Dynamic conditioning of porcine kidney grafts with extracellular vesicles derived from urine progenitor cells: A proof‐of‐concept study by Perrine Burdeyron, Sébastien Giraud, Maryne Lepoittevin, Nina Jordan, Sonia Brishoual, Maïté Jacquard, Virginie Ameteau, Nadège Boildieu, Estelle Lemarie, Jonathan Daniel, Frédéric Martins, Nicolas Mélis, Marine Coué, Raphaël Thuillier, Henri Leuvenink, Luc Pellerin, Thierry Hauet, Clara Steichen

“…Regarding perfusate analysis, metabolomic analyses and cytokine quantification showed an immunomodulation signature in G3 compared with G1 and highlighted potential metabolic targets. …”
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Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

“…Methods SSADHD subjects underwent clinical evaluations, neuropsychological assessments, biochemical quantification of γ-aminobutyrate (GABA) and related metabolites, electroencephalography (standard and high density), magnetoencephalography, transcranial magnetic stimulation, magnetic resonance imaging and spectroscopy, and genetic tests. …”
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Towards person-centred maternal and newborn care in Ethiopia: a mixed method study of satisfaction and experiences of care by Tigist Eshetu, Eshcolewyine Fekadu, Ahmed Abdella, Adiyam Mulushoa, Girmay Medhin, Merga Belina, Atalay Alem, Roxanne Keynejad, Tanya Robbins, Nadine Seward, Andrew Shennan, Louise M. Howard, Martin Prince, Jane Sandall, Charlotte Hanlon

“…Qualitative data were analysed thematically and triangulated with quantitative and observational data. Results Women reported lowest satisfaction in relation to family involvement (71.5% dissatisfied) and continuity of care (65.7% dissatisfied). …”
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Factors associated with physical fitness and disparities in population segments among older adults: A cross-sectional study by Yuqin Rao, Jingjing Wang, Kai Li, Fanhui Zheng, Ying Chen, Bo Zhai, Jintao Hong, Chen Wang, Bao Liu, Dao Wang

“…Participating in physical activities and exercise should be encouraged based on population segments for precise and quantitative interventions to improve physical fitness.…”
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Expectativas acerca das atividades síncronas na formação a distância do Programa Mais Médicos para o Brasil by Inara Pereira da Cunha, Sílvia Helena Mendonça de Moraes, Adriana Carvalho dos Santos, Débora Dupas Gonçalves do Nascimento

“…Métodos: Foi conduzido um estudo transversal, quanti-qualitativo com estudantes e tutores, utilizando um questionário on-line para coletar dados, incluindo questões discursivas sobre as expectativas dos participantes, em abril de 2024. …”
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The Loge GDR Was Strongly Associated with NAFLD as a Predictor in Normoalbuminuric Patients with Type 2 Diabetes by Ji B, Gao G, Zhao H, Sheng J, Ma X, Shi S, Ban B

“…Baolan Ji,1 Guanqi Gao,2 Hongyan Zhao,2,3 Jie Sheng,2,3 Xuan Ma,2,3 Shuwei Shi,1– 3 Bo Ban1,2 1Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China; 2Department of Endocrinology, Linyi People’s Hospital Affiliated to Shandong Second Medical University, Linyi, Shandong, 276034, People’s Republic of China; 3School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People’s Republic of ChinaCorrespondence: Bo Ban, Department of Endocrinology, Affiliated Hospital of Jining Medical University, 89 Guhuai Road, Jining, Shandong, 272029, People’s Republic of China, Email banbo2011@163.com Shuwei Shi, School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People’s Republic of China, Email ssw15689286547@163.comAim: Attenuated insulin-sensitivity (IS) is a characteristic of type 2 diabetes (T2D) and is closely linked to non-alcoholic fatty liver disease (NAFLD). …”
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Biologics as well as inhaled anti-asthmatic therapy achieve clinical remission: Evidence from the Severe Asthma Network in Italy (SANI) by Giorgio Walter Canonica, MD, Francesco Blasi, PhD, Pierluigi Paggiaro, MD, Enrico Heffler, PhD, Fulvio Braido, MD, Luisa Brussino, PhD, Giulia Scioscia, PhD, Cristina Cardini, MsC, Chiara Oriecuia, MsC, Isabella Sala, MsC, Vincenzo Bagnardi, PhD, Cecilia Calabrese, PhD, Gianna Camiciottoli, MD, Giovanna Elisiana Carpagnano, PhD, Stefano Centanni, PhD, Angelo Guido Corsico, PhD, Maria Teresa Costantino, MD, Claudia Crimi, PhD, Alice D'Adda, MD, Simona D’Alò, MD, Maria D'Amato, PhD, Corrado D'Andria, MD, Stefano Del Giacco, MD, Fabiano Di Marco, PhD, Nicola Cosimo Facciolongo, MD, Alessandro Farsi, MD, Manuela Latorre, PhD, Manlio Milanese, PhD, Eustachio Nettis, MD, Eleonora Nucera, MD, Giovanni Passalacqua, MD, Girolamo Pelaia, MD, Laura Pini, MD, Luisa Ricciardi, PhD, Fabio Luigi Massimo Ricciardolo, PhD, Luca Richeldi, PhD, Erminia Ridolo, PhD, Pierachille Santus, PhD, Nicola Scichilone, PhD, Gianenrico Senna, MD, Giuseppe Spadaro, MD, Antonio Spanevello, MD, Paolo Tarsia, MD

