Biodistribution of 89Zr-Radiolabeled Nanoassemblies for Monoclonal Antibody Delivery Revealed through In Vivo PET Imaging by Ana M. López-Estévez, Amaia Carrascal-Miniño, Dolores Torres, María José Alonso, Rafael T. M. de Rosales, Juan Pellico

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Novel Chlorin with a HYNIC: Synthesis, ^99mTc-Radiolabeling, and Initial Preclinical Evaluation by Alexander Popov, Nikita Suvorov, Mariia Larkina, Evgenii Plotnikov, Ruslan Varvashenya, Vitalina Bodenko, Gleb Yanovich, Petr Ostroverkhov, Maxim Usachev, Elena Filonenko, Mikhail Belousov, Mikhail Grin

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Development of Radiolabeled Compounds for Molecular Imaging and Imaging-Based Therapy by Kazuma Ogawa, Masahiro Ono, Mei Tian, Masashi Ueda, Takahiro Higuchi

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Foliar Application and Translocation of Radiolabeled Zinc Oxide Suspension vs. Zinc Sulfate Solution by Soybean Plants by Anita Beltrame, João Paulo Rodrigues Marques, Mariana Ayres Rodrigues, Eduardo de Almeida, Márcio Arruda Bacchi, Elisabete Aparecida De Nadai Fernandes, Rafael Otto, Hudson Wallace Pereira de Carvalho

“…After the first foliar spray, V4, the partition of radiolabeled Zn in plants treated with ZnO and ZnSO₄ was 99.22% and 98.12% in treated leaves, 0.15% and 0.39% in stems, 0.16% and 0.29% in roots, and 0.47% and 1.19% in newly expanded non-treated leaves, respectively. …”
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Radiolabeled Anti-Adenosine Triphosphate Synthase Monoclonal Antibody as a Theragnostic Agent Targeting Angiogenesis by Bok-Nam Park PhD, Su Jin Lee MD, PhD, Jung Hyun Roh MS, Kyung-Han Lee MD, PhD, Young-Sil An MD, PhD, Joon-Kee Yoon MD, PhD

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Construction and Radiolabeling of Adenovirus Variants that Incorporate Human Metallothionein into Protein IX for Analysis of Biodistribution by Lei Liu, Buck E. Rogers, Natalia Aladyshkina, Bing Cheng, Stephen J. Lokitz, David T. Curiel, J. Michael Mathis

“…We identified a dimeric MT construct fused to pIX that showed significantly increased radiolabeling capacity. After Ad radiolabeling, we characterized metal binding in vitro. …”
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Homologous In-Radiolabeled Platelet Survival and Sequestration Exploration for Refractory Immunologic Thrombocytopenic purpura in Children: A Strategy to Avoid Unnecessary Splenectomy by Julien Dubois PharmD, Florentin Kucharczak PhD, Léa De Neef PharmD, Virginie Kouyoumdjian PharmD, Gilles Palenzuela MD, Virginie Tunez MD, Denis Mariano-Goulart MD, PhD, Aurélie Bourdon MD, Tom Paunet MD

“…This increase in platelet levels allowed for 111 In-radiolabeled autologous platelet scintigraphy, which confirmed the absence of splenic sequestration. …”
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Colonoscopic Preoperative Localization Using Submucosal Injection of Radiolabelled Colloid by Carolyn Cho, Sanjiv Jain, Mark Pilbeam, Noel Tait, Andrew Thomson

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99mTc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles as an auspicious tumour targeting by Adli A. Selim, Tamer M. Sakr, Basma M. Essa, Galal H. Sayed, Kurls E. Anwer

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Position for Site-Specific Attachment of a DOTA Chelator to Synthetic Affibody Molecules Has a Different Influence on the Targeting Properties of Ga-Compared to In-Labeled Conjugat... by Hadis Honarvar, Joanna Strand, Anna Perols, Anna Orlova, Ram Kumar Selvaraju, Amelie Eriksson Karlström, Vladimir Tolmachev

“…Affibody molecules, small (7 kDa) scaffold proteins, are a promising class of probes for radionuclide molecular imaging. Radiolabeling of Affibody molecules with the positron-emitting nuclide 68 Ga would permit the use of positron emission tomography (PET), providing better resolution, sensitivity, and quantification accuracy than single-photon emission computed tomography (SPECT). …”
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Aspiration in the Context of Upper Gastrointestinal Endoscopy by A Thomson, J Tye-Din, S Tonga, J Scott, C Mclaren, P Pavli, F Lomas

“…Endoscopy-related aspiration has not been studied in procedures in which patients swallow a radiolabelled potential aspirate immediately before endoscopy and undergo nuclear scanning postprocedure.…”
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Immuno-PET Imaging of Siglec-15 Using the Zirconium-89-Labeled Therapeutic Antibody, NC318 by Elaine M. Jagoda, Falguni Basuli, Colleen Olkowski, Ido Weiss, Tim E. Phelps, Karen Wong, Anita Thien Ton, Kelly C. Lane, Steve Adler, Donna Butcher, Elijah F. Edmondson, Sol Langermann, Peter L. Choyke

