Hypericin mediated photodynamic therapy induces ferroptosis via inhibiting the AKT/mTORC1/GPX4 axis in cholangiocarcinoma by Wei An, Kai Zhang, Guangbing Li, Shunzhen Zheng, Yukun Cao, Jun Liu

“…This novel form of RCD has attracted great attention as a potential new target in clinical oncology during recent years. In this study, we observed that hypericin mediated PDT(HY-PDT) could significantly inhibit the proliferation of the cholangiocarcinoma cells and suppress migration and the epithelial mesenchymal transition (EMT) as well. …”
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Composting of selected organic wastes from peri-urban areas of Harare, Zimbabwe by Rangarirayi L Mhindu, Menas Wuta, Esther Ngorima

“…Background: The composting process of peri-urban household wastes, changes that occur during composting, and the properties of the composting products that are of importance for use as soil amendments were studied. …”
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Computational biology assisted exploration of phytochemicals derived natural inhibitors to block BZLF1 gene activation of Epstein–Bar virus in host by Muhammad Naveed, Muzamal Hussain, Tariq Aziz, Nimra Hanif, Nazia Kanwal, Arooj Arshad, Ayaz Ali Khan, Abdulrahman Alshammari, Metab Alharbi

“…Imperatorin was the best candidate for developing the drug against toxin protein Zta coded by the BZLF1 gene because it exhibited the lowest binding energy (− 6.3 kcal/mol) during natural inhibitor screening. Imperatorin’s compliance with Lipinski’s Rule of 5 and favorable pharmacokinetics make it an ideal therapeutic agent against EBV. …”
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A Credit Card Fraud Detection Algorithm Based on SDT and Federated Learning by Yuxuan Tang, Zhanjun Liu

“…Momentum updates are used for model parameter updates during training, which enhance model performance and ensure data privacy between banks. …”
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Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms by Mie Suzuki Okutani, Shinya Okamura, Tang Gis, Hitomi Sasaki, Suni Lee, Akiho Kashiwabara, Simon Goto, Mai Matsumoto, Mayuko Yamawaki, Toshiaki Miyazaki, Tatsuya Nakagawa, Masahito Ikawa, Wataru Kamitani, Shiro Takekawa, Koichi Yamanishi, Hirotaka Ebina

“…The neutralizing antibodies induced by BK2102 persisted for up to 364 days, which indicated that they confer long-term protection against infection. Furthermore, we confirmed the safety of BK2102 using transgenic (Tg) mice expressing human ACE2 (hACE2) that are highly susceptible to SARS-CoV-2. …”
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Accurate Needle Localization in the Image Frames of Ultrasound Videos by Mohammad I. Daoud, Samira Khraiwesh, Rami Alazrai, Mostafa Z. Ali, Adnan Zayadeen, Sahar Qaadan, Rafiq Ibrahim Alhaddad

“…Ultrasound imaging provides real-time guidance during needle interventions, but localizing the needle in ultrasound videos remains a challenging task. …”
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Low back pain treatment adherence barriers in Eswatini private physiotherapy practices: A pilot study by Tapiwa Chikaka, Monique M. Keller

“…Method: A cross-sectional descriptive pilot study using a self-developed Research Electronic Data Capture (REDCap) survey was conducted with 62 LBP patients. …”
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Nanoformulation of Polymyxin E Through Complex Coacervation: A Pharmacokinetic Analysis by Xiaobao Chen, Li Liu, Weidan Wang, Yuan Yuan, Wei Wang

“…<b>Methods:</b> Three negatively charged polyions: potassium sucrose octasulfate, polytamic acid, and sodium hyaluronate, were used for formulation. We performed characterization on the nanocomplex formed by the polyions and PME. …”
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Effect of Different Surface Modifications of Acrylic Teeth and Thermocycling on Shear Bond Strength to Polycarbonate Denture Base Material by Humam M. Al-Somaiday, Aula Kamal Rafeeq, Manar E. Al-Samaray

“…During prosthodontic clinical practice, the most commonly reported type of failure is the debonding of teeth to the denture base. …”
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Association between triglyceride-glucose-body mass index and risk of aortic stenosis progression in patients with non-severe aortic stenosis: a retrospective cohort study by Zhen Guo, Zhenyu Xiong, Lixiang He, Shaozhao Zhang, Xinghao Xu, Guanzhong Chen, Mengjie Xie, Wenjing Zhang, Ziwen Hui, Jiaying Li, Xinxue Liao, Xiaodong Zhuang

“…Cox regression and restricted subgroup analysis were used to evaluate the association of TyG-BMI index and progression of non-severe AS. …”
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Effects of iron supplement and exercise intensities on the levels of blood hemoglobin among Jimma University male soccer players by Biruk Amare, Molla Deyou, Sirak H Marıam