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Analysis of the focal relationship of level five leadership with school organizational excellence by Hosein Majooni, Siroos Ghanbari

“…The research method is quantitative, descriptive and correlational. Data collection was done based on five-level leadership questionnaire of Cham Asemani (2007), and Organizational Excellence of Amarloo (2018), whose Cronbach's alpha coefficient was 0.96 and 0.91, respectively. …”
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The value-added model of the supply chain of petrochemical industries with a sustainable development approach by ali amiri, seyed abbas heydari, vahidreza Mirabi

“…According to its purpose, the research method is applicable, qualitative-quantitative in terms of implementation, and survey in nature. …”
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Presenting Iran's new economic diplomacy model with an export approach for neighboring countries with an emphasis on cultural and media diplomacy capacities by sekhavat kheirkhah, sayed Ali Tabatabai Panah, Alireza Soltani, Hamid Reza Shirzad

“…According to the multivariate regression analysis and the number of observable variables, 195 people were selected as a quantitative sample. The data collection tool is a questionnaire with 86 items from the qualitative section. …”
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Designing a Digital Branding Pattern in Healthy Agricultural Products by Abolghasem Mohammadnezhad Ali Zamini, Arezo Ahmadi danyali, Mahmoud Ahmadi Sharif

“…The experts were selected through purposive and non-probability sampling, and in-depth and semi-structured interviews were conducted with them. In the quantitative part of the research, the fuzzy Delphi technique was used to screen the obtained indicators, then the interpretive structural modeling method was used to identify the causal relationships between the main research articles. …”
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Optimizing Muscle Performance in Young Soccer Players: Exploring the Impact of Resisted Sprint Training and Its Relationship with Distance Covered by Felipe Hermosilla-Palma, Juan Francisco Loro-Ferrer, Pablo Merino-Muñoz, Nicolás Gómez-Álvarez, Rodrigo Zacca, Hugo Cerda-Kohler, Ciro Brito, Jorge Pérez-Contreras, Moacyr Portes-Junior, Esteban Aedo-Muñoz

“…To analyze the influence of sprint distance in resisted sprints on muscle performance in young soccer players. Methods. This quantitative study utilized a pre-post experimental design. …”
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Effects of 24 Weeks of Growth Hormone Treatment on Bone Microstructure and Volumetric Bone Density in Patients with Childhood-Onset Adult GH Deficiency by Hongbo Yang, Kemin Yan, Yuping Xu, Linjie Wang, Qi Zhang, Fengying Gong, Huijuan Zhu, Weibo Xia, Hui Pan

“…High-resolution peripheral quantitative computerized tomography (HR-pQCT) of distal tibia and radius was performed at baseline and at the end of treatment. …”
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AI-based tumor-infiltrating lymphocyte scoring system for assessing HCC prognosis in patients undergoing liver resection by Zhiyang Chen, Tingting Xie, Shuting Chen, Zhenhui Li, Su Yao, Xuanjun Lu, Wenfeng He, Chao Tang, Dacheng Yang, Shaohua Li, Feng Shi, Huan Lin, Zipei Li, Anant Madabhushi, Xiangtian Zhao, Zaiyi Liu, Cheng Lu

“…The scoring system combined with artificial intelligence is essential for automated, quantitative, whole-slide image-level assessment of TILs, which can be widely applied to quantify the immune profile of multi-cancer disease types with the discussion of subsequent immunotherapy.…”
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Automated Synthesis and Initial Evaluation of (4′-Amino-5′,8′-difluoro-1′H-spiro[piperidine-4,2′-quinazolin]-1-yl)(4-[18F]fluorophenyl)methanone for PET/MR Imaging of Inducible Nit... by Skye Hsin-Hsien Yeh, Wen-Sheng Huang, Chuang-Hsin Chiu, Chuan-Lin Chen, Hui-Ting Chen, Dae Yoon Chi, Zhengxing Ge, Tsung-Hsun Yu, Pao-Yeh Wang, Yu-Yeh Kuo, Chun-Tse Hung, Geng-Ying Li, Chi-Wei Chang

