Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab by Meng Wu, Claudia A.M. Fulgenzi, Antonio D’Alessio, Alessio Cortellini, Ciro Celsa, Giulia F. Manfredi, Bernardo Stefanini, Y. Linda Wu, Yi-Hsiang Huang, Anwaar Saeed, Angelo Pirozzi, Tiziana Pressiani, Lorenza Rimassa, Martin Schoenlein, Kornelius Schulze, Johann von Felden, Yehia Mohamed, Ahmed O. Kaseb, Arndt Vogel, Natascha Roehlen, Marianna Silletta, Naoshi Nishida, Masatoshi Kudo, Caterina Vivaldi, Lorenz Balcar, Bernhard Scheiner, Matthias Pinter, Amit G. Singal, Joshua Glover, Susanna Ulahannan, Fredrich Foerster, Arndt Weinmann, Peter R. Galle, Neehar D. Parikh, Wei-Fan Hsu, Alessandro Parisi, Hong Jae Chon, David J. Pinato, Celina Ang

“…Impact and implications:: There is currently a lack of level 1 data on second-line treatment options for patients with advanced hepatocellular carcinoma who progress after frontline atezolizumab plus bevacizumab, as all second-line approvals were established during the frontline sorafenib era. Our study aims to fill in some of the knowledge gap by investigating real-world patient outcomes in the second-line treatment setting. …”
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Single dose of recombinant baculovirus vaccine expressing sigma B and sigma C genes provides good protection against novel duck reovirus challenge in ducks by Yufei Wang, Siyi Xu, Xia Chen, Yunlong Dou, Xingzhu Yang, Zenglei Hu, Shuang Wu, Xiaoquan Wang, Jiao Hu, Xiufan Liu

“…However, currently, no commercial vaccines are available to alleviate NDRV infection throughout the world. Here, we developed two subunit vaccine candidates for NDRV based on the insect cell-baculovirus expression system (IC-BEVS). …”
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An improved lightweight ConvNeXt for rice classification by Pengtao Lv, Heliang Xu, Qinghui Zhang, Lei Shi, Heng Li, Youyang Chen, Yana Zhang, Dengke Cao, Zhongyang Liu, Yixin Liu, Jingwen Han, Zhan Zhang, Yiran Qi

“…As a major food crop widely grown around the world, the seed type of rice plays a key role in ensuring food security and optimizing agricultural productivity. …”
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Knowledge, Attitude, and Barriers Influencing Seasonal Influenza Vaccination Uptake by Mazin A. Barry, Khalid I. Aljammaz, Abdulaziz A. Alrashed

“…Seasonal influenza is an acute respiratory infection caused by influenza viruses that are highly contagious and circulate in all parts of the world. It gives rise to an estimated 3 to 5 million cases of severe illness and about 250,000 to 500,000 deaths globally each year. …”
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Acupuncture Modulates Disrupted Whole-Brain Network after Ischemic Stroke: Evidence Based on Graph Theory Analysis by Xiao Han, He Jin, Kuangshi Li, Yanzhe Ning, Lan Jiang, Pei Chen, Hongwei Liu, Yong Zhang, Hua Zhang, Zhongjian Tan, Fangyuan Cui, Yi Ren, Lijun Bai, Yihuai Zou

“…The graph theory analysis was applied using the GRETNA and SPM12 software to construct the whole-brain network and yield the small-world parameters and network efficiency. Results. …”
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Megagrazer loss drives complex landscape-scale biophysical cascades by Olli Hyvarinen, Mariska te Beest, Elizabeth le Roux, Graham I H Kerley, Robert Buitenwerf, Dave J Druce, Jiquan Chen, Linda Rapp, Joana Fernandes, Joris P G M Cromsigt

“…Our path analysis revealed that areas in the park where more rhinos had been removed showed a stronger increase in burnt area and woody encroachment compared to areas with fewer rhinos removed, which were both related to a decrease in surface albedo. …”
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Blue rings in trees and shrubs as indicators of early and late summer cooling events at the northern treeline by Agata Buchwal, Agata Buchwal, Pawel Matulewski, Ylva Sjöberg, Alma Piermattei, Alma Piermattei, Alan Crivellaro, Alan Crivellaro, Angela Balzano, Maks Merela, Luka Krže, Katarina Čufar, Alexander V. Kirdyanov, Alexander V. Kirdyanov, Tatiana Bebchuk, Tito Arosio, Ulf Büntgen, Ulf Büntgen, Ulf Büntgen

