Using Standardized Evapotranspiration and Aridity Index at Bilate Watershed: Sub-Basins of Ethiopian Rift Valley by Bereket Tesfaye Haile, Kassahun Ture Bekitie, Tadesse Terefe Zeleke, Desalegn Yayeh Ayal, Gudina Legese Feyisa, Fikiru Abiko Anose

“…In Ethiopia, more prevalent drought happenings have been documented in the past century. …”
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Dynamics and regulatory roles of RNA m6A methylation in unbalanced genomes by Shuai Zhang, Ruixue Wang, Kun Luo, Shipeng Gu, Xinyu Liu, Junhan Wang, Ludan Zhang, Lin Sun

“…Aberrant expression of m6A components appears in a variety of human diseases. RNA m6A modification in Drosophila has proven to be involved in sex determination regulated by Sxl and may affect X chromosome expression through the MSL complex. …”
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Creation of body color mutants by CRISPR/Cas9 gene editing in largemouth bass, Micropterus salmoides by Lina Sun, Tian Gao, Zhiqiang Li, Xiaolong Yang, Zuliang Qin, Mingxiao Ye, Ying Li, Feilong Wang, Deshou Wang

“…Enzyme-digestion and sanger-sequencing demonstrated that the CRISPR/Cas9 system is available for the gene editing of LMB. …”
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Taxonomic structure of bacterial communities in sourdoughs of spontaneous fermentation by V. K. Khlestkin, M. N. Lockachuk, O. A. Savkina, L. I. Kuznetsova, E. N. Pavlovskaya, O. I. Parakhina

“…It was shown that as the relative number of lactic acid bacteria of the genus Lactobacillus increased, a gradual displacement of the coccal forms of Lactococcus, Leuconostoc, Weissella, Pediococcus happened. With further propagation of sourdough after 10 days, the position of the dominant groups of bacteria was occupied by representatives of the phylum Firmicutes, lactic acid bacteria of the genus Lactobacillus. …”
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How does gut microbiota affect the vaginitis axis? The mediating role of plasma metabolites by Mo Li, Qianyu Zhang, Tong Wu, Lanfang Ma, Dianxing Hu, Zixuan Yuan, Shixuan Wang, Aiyue Luo, Jinjin Zhang

“…The findings indicated that 3-phosphoglycerate and lysophosphatidylcholine antagonistically act against the two identified risk factors (Candidatus Soleaferrea and Dialister, respectively) of vaginitis, thus appearing to confer protective effects against vaginitis. …”
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A Network Pharmacology-Based Strategy for Unveiling the Mechanisms of Tripterygium Wilfordii Hook F against Diabetic Kidney Disease by Yuyang Wang, Tongtong Liu, Fang Ma, Xiaoguang Lu, Huimin Mao, Weie Zhou, Liping Yang, Ping Li, Yongli Zhan

“…Compounds correspond to more targets include kaempferol, beta-sitosterol, stigmasterol, and Triptoditerpenic acid B, which appeared to be high-potential compounds. Genes with higher degree including VEGFA, PTGS2, JUN, MAPK8, and HSP90AA1 are hub genes of TwHF against DKD, which are involved in inflammation, insulin resistance, and lipid homeostasis. …”
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Effect of Daily Fiber Intake Among Cirrhotic Patients With and Without Portosystemic Shunts by Simona Parisse, Sara Carnevale, Elio Damato, Flaminia Ferri, Monica Mischitelli, Mario Corona, Pierleone Lucatelli, Alfredo Cantafora, Adriano De Santis, Domenico Alvaro, Maurizio Muscaritoli, Stefano Ginanni Corradini

“…In particular, in the advanced cirrhosis stage with PSs, soluble fiber intake appears to significantly influence disease progression and should be kept low.…”
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Health and tuberculosis systems resilience, the role of the private sector and pandemic preparedness: insights from a cross-country qualitative study with policy-makers in India, I... by Madhukar Pai, Poshan Thapa, Charity Oga-Omenka, Angelina Sassi, Vijayashree Yellappa, Petra Heitkamp, Bony Wiem Lestari, Surbhi Sheokand, Nathaly Aguilera Vasquez, Laura Jane Brubacher, Bolanle Olusola-Faleye, Joel Shyam Klinton

