Integrated hepatic transcriptomics and metabolomics identify Pck1 as a key factor in the broad dysregulation induced by vehicle pollutants by Gajalakshmi Ramanathan, Yuqi Zhao, Rajat Gupta, Siri Langmo, May Bhetraratana, Fen Yin, Will Driscoll, Jerry Ricks, Allen Louie, James A. Stewart, Timothy R. Gould, Timothy V. Larson, Joel Kaufman, Michael E. Rosenfeld, Xia Yang, Jesus A. Araujo

“…Consistently, DEP treatment of HepG2 cells led to increased gluconeogenesis and glycogenolysis indicating the ability of the in-vitro approach to model effects induced by DE in vivo. …”
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Establishing a baseline for surgical care in Mongolia: a situational analysis using the six indicators from the Lancet Commission on Global Surgery by Raymond R Price, Ali Jalali, Anudari Zorigtbaatar, Sarnai Erdene, Sergelen Orgoi, Andrea Davis, Jonathan Nellermoe, Jade M Nunez, Simon Ruhnke, Battsetseg Gonchigjav, Nomindari Bat-Erdene, Kevin Bagley, Micah Katz, Hannah Pioli, Batsaikhan Bat-Erdene, Ganbold Lundeg

“…This situational analysis shows one lower middle-income country’s ability to collect the indicators aided by a well-developed health information system.Design An 11-year retrospective analysis of the Mongolian surgical system using data from the Health Development Center, National Statistics Office and Household Socio-Economic Survey. …”
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CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody by Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang

“…Structural analysis suggests how the surrogate, named 23ME–00611, acquires the ortholog binding ability at the equivalent epitope of 23ME–00610. This engineering approach does not require a priori knowledge of structural and functional mapping of antibody–antigen interaction and thus is generally applicable for therapeutic antibody development when desired ortholog binding is lacking. …”
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Achieving reliable patient reported outcomes collection to measure health care improvement in a learning health network: lessons from pediatric rheumatology care and outcomes impro... by Nancy Pan, Nancy Pan, Esi M. Morgan, Meghan Ryan, Beth Gottlieb, Beth Gottlieb, Julia G. Harris, Julia G. Harris, Tzielan Lee, Tzielan Lee, Y. Ingrid Goh, Y. Ingrid Goh

“…., self-completion on tablets) and automated transfer to electronic medical record (EMR) as key components enabling reliable PRO collection.ConclusionsThrough understanding our current ability to systematically collect PROs across all sites in PR-COIN and exploring successful implementation of PRO collection both within and outside our learning health network, we share lessons learned and identify the most influential factors for successful PRO collection in pediatric rheumatology.…”
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LIMFOMA NON-HODGKIN SEL B PADA MAMMAE by Ninda Septia Yuspar, Irza Wahid

“…Pada Pasien ini terjadi Limfoma Non-hodgkin pada Mammae Relaps selanjutnya diberikan kemoterapi lini kedua dengan regimen Rituximab, Etoposide, Actoplactin, Ifosfamide. memberikan hasil yang cukup baik.…”
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Effect of SY009, a novel SGLT1 inhibitor, on the plasma metabolome and bile acids in patients with type 2 diabetes mellitus by Haoyi Yang, Yuwen Zhang, Yuxin Hong, Yuan Wei, Yuning Zhu, Lei Huang, Yuanxun Yang, Runbin Sun, Runbin Sun, Runbin Sun, Juan Li, Juan Li, Juan Li

“…ContextAs a novel SGLT1 inhibitor, SY-009 has been preliminarily confirmed in a phase Ib clinical study for its ability to reduce postprandial blood glucose in patients with type 2 diabetes mellitus (T2DM). …”
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Bone Defect Repair Using a Bone Substitute Supported by Mesenchymal Stem Cells Derived from the Umbilical Cord by Michal Kosinski, Anna Figiel-Dabrowska, Wioletta Lech, Lukasz Wieprzowski, Ryszard Strzalkowski, Damian Strzemecki, Lukasz Cheda, Jacek Lenart, Krystyna Domanska-Janik, Anna Sarnowska