“…The high temperature sensitivity of pine trees in northern Fennoscandia has led to some of the most reliable tree-ring climate reconstructions in the world for the past millennia. However, wood anatomical anomalies that likely reflect temperature-induced reductions in cell wall lignification, the so-called Blue Rings (BRs), have not yet been systematically investigated in trees and shrubs in northern Europe. …”
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Advancing treatment choices: CDK4/6 inhibitor switching in HR+/HER2- metastatic breast cancer by Paola Zagami, Angela Esposito, Beatrice Taurelli Salimbeni, Pier Paolo Maria Berton Giachetti, Roberta Scafetta, Matteo Lambertini, Massimo Di Maio, Giuseppe Curigliano, Carmen Criscitiello, Saverio Cinieri

“…Among those who started the second CDK4/6i at full dosage, 66 % of patients didn't require a dose reduction. Conclusion: Our survey highlights the importance of allowing CDK4/6i switching, thus likely prompting oncologists to adapt their treatment choices, leading to better AEs management for improving patients’ outcome.…”
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Evaluation of three novel antigens and costimulatory agents for improvement of M. Tuberculosis specific interferon gamma release assays by Sandra Schwarzlose-Schwarck, Mark Reinwald, Torsten Bauer, Florian Hentschel, Til Kiderlen, Dorinja Zapf, Victor Herbst, Stefan Lüth, David Krieger, Werner Dammermann

“…Results The three novel antigens ACR, Rv1733 and Rv2626 failed to elicit equal or stronger IFN-γ-responses compared to the gold standard antigen formulation with ESAT-6, CFP-10 and TB10.4. The TLR9 agonist CpG ODN increased IFN-γ responses in whole blood of tuberculosis patients using our in-house assays (6,768 ± 21,097 mlU/ml vs. 2,971 ± 4,780 mlU/ml, p = 0.31), yet not significantly. …”
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Perspectives of nurses and patient representatives on the morally competent nurse: An international focus group study by Chris Gastmans, Evelyne Mertens, Alvisa Palese, Brian Keogh, Francesca Apolloni, Johanna Wiisak, Catherine Mc Cabe, Maria Dimitriadou, Alessandro Galazzi, Michael Igoumenidis, Nikos Stefanopoulos, Paraskevi Charitou, Evridiki Papastavrou, Riitta Suhonen, Stefania Chiappinotto

“…Background: Across the world, healthcare systems have become increasingly complex, making it more difficult for nurses to act ethically when faced with moral dilemmas. …”
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Impact of a cardio‐oncology unit on prevention of cardiovascular events in cancer patients by Alessandra Cuomo, Valentina Mercurio, Gilda Varricchi, Maria Rosaria Galdiero, Francesca Wanda Rossi, Antonio Carannante, Grazia Arpino, Luigi Formisano, Roberto Bianco, Chiara Carlomagno, Carmine De Angelis, Mario Giuliano, Elide Matano, Marco Picardi, Domenico Salvatore, Ferdinando De Vita, Erika Martinelli, Carminia Maria Della Corte, Floriana Morgillo, Michele Orditura, Stefania Napolitano, Teresa Troiani, Carlo G. Tocchetti

“…Abstract Aims As the world population grows older, the co‐existence of cancer and cardiovascular comorbidities becomes more common, complicating management of these patients. …”
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Laying the groundwork: Exploring pesticide exposure and genetic factors in south-eastern Brazilian farmers by Débora Dummer Meira, Victor Nogueira Da Gama Kohls, Matheus Correia Casotti, Luana Santos Louro, Gabriel Mendonça Santana, Thomas Erik Santos Louro, Adriana Madeira Alvares da Silva, Lorena Souza Castro Altoé, Raquel Reis Trabach, Sonia Groisman, Elizeu Fagundes de Carvalho, Jamila Alessandra Perini Machado, Stephanie Seneff, Iúri Drumond Louro

