Functional heterogeneity of mesenchymal stem cells and their therapeutic potential in the K18-hACE2 mouse model of SARS-CoV-2 infection by Kátia Nunes da Silva, Fernanda Martins Marim, Gisele Vieira Rocha, Zaquer Suzana Munhoz Costa-Ferro, Luciana Souza de Aragão França, Carolina Kymie Vasques Nonaka, Bruno Diaz Paredes, Erik Aranha Rossi, Erick Correia Loiola, Corynne Stephanie Ahouefa Adanho, Rachel Santana Cunha, Mayck Medeiros Amaral da Silva, Fernanda Ferreira Cruz, Vivian Vasconcelos Costa, Dalila Lucíola Zanette, Clarissa Araújo Gurgel Rocha, Renato Santana Aguiar, Patricia Rieken Macedo Rocco, Bruno Solano de Freitas Souza

“…In co-culture assays with lymphocytes activated with anti-CD3/CD28 beads, all MSC lines demonstrated the ability to inhibit TNF-α, to induce TGF-β and Indoleamine 2,3-dioxygenase (IDO), with varying degrees of inhibition observed for IFN-γ and IL-6, or induction of IL-10 expression. …”
Get full text

Multi-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling by Walid Mottawea, Basit Yousuf, Salma Sultan, Tamer Ahmed, JuDong Yeo, Nico Hüttmann, Yingxi Li, Nour Elhouda Bouhlel, Hebatoallah Hassan, Xu Zhang, Zoran Minic, Riadh Hammami

“…Our results highlight the ability of MEVs to cross the intestinal and blood-brain barriers to deliver their cargoes to distant organs, with potential implication for the gut-brain axis.IMPORTANCEMicrobiota-released extracellular vesicles (MEVs) have emerged as a key player in intercellular signaling. …”
Get full text

Perlindungan Hak Cipta Dari Tindakan Pembajakan Software di Tinjau  Dari Hukum Nasional by Delfiyanti

“…Akibatnya, Indonesia dihadapkan dengan dampak dan permasalahan pembajakan yang cukup signifikan dan dikenal baik di ranah internasional maupun di Indonesia sendiri. …”
Get full text

Maksilektomi Inferior pada Karsinoma Sel Skuamosa Palatum Durum by Sukri Rahman, Bestari Jaka Budiman, Irwan Triansyah, Heru Kurniawan Anwar Kurniawan Anwar

“…Prognosis karsinoma sel skuamosa palatum durum cukup baik dan angka harapan hidup lima tahun akan bertambah bila dilakukan operasi diikuti dengan pemberian radioterapi.…”
Get full text

Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interacti... by Francesco Verona, Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Matilde Todaro, Giuseppe Giannini, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi

“…TAMs have demonstrated the ability to communicate with CSCs via direct ligand/receptor (such as CD90/CD11b, LSECtin/BTN3A3, EPHA4/Ephrin) interaction. …”
Get full text

Development of a one-step multiplex RT-qPCR method for rapid detection of bovine diarrhea viruses by Dequan Yang, Li Ma, Zhongping Yang, Xianchao Yang, Jian Wang, Houbin Ju, Chunguang Lu, Yonggang Weng, Heping Zhao, Haixiao Shen, Xin Li, Feifei Ge, Xiaoxu Wang, Xiujuan Wu, Meng Xiang, Guidan Feng, Congsheng Tang, Shixin Huang, Hongjin Zhao

“…The sensitivity, specificity, and reproducibility ability were evaluated for the mRT-qPCR. Further, 80 bovine fecal samples were subjected to the mRT-qPCR, and the results were verified using conventional reverse-transcription PCR (RT-PCR) or PCR methods and sequencing methods.ResultsThis novel method demonstrated high sensitivity and specificity,achieving a detection limit of 24 copies/mL for each pathogen. …”
Get full text

