Incomplete human reference genomes can drive false sex biases and expose patient-identifying information in metagenomic data by Caitlin Guccione, Lucas Patel, Yoshihiko Tomofuji, Daniel McDonald, Antonio Gonzalez, Gregory D. Sepich-Poore, Kyuto Sonehara, Mohsen Zakeri, Yang Chen, Amanda Hazel Dilmore, Neil Damle, Sergio E. Baranzini, George Hightower, Teruaki Nakatsuji, Richard L. Gallo, Ben Langmead, Yukinori Okada, Kit Curtius, Rob Knight

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Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer’s disease in humans by Bryan J. Neth, Kevin Huynh, Corey Giles, Tingting Wang, Natalie A. Mellett, Thy Duong, Colette Blach, Leyla Schimmel, Thomas C. Register, Kaj Blennow, Henrik Zetterberg, Richa Batra, Annalise Schweickart, Amanda Hazel Dilmore, Cameron Martino, Matthias Arnold, Jan Krumsiek, Xianlin Han, Pieter C. Dorrestein, Rob Knight, Peter J. Meikle, Suzanne Craft, Rima Kaddurah-Daouk

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Dental implant placement accuracy with robotic surgery compared to free-hand, static and dynamic computer assisted techniques: Systematic review and meta-analysis by Hariram Sankar, M. Shalini, Anjana Rajagopalan, Satish Gupta, Amit Kumar, Rukhsar Shouket

“…Among the studies, two in vitro and two in vivo studies had a low RoB, while others had a high RoB. The meta-analysis of five studies showed significant improvements in coronal, apical, and angular deviations with robotic systems. …”
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Identification of Predictive Factors for Massive Transfusion Activation in Trauma Patients: A Systematic Review and Meta-analysis by Thosapol Ueamsaranworakul, Ratcharin Niamjumnong, Kumpol Kornthatchapong, Winchana Srivilaithon

“…Conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, this systematic review included original studies published in English, involving trauma patients aged 15 years or older who received MTP. The risk of bias (RoB) was assessed using the RoB in Nonrandomized Studies of Interventions-I and RoB 2 tools, and statistical analysis was performed, focusing on the homogeneity of effect sizes across trials. …”
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Role of antimicrobial photodynamic therapy for the management of peri‑implant diseases among habitual nicotinic product users: A systematic review by Abdulrahman M. AlMubarak

“…The aPDT was performed once (after MD) in all studies. All studies had a low RoB and their results were based on power-adjusted data. …”
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Acupuncture Therapy in the Management of Orofacial Pain and Headaches: A Systematic Review and Meta-Analysis by Ananya Neralla, Silpiranjan Mishra, Sangamesh Ningappa Chinnannavar, S. Bhuvaneshwari, Atul A. Bajoria, Dhirendra K. Singh

“…Standardized mean difference (SMD) was summarized using a random effect model. Results: Moderate to low ROB was revealed on quality assessment. The pooled estimate favored acupuncture in reducing orofacial pain – SMD = 0.76 (−1.27–0.26), reducing headache with SMD is 0.11 (−0.34–0.12) compared to alternative therapies. …”
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Baricitinib for the Management of SARS-CoV-2-Infected Patients: A Systematic Review and Meta-Analysis of Randomised Controlled Trials by Sivananthan Manoharan, Lee Ying Ying

“…Cochrane risk of bias (RoB) analysis revealed that three out of four articles were ranked as high-quality articles with low RoB. …”
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Effect of chitosan/inorganic nanomaterial scaffolds on bone regeneration and related influencing factors in animal models: A systematic review by Anjie Guo, Yi Zheng, Yu Zhong, Shuixue Mo, Shanbao Fang

“…None of these studies achieved high quality or had a low RoB. In the available studies, scaffolds reconstructed bone defects in radically different extensions. …”
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Effect of mechanical debridement with and without adjunct antimicrobial photodynamic therapy for the treatment of peri-implant disease in obese patients: A systematic review and me... by Sultan Albeshri, Raed AlRowis

“…The certainty of evidence was low, and the strength of recommendation was weak in all RCTs. …”
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The impact of weight loss interventions on disordered eating symptoms in people with overweight and obesity: a systematic review & meta-analysisResearch in context by Elena Tsompanaki, Dimitrios A. Koutoukidis, Gina Wren, Heather Tong, Annika Theodoulou, Danni Wang, Rebecca J. Park, Susan A. Jebb, Paul Aveyard

“…Sub-group analyses showed: (a) disordered eating scores improved more in people with an eating disorder at baseline compared with people without high scores, (b) no clear evidence that the association depended upon intervention type, and (c) disordered eating scores improved more in trials rated at low overall RoB. Interpretation: Despite heterogeneity in effect size, weight loss interventions consistently improved disordered eating scores. …”
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Anterior Knee Pain and Knee Functional Scores Following Common Approaches to Tibial Shaft Fractures by Sarthak Parikh, DO, Laurel Marsh, BS, Mateao Anderson, BS, Jeremy Scott, DO, Amar Patel, DO, Christopher Hendrix, MD, Keivan Abtahi, DO

