Toxicity of Organic Fluorophores Used in Molecular Imaging: Literature Review by Raphael Alford, Haley M. Simpson, Josh Duberman, G. Craig Hill, Mikako Ogawa, Celeste Regino, Hisataka Kobayashi, Peter L. Choyke

“…However, fluorophores can be toxic and must be investigated before they can be administered safely to patients. …”
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Quantitative Comparison of the Sensitivity of Detection of Fluorescent and Bioluminescent Reporters in Animal Models by Tamara Troy, Dragana Jekic-McMullen, Lidia Sambucetti, Brad Rice

“…A high-sensitivity imaging system that can detect steady-state emission from both bioluminescent and fluorescent reporters is described. …”
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High quality genome assembly of the brown hare (Lepus europaeus) with chromosome-level scaffolding by Michell, Craig, Collins, Joanna, Laine, Pia K., Fekete, Zsófia, Tapanainen, Riikka, Wood, Jonathan M. D., Goffart, Steffi, Pohjoismäki, Jaakko L. O.

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Brainstem Infarction and Panuveitis due to Sarcoidosis Successfully Treated with Steroid Pulse Therapy by Natsuyo Yoshida-Hata, Shigeko Yashiro, Noritoshi Arai, Sousuke Takeuchi

“…A 36-year-old man visited our hospital because of blurred vision and redness of the conjunctiva. Slit-lamp examination showed panuveitis. …”
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Interstitial pneumonia due to Japanese spotted fever by Katsunori Arai, Hirokazu Tokuyasu, Tatsuya Konishi, Toshiyuki Tatsukawa, Kenichi Takeda, Akira Yamasaki

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A Case of Myomatous Erythrocytosis Syndrome Associated with a Large Uterine Leiomyoma by Yosuke Ono, Takao Hidaka, Kaori Fukuta, Keiko Kouchi, Kuniaki Yasoshima, Kiyoshi Takagawa, Takashi Arai

“…We report a case of erythrocytosis associated with a large uterine leiomyoma, in which specific immunostaining for erythropoietin was positive. …”
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Beyond the Status of Health: A Collection of Stories Representing Diverse Maternal Mental Health Perspectives by Sara Santarossa, Ruth A. Blake, Heather Buchanan, Mercedes Price, Rachael Guzzardo, Craig Guzzardo, LaKenya M. Johnson, Jacobeth M. Morshall, Andrea Bate, Wayne Bate, Riziki Bakari, Leah Copeland, Dana Murphy, Ashley Redding, Amy Loree

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Effect of Proteinuria Before Lenvatinib Administration on Treatment Response After Atezolizumab Bevacizumab Combination Therapy by Hironori Ochi, Masayuki Kurosaki, Takaaki Tanaka, Nobuharu Tamaki, Kaoru Tsuchiya, Yutaka Yasui, Hiroyuki Marusawa, Toshifumi Tada, Shinichiro Nakamura, Takehiro Akahane, Eisuke Okamoto, Haruhiko Kobashi, Hirotaka Arai, Michiko Nonogi, Namiki Izumi

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Evaluation of the Efficacy of Lusutrombopag for Chronic Liver Disease Based on Pre‐Treatment Platelet Counts: A Retrospective Multicenter Study by Takayoshi Suga, Satoru Kakizaki, Atsushi Naganuma, Takeshi Hatanaka, Satoshi Takakusagi, Daichi Takizawa, Hirotaka Arai, Takashi Ueno, Keisuke Iizuka, Toru Fukuchi, Shuichi Saito, Hiroki Tojima, Yuichi Yamazaki, Toshio Uraoka

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Evaluation of Treatment Outcomes Using dNLR and GNRI in Combination Therapy With Atezolizumab and Bevacizumab for Hepatocellular Carcinoma by Atsushi Naganuma, Satoru Kakizaki, Atsushi Hiraoka, Toshifumi Tada, Takeshi Hatanaka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hidenori Toyoda, Chikara Ogawa, Hiroki Nishikawa, Takashi Nishimura, Kazuhito Kawata, Hisashi Kosaka, Masashi Hirooka, Yutaka Yata, Hideko Ohama, Hidekatsu Kuroda, Tomomitsu Matono, Tomoko Aoki, Yuki Kanayama, Kazunari Tanaka, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Shinichiro Nakamura, Hirayuki Enomoto, Masaki Kaibori, Yoichi Hiasa, Masatoshi Kudo, Takashi Kumada

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Geriatric nutritional risk index and newly developed scoring system as prognosis prediction for unresectable hepatocellular carcinoma patients treated with lenvatinib by Hideko Ohama, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Atsushi Naganuma, Hisashi Kosaka, Tomomitsu Matono, Hidekatsu Kuroda, Yutaka Yata, Hironori Tanaka, Hiroki Nishikawa, Hiroshi Shibata, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Hiroko Iijima, Masaki Kaibori, Yoichi Hiasa, Takashi Kumada

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Novel Fluorescent Dyes for Single DNA Molecule Techniques by Alexander Zarkov, Aleksey Vasilev, Todor Deligeorgiev, Stoyno Stoynov, Marina Nedelcheva-Veleva