Autoencoder Artificial Neural Network Model for Air Pollution Index Prediction by Nor Irwin Basir, Kathlyn Kaiyun Tan, Danny Hartanto Djarum, Zainal Ahmad, Dai-Viet N. Vo, Zhang Jie

“…Dapatan kajian menunjukkan bahawa pengautokod jarang ‘dalam’ mencapai ketepatan ramalan lebih baik, dengan nilai MSE dan R2 masing-masing sebanyak 0.1474 dan 0.8331, berbanding 0.1515 dan 0.8300 bagi pengautokod jarang ‘cetek’. …”
Get full text

The effect of temperature on the physiological condition and growth performance of freshwater eel elver Anguilla bicolor bicolor McClelland, 1844 by Latifa Fekri, Ridwan Affandi, Muhammad Fajar Rahardjo, Tatag Budiardi, Charles Parningotan Haratua Simanjuntak, Tezza Fauzan, Indrayani Indrayani

“…Hasil penelitian menunjukkan bahwa kisaran suhu 24‒30°C dapat digunakan dalam pemeliharaan elver ikan sidat, dan suhu 28‒30°C merupakan suhu yang sangat baik untuk mendukung kelangsungan hidup dan pertumbuhan elver ikan sidat. …”
Get full text

Analisis Sentimen pada Opini Pengguna Maskapai Penerbangan Menggunakan Hybrid Cuckoo Search by Nanang Fakhrur Rozi, Fandi Arianto, Dian Puspita Hapsari

“…Kualitas layanan yang diberikan oleh suatu maskapai, baik dari segi keselamatan, keamanan, maupun kenyamanan, umumnya dapat diketahui melalui opini penumpang lainnya. …”
Get full text

Arsitektur Sistem Percakapan Otomatis Berbahasa Indonesia dengan Normalisasi Bahasa Informal Menjadi Baku by Muhammad Fathur Rahman Khairul, Rizal Setya Perdana

“…Thus, the development of informal language occurs quickly and it is often to create new words as a substitute for formal language. …”
Get full text

An investigation on demands of clinical teaching among nursing undergraduates at school (在校本科护生临床教学需求调查分析) by GAN Lu (甘露), XIE Wei (谢薇), SHUAI Xuemei (帅雪梅), XUE Ting (徐婷), NI Dangcheng (倪当承), RAO Liu (饶柳), YUAN Zheng (袁铮), JIN Liping (金莉萍), TANG Jia (唐佳), LI Wei (李伟)

“…Conclusion Clinical teachers should help students build clinical thinking ability by adopting the teaching method combining theory with practice. …”
Get full text

Dukungan Sosial dan Religiusitas Dalam Penyesuaian Diri Mahasiswa Perantau by Tugimin Supriyadi, Mega Widyastuti, Aulia Yasmin Salsabilla, Mochamad Widjanarko

“…Untuk dapat melakukan self adjustment yang baik di perantauan, social support dan religiosity mungkin mempunyai pengaruh. …”
Get full text

Site selection for seaweed culture at Gerupuk Bay - West Nusa Tenggara using remote sensing and GIS by Kukuh Nirmala, Arlina Ratnasari, Syarif Budiman

“…Teknologi berupa penginderaan jauh (inderaja) dan sistem informasi geografis (SIG) menjadi solusi yang baik dalam penentuan lokasi yang sesuai untuk pengembangan budidaya rumput laut. …”
Get full text

Pendampingan Pengolahan dan Penyimpanan Makanan Pada Penjamah Makanan Pada Pondok Pesantren by Rusmiati Rusmiati, Narwati Narwati, Aldi Syahputra Nasution, Putri Arida Ipmawati

“…Antusiasme penjamah makanan dalam kegiatan penyuluhan dibuktikan dengan adanya beberapa pertanyaan dan diskusi yang disampaikan penjamah makanan kepada penyuluh, sehingga penjamah makanan menerima materi yang disampaikan dengan baik. Saran dalam kegiatan pengabdian masyarakat Pengelola Ruang Gizi Pesantren X dapat melakukan monitoring dan evaluasi pengolahan dan penyimpanan untuk menjamin kebersihan bahan makanan serta makanan yang akan di hidangkan untuk santri. …”
Get full text