“…Comparative data for MPP and LPP remain limited. Overall RoB was low. Conclusion:. SP has better patient-reported outcomes and lower anterior knee pain than IP. …”
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Downhill: a new rehabilitation frontier. A systematic review of the literature by Matteo Tamburlani, Rossana Cuscito, Alessio D’Angelo, Giovanni Galeoto, Leonardo Papi, Ilaria Ruotolo, Francesca Santini, Annamaria Servadio, Edoardo Tirelli, Giovanni Sellitto

“…PEDro scales and Risk of Bias 2 (RoB 2) assessment were used to evaluate the risk of bias. …”
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Efficacy and safety of transcutaneous electrical nerve stimulation (TENS) for acute and chronic pain in adults: a systematic review and meta-analysis of 381 studies (the meta-TENS... by Gareth Jones, Mark I. Johnson, Carole A. Paley, Matthew R. Mulvey, Priscilla G. Wittkopf

“…Pain intensity was lower during or immediately after TENS compared with placebo (91 RCTs, 92 samples, n=4841, SMD=−0·96 (95% CI −1·14 to –0·78), moderate-certainty evidence). Methodological (eg, RoB, sample size) and pain characteristics (eg, acute vs chronic, diagnosis) did not modify the effect. …”
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Cannabis related side effects in otolaryngology: a scoping review by Jobanjit S. Phulka, Joel W. Howlett, Amanda Hu

“…Risk of bias assessment with RoB2 was low to high and ROBINS-1 was moderate to critical. …”
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Impact of cigarette taxes and prices in Latin America tobacco smoking prevalence: A systematic review by Ana Leticia Mores, Maria Eduarda Pérez-de-Oliveira, Ana Gabriela Costa Normando, Leticia Rodrigues-Oliveira, Gustavo Nader Marta, Renata Ferrarotto, Thaís Bianca Brandão, Alan Roger Santos-Silva, Ana Carolina Prado-Ribeiro

“…The included studies were graded as having a low (57.1 %) or moderate (42.8 %) RoB. The use of cigarette taxes and prices measures are effective tools to reduce the prevalence of tobacco smoking. …”
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Lorentz violation alleviates gravitationally induced entanglement degradation by Wentao Liu, Cuihong Wen, Jieci Wang

“…At high mode frequencies, the effects of Lorentz violation are negligible, but they become significant at low frequencies. This suggests that investigating Lorentz violation at astrophysical scales requires low-frequency detectors, as the low energy of these fields enhances the significance of the Lorentz-violating field’s non-zero vacuum expectation value.…”
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Home and outpatient electrostimulation in the treatment of urinary incontinence in women: a systematic review by Suele Moura Oliveira Coelho Caetano, Elma Gomes Pereira, Aline Moreira Ribeiro, Júlia Barros Brito, Clarcson Plácido Conceição dos Santos

“…There were no restrictions on date and language. The RoB2 and GRADE tools were used to assess methodological quality and evidence recommendation. …”
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Association between Type 2 Diabetes Mellitus and Risk of Development of Oral Cancer: A Systematic Review and Meta-analysis by Anagha Kabra, Amar Kumar Shaw, Sakshi Kanjalkar, Aditi Panchal, Pradyumna Kumar Sahoo, Arti Gachake

“…Upon quality assessment, the studies demonstrated a range of moderate to low risk of bias (ROB), ensuring a comprehensive evaluation of the evidence base. …”
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A comparison of the alterations of oral microbiome with fixed orthodontic therapy and clear aligners: a systematic review by Alessandra Lucchese, Marta Marcolina, Nicasio Mancini, Roberto Ferrarese, Serena Acconciaioco, Enrico Gherlone, Chiara Bonini, Maurizio Manuelli, Antonella Polimeni

“…Two scales were applied to assess the quality of scientific evidence: ROBINS-I and RoB 2.Results A total of 484 articles emerged of which 9 met our inclusion/exclusion criteria. …”
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Ultrasound renal denervation in hypertensive patients: A systematic review and meta-analysis. by Roy Novri Ramadhan, Derren David Christian Homenta Rampengan, Felicia Angelica Gunawan, Nathania, Sebastian Emmanuel Willyanto, Hiroyuki Yamada, Mochammad Thaha, Satriyo Dwi Suryantoro, Maulana Antiyan Empitu

“…Quality appraisal used RoB 2.0, while meta-analysis used RevMan 5.4.<h4>Results</h4>Our analysis results indicated significant improvements in 24-hour, daytime, and home ambulatory blood pressure measurements, favoring the uRDN over control. …”
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