Estimation of peak current as a basis for sustainable watershed conservation using the number-curve land conservation by Naharuddin ., Rukmi ., S.D. Massiri, B. Toknok, Akhbar ., I.N. Korja

“…Moreover, carbón-nitrogen range was observed to have significantly large quantitative consequences on direct runoff. The trend showed the need for precision and effectiveness in planning watershed management and conservation. …”
Get full text

Healthy food prescription incentive programme for adults with type 2 diabetes who are experiencing food insecurity: protocol for a randomised controlled trial, modelling and implem... by Colleen Norris, Tyler Williamson, Richard Oster, Dana Lee Olstad, Laura White, David J T Campbell, Sharlette Dunn, Kim D Raine, Mary L'Abbé, Richard Lewanczuk, Lorraine L Lipscombe, Eldon Spackman, Reed Beall, Kienan Williams, Sara Scott, Gabrielle L Zimmermann, Kerry A McBrien, Kieran J D Steer, Catherine B Chan, Sheila Tyminski, Seth Berkowitz, Alun L Edwards, Terry Saunders-Smith, Saania Tariq, Naomi Popeski, Sara Nejatinamini, Aruba Naser, Carlota Basualdo-Hammond, Petra O’Connell, Judy Seidel, Jason Cabaj

“…Implementation processes and outcomes will be continuously measured via quantitative and qualitative data.Ethics and dissemination Ethical approval was obtained from the University of Calgary and the University of Alberta. …”
Get full text

Genetic variation in patent foramen ovale: a case-control genome-wide association study by Bosi Dong, Yajiao Li, Fandi Ai, Jia Geng, Ting Tang, Wan Peng, Yusha Tang, Hui Wang, Zixuan Tian, Fengxiao Bu, Lei Chen

“…Single-nucleotide polymorphisms (SNPs) associated with PFO were further validated by Sanger sequencing and subsequently were evaluated in a validation cohort. Expression quantitative trait loci (eQTL) analysis was conducted using the GTEx database. …”
Get full text

Association between glyphosate exposure and cardiovascular health using “Life’s Essential 8” metrics in US adults by Yuankang Zhu, Zhenlin Yang, Yuhao Chen, Lingzi Qian, Changning Hao, Liangshi Hao, Boshen Yang, Junli Duan

“…There was a negative correlation between the total CVH score and the lowest quantiles of ln-transformed glyphosate (Q1), Q2, Q3, and Q4 with p for trend < 0.05. …”
Get full text

Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2 by Charlotte Laurfelt Munch Rasmussen, Signe Frost Frederiksen, Christian Würtz Heegaard, Maj Schneider Thomsen, Eva Hede, Bartosz Laczek, Jakob Körbelin, Daniel Wüstner, Louiza Bohn Thomsen, Markus Schwaninger, Ole N. Jensen, Torben Moos, Annette Burkhart

“…Post-mortem analyses included gene expression analyses, verification of neurodegeneration in Purkinje cells, determination of NPC2 transduction in the CNS, assessment of gliosis, quantification of gangliosides, and co-detection of cholesterol with NPC2 in degenerating neurons. …”
Get full text

Optimization of treatment and prevention of recurrences of bacterial vaginosis in postmenopausal women by S.O. Ostafiichuk, N.V. Drogomyretska, O.M. Kusa, O.V. Neiko, I.V. Levitsky, N.M. Kinash

“…A gynecological examination, determination of the pH reaction of vaginal contents, aminotest, microscopy of vaginal smears, bacteriological cultures on nutrient media for the determination of facultatively anaerobic bacteria, Gardnerella vaginalis, quantitative analysis of vaginal microflora, species composition and frequency of lactobacilli were performed. …”
Get full text

Perfil clínico-epidemiológico de pacientes oncológicos internados em uma Unidade de Terapia Intensiva Pediátrica by Ana Paula Silva e Silva, Larissa da Silva Baltazar, Antônio Felipe Silva Carvalho, Luna Mayra da Silva e Silva, Danielle França Furtado, Nilviane Pires Silva, Talison Taylon Diniz Ferreira, José Antônio Costa Leite

“…ABSTRACT Objective: To analyze the clinical-epidemiological profile of cancer patients admitted to a Pediatric Intensive Care Unit. Methodology: Quantitative, retrospective and cross-sectional study, carried out by collecting data provided by the clinical pharmacy of the Hospital Universitário Materno Infantil, of the Universidade Federal do Maranhão located in São Luís - MA. …”
Get full text

Association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate: Mediating role of serum albumin by Hua Fang, Huajing Chang, Danjing Chen, Wenxin Qiu, Jiangwang Fang, Yunli Wu, Xian-E. Peng