“…India, Indonesia and Nigeria are high TB-burden countries where the majority of initial care-seeking happens in the private health sector. The objectives of this study were to (1) explore policy-makers’ perspectives on the impact of the COVID-19 pandemic on private sector TB service delivery in India, Indonesia and Nigeria and (2) identify cross-cutting insights for pandemic preparedness with respect to TB service delivery.Methods From May to November 2021, 33 interviews were conducted with key policy-makers involved in health service administration, TB service delivery and/or the COVID-19 response in India, Indonesia and Nigeria (n=11 in each country). …”
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Experimental Evaluation Study on High Temperature Tolerance Foam for Profile Control of Steam Huff-n-Puff by Yang Liu, Xiao Yuan, Yu Bao

“…It is important to find an economical and efficient method to prevent steam channeling from happening at steam huff and puff production; thus, a DF-2 high temperature tolerance foam system is proposed to assist steam huff and puff production in this paper. …”
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Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya by Victor Osoti, Kevin Wamae, Leonard Ndwiga, Paul M. Gichuki, Collins Okoyo, Stella Kepha, Kibor Keitany, Regina Kandie, Stephen Aricha, Rosebella Kiplagat, Charles Mwandawiro, Philip Bejon, Robert W. Snow, Lynette Isabella Ochola-Oyier

“…The A578S mutation, was also identified in mixed infections, appearing in 15.2% of the 87 samples analysed. The Pfdhfr 51I and 108 N pyrimethamine-resistance mutations were at fixation (100% frequency), and the Pfmdr1 Y184F mutation, which is linked to reduced susceptibility to several antimalarial drugs, especially those used in combination therapies for malaria treatment, was detected in 97.5% of the samples as mixed-genotype infections. …”
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Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction by Aric A. Prather, PhD, Ying Gao, MS, Legna Betancourt, BS, Rose C. Kordahl, BS, Anya Sriram, BS, Chiung-Yu Huang, PhD, Steven R. Hays, MD, Jasleen Kukreja, MD, Daniel R. Calabrese, MD, Aida Venado, MD, Bhavya Kapse, PhD, John R. Greenland, MD, PhD, Jonathan P. Singer, MD, MS

“…Conclusions: Poor sleep after lung transplant appears associated with PROs, frailty, CLAD, and death. …”
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Genomic and Pathogenic Characteristics of Virulent Newcastle Disease Virus Isolated from Chicken in Live Bird Markets and Backyard Flocks in Kenya by Irene N. Ogali, Paul O. Okumu, Erick O. Mungube, Jacqueline K. Lichoti, Stephen Ogada, Grace K. Moraa, Bernard R. Agwanda, Sheila C. Ommeh

“…In Kenya, despite rampant annual ND outbreaks, implementation of control strategies is hampered by a lack of adequate knowledge on the circulating and outbreak causing-NDV strains. …”
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Laparoscopic excision of deep rectovaginal endometriosis in BSGE endometriosis centres: a multicentre prospective cohort study by Paul Smith, Lucky Saraswat, Sanjay Vyas, Thomas Ind, Ertan Saridogan, Elizabeth Ball, Edward Morris, James Clark, Tony Chalhoub, David Rowlands, Moiad Alazzam, Dominic Byrne, Tamara Curnow, Alfred Cutner, T Justin Clark, Iris Menninger, Yousri Afifi, Kevin Phillips, Saikat Banerjee, Robert Richardson, Jeremy Hawe, Barry Whitlow, Emmanuel Ofuasia, Ashwini Trehan, Tyrone Carpenter, Christian Becker, Stuart Jack, Kumar Kunde, Chris Barnick, Alan Farthing, Graham Phillips, John Bidmead, Mohamed Abdel-aty, George Botros, Marlin Mubarak, Christian Kremer, Stanley Okolo, Edmond Edi-osagi, Kamel Shehata-iskander, Gaity Ahmad, Jonathan Frappell, Brice Rodriguez, Yemi Coker, Gourab Misra, Adam Moors, Chris Guyer, Caroline Overton, Suku George, Oliver Chappatte, Richard Penketh, Funlayo Odejinmi, Keith Louden, Jon Hughes

