Imaging of Non— or Very Subtle Contrast-Enhancing Malignant Gliomas with [C]-Methionine Positron Emission Tomography by Norbert Galldiks, Lutz W. Kracht, Veronika Dunkl, Roland T. Ullrich, Stefan Vollmar, Andreas H. Jacobs, Gereon R. Fink, Michael Schroeter

“…These findings support the use of combined PET-MRI with radiolabeled amino acids (eg, MET) for the delineating of the true extent of active tumor in the diagnosis and treatment planning of patients with gliomas.…”
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Pitfalls in Labelled Leukocyte Scanning by H Hodgson, M Roddie

“…Radiolabelled leukocyte scanning is a valuable tool in the diagnosis and management of inflammatory bowel disease (IBO). …”
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PET imaging of 52Mn labeled DOTATATE and DOTAJR11 by James M. Omweri, Hailey A. Houson, Shannon E. Lynch, Volkan Tekin, Anna G. Sorace, Suzanne E. Lapi

“…A comparison of these two compounds was performed in in vitro and in vivo studies in animals with somatostatin receptor-positive xenografts to characterize differences in cell, tumor, and tissue uptake. Radiolabeling of DOTATATE and DOTA-JR11 was carried out by combining varying concentrations of the peptides with [52Mn]MnCl2. …”
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The fibronectin-targeting PEG-FUD imaging probe shows enhanced uptake during fibrogenesis in experimental lung fibrosis by Thomas J. Harr, Nikesh Gupta, Babita Rahar, Kristen Stott, Yadira Medina-Guevara, Metti K. Gari, Angie T. Oler, Ivy Sohee McDermott, Hye Jin Lee, Morteza Rasoulianboroujeni, Ashley M. Weichmann, Amir Forati, Kelsey Holbert, Trevor S. Langel, Kade W. Coulter, Brian M. Burkel, Bianca R. Tomasini-Johansson, Suzanne M. Ponik, Jonathan W. Engle, Reinier Hernandez, Glen S. Kwon, Nathan Sandbo, Ksenija Bernau

“…We first analyzed the binding of radiolabeled PEG-FUD following direct incubation to precision cut lung slices from mice at different stages of experimental lung fibrosis. …”
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Cobalamin Malabsorption due to a Dysfunctional Intrinsic Factor by Jeanne Drouin, Nadia Mikhael

“…Serum anti-intrinsic factor blocking antibodies were not present. Absorption of radiolabelled cobalamin given orally in the Schilling test was decreased but this was corrected by using hog intrinsic factor. …”
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The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy by Suxia Han, Guihua Jin, Lijuan Wang, Meng Li, Chenchen He, Xijing Guo, Qing Zhu

“…Several different radiolabeled immunodiagnostic and immunotherapeutic agents of PAM4 have been developed and some are being evaluated in preclinical and/or clinical studies. …”
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Clearance In Vivo of Instilled [H]Cholesterol from the Rat Lung by Michael A. Wyder, Shannon M. Griffin, D. Nicole Worsham, Edna S. Kaneshiro

“…Here we report on experiments in which radiolabeled cholesterol was instilled into the lungs of rats, then at various postinstillation periods, radioactive sterols in lavage fluid, and in postlavage whole lungs were measured in individual animals. …”
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Comparison of New Tau PET-Tracer Candidates With [F]T808 and [F]T807 by Lieven Declercq Pharmacist, Sofie Celen PhD, Joan Lecina PhD, Muneer Ahamed PhD, Thomas Tousseyn Prof, MD, PhD, Diederik Moechars PhD, Jesus Alcazar PhD, Manuela Ariza PhD, Katleen Fierens PhD, Astrid Bottelbergs PhD, Jonas Mariën PhD, Rik Vandenberghe Prof, MD, PhD, Ignacio Jose Andres PhD, Koen Van Laere Prof, MD, PhD, Alfons Verbruggen Prof, PhD, Guy Bormans Prof, PhD

“…Therefore, these data are helpful to identify structural requirements for selective interaction with tau and to compare the performance of new highly selective and specific radiolabeled tau tracers.…”
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Utilisation of the Innovative [18F]-Labelled Radiotracer [18F]-BIBD-071 Within HR+ Breast Cancer Xenograft Mouse Models by Di Fan, Xin Wang, Xueyuan Ling, Hongbin Li, Lu Zhang, Wei Zheng, Zehui Wu, Lin Ai

“…<b>Methods:</b> [18F]BIBD-071 was synthesised, radiolabelled, and then subjected to in vitro stability testing. …”
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Preclinical evaluation and preliminary clinical study of 68Ga-NODAGA-NM-01 for PET imaging of PD-L1 expression by Lingzhou Zhao, Jiali Gong, Sisi Liao, Wenhua Huang, Jinhua Zhao, Yan Xing

“…Additionally, a preliminary clinical study was performed on two patients with NSCLC. NM-01 was radiolabeled with 68Ga without further purification under mild conditions. …”
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PET imaging of AAV9 and AAVBR1 trafficking in normal mice by Aditya Bansal, Shalini Sharma, Manasa Kethamreddy, Mukesh K. Pandey

“…A radiolabeling synthon, [89Zr]Zr-DFO-Bn-NCS or [89Zr]Zr-DBN, was employed for the direct radiolabeling of AAVs, which enables tracking of AAVs by PET imaging for up to 18 days post-injection. …”
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Local and distant response to intratumoral immunotherapy assessed by immunoPET in mice by Aurélien Marabelle, Louis Meyblum, Lambros Tselikas, Thierry de Baere, Sandrine Susini, Fréderic Deschamps, Baptiste Bonnet, Céline Chevaleyre, Benoit Jego, Dimitri Kereselidze, Vincent Lebon, Charles Truillet