“…WJ-MSCs in osteodifferentiation medium are able to attach and proliferate on Bio-Oss® scaffolds. Results obtained from qPCR and Luminex® indicate that WJ-MSCs possess the ability to differentiate into osteoblast-like cells and may induce osteoclastogenesis, angiogenesis, and mobilization of host MSCs. …”
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Nanotechnology-based herbal medicine: Preparation, synthesis, and applications in food and medicine by Farhang H. Awlqadr, Kithar Rasheed Majeed, Ammar B. Altemimi, Arkan Mohammed Hassan, Syamand Ahmed Qadir, Mohammed N. Saeed, Aryan Mahmood Faraj, Tablo H. Salih, Alaa Jabbar Abd Al‐Manhel, Mazin A.A. Najm, Efstathia Tsakali, Jan F.M. Van Impe, Ahmed A. Abd El-Maksoud, Tarek Gamal Abedelmaksoud

“…Phytosomes, liposomes, nanocapsules, and nanoemulsions have ensured that bioactive ingredients' stability has been secured, bioavailability and targeted administration have been improved, and negative side effects have been cut considerably. The ability of nanoherbal formulations to deliver drugs to tumor cells in an improved permeability and retention manner, such as, cancer therapy while minimizing tissue damage, has been largely practiced in many laboratories. …”
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Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model by Sanghee Lim, Minhye Kwak, Jeonghan Kang, Melissa Cesaire, Kayen Tang, Robert W. Robey, William J. E. Frye, Baktiar Karim, Donna Butcher, Martin J. Lizak, Mahalia Dalmage, Brandon Foster, Nicholas Nuechterlein, Charles Eberhart, Patrick J. Cimino, Michael M. Gottesman, Sadhana Jackson

“…Ibrutinib, FDA-approved lymphoma agent, inhibits Bruton tyrosine kinase (BTK) and has previously been shown to independently impair aortic endothelial adhesion and increase rodent glioma model survival in combination with cytotoxic therapy. …”
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Efektivitas pemberian vitamin terhadap pertumbuhan dan kelangsungan hidup ikan lele (Clarias sp.) by Hermancon Sembiring, Ni Putu Putri Wijayanti, Dewa Ayu Angga Pebriani

“…Penilaian kualitas air dalam lingkungan pemeliharaan perlu disesuaikan agar ikan lele dapat tumbuh dan hidup dengan baik. Rata-rata kualitas air yang diperoleh adalah pH antara 7,6-7,7, suhu antara 27,22-27,62°C, dan DO sebesar 4,01-4,25 mg/L dimana masih optimal untuk pertumbuhan ikan lele.…”
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Konsep model latihan fisik pada sepakbola by Seftrio Putra, Emral  Emral, Arsil Arsil, Tjung Hauw Sin

“…Kemudian dilakukan uji validasi ahli dengan penilaian angket sehingga diperoleh validitas 89,6% kategori “Sangat Baik/layak” dan uji reliabilitas kelompok kecil sebesar 0.999 dengan kategori “Tinggi” dan kelompok besar sebesar 0.997dengan kategori reliabilitas keduanya “Tinggi”.…”
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How trait mindfulness protects late adolescents from stress-induced sleep problems: the unique role of mindfulness facets and gender differences by Huiting Cao, Jing Qian, Fenghua Tang, Yunyan Dong, Haining Ren, Xiaoran Xue, Ningning Mao, Xiaoyu Liu

“…Since the measurement tool for the Observing facet only had 1 question tested on observing inner feelings, and other questions are all about observing bodily sensations and outer environments, this study implies that insomnia therapies focus on enhancing the ability to anchor attention in the present moment, especially towards bodily sensations and the outer environment, may be particularly effective in buffering the long-term impact of daily stressors on sleep for young females. …”
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Bilevel Optimization of Regular Bus-Subway-Shared Bicycle Cooperative Operation considering Dual Uncertainties by Yunqiang Xue, Tong He, Tao Li, Hongzhi Guan, Yang Qiu