“…Gastrointestinal complications (enterotomy, anastomotic leak or fistula) occurred in 52 (1.1%) operations and of the urinary tract (ureteric/bladder injury or leak) in 49 (1.0%) procedures.Conclusion Laparoscopic surgical excision of rectovaginal endometriosis appears to be effective in treating pelvic pain and bowel symptoms and improving health-related quality of life and has a low rate of major complications when performed in specialist centres.…”
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Adjuvant Therapy after Esophagectomy for Esophageal Cancer: Who Needs It?: Multi-institution Worldwide Observational Study by Siva Raja, MD, PhD, Thomas W. Rice, MD, Min Lu, PhD, Marie E. Semple, MPH, Andrew J. Toth, MS, Eugene H. Blackstone, MD, Sudish C. Murthy, MD, PhD, Usman Ahmad, MD, Michael McNamara, MD, Hemant Ishwaran, PhD, for the Worldwide Esophageal Cancer Collaboration Investigators

“…Adjuvant therapy after esophagectomy appears to benefit most patients with node-positive squamous cell carcinoma, but for adenocarcinoma, its value is limited to deep cancers and to those with substantial nodal burden. …”
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Molecular investigation reveals three hemotropic mycoplasmas in cats and three tick species in China by Hongfei Shi, Guoguang Li, Dandan Li, Hongyue Zhai, Shidong Ji, Yun Hu, Long Wang, Lunguang Yao

“…‘Ca. M. haemominutum’ appears to be associated with anemic syndrome in cats, while further research is needed to explore the relationship between ‘Ca. …”
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Financial Management and Performance of SACCOS in Kisoro District: A Case Study of Chahi Dukore SACCO in Chahi Sub County. by Tuyambaze, Medad

“…The respondents also said that if there is efficient financial management, employment opportunities increase. This happens when the SACCO opens up branches in many parts of the district hence this accounted for l 0( 19%) of the respondents. …”
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Post Covid-19 Syndromes, The Time line of Covid by Nadia Shams, Zaid Umar, Lubna Meraj, Neelam Ayub, Muhammad Waseem, Kazim Abbas Virk

“…X-ray findings showed lung fibrosis in 12, ground glass appearance 10. Spirometry showed reduced exercise capacity in 11. …”
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Microscale bone interlocking enhances osseointegration strength on the rough surface of 3D-printed titanium implants: experimental and finite element analysis by Tianyu Shu, Haoyu Shi, Meng Li, Yu-Chia Lin, Ang Li, Dandan Pei

“…Notably, after week 2, bone interlocking phenomenon appeared on the SLM implants. The removal torque for the SLM implants at week 2 were significantly greater (P < 0.05) than that for the CNC-SLA implants at the same time point and was comparable to the CNC-SLA implants at week 8 (P = 0.775). …”
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Sand body architecture of braided river deltas in the Upper Triassic Xujiahe Formation, Sichuan Basin by Yanqing Huang, Meizhou Deng, Nan Duan, Wujun Jin, Junlong Liu, Na Niu, Ai Wang, Xiaolin Lu

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INBRX-120, a CD8α-targeted detuned IL-2 that selectively expands and activates tumoricidal effector cells for safe and durable in vivo responses by Jason Ho, Chelsie Macedo, Garrett Cyprus, Rajay Pandit, Anya Polovina, Nadja Kern, Abrahim Hussain, Sae Jeong Ahn, William Crago, Emily Rowell, Florian J Sulzmaier, John C Timmer, Brendan P Eckelman

“…Despite promising activity in a subset of patients, wider therapeutic utility of IL-2 (aldesleukin) has been hampered by severe dose-limiting toxicities, the expansion of immunosuppressive regulatory T cells and a poor pharmacokinetic (PK) profile. …”
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