A copy number variation detection method based on OCSVM algorithm using multi strategies integration by Mengjiao Zhou, Jinxin Dong, Hua Jiang, Zuyao Zhao, Tianting Yuan

“…Abstract Copy number variation (CNV) is an important part of human genetic variations, which is associated with various kinds of diseases. …”
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Drag Reduction Mechanism of Viscoelastic Slick-Water Fracturing Fluid in Tortuous and Rough Fractures by Zhiyu Liu, Fan Fan, Donghang Zhang, Yang Li, Yuan Li, Kai Yang, Hongkui Ge, Fujian Zhou

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Research of the Plunge Milling for Face Gear by Tang Jinyuan, Yang Xiaoyu

“…Study the face gear machining method by using the plunge milling processing,according to the face gear slotting processing principle and gear engagement principle,a plunging processing method with multi group envelops processing is proposed.Based on the concept of virtual copying of plunge milling cutter to the gear shaper tool,the rotation relation between the gear shaper cutter tooth surface equation,contour surface equation and cutting tool and the face gear moving coordinate system are deduced,and the spur face-gear is processed through multi group envelops.The mathematical formula of the plug mill copying the of the profile of gear shaper cutter and the based on gear shaper cutter and the machine tool structure are given.According to numerical control manufacturing techniques,the NC code based on face gear machined equation is obtained.It is imported into VERICUT to simulate and process.Through the contrasting between simulation and theoretical tooth surface,the feasibility of the proposed method is proved.The proposed method is a new rough machining method for face gear numerical control plunge milling processing,it has great reference value for face gear manufacturing.…”
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Widespread mutagenesis and chromosomal instability shape somatic genomes in systemic sclerosis by Sriram Vijayraghavan, Thomas Blouin, James McCollum, Latarsha Porcher, François Virard, Jiri Zavadil, Carol Feghali-Bostwick, Natalie Saini

“…Abstract Systemic sclerosis is a connective tissue disorder characterized by excessive fibrosis that primarily affects women, and can present as a multisystem pathology. Roughly 4-22% of patients with systemic sclerosis develop cancer, which drastically worsens prognosis. …”
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