“…However, a comprehensive understanding of the local and systemic distribution of ICBs following intratumoral administration, as well as their impact on distant tumors, remains crucial for optimizing their therapeutic potential.To comprehensively investigate the distribution patterns following the intratumoral and intravenous administration of radiolabeled anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and to assess its corresponding efficacy in both injected and non-injected tumors, we conducted an immunoPET imaging study.Methods CT26 and MC38 syngeneic colorectal tumor cells were implanted subcutaneously on both flanks of Balb/c and C57Bl/6 mice, respectively. …”
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99mTc(CO)3-Labeled 1-(3-Nitropyridin-2-yl) Piperazine as Potential Radioligand for 5-HT7 Receptors by Sajjad Molavipordanjani

“…Conclusion: Compound 5 can be quantitatively radiolabeled with fac-[99mTc(CO)3(H2O)3]+  resulting in the radiotracer (99mTc(CO)3-[5]). …”
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In Vitro and In Vivo Characterization of a Dual-Function Green Fluorescent Protein–HSV1-Thymidine Kinase Reporter Gene Driven by the Human Elongation Factor 1α Promoter by Gary D. Luker, Kathryn E. Luker, Vijay Sharma, Christina M. Pica, Julie L. Dahlheimer, Joe A. Ocheskey, Timothy J. Fahrner, Jeffrey Milbrandt, David Piwnica-Worms

“…Furthermore, in high ETK cells, net retention of various radiolabeled nucleoside analogues varied; the rank order was 8-[ 3 H]GCV < 9-(4-fluoro-3-hydroxymethylbutyl)guanine ([ 18 F]FHBG) ≈ 8-[ 3 H]penciclovir (8-[ 3 H]PCV) < 2′-fluoro-2′-deoxy-5-iodouracil-beta- d -arabinofuranoside (2-[ 14 C]FIAU). …”
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Granzyme B PET Imaging Stratifies Immune Checkpoint Inhibitor Response in Hepatocellular Carcinoma by Julian L. Goggi, Boominathan Ramasamy, Yun Xuan Tan, Siddesh V. Hartimath, Jun Rong Tang, Peter Cheng, Rasha Msallam, Ann-Marie Chacko, You Yi Hwang, Edward G. Robins

“…We have evaluated [18F]AlF-mNOTA-GZP, a radiolabeled peptide targeting granzyme B, to stratify response to ICIs in a HEPA 1-tumours, a syngeneic model of HCC. …”
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Radiochemistry and Preclinical PET Imaging of Ga-Desferrioxamine Radiotracers Targeting Prostate-Specific Membrane Antigen by Eleni Gourni PhD, Luigi Del Pozzo BSc, Mark Bartholomä PhD, Yvonne Kiefer BSc, Philipp T. Meyer MD, PhD, Helmut R. Maecke PhD, Jason P. Holland D.Phil

“…Here, the synthesis, radiolabeling, and in vitro and in vivo characterization of two 68 Ga-radiolabeled Glu-NH-C(O)-NH-Lys radiotracers conjugated to the desferrioxamine B (DFO) chelate were evaluated. …”
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Currents status of radiotracers for breast cancer imaging in PET by Chloé Jean, Stéphane Roux, Abdelilah Aziz, Maxence Mocquery-corre, Rana Bazzi, Yacine Merrouche, Stéphane Dedieu, Nicolas Etique, Dimitri Papathanassiou, Jérôme Devy

“…Radiolabeled molecules have become valuable tools in the diagnosis, monitoring, and treatment of cancer, particularly breast cancer. …”
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Click Synthesis and Biologic Evaluation of ()- and ()-2-Amino-3-[1-(2-[F]Fluoroethyl)-1-[1,2,3]Triazol-4-yl]Propanoic Acid for Brain Tumor Imaging with Positron Emission Tomography by Jonathan McConathy, Dong Zhou, Stephany E. Shockley, Lynne A. Jones, Elizabeth A. Griffin, Hsiaoju Lee, Susan J. Adams, Robert H. Mach

“…Based on these results, the 1 H -[1,2,3]triazole-substituted amino acid ( S )-[ 18 F]4 has promising PET properties for brain tumors and represents a novel class of radiolabeled amino acids for tumor imaging.…”
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Pharmacokinetics of PEGylated Recombinant Human Erythropoietin in Rats by Xiaohan Cao, Zhiyong Chen, Zhuoran Yu, Yonghong Ge, Xianyin Zeng

“…Following a 2 μg/kg single intramuscular administration, approximately 21% of the radiolabeled dose was recovered after almost seven days of study. …”
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PET imaging of HIV-1 envelope protein gp120 using 18F-labeled nanobodies by Neysha Martinez-Orengo, Swati Shah, Jianhao Lai, Falguni Basuli, Anna Lyndaker, Mitchell L. Turner, Morteza Peiravi, Suman Sourabh, Kevon Sampson, Peng Zhang, Rolf E. Swenson, Paolo Lusso, Frank Maldarelli, Avindra Nath, Chuen-Yen Lau, Dima A. Hammoud

“…Summary: Radiolabeled antibodies against the HIV-1 envelope protein, gp120, have been previously tested in animal models and in people with HIV (PWH). …”
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