“…Brazil is the world leader in pesticide consumption, and its indiscriminate use puts farmers’ health at risk. …”
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Knowledge Distillation in Object Detection for Resource-Constrained Edge Computing by Arief Setyanto, Theopilus Bayu Sasongko, Muhammad Ainul Fikri, Dhani Ariatmanto, I. Made Artha Agastya, Rakandhiya Daanii Rachmanto, Affan Ardana, In Kee Kim

“…Edge computing, a distributed computing paradigm that places small yet capable computing devices near data sources and IoT sensors, is gaining widespread adoption in various real-world applications, such as real-time intelligent drones, autonomous vehicles, and robotics. …”
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Presenting the professional thinking model of employees based on the dimensions of ambivalence and psychological empowermen by Abdolmajid Kord, Mansur Garkaz, Alireza Maetoofi, Ali khuzin, Alireza Hasan Maleki

“…Bagher Pur et al, (2022) investigated the effect of the source of control on the relationship between auditors' psychological empowerment and audit quality. …”
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Comprehensive FR1(C) and FR3 Lower and Upper Mid-Band Propagation and Material Penetration Loss Measurements and Channel Models in Indoor Environment for 5G and 6G by Dipankar Shakya, Mingjun Ying, Theodore S. Rappaport, Hitesh Poddar, Peijie Ma, Yanbo Wang, Idris Al-Wazani

“…This work also presents results from extensive material penetration loss measurements at 6.75 GHz and 16.95 GHz using co and cross polarized antenna configurations for ten common construction materials found inside buildings and on building perimeters, including concrete walls, low-emissivity glass, wood, doors, drywall, and whiteboard. Our findings show penetration loss increases with frequency for all of the ten materials and partitions tested, and suggest further investigation of 3GPP material penetration loss models for at least infrared reflective (IRR) glass and concrete may be necessary. …”
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Telehomecare Monitoring for Patients Receiving Anticancer Oral Therapy: Protocol for a Mixed Methods Evaluability Study by Dominique Tremblay, Thomas Joly-Mischlich, Annick Dufour, Marie-Claude Battista, Djamal Berbiche, José Côté, Marco Décelles, Catherine Forget, Brigitte Guérin, Manon Larivière, Frédéric Lemay, Manon Lemonde, Éric Maillet, Nathalie Moreau, Michel Pavic, Sara Soldera, Catherine Wilhelmy

“…The methodological choice aims to provide real-world data that are rigorous, rapidly usable in practice, and transferable to other settings. …”
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Designing an educational model based on identity development with an Iranian-Islamic approach for primary school students. by Ali Oladhamzehzadeh, masoumeh oladiyan, Mahmoud Safari

“…In building national identity and changing its layers, endogenous political developments such as ideology, culture, thought, crisis and national security play a role in the identity of the Iranian people and the ruling system of the world. Due to its geographical location, the historical land of Iran has been the center of various cultures and civilizations, and this situation has become the basis for identity diversity in our country (Farzbod et al, 2018). …”
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Health-related quality of life and health state utility value in idiopathic pulmonary fibrosis: a systematic review and meta-analysis by Guixiang Zhao, Siyuan Lei, Ya Li, Zhenzhen Feng, Jiansheng Li

“…Regretfully, subgroup analyses did not identify the source of heterogeneity, but sensitivity analyses demonstrated robustness of our results. …”
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The impact of trauma and how to intervene: a narrative review of psychotraumatology over the past 15 years by Miranda Olff, Irma Hein, Ananda B. Amstadter, Cherie Armour, Marianne Skogbrott Birkeland, Eric Bui, Marylene Cloitre, Anke Ehlers, Julian D. Ford, Talya Greene, Maj Hansen, Nathaniel G. Harnett, Debra Kaminer, Catrin Lewis, Alessandra Minelli, Barbara Niles, Nicole R. Nugent, Neil Roberts, Matthew Price, Anthony N. Reffi, Soraya Seedat, Antonia V. Seligowski, Anka A. Vujanovic

“…In all sections of this paper, we provide perspectives on sex/gender aspects, life course trends, and cross-cultural/global and systemic societal contexts. …”
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Impactos ambientales en la ciudad de Manaus: una búsqueda de comprensión Ambient impacts in the city of Manaus: an understanding search by Eveline Maria Damasceno do Nascimento, Iraildes Caldas Torres

“…The development pattern that has characterized our civilization in the two last centuries leads irremediably to the situation of the current environmental degradation in our cities. …”
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