“…Aminoguanidine, selective iNOS inhibitor, pretreatment significantly reduced the AUC0-30min and Vt values in LPS-induced mice. Quantitative analysis of immunohistochemically stained brain sections confirmed iNOS was preferentially upregulated in the cerebellum and cortex of mice injected with LPS. …”
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Anti-SARS-CoV-2 serology based on ancestral RBD antigens does not correlate with the presence of neutralizing antibodies against Omicron variants by Léa Dépéry, Isabelle Bally, Axelle Amen, Benjamin Némoz, Marlyse Buisson, Laurence Grossi, Aurélie Truffot, Raphaële Germi, Delphine Guilligay, Mélanie Veloso, Antoine Vilotitch, Olivier Epaulard, Patrice Morand, Winfried Weissenhorn, Pascal Poignard, Julien Lupo

“…We compared anti-SARS-CoV-2 antibody titers in four quantitative serological tests based on variable ancestral spike antigens (three in-house ELISAs and the prototype VIDAS SARS-CoV-2 IgG QUANT assay) and neutralization assays against the pseudotyped Wuhan, BA.2, BA.4/5, BQ.1.1, and XBB.1.1 viruses in a cohort of 100 patients infected in 2020 or during the Omicron waves. …”
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Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins by Maria Angelica Freitas-Cortez, Fatemeh Masrorpour, Hong Jiang, Iqbal Mahmud, Yue Lu, Ailing Huang, Lisa K. Duong, Qi Wang, Tiffany A. Voss, Claudia S. Kettlun Leyton, Bo Wei, Wai-Kin Chan, Kevin Lin, Jie Zhang, Efrosini Tsouko, Shonik Ganjoo, Hampartsoum B. Barsoumian, Thomas S. Riad, Yun Hu, Carola Leuschner, Nahum Puebla-Osorio, Jing Wang, Jian Hu, Michael A. Davies, Vinay K. Puduvalli, Cyrielle Billon, Thomas P. Burris, Philip L. Lorenzi, Boyi Gan, James W. Welsh

“…Methods included mass spectrometry-based lipidomics, targeted lipidomics, Oil Red O staining, Seahorse analysis, quantitative PCR, immunohistochemistry, PPARγ transcription factor assays, ChIP-seq, untargeted lipidomic analysis, ROS assay, ex vivo co-culture of CD8+ T cells with cancer cells, ATAC-seq, RNA-seq, Western blotting, co-immunoprecipitation assay, flow cytometry and Imaging Mass Cytometry. …”
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Impact of glucocorticoids on patients’ quality of life: a qualitative study assessing face validity and feasibility of the Steroid PRO in patients with inflammatory gastroenterolog... by Shaney L Barratt, Emma Dures, Mwidimi Ndosi, Michelle Sharp, Sebastian E Sattui, Jill Dawson, Susan M Goodman, Sarah L Mackie, Tom Creed, Catherine L Hill, Joanna C Robson, Pamela Richards, Susan Bridgewater, Christine A Silverthorne, Jen Orme, Anne-Marie T Sweeney, Elizabeth Arthurs, Genevieve Osborne, Giles Dunhill, Richard P Ramonell, Timothy Patton

“…Future work should include quantitative testing of the Steroid PRO as an outcome measure within clinical trials in these conditions.Trial registration number NCT06314451.…”
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Targeting NANOS1 in triple-negative breast cancer: synergistic effects of digoxin and PD-1 inhibitors in modulating the tumor immune microenvironment by Tangyi Wang, Yadian Lei, Jingwei Sun, Li Wang, Yuxin Lin, Zhijing Wu, Shoude Zhang, Chengzhu Cao, Chengzhu Cao, Chengzhu Cao, Haiyan Wang, Haiyan Wang, Haiyan Wang

“…Validation of findings was conducted through quantitative PCR and Western blot analysis.ResultsTOE inhibited TNBC cell growth, migration, and invasion, as assessed by CCK-8 and transwell assays. …”
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Early bactericidal activity of sitafloxacin against pulmonary tuberculosis by Lihui Nie, Jing Tong, Guihui Wu, Juan Du, Yuanyuan Shang, Yufeng Wang, Zhangjun Wu, Yuanhong Xu, Yi Ren, Youyi Rao, Yu Pang, Mengqiu Gao

“…In this early bactericidal activity study, 30 patients with primary smear-positive tuberculosis were randomized to the once-daily oral administration of 200 mg sitafloxacin, 500 mg levofloxacin, or 300 mg isoniazid (INH) for 7 days. Sputum for quantitative culture was collected 2 days before the study of drug administration, followed by 16 hours of overnight sputum collected daily for 7 days of monotherapy. …”
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