Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“… Photo by Diana Polekhina on Unsplash ABSTRACT Randomized placebo-controlled trials are often used in clinical research, though there are ethical concerns regarding their use. …”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Setting General practices in England and Wales. Participants Men (16 years and over) consulting their general practitioner with lower urinary tract symptoms. …”
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An Agent-Based Model of Leader Emergence and Leadership Perception within a Collective by Shun Cao, Neil G. MacLaren, Yiding Cao, Yingjun Dong, Hiroki Sayama, Francis J. Yammarino, Shelley D. Dionne, Michael D. Mumford, Shane Connelly, Robert Martin, Colleen J. Standish, Tanner R. Newbold, Samantha England, Gregory A. Ruark

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Field Observations during the Eleventh Microwave Water and Energy Balance Experiment (MicroWEX-11): from April 25, 2012, through December 6, 2012 by Tara Bongiovanni, Pang-Wei Liu, Karthik Nagarajan, Daniel Preston, Patrick Rush, Tim H.M. van Emmerik, Robert Terwilleger, Alejandro Monsivais-Huertero, Jasmeet Judge, Susan Steele-Dunne, Roger De Roo, Ruzbeh Akbar, Ella Baar, Max Wallace, Anthony England

“… This new report from UF/IFAS researchers provides another set of observation data that can be used to develop better models for accurate prediction of weather and near-term climate. …”
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Field Observations during the Eleventh Microwave Water and Energy Balance Experiment (MicroWEX-11): from April 25, 2012, through December 6, 2012 by Tara Bongiovanni, Pang-Wei Liu, Karthik Nagarajan, Daniel Preston, Patrick Rush, Tim H.M. van Emmerik, Robert Terwilleger, Alejandro Monsivais-Huertero, Jasmeet Judge, Susan Steele-Dunne, Roger De Roo, Ruzbeh Akbar, Ella Baar, Max Wallace, Anthony England

“… This new report from UF/IFAS researchers provides another set of observation data that can be used to develop better models for accurate prediction of weather and near-term climate. …”
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The Eczema Bathing Study: Weekly versus daily bathing for people with eczema? Protocol of an online, randomised controlled trial [version 2; peer review: 1 approved, 2 approved wit... by Paul Leighton, Wei Chern Gavin Fong, Ingrid Muller, Laura Howells, Arabella Baker, Eleanor J Mitchell, Eleanor Harrison, Leila Thuma, Yimin Jiang, Lucy Bradshaw, Alan Montgomery, Fiona Cowdel, Matthew J Ridd, Jane Ravenscroft, Reiko J Tanaka, Miriam Santer, Richard Swinden, Nicholas Hilken, Carron Layfield, Richard Dooley, Sophia Collins, Clare Upton, Tracy Owen, Firoza Davies, Devin Patel, Mars Eddis-Finbow, Hywel C Williams, Goldie Putrym, Kim S Thomas, Amanda Roberts

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Exome sequencing of UK birth cohorts [version 2; peer review: 2 approved, 1 approved with reservations] by Petr Danecek, Amy Hough, John Wright, Karen Ho, Nicholas J. Timpson, Sarah J. Lindsay, Davide Bonfanti, Daniel S. Malawsky, Rafaq Azad, Deborah Plowman, Sara Widaa, Gemma Shireby, Emla Fitzsimons, David Bann, Matthew E. Hurles, Hilary C. Martin, Susan M. Ring, Dan Mason, Michael A. Quail, Wei Huang, Vivek Iyer, Mahmoud Koko, Iaroslav Popov, Laurie Fabian, Gennadii Zakharov, Ruth Y. Eberhardt, Emma E. Wade, Qin Qin Huang

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Palaeontological And Geological Highlights Of The Black Country UNESCO Global Geopark by Graham Worton, Colin Prosser, Jonathan Larwood

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improving Pain mAnagement for childreN and young people attendeD by Ambulance (PANDA): protocol for a realist review. [version 3; peer review: 2 approved, 1 approved with reservati... by Paul Leighton, Georgette Eaton, Georgie Nicholls, Kacper Sumera, Marishona Ortega, Jessica Hodgson, Michael Baliousis, Aloysius Niroshan Siriwardena, Despina Laparidou, Bill Lord, Sarah Redsell, Gregory Adam Whitley, Tatiana Bujor

“…Background Each year in England, 450,000 children and young people (CYP) under 18 years of age are transported by ambulance to emergency departments. …”
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Efficacy of Primate Humoral Passive Transfer in a Murine Model of Pneumonic Plague Is Mouse Strain-Dependent by V. A. Graham, G. J. Hatch, K. R. Bewley, K. Steeds, A. Lansley, S. R. Bate, S. G. P. Funnell

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Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions by S. D. Dowall, V. A. Graham, K. Corbin-Lickfett, C. Empig, K. Schlunegger, C. B. Bruce, L. Easterbrook, R. Hewson

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The genome sequence of a beetle, Brachypterus glaber (Newman, 1834) [version 1; peer review: 2 approved] by Michael F. Geiser, Talay Namintraporn, Freya Read, Maxwell V.L. Barclay

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Mapping decision-making pathways: Determination of intervention entry points for diagnostic tests in suspected serious infection [version 2; peer review: 2 approved] by Raasti Naseem, Sara Pretorius, Nicola Howe, Clare Lendrem, Cameron Williams, Enitan D Carrol, Philip Pallmann

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Feasibility of Dual-Task Gait Training for Community-Dwelling Adults after Stroke: A Case Series by Prudence Plummer, Raymond M. Villalobos, Moira S. Vayda, Myriam Moser, Erin Johnson

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Pharmacist-led DE-eSCALation of opioids post-surgical dischargE (DESCALE) – A multi-centre, non-randomised, feasibility study protocol [version 2; peer review: 1 approved, 2 approv... by Ellie Santer, Julie H Hedayioglu, Vanessa J Short, Sabina Hulbert, Emma L Veale, Melanie Rees-Roberts, Johanna Theron

“…Conclusion Data collected with respect to opioid use post-surgery, feasibility and acceptability of the intervention, patient experience and outcome data will inform the design of future research and larger clinical trials.…”
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Coring is not boring! – What should, could and has been be done to celebrate the borehole core. by Phillip Murphy

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The genome sequence of a sawfly, Abia candens Konow, 1887 [version 1; peer review: 2 approved] by Andrew Cunningham, Andrew Halstead

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The genome sequence of the Pacific oyster, Magallana gigas (Thunberg, 1793) [version 2; peer review: 2 approved, 1 approved with reservations] by Rebekka Uhl, Rob Mrowicki

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The genome sequence of Radford’s Flame Shoulder, Ochropleura leucogaster (Freyer, 1831) [version 1; peer review: 2 approved] by Mark J. Sterling, David C. Lees

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Who do you think they are? An exploratory analysis of face-based impressions formed by cisgender, transgender and gender nonbinary individuals [version 2; peer review: 2 approved,... by Ivvy Divine, Fabio Fasoli, Aífe Hopkins-Doyle

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