Nationwide carrier screening for congenital adrenal hyperplasia: integrated approach of CYP21A2 pathogenic variant genotyping and comprehensive large gene deletion analysis by Yossawat Suwanlikit, Bhakbhoom Panthan, Pawares Chitayanan, Sommon Klumsathian, Angkana Charoenyingwattana, Wasun Chantratita, Objoon Trachoo

“…Remarkably, two carriers exhibited significant large-scale deletions, while another manifested a carrier state due to minor-scale gene conversion. The estimated carrier frequency in our cohort using these methods was approximately 1 in 65 individuals. …”
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Application of machine learning algorithms in predicting new onset hypertension: a study based on the China Health and Nutrition Survey by Manhui Zhang, Xian Xia, Qiqi Wang, Yue Pan, Guanyi Zhang, Zhigang Wang

“…We modeled using 16 and 29 features, respectively. …”
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A multicenter retrospective study of early cardiac toxicity in operable breast cancer patients receiving concurrent dual or mono anti-HER2 therapy with postoperative radiation ther... by Jing Yang, Meng-Yun Zhou, Bo Yu, Qing Lin, Yuan Yao, Hua-Ling Wu, Qi-Wei Zhu, Ming Ye, Hua-Ying Xie, Jian-Wei Wu, Gang Cai, Rong Cai, Wei-Xiang Qi, Jia-Yi Chen, Lu Cao

“…Cardiac examinations included echocardiography, electrocardiogram (ECG), NT-proBNP, and cTnI at baseline before RT and during the follow-up. The cardiac event is any new-onset symptomatic heart disease or abnormality in the cardiac examination after RT. …”
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Utilizing deep learning-based causal inference to explore vancomycin’s impact on continuous kidney replacement therapy necessity in blood culture-positive intensive care unit patie... by Min Woo Kang, Yoonjin Kang

“…This study developed a machine learning model to predict CKRT and examined vancomycin’s impact using deep learning-based causal inference. We analyzed ICU patients with positive blood cultures, utilizing the Medical Information Mart for Intensive Care III data set. …”
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Development of autonomic innervation at the venous pole of the heart: bridging the gap from mice to human by Fleur Zwanenburg, Thomas A. Bos, Arend D. J. Ten Harkel, Monique C. Haak, Nathan D. Hahurij, Robert E. Poelmann, Conny J. van Munsteren, Lambertus J. Wisse, Nico A. Blom, Marco C. DeRuiter, Monique R. M. Jongbloed

“…Cardiac autonomic function was assessed through heart rate variability (HRV) analysis using ultrasound. Morphological assessment of the venous pole was performed using immunohistochemical stainings for neural crest cells and autonomic nerve markers. …”
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Advancing breast cancer diagnosis: token vision transformers for faster and accurate classification of histopathology images by Mouhamed Laid Abimouloud, Khaled Bensid, Mohamed Elleuch, Mohamed Ben Ammar, Monji Kherallah

“…This hybrid architecture aims to enhance feature extraction and classification accuracy with shorter training time and fewer parameters by minimizing the number of input patches employed during training, while incorporating tokenization of input patches using convolutional layers and encoder transformer layers to process patches across all network layers for fast and accurate breast cancer tumor subtype classification. …”
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Growth Traits and Yield Performance of Japonica Hybrid Rice Bred by the New Strategy in the Yangtze River Region of China by Yutiao Chen, Jiayu Song, Xiaofu Hong, Huaijie Zhang, Tiejun Hu, Guanglong Zhu

“…The optimal plant height at maturity and seedling dry weight for achieving a high grain yield in japonica hybrid rice were approximately 130 cm and 300 mg plant⁻¹, respectively. This study provides useful information for breeding high-yield japonica hybrid cultivars.…”
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Screening Evaporative Dry Eyes Severity Using an Infrared Image by Qing Zhang, Yi Wu, Yilin Song, Guanghao Qin, Lanting Yang, Sumeet Singh Talwar, Tiezhu Lin, Gagan Deep Singh Talwar, Hongda Zhang, Ling Xu, Jonathan E Moore, Emmanuel Eric Pazo, Wei He

“…Dry eye disease (DED) is a multifactorial and one of the most common problems treated in an ophthalmic outpatient clinic. Due to the variability in presentation, diagnosis of DED consists of a combination of subjective and objective clinical tests. …”
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The pneumococcal bacteriocin streptococcin B is produced as part of the early competence cascade and promotes intraspecies competition by J. D. Richardson, Emily Guo, Ryan M. Wyllie, Paul Jensen, Suzanne Dawid

“…In these backgrounds, the scbABC locus is part of the early competence cascade due to a ComE binding site in the promoter region. …”
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Companion animal and equine clinical research: a Nordic perspective by Bodil Ström Holst, Alejandro Engelmann, Gittan Gröndahl, Lotta Gunnarsson, Anita Haug Haaland, Anna Hielm-Björkman, Lars Moe, Marie Rhodin, Henrik Rönnberg, Marie Stråhle, Ylva Toljander, Annemarie Thuri Kristensen, Malin Hagberg Gustavsson

“…A large proportion of grants were received from small- to medium-sized funding bodies, mainly funding running costs and only to a limited degree salaries. During 2010–2019, costs for veterinary and other services for cats and dogs steadily increased. …”
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Relationship between social capital and medication adherence among frail and pre-frail older people: a cross-sectional study from China by Zixuan Hong, Ying Guo, Wenwen Cao, Chenglin Cao, Zhi Hu, Jing Yan, Ren Chen, Zhongliang Bai

