Long-term effects of dupilumab on chronic rhinosinusitis with nasal polyps: A step towards clinical remission by Mona Al-Ahmad, MD, FRCPC, Asmaa Ali, MD, PhD, Wafaa Talat, MD, PhD, Haitham A. Dawood, MD, PhD, Osama Imam, MD, PhD

“…Background and objectives: Clinical remission, defined as the absence of disease activity and symptoms, is an emerging goal in the management of chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to evaluate the long-term effects of dupilumab on patients with CRSwNP, with or without asthma, and explore the potential for achieving clinical remission. …”
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Patient-centered outcomes for clinical trials in chronic rhinosinusitis with or without nasal polyps and allergic fungal rhinosinusitis by Brittany Klooster, Kaitlin Chatterton, Nazifa Ibrahim, Madison C. Bernstein, Alan L. Shields, Veleka Allen

“…Abstract Background Chronic rhinosinusitis (inclusive of subtypes with nasal polyps [CRSwNP], without nasal polyps [CRSsNP], and allergic fungal rhinosinusitis [AFRS]) causes inflammation of the nose mucosa and paranasal sinuses. …”
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Matrix metalloproteinase-12 by M2 macrophages induced epithelial to mesenchymal transition in chronic rhinosinusitis with nasal polyps. by Joo-Hoo Park, Jae-Min Shin, Hyun-Woo Yang, Tae Hoon Kim, Seung Hoon Lee, Ok Sarah Shin, Il-Ho Park

“…Th2 inflammation and epithelial-mesenchymal transition (EMT) play crucial roles in the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to investigate the hypothesis that MMP-12, produced by M2 macrophages, induces EMT in nasal epithelial cells, thereby contributing to airway inflammation and remodeling in CRSwNP. …”
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HMOX1 as a potential drug target for upper and lower airway diseases: insights from multi-omics analysis by Enhao Wang, Shazhou Li, Yang Li, Tao Zhou

“…Methods Differentially expressed genes (DEGs) between healthy nasal mucosa and chronic rhinosinusitis with nasal polyps (CRSwNP) were identified from Gene Expression Omnibus (GEO). …”
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Effect of Exfoliation Corrosion on the Mechanical Properties of Friction Stir Spot Welded 2024-T3 AA Joints by Ramadhan H. Gardi, Abdulkader kadauw, Bertrand Hanschel

“…This study aims to detect the impact of preexfoliation corrosion on the efficiency of 2 mm thick 2024-T3 aluminum alloy friction stir spot welded (FSSW) joints. Five specimens of FSSW joints, welded with 620 r·min−1 rotational speed and a dwell time of 10 seconds, were immersed in an exfoliation corrosion solution for five different times: 10 h, 20 h, 30 h, 40 h, and 50 h. …”
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Research on Friction Stir Spot Welding Brazing Process and Properties of Dissimilar Metals DP590 and 6061 by Kai Xu, Shu-quan Zhang

“…Friction stir welding (FSW) is the most popular and efficient method for solid-state joining of similar or dissimilar metals and alloys. …”
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Chronic rhinosinusitis with nasal polyps: Key considerations in the multidisciplinary team approach by Oliver Pfaar, Anju T. Peters, Camille Taillé, Thijs Teeling, Jared Silver, Robert Chan, Peter W. Hellings

“…Abstract Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a recurrent inflammatory disease associated with several comorbidities and a significant disease burden for patients. …”
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First record of a cave maternity roost of Rhinolophus hipposideros (Bechstein, 1800) in Slovenia by Primož Presetnik, Borut Kumar

“…The cave is located in the Idrijca River canyon, SSW of the town of Idrija (Western Slovenia). Here, we present information on preliminary observations as to the number of adult and juvenile animals, along with temperature statistics and cave morphology. …”
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„Zakazana komnata Lei”. Pismo Święte w bulli kanonizacyjnej „Mira circa nos” by Paweł Paszko

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Chronic Rhinosinusitis with Nasal Polyps and Biologics: A Call for Better Data Standardisation and Presentation in Clinical Studies by Kariyawasam HH, Langan D, Rimmer J

“…Recent randomised control trials (RCTs) of biologics that target key inflammatory pathways have demonstrated clinical efficacy in treating CRSwNP. Such RCTs must facilitate meta-analysis. …”
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Improving predictability of IgE-high type 2 chronic sinusitis with nasal polyps in the biologic era by Austin Heffernan, Jobanjit Phulka, Andrew Thamboo