“…By establishing a coordinated dual-level optimization model for regular bus, subway, and bike-sharing networks under dual uncertainty conditions, we employed convex combination techniques to unify the dual uncertain variables into a single objective, which was then incorporated into a chance-constrained bilevel programming model. …”
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Microenvironment Influences on Human Umbilical Cord Mesenchymal Stem Cell-Based Bone Regeneration by Lingling E, Rongjian Lu, Jianwei Sun, Hongbo Li, Wen Xu, Helin Xing, Xing Wang, Tao Cheng, Shuo Zhang, Xiaocao Ma, Rong Zhang, Hongchen Liu

“…This study is aimed at investigating the effects of the in vitro culture microenvironment (hUC-MSCs, nano-hydroxyapatite/collagen/poly (L-lactide) (nHAC/PLA), osteogenic media (OMD), and recombinant human bone morphogenetic protein-7 (rhBMP-7)) and the in vivo transplanted microenvironment (ectopic and orthotopic) on bone regeneration ability of hUC-MSCs. The isolated hUC-MSCs showed self-renewal potential and MSCs’ characteristics. …”
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Phytochemical Profile Screening and Selected Bioactivity of <i>Myrtus communis</i> Berries Extracts Obtained from Ultrasound-Assisted and Supercritical Fluid Extraction by Ilir Mërtiri, Gigi Coman, Mihaela Cotârlet, Mihaela Turturică, Nicoleta Balan, Gabriela Râpeanu, Nicoleta Stănciuc, Liliana Mihalcea

“…The results highlighted the ability of myrtle berry extracts to inhibit <i>α</i>-amylase enzymatic activity, suggesting its potential as an alternative for controlling postprandial hyperglycemia. …”
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Pengujian Usability Google Classroom Berdasarkan Model Use-Questionnaire by Suci Ramadhani Arifin, Etha Gustin Merdekawati

“…Maka dapat disimpulkan bahwa mahasiswa setuju tingkat usability Google Classroom dirasakan sudah baik dan penggunaan layanan Google Classroom telah efektif, efisien, dan memberikan kepuasan terhadap mahasiswa dengan tingkat presentase sebesar 76%.   …”
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T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint pr... by Stephanie Schlichtner, Inna M Yasinska, Gurprit S Lall, Steffen M Berger, Sabrina Ruggiero, Dietmar Cholewa, Nijas Aliu, Bernhard F Gibbs, Elizaveta Fasler-Kan, Vadim V Sumbayev

“…Background Galectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the anticancer activities of T lymphocytes and natural killer cells. …”
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BeatProfiler: Multimodal In Vitro Analysis of Cardiac Function Enables Machine Learning Classification of Diseases and Drugs by Youngbin Kim, Kunlun Wang, Roberta I. Lock, Trevor R. Nash, Sharon Fleischer, Bryan Z. Wang, Barry M. Fine, Gordana Vunjak-Novakovic

“…We further confirm its ability to robustly characterize disease and dose-dependent drug response. …”
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Biofeedback Acupoint Stimulation Combined with Rood Technique on Walking Function of Stroke Patients in Convalescent Period by MENG Haichao, QU Shujie, CHANG Yongxia, HAO Lisha, ZHAO Hailu, MA Qiuyun, ZUO Xiaohong, WANG Zhengtian

“…The Rood technique included sensory stimulation induced muscle response training, sensory stimulation inhibited muscle response training, the individual development principle guided motor control ability training, once a day, 40 minutes a time, five days a week, lasting for four weeks. …”
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Designing and Explaining the Competence Model of Knowledge Engineers in Municipalities (Study Case: Tehran Municipality) by Amin Seyyed Nosrati, Zahra Foroutani, Atyieh Bohrani

“…Interpersonal and personality competencies were defined by perceptive abilities, trustworthiness, charisma, flexibility, enthusiasm, extroversion, a jihadist spirit, work discipline, and strong memory. …”
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