“…Associations between perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoic acid (PFNA) with eGFR and the risk of decreased renal function (eGFR < 90 vs. eGFR ≥ 90) using linear and logistic regression, weighted quantile sum (WQS) regression, Bayesian kernel machine regression (BKMR), and restricted cubic spline (RCS) analyses. …”
Get full text

Mailed smoking cessation support for Aboriginal and Torres Strait Islander people who smoke: protocol for a hybrid type 1 effectiveness – implementation trial by Raglan Maddox, Catherine Chamberlain, Billie Bonevski, Amanual Getnet Mersha, Jamie Bryant, Michelle Kennedy, Nathan Taylor, Cathy Segan, Kayden Roberts-Barker, Zabowie Mills, Kade Booth, Joley Foster

“…Outcome data will be obtained using quantitative surveys and qualitative Yarning. Effectiveness outcomes will include assessment of 7-day point prevalence, continuous abstinence and quit attempts at 3- and 6-month follow-up. …”
Get full text

PrEP15-19 Choices: an implementation study protocol of HIV prevention with oral and long-acting injectable cabotegravir PrEP in real-world settings among sexual and gender minority... by Inês Dourado, Eliana Miura Zucchi, Laio Magno, Alexandre D Grangeiro, Márcia Thereza Couto, Mateus Westin, Eduardo Oliveira, Maria Mercedes Escuder, Dirceu Greco, Thais Regis Aranha Rossi, Fabiane Soares, Lorenza Dezanet, Paula Massa, Priscilla Caires, Ricardo de Paula Vasconcelos, Unaí Tupinambas, Beo Leite, Joilson Nascimento Paim, Guilherme Barreto Campos, Lucas Miranda Marques, Nathalia Suzart, Suilan Pedreira, DulceAurélia deSouza Ferraz, Dyemison Pinheiro, Eliane Sala, Raphaella Goulart, Ana Paula Silva, Erica Dumont Pena, Gabriella Jomara daSilva, Marília Greco, Matheus dePaula Alves

“…Safe and effective long-acting agents for pre-exposure prophylaxis (PrEP) for HIV infection are needed to increase preventive options among sexual and gender minority adolescents.Methods and analysis This is a multisite, prospective implementation study of three PrEP modalities (LAI-PrEP, event-driven (ED) and daily oral), using a mixed-method design with quantitative and qualitative approaches. The study will include a sample of 550 HIV-negative adolescent men who have sex with men, non-binary individuals assigned male at birth, transgender men and women, aged 15–19 years, in three Brazilian capital cities. …”
Get full text

Sevoflurane Exacerbates Cognitive Impairment Induced by Aβ1–40 in Rats through Initiating Neurotoxicity, Neuroinflammation, and Neuronal Apoptosis in Rat Hippocampus by Yue Tian, Ke-yan Chen, Li-dan Liu, Yun-xia Dong, Ping Zhao, Shan-bin Guo

“…Expression levels for Bcl-xL, caspase-9, receptor for advanced glycation end products (RAGE) and brain-derived neurotrophic factor (BDNF) were significantly different in quantification of band intensity between the rats that inhaled O2 and sevoflurane in Aβ-treated groups (all P<0.05). …”
Get full text

Refinement of a meaning-centered counseling program for Chinese patients with advanced cancer: integrating cultural adaptation and implementation science approaches by Florence Lui, Qingyi Zhang, George Chengxi Bao, Bharat Narang, Ruo Yan Chen, Yunshan Niu, Jennifer Leng, William Breitbart

“…Three analysts independently coded the transcripts according to EVM and PRISM domains; discrepancies were resolved through discussion and consensus. Results Quantitative findings showed high appropriateness and relevance of MCP-Ch across five EVM domains of Language, Metaphors/Stories, Goals, Content, and Concepts. …”
Get full text

Innate Immune Responses Associated with Resistance against Haemonchus contortus in Morada Nova Sheep by João Henrique Barbosa Toscano, Cintia Hiromi Okino, Isabella Barbosa dos Santos, Luciana Aparecida Giraldelo, Marei Borsch von Haehling, Sérgio Novita Esteves, Ana Carolina de Souza Chagas

“…RNA was extracted from tissue and blood samples for relative quantification of innate immune-related genes by RT-qPCR. …”
Get full text

Improving Meat Quality and Reducing Breast of Myopathies in Broiler Chickens Subjected to Cyclic Heat Stress by Supplementing of Chromium-Methionine by G. L. S. Tesser, N. Rohloff Junior, T. S. Andrade, C. Kaufmann, A. P. G. C. Costa, M. F. C. Pereira, A. A. Calderano, F. S. Dadólio, E. S. Klosowski, C. Eyng, R. V. Nunes

