The role of SASP in ischemic stroke: a deep dive into cellular mechanisms by Dong Xie, Yang Liu, Fang-Biao Xu, Jin-Sheng Zhang

“…Aging, a prominent risk factor, implicates the senescence-associated secretory phenotype (SASP) in IS pathogenesis. We postulated that alterations in SASP-related factor expression during IS correlate with remodeling of intercellular interaction networks and disease advancement. …”
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Link between bilaterality and type 2 inflammation in respiratory epithelial adenomatoid hamartomas: A two-center retrospective cohort study. by Yujin Heo, Sang Duk Hong, Hyo Yeol Kim, Gwanghui Ryu, Kyung Won Kwon, Yong Gi Jung

“…Neither group showed recurrence during a mean follow-up of 11.91 months.<h4>Conclusion</h4>Bilaterally originating REAH in the superior nasal septum and olfactory cleft demonstrates pronounced type 2 inflammatory characteristics, suggesting potential differences in pathogenesis compared to unilateral REAH. …”
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Loss of Appetite in Adult Patients: Effectiveness and Safety of an Appetite Stimulating Medication in an Open-Label, Investigator-Initiated Study in India by S. Nagaraj

“…The current study assessed the effects of an appetite-stimulating medication containing multivitamins, lysine, and zinc in Indian patients with a history of LOA. Using an investigator-initiated, single-center, open-label, single-arm design, we evaluated the effectiveness and safety of the appetite-stimulating medication (15 mL) in 50 male or female patients (18–55 years old) attending the outpatient department, with a confirmed diagnosis of LOA after two weeks of therapy and assessed the change in Council on Nutrition Appetite Questionnaire (CNAQ) score and safety of the medication after two weeks of treatment. …”
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Prognostic factors in severe dengue patients: A multi-center retrospective cohort study. by Cheng-Hsun Yang, Ing-Kit Lee, Yi-Chun Chen, Wen-Chi Huang, Jui-Chi Hsu, Chien-Hsiang Tai, Chung-Hao Huang, Chun-Yu Lin, Yen-Hsu Chen

“…Multivariable regression analysis revealed increasing odds of death associated with older age (odds ratio [OR], 1.037; 95% confidence interval [CI], 1.009-1.066), altered consciousness (OR, 8.591; 95% CI, 2.914-25.330), gastrointestinal bleeding (OR, 1.939; 95% CI, 1.037-3.626), and leukocytosis (OR, 2.504; 95% CI, 1.124-5.578) upon arrival, as well as organ impairment during hospitalization, including acute kidney injury (OR, 2.627; 95% CI, 1.373-5.028), severe hepatitis (OR, 5.324; 95% CI, 2.199-12.889), and pneumonia (OR, 2.250; 95% CI, 1.054-4.802).…”
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Radiofrequency ablation as a method of choice for the treatment of lower extremity varicose veins disease by O. Yu. Atamaniuk, V. D. Skrypko, V. M. Atamaniuk

“…After 2 years the partial occlusion was diagnosed in 4 (1.9 %) patients. During the first 2 weeks after treatment, 64 (30.5 %) patients reported complications, which didn’t require treatment. …”
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Evaluation of video-assisted HPV education in government-supported clinics in Western Kenya. by Haley Dion, Hanul Choi, Michelle Huang, Laya Sathyan, Emily Herfel, Breandan Makhulo, Jeniffer Ambaka, Saduma Ibrahim, Megan Huchko

“…This research is fully funded by the Duke University Global Health Institute.…”
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A Bore-Integrated Patch Antenna Array for Whole-Body Excitation in Ultra-High-Field Magnetic Resonance Imaging by Svetlana S. Egorova, Nikolai A. Lisachenko, Egor I. Kretov, Yang Gao, Xiaotong Zhang, Stanislav B. Glybovski, Georgiy A. Solomakha

