Addressing the “Black Hole” of Low Back Pain Care With Clinical Decision Support: User-Centered Design and Initial Usability Study by Robert S Rudin, Patricia M Herman, Robert Vining

“…Although there are specific types of LBP, each with evidence-based treatment recommendations, most patients receive a nonspecific diagnosis that does not facilitate evidence-based and individualized care. ObjectivesWe designed, developed, and initially tested the usability of a LBP diagnosis and treatment decision support tool based on the available evidence for use by clinicians who treat LBP, with an initial focus on chiropractic care. …”
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FKBP5 as a key regulator of metabolic processes in birds: Insights from chicken pectoral muscle by Pengfei Du, Xiangli Zhang, Yao Zhu, Ziyang Wang, Xuemeng Si, Huaiyong Zhang, Yanqun Huang, Wen Chen

“…The FKBP5 levels in birds are dramatically modulated during development in insulin-sensitive tissues, with the highest expression observed in striated muscle and liver at embryonic day 19 (E19) (P < 0.01). …”
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IMPACT OF ENERGY PRICES ON PRICES OF BASIC TOURISM SERVICES IN THE EURO AREA by Lachezar Borisov

“…It seems plausible to suggest that the fluctuations in energy prices observed during the period 2019-2024 could serve as an indicator of potential shifts in the pricing of basic tourism services. …”
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RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER+ breast cancer by Charlotte K. Kindt, Sidse Ehmsen, Sidse Ehmsen, Sidse Ehmsen, Sofie Traynor, Benedetta Policastro, Nikoline Nissen, Mie K. Jakobsen, Monique F. Hundebøl, Lene E. Johansen, Martin Bak, Elsa Arbajian, Johan Staaf, Henrik J. Ditzel, Henrik J. Ditzel, Henrik J. Ditzel, Carla L. Alves

“…High expression of the receptor tyrosine kinase REarranged during Transfection (RET) has been associated with resistance to endocrine therapy in breast cancer, but the role of RET in CDK4/6i treatment response/resistance remains unexplored.MethodsTo identify gene expression alterations associated with resistance to combined endocrine therapy and CDK4/6i, we performed RNA sequencing of two ER+ breast cancer cell models resistant to this combined therapy. …”
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Myofascial trigger points therapy increases neck mobility and reduces headache pain in migraine patients – pilot study by Maciej Olesiejuk, Małgorzata Chalimoniuk, Tomasz Sacewicz

“…Outcome measures included: CS-ROM (assessed using an accelerometer system), subjective headache pain intensity (evaluated via the Visual Analog Scale (VAS)), and calcitonin gene-related peptide (CGRP) concentrations. …”
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Risk factors and consequences of traumatic brain injury in a Swiss male population cohort by Jean-Bernard Daeppen, Gerhard Gmel, Joseph Studer, Valentin Petre Matei, Alina Elena Rosca, Alexandru Neculai Pavel, Radu Mihai Paun

“…Objective To investigate the risk factors for and the consequences (ie, substance use disorders (SUD), depression, personality traits) of traumatic brain injury (TBI) in young Swiss men.Design This is a three-wave cohort study. …”
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Transfer of aflatoxin M1 and sterigmatocystin from buffalo milk to soft cheeses by Maurizio Cossu, Andrea Sanna, Giannina Chessa, Stefano Sdogati, Ivan Pecorelli, Ilaria Di Marco Pisciottano, Sara Lambiase, Pasquale Gallo, Stefania Massafra, Elena Torres, Marilena Gili, Giovanni Lo Cascio, Antonio Vella, Roberto Condoleo, Bruno Neri, Guglielmo Militello, Gilberto Giangolini, Carlo Boselli

“… Aflatoxin M1 (AFM1) may be present in milk as a result of the ingestion of aflatoxin B1 (AFB1), which could potentially be contained in dairy feed due to contamination by molds such as Aspergillus flavus and A. parasiticus. …”
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Concentrations and health risks of metal elements in ambient air PM2.5 in two urban districts of Hefei city from 2015 to 2023: analysis of monitoring data by Yu ZHU, Linling YU, Derui YAN, Changchun XIAO