“…The analyses were carried out by the descriptive statistical analysis included mean and standard deviation, using SPSS version 16.0 software with a p-value lt;0.05. 5ml of blood sample were collected before, during and after supplying iron with folic acid in the 12 weeks of the study period. …”
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Assessing the suitability of sites near Pine Island Glacier for subglacial bedrock drilling aimed at detecting Holocene retreat–readvance by J. S. Johnson, J. Woodward, I. Nesbitt, K. Winter, S. Campbell, K. A. Nichols, R. A. Venturelli, S. Braddock, B. M. Goehring, B. Hall, D. H. Rood, G. Balco, G. Balco

“…Based on our experiences during this study, we conclude with a series of recommendations for assessing site suitability for future bedrock drilling campaigns. …”
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Skok pokwitaniowy i budowa ciała dziewcząt z Meridy (Jukatan, Meksyk) jako sposób przystosowania do warunków życia by Anna Zielińska

“…The ethnicity of girls was defined using their two surnames (from the father and mother side). …”
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Increased rate of multidrug-resistant gram-negative bacterial infections in hospitalized immunocompromised pediatric patients by Sarah Khafaja, Sarah Khafaja, Yara Salameh, Celina F. Boutros, Cherine Awad, Kawthar Faour, Nadim Tfaily, Sarah Merhi, Zeinab El Zein, Zeinab El Zein, Samer Bou Karroum, Dana Oweini, Danielle Fayad, George F. Araj, George F. Araj, George F. Araj, Ramia Zakhour, Ghassan S. Dbaibo, Ghassan S. Dbaibo

“…The aim of this study was to describe the frequency of infections with multidrug resistant (MDR) Gram-negative bacteria (GNB) in immunocompromised pediatric patients and to determine the risk factors. In addition, we aimed to identify the antimicrobial resistance patterns of these isolates.Materials and methodsThis was a retrospective observational study conducted at the American University of Beirut Medical Center (AUBMC) from 2009 to 2017. …”
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MODERN TECHNOLOGIES OF WINE PRODUCTION IN THE CONTEXT OF GLOBAL WARMING AND ORGANIC APPROACH IN VINEYARD by N. Kamenieva, O. Verechuk

“…The directions of development of organic viticulture and winemaking have been identified, using local grape varieties, local yeast races, no additives, irregular temperature control during fermentation and less sulphites, which are more suitable for the sustainable terroirs of historical regions. …”
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Short-Term Trends in Economic Burden and Catastrophic Costs of Type 2 Diabetes Mellitus in Rural Southwest China by Hui-fang Li, Le Cai, Allison Rabkin Golden

“…A prevalence-based cost-of-illness method was used to estimate the cost of diabetes. Information about the participants’ demographic characteristics and economic consequences of diabetes was obtained using a standard questionnaire. …”
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Prediction and Analysis of metabolic mechanism for regional water system from the perspective of quantity-quality collaborative control——A case study of Zhejiang Province, China... by Siqi Li, Yang Zhang, Tianqi Liu, Jinbo Zhang, Huaicheng Guo, Xiao Pu, Lu Lu, Changbo Qin

“…The water metabolic mechanism depicts how material elements interact and operate during the inflow and outflow of water resources and pollutants in regional water system contexts, so exploring it from the perspective of dual control of quantity and quality provides a new view for identifying efficient management pathways. …”
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An in vitro study on comparative evaluation of shear bond strength of bioactive composite to tooth structure with various dentin conditioning agents by Priyanka Pokkula, Shaik Mohammed Asif, Abdullah Alqarni, Shahabe Saquib Abullais, Shaik Mohamed Shamsudeen, Syed M Yassin, Abosofyan S. Atta, Wahaj Ahmad Khan

“…Applying citric acid and maleic acid is an added advantage in removing the formed smear layer during cavity preparation. This study uses various bonding and conditioning agents to evaluate the strength of bioactive composite shear bonds to the tooth structure. …”
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Effect of Alternate Treatment with Intravitreal Corticosteroid and Anti-VEGF for Macular Edema Secondary to Retinal Vein Occlusion by Young Hwan Bae, Seong Mi Kim, Jin Young Kim, So Hyun Bae, Hakyoung Kim, Dae Joong Ma

“…This dual-center retrospective study included 112 eyes with treatment-naïve ME secondary to RVO that were alternately treated with intravitreal corticosteroid and anti-VEGF injections (33 eyes, alternate group) or treated only with intravitreal anti-VEGF injections (79 eyes, anti-VEGF group) on a pro re nata basis. Results. During the 12-month follow-up period, the alternate group achieved a visual acuity gain of 0.39 logMAR, while the anti-VEGF group achieved a gain of 0.21 logMAR (P=0.042). …”
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Liver transplantation in glycogen storage disease type III: A case‐series by Simon Gay, Adrien Bigot, Louis d'Alteroche, Fanny Dujardin, Gaëlle Fromont‐Hankard, Nathalie Tressel, Ephrem Salame, François Maillot

“…In some severe cases, liver transplantation (LT) may be necessary to treat life‐threatening complications. Here, we report the cases of three adult patients who required LT during the course of GSD III. …”
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