Benefits, limits, and risks of ChatGPT in medicine by Jonathan A. Tangsrivimol, Jonathan A. Tangsrivimol, Erfan Darzidehkalani, Hafeez Ul Hassan Virk, Zhen Wang, Zhen Wang, Jan Egger, Michelle Wang, Sean Hacking, Benjamin S. Glicksberg, Markus Strauss, Markus Strauss, Chayakrit Krittanawong, Chayakrit Krittanawong

“…Additionally, ChatGPT facilitates remote monitoring and chronic disease management, providing personalized advice, medication reminders, and emotional support, thus bridging gaps between clinical visits. Its ability to process and synthesize vast amounts of data accelerates research workflows, aiding in literature reviews, hypothesis generation, and clinical trial designs. …”
Get full text

Deciphering the functional roles of PE18 and PPE26 proteins in modulating Mycobacterium tuberculosis pathogenesis and immune response by Aquib Ehtram, Mohd Shariq, Neha Quadir, Neha Quadir, Salma Jamal, Manjunath Pichipalli, Sheeba Zarin, Sheeba Zarin, Javaid Ahmad Sheikh, Nasreen Z. Ehtesham, Seyed E. Hasnain, Seyed E. Hasnain

“…The observed disruption of actin dynamics and endosome-phagosome maturation underscores a novel mechanism by which Mtb evades host defenses. The ability of PE18 and PPE26 to induce effector T-cell responses highlights their potential as targets for host-directed therapies or vaccine development against TB. …”
Get full text

Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway by Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu, Yuanyuan Ji

“…This is attributed to its ability to regulate the LIMS1/ILK signaling pathway, which represents a common molecular mechanism in both heart and kidney tissues.…”
Get full text

Brucea javanica oil inhibited the proliferation, migration, and invasion of oral squamous carcinoma by regulated the MTFR2 pathway by Yihan Lai, Yihan Lai, Mingkang Li, Mingkang Li, Juan Zhan, Juan Zhan, Lin Jiang, Lin Jiang, Yuan Wu, Zhiyi Fang, Jianhan Zhou, Jianhan Zhou, Yujie Ma, Yisen Shao, Yisen Shao, Wei Wang, Wei Wang

“…MethodsCCK8, Colony formation, Scratch test and Transwell invasion assays were applied to determine the effects of BJO on the proliferation, migration, and invasion ability of OSCC cells in vitro. MTFR2 knockdown (shRNA) and overexpression (cDNA) OSCC cells were constructed to evaluate the effect of MTFR2 on the proliferation and invasion of OSCC cells. …”
Get full text

Deteksi Gulma Berdasarkan Warna HSV dan Fitur Bentuk Menggunakan Jaringan Syaraf Tiruan by Hurriyatul Fitriyah, Rizal Maulana

“…Algoritma yang dibuat menggunakan segmentasi berdasarkan warna hijau dalam ruang warna HSV untuk mendeteksi daun, baik gulma maupun tanaman pada beragam pencahayaan. …”
Get full text

Hubungan Ketahanan Pangan, Pola Asuh, dan Tingkat Kecukupan Gizi dengan Kejadian Stunting Balita 6-59 Bulan di Puskesmas Dawe, Kabupaten Kudus by Tarisca Rahmatika, Dina Rahayuning Pangestuti, Alfi Fairuz Asna

“…Hasil: Hasil menunjukkan pola asuh ibu balita kategori baik (58,1%), keluarga tahan pangan (74,4%), tingkat kecukupan gizi balita pada energi (73,3%), zinc (91,9%), kalsium (57%), zat besi (54,7%), dan vitamin D (38,4%) cukup dan semua balita tercukupi pada protein dan vitamin A. …”
Get full text