“…ResultsA total of 1 522 valid filter samples were collected in the two districts of the city during the period. The concentrations of aluminum, selenium, and antimony in the PM2.5 samples collected in Yaohai district were higher than those in Baohe district (Zaluminum = – 3.505, Paluminum < 0.001; Zselenium = – 2.148, Pselenium = 0.032; Zantimony = – 4.919, Pantimony < 0.001), while the differences in the concentrations of other metal elements between the two districts were not significant (P > 0.05 for all). …”
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A Proteomic Study Based on Home Quarantine Model Identifies NQO1 and Inflammation Pathways Involved in Adenoid Hypertrophy by Chen P, Hou S, Pang X, Li L, Wei W

“…At the beginning of the COVID-19 pandemic, there was a significant reduction in the incidence of adenoid hypertrophy in children under long-term home quarantine, providing a rare research model to explore the pathogenesis and treatment targets of adenoidal hypertrophy in children.Methodology: Before and during the home quarantine period, adenoids that underwent surgery were detected using label-free proteomics. …”
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Effectiveness of potent topical corticosteroids versus mild ones in primary care for children with moderate flare-ups of atopic dermatitis; results of a randomised controlled trial by Patrick J E Bindels, Arthur M Bohnen, Gijs Elshout, Suzanne G M A Pasmans, Karlijn F van Halewijn

“…Finally, 32 patients (15%) were randomised and assigned to the trial (13 girls; 19 boys; median age 4.0 years).Interventions If cohort participants experienced a moderate flare-up (ie, need to intensify topical treatment from the child’s and/or parents’ point of view of AD and a three-item severity score from three to&lt;6 scored by their GP) during cohort follow-up, they were randomised to either the intervention group, a strong TCS (class III, fluticasone propionate 0.05%), or the control group, a mild TCS (class I, hydrocortisone acetate 1%).Primary and secondary outcome measures We measured outcomes at baseline and at 1, 4 and 24 weeks. …”
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Maternal prepregnancy overweight/obesity increase the risk of low Apgar scores in twins: a population-based cohort study in China by Zhoushan Feng, Zhoushan Feng, Xiaohong Wu, Xiaomei Tong, Zheng He, Chunxia Yang, Wei Shen, Yueqin Ding, Jin Liu, Qiong Meng, Aiqin Zhang, Hong Jiang, Wenkang Yan, Jianwu Qiu, Xian Wei, Yayu Zhang, Xiaobo Lin, Lijun Liu, Ya Jin, Youfen Wei, Xiufang Yang, Yitong Wang, Yangfan Cai, Xinzhu Lin, Qiliang Cui

“…These findings highlight the importance of managing weight before pregnancy and ensuring readiness for neonatal resuscitation during delivery.…”
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Development of a framework to structure decision-making in environmental and occupational health: A systematic review and Delphi study by Emily Senerth, Paul Whaley, Elie Akl, Brandy Beverly, Pablo Alonso-Coello, Ezza Jalil, Jayati Khattar, Nicole R. Palmer, Andrew Rooney, Holger J. Schünemann, Kristina A. Thayer, Katya Tsaioun, Rebecca L. Morgan

“…We abstracted and analyzed decision considerations from each framework through narrative synthesis. …”
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Investigation of gut microbiota in pediatric patients with peanut allergy in outpatient settings by Shouming Li, Jingyi Huang, Yunyun Xie, Di Wang, Xin Tan, Yufan Wang

“…Identify potential gut microbial biomarkers for the diagnosis and treatment of peanut allergies.MethodsTwenty-nine children with peanut allergy who visited the hospital from December 2020 to December 2022 were selected as the test group (PA), and twenty-seven healthy children who underwent physical examination during the same period and tested negative for peanut IgE were selected as the control group (Ctl). …”
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Determinants of Change in Glycemic Status in Individuals with Prediabetes: Results from a Nationwide Cohort Study in Germany by Rebecca Paprott, Christa Scheidt-Nave, Christin Heidemann

“…Previous studies investigating determinants of changes in glycemic status among individuals with prediabetes mainly focused on glucose-defined prediabetes. In this study, we examined determinants of a regression to normoglycemia or a progression to diabetes among individuals with HbA1c-defined prediabetes. …”
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Lower Kinetic Chain, Meet the Thinking Brain: A Scoping Review of Cognitive Function and Lower Extremity Injury Risk by Michaela A. Reyes, Mark O. Probasco, Trina N. Worby, Dylan E. Loertscher, Lyndsey K. Soderbeck, Wendy E. Huddleston

