Comparison of different severe obesity definitions in predicting future cardiometabolic risk in a longitudinal cohort of children by Gilles Paradis, Melanie Henderson, Lisa Kakinami, Angelo Tremblay, Anna Smyrnova

“…Whether SO definitions differentially predict cardiometabolic disease risk is critical for proper clinical care and management but is unknown.Design Prospective cohort studySetting SO definitions were applied at baseline (2005–2008, Mage=9.6 years, n=548), and outcomes (fasting lipids, glucose, homoeostatic model assessment (HOMA-IR) and blood pressure) were assessed at first follow-up (F1: 2008–2011, Mage=11.6 years) and second follow-up (2015–2017, Mage=16.8 years) of the Quebec Adipose and Lifestyle Investigation in Youth cohort in Montreal, Quebec.Participants Respondents were youth who had at least one biological parent with obesity.Primary outcome measures Unfavourable cardiometabolic levels of fasting blood glucose (≥6.1 mmol/L), insulin resistance (HOMA-IR index ≥2.0), high-density lipoprotein <1.03 mmol/L, low-density lipoprotein ≥2.6 mmol/L and triglycerides >1.24 mmol/L. …”
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