“…We propose using patch antenna elements separated by compact dual-loop decoupling resonators to overcome this limitation. …”
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Glu4: An open-source package for real-time forecasting and alerting post-bariatric hypoglycemia based on continuous glucose monitoring by Luca Cossu, Francesco Prendin, Giacomo Cappon, David Herzig, Lia Bally, Andrea Facchinetti

“…This leaves individuals vulnerable to recurrent, unpredictable hypoglycemia, posing significant health risks. To address this gap, we propose Glu4, an open-source software package designed to predict and notify users of impending PBH events using CGM data. …”
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Coverage and effectiveness of conditional cash transfer for people with drug resistant tuberculosis in Zimbabwe: A mixed methods study. by Collins Timire, Charles Sandy, Rashida A Ferrand, Regina Mubau, Peter Shiri, Obert Mbiriyawanda, Fredrick Mbiba, Rein M G J Houben, Debora Pedrazzoli, Virginia Bond, Nicola Foster, Katharina Kranzer

“…Qualitative data were analyzed using thematic analysis. A total of 481 people were included in the quantitative study. …”
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mTORC2 Activation Mediated by Mesenchymal Stem Cell-Secreted Hepatocyte Growth Factors for the Recovery of Lipopolysaccharide-Induced Vascular Endothelial Barrier by Shan-Shan Meng, Feng-Mei Guo, Li-Li Huang, Ying-Zi Huang, Jian-Feng Xie, Cong-Shan Yang, Hai-Bo Qiu, Yi Yang

“…These revealed that HGF could promote quick reestablishment of adherent junction VE-cadherin and decrease endothelial paracellular and transcellular permeability during LSP-induced endothelial dysfunction with the involvement of mTORC2 (rictor) and mTORC1 (raptor) pathways. …”
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Effects of supplementing a polyphenol-rich sugarcane extract through drinking water on egg production and quality of laying hens. by Namalika D Karunaratne, Sasmitha De Silva, Minoli Herath, Ruvini Liyanage, Pabodha Weththasinghe, Barana C Jayawardana, Eranga De Seram, Anil Pushpakumara, Mathew Flavel

“…The results indicated that PRSE supplementation led to a significant reduction in yolk colour during week 45 (P = 0.001), although no differences were observed in subsequent weeks. …”
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The Impact of Perioperative Multimodal Pain Management on Postoperative Outcomes in Patients (Aged 75 and Older) Undergoing Short-Segment Lumbar Fusion Surgery by Shuaikang Wang, Tongtong Zhang, Peng Wang, Xiangyu Li, Chao Kong, Wenzhi Sun, Shibao Lu

“…Background. Due to the presence of multimorbidity and polypharmacy, patients aged 75 and older are at a higher risk for postoperative adverse events after lumbar fusion surgery. …”
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QUALITY EVALUATION OF THE TPP POWER GENERATING UNITS WEAR RECONDITIONING by E. M. Farhadzadeh, A. Z. Muradaliyev, Yu. Z. Farzaliyev

“…Reconditioning of the power generating unit worn equipment and devices is conducted during the scheduled repair period. Quality of wear reconditioning is evaluated by technical state and repair work implementation. …”
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Analysis of vulnerability, its drivers, and strategies applied towards reducing the pastoral and agro-pastoral livelihood vulnerability to climatic shocks by Daniel Assefa Tofu, Tegegn Dilbato, Chalchisa Fana, Niguse Bekele Dirbaba, Gutu Tesso

“…Managing livestock, taking advantage of social capital, storing hay and crop residue, and destocking animals during the period of severe drought were the main strategies used to reduce the vulnerability and enhance the adaptive capacity. …”
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Autoregulatory Feedback Mechanism of P38MAPK/Caspase-8 in Photodynamic Therapy-Hydrophilic/Lipophilic Tetra-α-(4-carboxyphenoxy) Phthalocyanine Zinc-Induced Apoptosis of Human Hepa... by Yu Wang, Chunhui Xia, Wei Chen, Yuhang Chen, Yiyi Wang, Tao Li