“…Methods Information concerning the socio-demographics, frailty, social capital, and medication adherence of 4218 participants was collected through a structured questionnaire during November and December 2020. This study employed descriptive analysis and binary logistic regression to fit their relationship. …”
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BRCA1 is involved in sustaining rapid antler growth possibly via balancing of the p53/endoplasmic reticulum stress signaling pathway by Qianqian Guo, Zhen Wang, Jiping Li, Chao Ma, Junjun Zheng, Hengxing Ba, Guokun Zhang, Chunyi Li

“…Antler regeneration is based on the proliferation and differentiation of antler stem cells (AnSCs). Results We identified 39 hub genes which may function in regulating the balance between rapid proliferation and genomic stability in the AnSCs during antler regeneration. …”
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Attendance of Patients with ophthalmological problems about Eye Protection from UV/blue Light Radiation from Sun light and Electronic Devices in Sulaimani City by Salah Qadir Mahmood, Muhammad Babakir-Mina, Salar Ibrahim Ali, Abdulrahman M. Ibrahem, Bakhtyar Kamal Talabany

“…Ultraviolet (UV) and blue light are affecting eyes during the daily time and may cause many eye’s problems and diseases. …”
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Identification and expression analysis of the heat shock proteins Hsp70, Hsp90, and Hsp90b in Litopenaeus vannamei under low-temperature stress by Min Peng, Hui Wang, Shuiping Wen, Zheng Liang, Zheng Huang, Bin Zhang, Tianchong Chen, Qingyun Liu, Qiangyong Li, Yuan Meng, Yuliu Huang, Chunling Yang, Digang Zeng, Manyuan Li, Weilin Zhu, Yongzhen Zhao

“…The expression level of hsp90 was considerably elevated in the cold-tolerant family following exposure to low temperatures (18 °C and 10 °C) compared to that of the common family. During low-temperature stress, hsp70 and hsp90 expression levels increased gradually in both families, while hsp90b expression decreased. …”
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The Identification and synthesis of metabolites of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide by Alexander L. Khokhlov, Ilya I. Yaichkov, Anton A. Shetnev, Valeria A. Panova, Julia A. Efimova, Sergey A. Ivanovskiy, Mikhail K. Korsakov, Nikita N. Volkhin, Sergey S. Petukhov

“…The identification of metabolites in these objects was performed using HPLC-MS/MS. Then the detected biotransformation products were synthesized. …”
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The Role of Leaders in Formulation of the Foreign Policy Identity in Egypt by I. E. Ibragimov

“…Egypt has a long history of authoritarian rule, because it is impossible to separate national identity from foreign policy identity. …”
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Reproductive Diseases and Disorders of Female Camels: An Assessment and Pathological and Bacteriological Study in Eastern Ethiopia by Dinaol Belina, Amare Eshetu, Sisay Alemu, Bekyad Shasho, Tajudin Mohammed, Ahmedin Mohammed, Bahar Mummed, Dereje Regassa

“…In Ethiopia, they are the main livestock kept to sustain the livelihoods of pastoralists, as camels are used for milk and meat production and also for transportation. …”
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Impact of Late Ventricular Arrhythmias on Cardiac Mortality in Patients with Acute Myocardial Infarction by Takuma Takada, Koki Shishido, Takahiro Hayashi, Shohei Yokota, Hirokazu Miyashita, Hiroaki Yokoyama, Takashi Nishimoto, Tomoki Ochiai, Noriaki Moriyama, Kazuki Tobita, Shingo Mizuno, Futoshi Yamanaka, Masato Murakami, Yutaka Tanaka, Saeko Takahashi, Shigeru Saito

“…Of these patients, 888 did not have VT/VF (non-VT/VF group) and 116 had sustained VT/VF during prehospitalization or hospitalization. Patients with VT/VF were divided into two groups: early VT/VF (VT/VF occurrence before and within 2 days of admission, 92 patients) and late VT/VF (VT/VF occurrence >2 days after admission; 24 patients) groups. …”
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Systolic Blood Pressure, Cardiac Index and Eisenmenger Syndrome are Predictors of Mortality in Pulmonary Arterial Hypertension-associated with Congenital Heart Disease: An Analysis... by Muflihatul Baroroh Rochmat, Budi Yuli Setianto, Dyah Wulan Anggrahini, Lucia Kris Dinarti, Anggoro Budi Hartopo

“…There are several known predictors of mortality in PAH patients, however predictors of mortality in LtR-shunt CHD-associated PAH need to be validated. Objectives: We aimed to investigate the predictors of mortality among adult LtR-shunt CHD-associated PAH patients.  …”
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Molecular mechanism underlying cardioprotective effect of dehydroepiandrosterone on endoplasmic reticulum stress induced apoptosis in human vascular smooth muscle cells and human u... by Ye Zhu, Junxiu Wei, Xin Yang, Wei Zhu

“…IntroductionThis study aimed to investigate the underlying mechanisms involved in the cardioprotective effects of dehydroepiandrosterone (DHEA) on endoplasmic reticulum stress (ERS) -mediated apoptosis in human vascular smooth muscle cells (HVSMCs) and human umbilical vein endothelial cells (HUVECs).Material and methodsVarious concentrations of Dithiothreitol (DTT) were used to induce ERS-mediated apoptosis. DHEA was utilized to inhibit the apoptotic effects of DTT, while estrogen receptor (ER) antagonists ICI 182,780 and G15, the androgen receptor (AR) antagonist flutamide and the aromatase inhibitor letrozole were used to identify the receptors activated during DHEA treatment in HVSMCs and HUVECs. …”
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