“…However, in contrast to YOYO-1, which is visualized under a green filter only, their emission permits red filter visualization. As their photostability highly exceeds that of similar spectrum POPO-3 dye, the studied dyes stand out as the best choice for a broad range of solid surface single-molecule applications when yellow to red DNA backbone fluorescence is needed.…”
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Oxygen Sensitivity of Reporter Genes: Implications for Preclinical Imaging of Tumor Hypoxia by Ivana Cecic, Denise A. Chan, Patrick D. Sutphin, Pritha Ray, Sanjiv Sam Gambhir, Amato J. Giaccia, Edward E. Graves

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Noninvasive Monitoring of mRFP1- and mCherry-Labeled Oncolytic Adenoviruses in an Orthotopic Breast Cancer Model by Spectral Imaging by Anton V. Borovjagin, Lacey R. McNally, Minghui Wang, David T. Curiel, Mary J. MacDougall, Kurt R. Zinn

“…Although mCherry appeared to be superior to mRFP1 as an imaging tag, both reporters showed utility for CRAd imaging applications.…”
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Gold Nanorods Targeted to Delta Opioid Receptor: Plasmon-Resonant Contrast and Photothermal Agents by Kvar C. Black, Nathaniel D. Kirkpatrick, Timothy S. Troutman, Liping Xu, Josef Vagner, Robert J. Gillies, Jennifer K. Barton, Urs Utzinger, Marek Romanowski

“…Molecularly targeted gold nanorods were investigated for applications in both diagnostic imaging and disease treatment with cellular resolution. …”
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Optimizing Imaging of Three-Dimensional Multicellular Tumor Spheroids with Fluorescent Reporter Proteins Using Confocal Microscopy by Lucia le Roux, Andrei Volgin, David Maxwell, Katashi Ishihara, Juri Gelovani, Dawid Schellingerhout

“…In this article, we show a series of optimizations that allowed us to obtain excellent quality confocal microscopy images at imaging depths of up to 320 μm. The combined use of special objectives, glass-bottomed culture dishes, and depth-dependent laser output modulation extended our depth range beyond previously accepted limits. …”
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Simultaneous Anti-Tuberculosis and Anti-Tumor Treatment with Immune Checkpoint Inhibitors for Co-Existent Pulmonary Tuberculosis and Advanced Lung Cancer by Wang H, Gao L, Cai X, Li J, Lang Y, Zheng R, Yang S

“…Huaichong Wang,1 Liujie Gao,2 Xinjun Cai,1 Jinmeng Li,1 Yuying Lang,1 Ren Zheng,1 Shengya Yang3 1Department of Pharmacy, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang Province, People’s Republic of China; 2Department of Oncology, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang Province, People’s Republic of China; 3Tuberculosis Diagnosis and Treatment Center, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang Province, People’s Republic of ChinaCorrespondence: Shengya Yang, Tuberculosis Diagnosis and Treatment Center, Hangzhou Red Cross Hospital, East Huancheng Road No. 208, Hangzhou, Zhejiang Province, People’s Republic of China, Email 15967116949@163.comBackground: Immune checkpoint inhibitors (ICIs) have emerged as the first-line treatment for driver-negative advanced non-small cell lung cancer (NSCLC). …”
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Ex Vivo and in Vivo Administration of Fluorescent CNA35 Specifically Marks Cardiac Fibrosis by Sanne de Jong, Lars B. van Middendorp, Robin H.A. Hermans, Jacques M.T. de Bakker, Marti F.A. Bierhuizen, Frits W. Prinzen, Harold V.M. van Rijen, Mario Losen, Marc A. Vos, Marc A.M.J. van Zandvoort

“…After quantification of CNA35, sections were examined with picrosirius red (PSR) and compared to CNA35. …”
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Use of fluorescence imaging and spectrometry in detection of oral squamous cell carcinoma and oral potentially malignant disorders by Vivek Nayyar, Pramila Thapa, Dalip Singh Mehta, Rahul Yadav, Krushna Bhatt, Varun Surya, Deepika Mishra

“…Objective: Changes in the autofluorescence of cancerous tissue in comparison to normal tissue due to alteration in the endogenous fluorophores and protein like NAD and FAD has been utilized in various oral cancer screening devices. …”
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Micro–Positron Emission Tomography/Contrast-Enhanced Computed Tomography Imaging of Orthotopic Pancreatic Tumor–Bearing Mice Using the αβ Integrin Tracer Cu-Labeled Cyclam-RAFT-c(-... by Winn Aung, Zhao-Hui Jin, Takako Furukawa, Michael Claron, Didier Boturyn, Chizuru Sogawa, Atsushi B. Tsuji, Hidekatsu Wakizaka, Toshimitsu Fukumura, Yasuhisa Fujibayashi, Pascal Dumy, Tsuneo Saga

“…The cell line BxPC-3, which is stably transfected with a red fluorescence protein (RFP), was used for surgical orthotopic implantation. …”
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