“…In contrast, SB203580 or Ac-IEFD-CHO attenuated induction of apoptosis, activation of P38MAPK, Caspase-8, Caspase-3, and Bid, downregulation of Bcl-2, release of Cytochrome c from mitochondria, and disruption of mitochondrial membrane potential in TαPcZn-PDT-treated Bel-7402 cells. Taken together, we conclude that Caspase-3, Bcl-2, Bid, and mitochondria are involved in autoregulatory feedback of P38MAPK/Caspase-8 during TαPcZn-PDT-induced apoptosis of Bel-7402 cells.…”
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Role of hypothalamic-pituitary-adrenal axis and catecholamine factors in independent and primary multiple types of tumor growth by E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. I. Surikova, Yu. A. Pogorelova, N. D. Cheryarina, L. K. Trepitaki, I. V. Neskubina, A. A. Vereskunova, I. M. Kotieva, K. A. Shumarin, A. I. Shikhlyarova, I. V. Goroshinskaya

Subjects: “…nude mice…”
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大肠癌组织CD137L的表达及意义

“…【目的】 检测大肠癌组织及癌旁组织中CD137L mRNA及蛋白的表达情况,探讨其在大肠癌发生进展中的意义65377; 【方法】 运用实时荧光定量逆转录聚合酶链反应及冰冻切片免疫组化的方法检测大肠癌组织及癌旁组织中CD137L的表达情况,并分析其表达情况与各临床因素的相关性65377; 【结果】 54例大肠癌组织中CD137L mRNA的相对表达水平为 0.035 ± 0.013,显著高于癌旁组织的0.008 ± 0.005(P < 0.05)65377;但在不同性别65380;年龄65380;肿瘤发生部位65380;Dukes分期65380;病理分化及血清CEA水平情况下,CD137L mRNA的表达水平无显著性差异(P > 0.05)65377;随机抽取8例大肠癌肿瘤组织及3例癌旁组织,进行免疫组化检测,结果显示6例CD137L蛋白呈阳性表达,CD137L表达于肿瘤细胞表面;3例癌旁组织该分子的表达均为阴性65377;【结论】 CD137L mRNA在大肠癌组织中高表达,CD137L分子表达于大肠癌肿瘤细胞表面,提示该分子可能在大肠癌的发生进展中发挥作用65377;…”
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A new guide for basic psychological support for persons affected by neglected tropical diseases: A peer support tool suitable for persons with a diagnosis of leprosy and lymphatic... by Pradeepta K Nayak, Charles D Mackenzie, Ashok Agarwal, Robin van Wijk, Marente M Mol, Julian Eaton, Maya Semrau, Carmen Valle-Trabadelo, Gauri S Kaloiya, Alok Pratap, Jayashree P Kunju, Suma Krishnasastry, Astri Ferdiana, Ariana Marastuti, Rohit K Tiwari, Wim H van Brakel

“…The first meeting was a 3-day virtual workshop held on 9-11 June 2020, followed by other online meetings. The BPS-N guide development happened during the COVID-19 lockdowns. …”
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Global Mean and Relative Sea-Level Changes Over the Past 66 Myr: Implications for Early Eocene Ice Sheets by K. G. Miller, W. J. Schmelz, J. V. Browning, Y. Rosenthal, A. V. Hess, R. E. Kopp, J. D. Wright

“…We estimate ice-volume driven (barystatic; BSL) sea-level changes for the Cenozoic using new Mg/Ca data from 58 to 48 Ma and a revised analysis of Mg/Ca trends over the past 66 Myr. …”
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Comparative efficacy of hydroxychloride and organic sources of zinc, copper, and manganese on hatching eggs, embryo and hatchlings attributes by Reza Bakhshalinejad, Stephanie Torrey, Elijah G. Kiarie

“…Six eggs per pen were sampled prior to incubation and during d 14 and 19 of incubation for analyses. At hatch, 3 male and 3 female chicks were randomly selected from each pen, bled for plasma concentration of minerals and subsequently euthanized for liver and gizzard weight. …”
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