“…This study aimed to evaluate the effects of chromium-methionine on carcass yield, relative weights of the liver and fat pad, incidence and severity of myopathies, muscle color quantification, water-holding capacity, cooking loss, shear force, lipid peroxidation in breast muscle, and composition of breast meat in broiler chickens subjected to cyclic heat stress. …”
Get full text

Fusarium Head Blight in Argentina, a Profile of Produced Mycotoxins and a Biocontrol Strategy in Barley During Micro-Malting Process by María Silvina Alaniz-Zanon, Marianela Bossa, Lorenzo Antonio Rosales Cavaglieri, Juan Manuel Palazzini, Michael Sulyok, Sofía Noemí Chulze, María Laura Chiotta

“…In the 2017 harvest season, 53.6% of grains were contaminated with DON (mean: 0.42 mg/kg), and 21% with NIV (mean: 0.8 mg/kg). Quantification of <i>F. graminearum</i> ss by real-time PCR during the micro-malting process showed that application of the biocontrol agent before the germination stage was the most effective treatment, with a 45% reduction in fungal DNA levels. …”
Get full text

Altered AKT1 and MAPK1 Gene Expression on Peripheral Blood Mononuclear Cells and Correlation with T-Helper-Transcription Factors in Systemic Lupus Erythematosus Patients by Sonia Garcia-Rodriguez, Jose-Luis Callejas-Rubio, Norberto Ortego-Centeno, Esther Zumaquero, Raquel Ríos-Fernandez, Salvador Arias-Santiago, Pilar Navarro, Jaime Sancho, Mercedes Zubiaur

“…Kinases have been implicated in the immunopathological mechanisms of Systemic Lupus Erythematosus (SLE). v-akt murine-thymoma viral-oncogene-homolog 1 (AKT1) and mitogen-activated-protein-kinase 1 (MAPK1) gene expressions in peripheral mononuclear cells from thirteen SLE patients with inactive or mild disease were evaluated using quantitative real-time reverse-transcription polymerase-chain-reaction and analyzed whether there was any correlation with T-helper (Th) transcription factors (TF) gene expression, cytokines, and S100A8/S100A9-(Calprotectin). …”
Get full text

Laser Applications in Metal Orthodontic Bracket Debonding: A Systematic Review by Patryk Woś, Sylwia Kiryk, Tomasz Dyl, Jan Kiryk, Tomasz Horodniczy, Magdalena Szablińska, Magdalena Aleksandra Dubowik, Wojciech Dobrzyński, Marcin Mikulewicz, Jacek Matys, Maciej Dobrzyński

“…After eliminating 256 duplicates, 197 unique records were left for screening, which ultimately led to the qualification of 8 articles that met the inclusion criteria for both qualitative and quantitative analyses. The risk of bias in the articles was assessed by two independent reviewers. …”
Get full text

Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NF-κB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways by Nami Lee, Yu Jung Heo, Sung-E Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim

“…RAW 264.7 macrophages were first stimulated with lipopolysaccharide (LPS), then cotreated with empagliflozin, gemigliptin, or empagliflozin plus gemigliptin. We conducted quantitative RT-PCR (qRT-PCR) to determine the most effective anti-inflammatory doses without cytotoxicity. …”
Get full text

Experimental infection of wild boars (Sus scrofa) with Rickettsia rickettsii and evaluation of the transmission potential to Amblyomma sculptum ticks by Lucianne Cardoso Neves, Lina de Campos Binder, Warley Vieira de Freitas Paula, Nicolas Jalowitzki de Lima, Ennya Rafaella Neves Cardoso, Rayane Almeida Santos, Raphaela Bueno Mendes Bittencourt, Gracielle Teles Pádua, Gabriel Cândido dos Santos, Mariana Avelar Tavares, Maria Carolina de Azevedo Serpa, Adriano Pinter, Artur Luiz de Almeida Felicio, Marcelo B. Labruna, Felipe da Silva Krawczak

“…The wild boars were monitored for 28 days by clinical examination and hematological tests, real-time quantitative PCR (qPCR) of blood for the detection of Rickettsia and inoculation of blood in guinea pigs. …”
Get full text

Association between plasma perfluoroalkyl substances and high-grade serous ovarian cancer overall survival: A nested case-control study by Wei-Yi Xing, Fang-Hua Liu, Dong-Dong Wang, Jia-Ming Liu, Wen-Rui Zheng, Jia-Xin Liu, Lang Wu, Yue-Yang Zhao, He-Li Xu, Yi-Zi Li, Yi-Fan Wei, Dong-Hui Huang, Xiao-Ying Li, Song Gao, Qi-Peng Ma, Ting-Ting Gong, Qi-Jun Wu

“…To elucidate the combined effects, Bayesian kernel machine (BKMR), and regression quantile g-computation (QGC) models were utilized. …”
Get full text