“…Omalizumab is an anti-IgE biologic that was recently approved by the FDA and Health Canada for use in severe CRS with nasal polyps (CRSwNP) recalcitrant to intranasal corticosteroids. …”
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La significación de caminar cabeza abajo (<em>sxd</em>) en la literatura funeraria egipcia by Mariano Bonanno

“…La variedad de castigos es amplia, pero por su característica, por las reiteradas menciones en los textos y por la diversidad de explicaciones que se han ensayado al respecto, la situación de estos sxd.w es particularmente interesante. Lo que este estudio se propone, además de un recorrido por los diferentes contextos funerarios en que se los cita, es explicar su significación para entender por qué era uno de los castigos más temidos por los condenados. …”
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Mechanical Behaviors of Friction Stir Spot Welded Joints of Dissimilar Ferrous Alloys under Opening-Dominant Combined Loads by Md. Abu Mowazzem Hossain, Md. Tariqul Hasan, Sung-Tae Hong, Michael Miles, Hoon-Hwe Cho, Heung Nam Han

“…Mechanical properties and failure behaviors of friction stir spot welded (FSSW) joints of two dissimilar ferrous alloys, cold-rolled carbon steel (SPCC) and 409L stainless steel (SUS 409L), are investigated under opening-dominant combined loads. …”
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Unveiling and validating biomarkers related to the IL-10 family in chronic sinusitis with nasal polyps: insights from transcriptomics and single-cell RNA sequencing analysis by Xinghong Liu, Yi Peng, Ling Guo, Weilan Xiong, Weijiang Liao, Jiangang Fan

“…Candidate genes were identified by intersecting differentially expressed genes (DEGs) between the CRSwNP and control groups (DEGsall) with those between the high- and low-score groups within the CRSwNP cohort (DEGsNP). …”
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Canadian real-world study of access and clinical results using dupilumab for chronic rhinosinusitis with polyps by Shaun J. Kilty, Andrea Lasso

“…Conclusion Patients treated with dupilumab for CRSwNP at out tertiary rhinology clinic showed substantial clinical symptom improvement that is similar to that observed in prior randomised clinical trials. …”
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PLACE ATTACHMENT AND PRO-ENVIRONMENTAL BEHAVIOUR PARALYSIS: A STUDY OF HOUSEHOLD SOLID WASTE MANAGEMENT by Hope Iyawe

“…One of the implications of this strong correlation is that household solid waste (HHSW) have been successfully managed. While individuals residing in cities of developing countries in places such as Nigeria are known to have strong PA, contemporary literature suggests that this nexus has not impacted positively on how HHSW has been managed. …”
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Eclecticism in child welfare by Terje Halvorsen

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人神经生长因子基因真核细胞表达载体的构建与鉴定

“…方法: 应用基因重组技术将 hNGF cDNA 克隆到逆转录病毒载体 pLXSN 中 ,用限制性内切酶酶切分析重组质粒 pLNGFSN 中 hNGF 基因的插入方向,用 PCR、斑点杂交和 Southern 杂交对重组质粒 pLNGFSN 作进一步鉴定。…”
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非清髓性干细胞移植治疗狼疮鼠 by 李　娟

“…【目的】探索用非清髓性干细胞移植治疗BXSB 狼疮鼠的有效性及安全性。【方法】实验组用氟哒拉宾、环磷酰 胺作预处理, 对照组用马利兰+环磷酰胺作预处理, 动态观察两组外周血细胞变化, 流式细胞仪检测移植后受者CD3 -CD5 + 、 CD3 +CD5 +的改变, 聚合酶链反应-短串联重复序列分析移植后BXSB 鼠嵌合状态, 免疫荧光法检测移植前后受者的肾病理变 化。…”
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Predicting the effectiveness of omalizumab in patients with refractory chronic rhinosinusitis with nasal polyps comorbid with asthma based on inflammatory biomarkers by Yutong Sima, MD, Ming Zheng, MD, Yan Zhao, PhD, Siqi Ge, PhD, Chengyao Liu, MD, Ping Wang, BS, Xiangdong Wang, MD, PhD, Luo Zhang, MD, PhD

“…Background: The treatment of refractory chronic rhinosinusitis with nasal polyps (CRSwNP) with omalizumab has been well studied based on clinical evaluation. …”
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