In Vitro and In Vivo Characterization of Three Ga- and In-Labeled Peptides for Cholecystokinin Receptor Imaging by Susan Roosenburg, Peter Laverman, Lieke Joosten, Annemarie Eek, Floris P.J.T. Rutjes, Floris L. van Delft, Otto C. Boerman

“…In this study, we evaluated whether radiolabeled DOTA-sCCK8 and its stabilized derivative, DOTA-sCCK8[Phe 2 (p-CH 2 SO 3 H), Nle 3,6 ], are suitable for imaging of CCK2R-positive tumors, using DOTA-MG0 as a reference. …”
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Flow-based In Vivo Method to Enumerate Translating Ribosomes and Translation Elongation Rate by Mina Seedhom, Devin Dersh, Jonathan Yewdell

“…Measurement of average transit rates entails in vitro pulse-chase radiolabeling of isolated cells or ribosome profiling after ribosome runoff, which is expensive and extremely demanding technically. …”
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-Tyrosine Confers Residualizing Properties to a -Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies by Fook T. Lee PhD, Ingrid J. G. Burvenich PhD, Nancy Guo MBBS, MSc, Pece Kocovski BSc (Honors), Henri Tochon-Danguy PhD, Uwe Ackermann PhD, Graeme J. O’Keefe PhD, Sylvia Gong PhD, Angela Rigopoulos BSc, MSc, Zhanqi Liu MBBS, PhD, Hui K. Gan MBBS, FRACP, PhD, Andrew M. Scott MBBS, FRACP, MD

“…Azido-derivatized radiolabeled peptides were conjugated to dibenzylcyclooctyne-derivatized ch806 antibody via click chemistry. …”
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Microfluidics for Positron Emission Tomography Probe Development by Ming-Wei Wang, Wei-Yu Lin, Kan Liu, Michael Masterman-Smith, Clifton Kwang-Fu Shen

“…Owing to increased needs for positron emission tomography (PET), high demands for a wide variety of radiolabeled compounds will have to be met by exploiting novel radiochemistry and engineering technologies to improve the production and development of PET probes. …”
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Biodistribution of a Mitochondrial Metabolic Tracer, [18F]F-AraG, in Healthy Volunteers by Jelena Levi, Heying Duan, Shahriar Yaghoubi, Juliet Packiasamy, Lyna Huynh, Tina Lam, Faiq Shaikh, Deepak Behera, Hong Song, Joseph Blecha, Salma Jivan, Youngho Seo, Henry F. VanBrocklin

“…Purpose. [18F]F-AraG is a radiolabeled nucleoside analog that shows relative specificity for activated T cells. …”
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Technetium 99m–Labeled VQ Peptide: A New Imaging Agent for the Early Detection of Tumors or Premalignancies by Jiyun Shi, Liyang Cui, Bing Jia, Zhaofei Liu, Peng He, Chengyan Dong, Xiaona Jin, Huiyun Zhao, Fang Li, Fan Wang

“…Although the mechanism of accumulation of radiolabeled VQ peptide in tumors and inflammation needs to be further investigated, 99m Tc-HYNIC-VQ is a promising imaging agent for the early detection of tumors or premalignancies, at least for screening patients with a high risk of developing cancers.…”
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Positron emission tomography molecular imaging for pathological visualization in multiple system atrophy by La Dong, Rui Zhou, Jinyun Zhou, Ke Liu, Chentao Jin, Jing Wang, Chenxi Xue, Mei Tian, Hong Zhang, Yan Zhong

“…Positron emission tomography (PET) is a non-invasive technique that enables the visualization, characterization, and quantification of these pathological processes from diverse perspectives using radiolabeled agents. PET imaging of molecular events provides valuable insights into the underlying pathomechanisms of MSA and holds significant promise for the development of imaging biomarkers, which could greatly improve disease assessment and management. …”
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Multi-modality Imaging Identifies Key Times for Annexin V Imaging as an Early Predictor of Therapeutic Outcome by Stefanie J. Mandl, Carina Mari, Matthias Edinger, Robert S. Negrin, Jonathan F. Tait, Christopher H. Contag, Francis G. Blankenberg

“…Radiolabeled annexin V may provide an early indication of the success or failure of anticancer therapy on a patient-by-patient basis as an in vivo marker of tumor cell killing. …”
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Radiochemistry for positron emission tomography by Jian Rong, Achi Haider, Troels E. Jeppesen, Lee Josephson, Steven H. Liang

“…The wide applications and rapid development of PET have ultimately led to an increasing demand for new methods in radiochemistry, with the aim to expand the scope of synthons amenable for radiolabeling. In this work, we provide an overview of commonly used chemical transformations for the syntheses of PET tracers in all aspects of radiochemistry, thereby highlighting recent breakthrough discoveries and contemporary challenges in the field. …”
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