Rational design of novel phenol ether derivatives as non-covalent proteasome inhibitors through 3D-QSAR, molecular docking and ADMET prediction by Miao Yuan, Hanwen Ji, Fengxin Sun, Qiang Chen, Ping Cheng

“…Methods: In this work, computer-aided drug design methods, including quantitative structure-activity relationship (QSAR), molecular docking, absorption, distribution, metabolism, excretion, and toxicology (ADMET) prediction, and drug-likeness prediction methods were performed. …”
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Environmental, social, and governance performance: The role of Chinese employee stock ownership plans by Yasi Liu, Shaun McDowell, Chunxiao Xue, Jianing Zhang

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LDWLE: self-supervised driven low-light object detection framework by Xiaoyang shen, Haibin Li, Yaqian Li, Wenming Zhang

“…Extensive experiments on the COCO, VOC, and ExDark datasets have demonstrated the effectiveness of LDWLE in low-light object detection. In quantitative measurements, it achieves an AP of 25.5 and 38.4 on the synthetic datasets COCO-d and VOC-d, respectively, and achieves the best AP of 30.5 on the real-world dataset ExDark. …”
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Apoptosis antagonizing transcription factor expression and its validation as a potential diagnostic and prognostic biomarker in oral squamous cell carcinoma by Ainiwaerjiang Abudourousuli, Zumulaiti Aierken, Hasiyati Mamuti, Tuxunayi Yimamu, Chengli Da

“…Validation of AATF expression was performed using quantitative real-time PCR (qRT-PCR)ResultsAATF was significantly overexpressed in OSCC, and high AATF expression correlated with adverse clinicopathological features, including histologic grade and lymph node metastasis. …”
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Clinical and Hematological Manifestation of Dengue Patients in 2022 Outbreak: A Tertiary Care Hospital‐Based Cross‐Sectional Study by Md. Jubayer Hossain, Manisha Das, Muhibullah Shahjahan, Md. Wahidul Islam, Syeda Tasneem Towhid

“…This study focused on the clinical and hematological profiles of patients during the 2022 outbreak, which was notably severe. Methods This quantitative cross‐sectional study at Dhaka Medical College and Hospital classified 67 dengue‐positive patients as having dengue fever (DF), dengue fever with warning signs (DFWS), and severe dengue (SD). …”
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Identification and functional analysis of energy metabolism and pyroptosis-related genes in diabetic nephropathy by Shan He, Jian Ye, Yu Wang, Lu yang Xie, Si Yi Liu, Qin kai Chen

“…Immune cell infiltration in DN was assessed using the ssGSEA algorithm, and the expression levels of EMAPRDEGs in DN tissues were validated by quantitative real-time PCR (qRT-PCR). Results: Thirteen EMAPRDEGs were identified, with GO and KEGG analyses indicating their involvement in energy metabolism pathways. …”
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Effects of Cranberry Extract (Vaccinium macrocarpon) Supplementation on Lipid Peroxidation and Inflammation in Patients with Chronic Kidney Disease (Stages 3-4): A Randomized Contr... by Laís de Souza Gouveia Moreira, Karla Thaís Resende Teixeira, Ludmila F. M. F. Cardozo, Livia Alvarenga, Bruna Regis, Jessyca Sousa de Brito, Viviane de Oliveira Leal, Natalia Alvarenga Borges, Isabela de Souza da Costa Brum, José Carlos Carraro-Eduardo, Giovanna B. Borini, Andresa A. Berretta, Marcelo Ribeiro-Alves, Denise Mafra

“…The mRNA expression of nuclear factor-erythroid 2-related factor-2 (Nrf2) and nuclear factor-kB (NF-kB) was evaluated in peripheral blood mononuclear cells (PBMCs) by quantitative real-time polymerase chain reaction. Thiobarbituric acid reactive substances (TBARS) were measured in the plasma to assess oxidative stress. …”
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Improving remote sensing dehazing quality through local hybrid correction and optimization of atmospheric attenuation model based on wavelength by Daihong Zhao, Kun Shi, Zheng Li, Zheng Li, Meixiang Chen

“…Furthermore, LHC outperformed both gamma and logarithmic corrections in terms of image clarity and artifact reduction, even after applying additional post-processing methods such as multi-exposure fusion and guided filtering. The quantitative analysis of the dehazed images, using gray-level co-occurrence matrix (GLCM) metrics, indicated that the LHC method offered a balanced advantage in enhancing image details, texture consistency, and structural complexity. …”
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INFORMACIJOS VISUOMENĖS STUDIJŲ PASTOLIAI: NAUJŲJŲ VYNMAIŠIŲ BEIEŠKANT by Marius P. P. Šaulauskas

“…Furthermore, an adequate criterion of information society cannot be quantitative, it should be qualitative and formulated counterfactually, i. e. arguing, that systematic dysfunction of telematic infrastructure, posited as a conditio sine qua non of habitat, would necessarily undermine the whole societal framework and force it to collapse. …”
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Factors Associated with the Severity of Stress Urinary Incontinence in Elderly Women by Suting Li, Zhi Wang, Lian Yang, Shaoying Liu, Lili Jing, Li Hong