“…Desferrioxamine-conjugated NC318 was radiolabeled with zirconium-89 to synthesize [89Zr]Zr-DFO-NC318. …”
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Prostate-Specific Membrane Antigen-Based Therapeutics by Naveed H. Akhtar, Orrin Pail, Ankeeta Saran, Lauren Tyrell, Scott T. Tagawa

“…While initial anti-PSMA monoclonal antibodies were suboptimal, the development of monoclonal antibodies such as J591 which are highly specific for the external domain of PSMA has allowed targeting of viable, intact prostate cancer cells. Radiolabeled J591 has demonstrated accurate and selective tumor targeting, safety, and efficacy. …”
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In Vitro and In Vivo Evaluation of Alexa Fluor 680-Bombesin[7–14]NH Peptide Conjugate, a High-Affinity Fluorescent Probe with High Selectivity for the Gastrin-Releasing Peptide Rec... by Lixin Ma, Ping Yu, Bhadrasetty Veerendra, Tammy L. Rold, Lauren Retzloff, Adam Prasanphanich, Gary Sieckman, Timothy J. Hoffman, Wynn A. Volkert, Charles J. Smith

“…In vitro competitive binding assays, using 125 I-Tyr 4 -BBN as the radiolabeling gold standard, demonstrated an inhibitory concentration 50% value of 7.7 ± 1.4 nM in human T-47D breast cancer cells. …”
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Cyclotron Production of High–Specific Activity Co and In Vivo Evaluation of the Stability of Co Metal-Chelate-Peptide Complexes by Tara Mastren, Bernadette V. Marquez, Deborah E. Sultan, Elizabeth Bollinger, Paul Eisenbeis, Tom Voller, Suzanne E. Lapi

“…This work describes the production of high–specific activity 55 Co and the evaluation of the stability of 55 Co-metal-chelate-peptide complexes in vivo. 55 Co was produced via the 58 Ni(p,α) 55 Co reaction and purified using anion exchange chromatography with an average recovery of 92% and an average specific activity of 1.96 GBq/μmol. 55 Co-DO3A and 55 Co-NO2A peptide complexes were radiolabeled at 3.7 MBq/μg and injected into HCT-116 tumor xenografted mice. …”
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Basic Studies on Radioimmunotargeting of CD133-Positive HCT116 Cancer Stem Cells by Zhao-Hui Jin, Chizuru Sogawa, Takako Furukawa, Yuriko Saito, Winn Aung, Yasuhisa Fujibayashi, Tsuneo Saga

“…Our results indicate that noninvasive in vivo targeting of CSCs could be possible with radiolabeled antibodies against cell membrane markers.…”
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Radioiodine Labeled Anti-MIF McAb: A Potential Agent for Inflammation Imaging by Chao Zhang, Gui-hua Hou, Jian-kui Han, Jing Song, Ting Liang

“…Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that may play a role in the pathogenesis of inflammation. Radiolabeled anti-MIF McAb can be used to detect in vivo inflammatory changes. …”
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Development of a New Reporter Gene System-dsRed/Xanthine Phosphoribosyltransferase-Xanthine for Molecular Imaging of Processes Behind the Intact Blood-Brain Barrier by Mikhail Doubrovin, Vladimir Ponomarev, Inna Serganova, Suren Soghomonian, Tadashi Myagawa, Tatiana Beresten, Lyudmila Ageyeva, Michel Sadelain, Jason Koutcher, Ronald G Blasberg, Juri G. Gelovani Tjuvajev

“…We report the development of a novel dual-modality fusion reporter gene system consisting of Escherichia coli xanthine phosphoribosyltransferase (XPRT) for nuclear imaging with radiolabeled xanthine and Discosoma red fluorescent protein for optical fluorescent imaging applications. …”
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Feasibility of Vascular Endothelial Growth Factor Imaging in Human Atherosclerotic Plaque Using Zr-Bevacizumab Positron Emission Tomography by Reza Golestani, Clark J. Zeebregts, Anton G.T. Terwisscha van Scheltinga, Marjolijn N. Lub-de Hooge, Gooitzen M. van Dam, Andor W.J.M. Glaudemans, Rudi A.J.O. Dierckx, René A. Tio, Albert J.H. Suurmeijer, Hendrikus H. Boersma, Wouter B. Nagengast, Riemer H.J.A. Slart

“…Cardiovascular molecular imaging can be used for the detection of rupture-prone plaques. Imaging with radiolabeled bevacizumab, a monoclonal anti-vascular endothelial growth factor (VEGF)-A, can depict VEGF levels corresponding to the angiogenic status in tumors. …”
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Immunotargeting of Integrin αβ for Single-Photon Emission Computed Tomography and Near-Infrared Fluorescence Imaging in a Pancreatic Cancer Model by Winn Aung MBBS, PhD, Atsushi B. Tsuji PhD, Hitomi Sudo PhD, Aya Sugyo M.Ed, Takako Furukawa PhD, Yoshinori Ukai PhD, Yoshikazu Kurosawa PhD, Tsuneo Saga MD, PhD

“…Here, we propose that α 6 β 4 is a desirable target for the diagnosis of pancreatic cancer and that it could be detected by radionuclide imaging and NIR imaging using a radiolabeled or ICG-labeled α 6 β 4 antibody.…”
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