Postprogression therapy and confounding for the estimated treatment effect on overall survival in phase III oncology trials by Pavlos Msaouel, Ramez Kouzy, Joseph Abi Jaoude, Ethan B Ludmir, Alexander D Sherry, Timothy A Lin, Esther J Beck, Avital M Miller, Adina H Passy, Gabrielle S Kupferman, Eugene J Koay, Clifton David Fuller, Charles R Thomas, Zachary R McCaw

“…PPT adjustments were often prespecified (N=23, 56%), and appeared to be more likely in cross-over studies (OR 5.04, 95% CI 2.42 to 10.38) and studies with discordant surrogate-OS findings (OR 2.26, 95% CI 1.16 to 4.38). …”
Get full text

Application of Food Mechanics and Oral Processing in Modelling First Bite of Grilled Meat by Ilija V. Djekic, Jovan G. Ilic, Bartosz G. Sołowiej, Rastko I. Djekić, Igor B. Tomasevic

“…Presented models demonstrate that the highest values are around teeth pressure and lead to a conclusion that upon biting, the meat structure will suffer irreversible damage dividing the grilled meat into two pieces, as it happens during the first bite. The main conclusion of this study is that by combining results from oral processing and testing of mechanical properties of the grilled products, it is possible to simulate the first bite.…”
Get full text

Être correspondant régional en Tunisie : De l’aliénation au pouvoir à la liberté totale by Hamida El Bour

“…The uprisings that took place in Tunisia from 17th of December 2010 to 14 January 2011 show how the mainstream Tunisian media made a blackout on what was happening in the regions inside the country. This is how did the media system during the former Ben Ali’s regime era used to deal with the real concerns of the citizens. …”
Get full text

Molecular genetic and bacteriological methods of bovine mycoplasmosis diagnosis by E. V. Remizova, A. V. Gorbatov, L. K. Semina, Z. A. Skulyabina, N. V. Shmidt, G. A. Baldicheva, N. N. Avduevskaya

“…Mycoplasma colonies, as well as colonies of L-form bacteria, have a typical «fried egg» appearance, therefore it is necessary to differentiate them for the accurate diagnosis and choice of treatment. …”
Get full text

Clinical and Technical Characteristics of Coronary Angiography and Percutaneous Coronary Interventions Performed before and after Transcatheter Aortic Valve Replacement with a Ball... by Alfredo Nunes Ferreira-Neto, Rishi Puri, Lluis Asmarats, Victoria Vilalta, Leonardo Guimaraes, Robert Delarochellière, Jean-Michel Paradis, Siamak Mohammadi, Eric Dumont, Josep Rodés-Cabau

“…To report on the feasibility and technical differences between coronary procedures performed before and after TAVR with the balloon-expandable Edwards-SAPIEN or the SAPIEN XT valves. Background. Coronary artery disease (CAD) and aortic stenosis often coexist. …”
Get full text

Ex vivo delivery of recombinant IL-10 to human donor lungs by Jonathan C. Yeung, Terumoto Koike, Dirk Wagnetz, Tiago N. Machuca, Riccardo Bonato, Mingyao Liu, Stephen Juvet, Marcelo Cypel, Shaf Keshavjee

“…Results: Perfusate and intratracheal delivery of rIL-10 did not provide the therapeutic anti-inflammatory action that has been traditionally achieved with gene therapy. It appears that intratracheally delivered rIL-10 moves into the perfusate where it seems to be biologically inactive. …”
Get full text

Effect of Manganese Ions on Spectroscopic and Insulating Properties of Aluminophosphate Glasses by B. Kassa, J. Leta Tesfaye, B. Bulcha, R. Kiran, T. Deepak, Dayanand Lal, S. Venkatesh, R. Krishnaraj

“…The stability of the glass network appears to increase with the increase of MnO concentration, according to the findings. …”
Get full text

Mutational Analysis of a Familial Adenomatous Polyposis Pedigree with Bile Duct Polyp Phenotype by Li-jun Xie, Dan-dan Ruan, Jian-hui Zhang, Yi Li, Li Chen, Mao-lin Yan, Ming-dian Yu, Jie-wei Luo, Hui-zhen Zhang

“…Due to the deletion of two bases, a stop codon appeared after 31 amino acids, and the protein was truncated prematurely, which affected the conformation of the protein. …”
Get full text

Enhanced Optical and Thermal Stability of Blue Pyrrole Derivatives for Color Filter in Image Sensors by Sunwoo Park, Sangwook Park, Saeyoung Oh, Hyukmin Kwon, Hayoon Lee, Kiho Lee, Chun Yoon, Jongwook Park

“…When the thermal stability of color filter films for image sensors was evaluated, BAPCP demonstrated excellent optical properties before and after thermal stability testing, maintaining its characteristics in an optimized molecular form. Accordingly, BAPCP appears to have favorable potential as a blue colorant for image sensors, attributed to its superior optical and thermal stability characteristics.…”
Get full text

Experiencing the Loss of an Adult Child in Old Age by A.A. Agisheva

“…Based on the analysis of 76 literary sources, a comparison and specification of the empirical research results were carried out, which preliminary revealed universal psychological consequences of losing a child at an older age, including a sense of guilt, a feeling of abnormality of what happened, complication of the age crisis, deformation of the "Self-concept", chronification of grief. …”
Get full text