“…Included articles were appraised using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies…”
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Botulinum Toxin Injection with Conjunctival Microincision for the Treatment of Acute Acquired Comitant Esotropia and Its Effectiveness by Hongjia Xu, Weifeng Sun, Shuying Dai, Yanyan Cheng, Jing Zhao, Yuan Liu, Juan Wang, Ya’nan Wang, Yu Gao, Huifang Han, Aijun Han

“…Mean stereoacuity improved from 338 to 88 arc seconds. During the follow-up period, 5 of 29 patients had recurrent esotropia. …”
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ENTREPRENEURSHIP OF MEMORY IN PUBLIC SPACE AND SOCIAL COMMUNICATION: A POSTCOLONIAL APPROACH IN TIME OF WAR by Viktoriia Kovpak, Nataliia Lebid, Viktor Burenkov

“…The purpose of the research is to analyse cases of constructive and destructive use of organisational imprinting in the economy as a strategic practice of memory politics, using the example of "heritage restaurants". …”
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Intestinal protozoa infections and associated factors among diarrheal under-five children in Borena district, central Ethiopia by Alebie Mesfin, Woynshet Gelaye, Getaneh Alemu

“…These findings revealed that Giardia lamblia and Entamoeba histolytica are public health problems causing diarrhea among under-five children in the study area, and their transmission is associated with the illiteracy of mothers/guardians, the absence of functional toilets, not using soap/ash during hand washing, and frequent contact with domestic animals. …”
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Phase IV adaptive randomised clinical trials evaluating efficacy and cost-efficacy of pre-emptive pharmacogenetic genotyping strategies in the Spanish National Health System: iPHAR... by Xandra García-González, Alberto M Borobia, Antonio J Carcas, Miriam Estébanez, Montserrat Carmona, Irene García García, Francisco Abad-Santos, Luis A López-Fernández, Esther Cubo, Iñaki Imaz-Iglesia, Alicia Marín-Candón, Miriam Saiz-Rodríguez, Irene Taladriz-Sender, Pedro Arias, Rocío Rosas-Alonso, Enrique Seco-Meseguer, Stefan Stewart, Elena Diago-Sempere, María del Mar García Saiz, Emilio J Laserna-Mendieta, Ana M Peiró, Magí Farré, Consuelo Rodriguez-Jimenez, Judith Sanabria-Cabrera, Lucia Pedrosa, Ignacio Bernardino, Javier Guiijarro-Eguinoa, Arturo Gómez López De Las Huertas, Susana Martín-López, Olga Hladun Alvaro, Vicente Arrate, Ana Fries, Daniel Rodriguez Díaz, Fernando Marqués García, Núria Alonso Pedrol, Modesto M Maestre Muñiz, Leticia Rodríguez Alcolado, Carlos Ortiz-Bautista, Angela Remesal-Doblado, María Isabel Lucena, Zaida Salmón González, Inmaculada Coca-Prieto

“…However, the adoption of pre-emptive pharmacogenetic testing for commonly prescribed drugs, such as statins, outside of tertiary hospitals is limited due to a lack of pharmacoeconomic evidence to support widespread implementation by healthcare policy-makers. …”
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Study on the changes and influencing factors of depression in Chinese women with cancer: an analysis based on CHARLS panel data by Na Wang, Mengran Chang, Shidong Liu, Bing Chen

“…However, previous studies have largely focused on teenage girls, perimenopausal women, or women during pregnancy and the postpartum period, neglecting the adverse effects of major diseases, which is detrimental to enhancing the psychological well-being of women with cancer.ObjectiveBased on cancer impacts, this study aims to clarify the depressive state, development trends, and influencing factors in Chinese women with cancer, a group particularly susceptible to depression, to provide decision-making references for improving their psychological well-being.MethodsUsing follow-up panel data from five waves of China Health and Retirement Longitudinal Study (CHARLS), Chinese women with cancer who had complete observed values were selected as research subjects. …”
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