“…Data collection encompassed demographic information, clinical features (including obstetric history, chronic diseases, Urogenital Distress Inventory-6 (UDI-6), and International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) scores), as well as physical examinations (including assessments of pelvic floor muscle strength, pelvic organ prolapse quantification (POP-Q) system, and pelvic floor ultrasound imaging). …”
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Predictors for recurrence of chronic osteomyelitis following long bones cavity defect replacement with synthetic materials by Alexander V. Afanasyev, Svetlana A. Bozhkova, Vasily A. Artyukh

“…The degree of the osteomyelitis recurrence risk, threshold values ​​for quantitative factors and the total score the scale were established. …”
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Impaired fracture healing is associated with callus chondro-osseous junction abnormalities in periostin-null and osteopontin-null mice by Marc Teitelbaum, Marc Teitelbaum, Maya D. Culbertson, Charlene Wetterstrand, J. Patrick O’Connor, J. Patrick O’Connor

“…Apparent changes in specific protein levels identified by immunohistochemistry were confirmed by mRNA quantitation. Comparisons between the PostnKO and Spp1KO fracture calluses were confounded by interactions between the two genes; loss of Postn reduced Spp1 expression and loss of Spp1 reduced Postn expression. …”
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Safety outcome trials in four mainline medical journals 30 years apart: a narrative review and the need for the transparency of informed consents by Sinem Nihal Esatoglu, Ayse Ozdede, Yesim Ozguler, Koray Tascilar, Hasan Yazici

“…These raise the issue of autonomy related to how clearly the sought-after safety through designing empirical studies primarily to quantitate harm had been worded to the trial participants in plain language. …”
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Comparative effectiveness of laparoscopic versus open colectomy in colon cancer patients: a study protocol for emulating a target trial using cancer registry data by Semaw Ferede Abera, Gabriele Robers, Anika Kästner, Ulrike Stentzel, Kerstin Weitmann, Wolfgang Hoffmann

“…This will be approached in a quantitative bias analysis using the E-method. The results will substantiate existing evidence on the comparative effectiveness of laparoscopic versus open colectomy in patients with stage I–III colon cancer and may guide clinical decisions as to whether a laparoscopic approach is as safe as an open approach in terms of improving 5-year overall survival in these patient groups.…”
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Development and comprehensive greenness assessment of HPLC method for quality control of β-sitosterol in pharmaceutical ointments with trio-color coded evaluation by Haya I. Aljohar, Abdullah M. Al-Hossaini, Seham A. Alzammay, Samiah Alhabardi, Hadir M. Maher, Aya R. Ahmed

“…The developed method was validated for its specificity, linearity, accuracy, precision, the limit of detection, the limit of quantification, robustness, and solution stability based on International Council for Harmonisation (ICH) guidelines Q2 (R1). …”
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The MADS-Box Transcription Factor ClAG2 Is a Key Regulator for the Formation of Double Flower in <i>Clematis</i> L. by Xuerong Chen, Ping Zhou, Nanhong Guo, Yiping Zheng, Xiumei Hou, Lihui Zeng

“…‘Amethyst Beauty’. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis revealed tissue-specific expression patterns among these genes. …”
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Cost analysis of MOUD implementation and sustainability in Massachusetts jails by Danielle Ryan, Don Lochana Ekanayake, Elizabeth Evans, Edmond Hayes, Thomas Senst, Peter D. Friedmann, Kathryn E. McCollister, Sean M. Murphy

“…Methods Resources required to implement and sustain the MOUD programs were identified through detailed, site-specific microcosting analyses at six participating jails in Massachusetts. Quantitative resource utilization data were captured primarily through in-person site-visits and semi-structured interviews with key personnel. …”
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Food Acquisition Coping Strategies Vary Based on Food Security Among University Students by Emily Sklar, Gwen M Chodur, Leslie Kemp, Deborah S Fetter, Rachel E Scherr

“…Differences based on FSS classification were examined through regression analyses. Quantitative and qualitative data were integrated using concurrent triangulation. …”
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Human Umbilical Cord Mesenchymal Stem Cells Attenuate Ocular Hypertension-Induced Retinal Neuroinflammation via Toll-Like Receptor 4 Pathway by Shangli Ji, Jie Xiao, Jian Liu, Shibo Tang

“…The expression levels of glial fibrillary acidic protein (GFAP), ionized calcium binding adapter molecule 1 (iba-1), and toll-like receptor 4 (TLR4) were assessed via immunohistochemistry, real-time quantitative PCR, and Western blot. RNA and proteins were extracted 14 days following transplantation, and the expression levels of the TLR4 signaling pathways and proinflammatory cytokines—myeloid differentiation factor 88 (MyD88), IL-1β, IL-6, and TNF-α—were determined. …”
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The Association between Deoxyribonucleic Acid Hypermethylation in Intron VII and Human Leukocyte Antigen-C∗07 Expression in Patients with Endometriosis by Wenrong Zhao, Lei Lei, Rui Chen, Yanmin Zhang, Linlin Chang, Jingxin Cheng

“…The differential DNA methylation of the selected genes was validated via direct bisulfite sequencing and analysis of their messenger ribonucleic acid (mRNA) levels using quantitative reverse transcription polymerase chain reaction (qRT-PCR). …”
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