Intensification of Hurricane Idalia by a river plume in the eastern Gulf of Mexico by Jing Shi, Chuanmin Hu, Jennifer Cannizzaro, Brian Barnes, Yingjun Zhang, Chad Lembke, Matthieu Le Henaff

“…Therefore, incorporating the river plume in future forecast models appears to be essential to improve the accuracy of intensity predictions, especially in the areas affected by the plume, where stratification plays an important role in the intensification dynamics.…”
Get full text

Tearing-mediated Alfvénic Turbulence in a Relativistic Plasma by Stanislav Boldyrev, Nuno F. Loureiro

“…Below the critical scale, the energy spectrum of magnetic fluctuations steepens to W ( k ) dk ∝ k ^−(7 ^n ^+2)/3 ^n dk . However, this happens only when $\tilde{\sigma }\ll {\left({L}_{\perp }/{d}_{\mathrm{rel}}\right)}^{(2+4n)/(4+5n)}$ , where $\tilde{\sigma }$ is the magnetization parameter based on the magnetic fluctuations. …”
Get full text

Simulation and Analysis of the Optimal Electric Field from Modifications to the Winding Design for the Tesla Transformer by Nattachote Rugthaicharoencheep, Supawud Nedphokaew

“…We created a design of the Tesla transformer to reduce the high-voltage electric field-stress problem that happens between primary winding and secondary winding. …”
Get full text

Truffle Species Discrimination Based on Their Chemical Composition, Chromaticity Coordinates and Antioxidant Capacity by Cristina Valencia-Sullca, Anja Rakotondramavo, Catherine Verret, Jean-Philippe Blondeau, Sullivan Renouard

“…Some edible truffle species are more sought after and expensive than others while they have a similar colour and appearance. This therefore leads to high risk of fraud. …”
Get full text

Exhausting the (Human) Problem by Annalaura Alifuoco

“… What happens when exhaustion becomes not defeat but necessity? …”
Get full text

ANALISIS KELAYAKAN USAHA BURUNG PUYUH PETELUR (Coturnix coturnix japonica) DI KELURAHAN TEBING TINGGI OKURA KECAMATAN RUMBAI PESISIR KOTA PEKANBARU by Boni Sanjaya, Amalia Amalia, Hamdan Yasid

“…Of the three analysis shows the results of operations of livestock quail in the Tebing Tinggi Okura Village, Rumbai Pesisir District, Pekanbaru city well worth the effort and Pay Back Period (PBP) 2 years 7 months 27 days (2) Analysis of the feasibility of livestock quail from the aspect of Break Event Point (BEP) seen from the time period is 5 years 2 months 8 days, 3) Problems faced by entrepreneurs is a quail farm in the event of increased supply increases demand for quail eggs also increased so as to lower prices, usually occurs in the month of Ramadan. What happens is the tendency of declining revenues …”
Get full text

Divergent Adsorption Regulation in Metal–Organic Frameworks for Highly Efficient CF4/C2F6 Separation by Guihong Xu, Tian Ke, Rongrong Fan, Kaiyuan Tan, Wenjun Zhang, Baogen Su, Zhiguo Zhang, Zongbi Bao, Qilong Ren, Qiwei Yang

“…Abstract The efficient removal of low‐concentration components from homologous mixtures is often hampered by the co‐directional effect of traditional thermodynamic regulation approaches, typically leading to a trade‐off between adsorption capacity and selectivity. …”
Get full text

Vaccine Prophylaxis of Pneumococcal Infections in Children under Conditions of Severe Flood in the Amur River Basin by Aleksandr G. Chuchalin, Gennadiy G. Onishchenko, Victor P. Kolosov, Olga P. Kurganova, Tatiana A. Zaitseva, Leonid G. Manakov, Galina N. Kholodok, Juliy M. Perelman, Roman S. Kozlov, Natalia M. Ivakhnishina, Olga E. Trotsenko, Albina P. Bondarenko

“…Differences in the frequency and range of serovariants of circulating isolates of pneumococcus in the postvaccinal period and in unvaccinated children, elimination of a number of serotypes, and appearance of circulation of nonvaccinated strains were revealed. …”
Get full text

Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in HCV-Positive Egyptian Patients Treated with Sofosbuvir by Ali Nada, Mohamed Abbasy, Aliaa Sabry, Azza Mohamed Abdu Allah, Somaia Shehab-Eldeen, Nada Elnaidany, Hanan Elimam, Kawthar Ibraheem Mohamed Ibraheem, Abdallah Essa

“…Conclusions. Sofosbuvir appears to have no nephrotoxic effects and is safe to treat patients with chronic HCV infection.…”
Get full text

Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway by Orlei Ribeiro de Araujo, Reinaldo Salomão, Milena Karina Coló Brunialti, Dafne Cardoso Bourguignon da Silva, Andreza Almeida Senerchia, Fabianne Altruda de Moraes Costa Carlesse, Antonio Sergio Petrilli

“…On day 1, IL-6, IL-8, and IL-10 appeared upregulated in patients who received filgrastim. …”
Get full text