Clinical Study of Limosilactobacillus reuteri for the Treatment of Children with Chronic Tic Disorders/Tourette Syndrome: A Mid-Term Efficacy Evaluation by Yan Liang, Lin Wan, Guanglei Wang, Huimin Yan, Jing Zhang, Xinting Liu, Ziyan Zhang, Gang Zhu, Guang Yang

“…For hyperactivity disorder, after matching patients in both groups for age, sex, age at onset, tic type, and Children’s Yale-Brown Obsessive Compulsive Scale (CY-BOCS) scores, a significant difference in improvement was observed between the groups (p = 0.010), with the probiotics group showing greater improvement (0.3 ± 0.58 vs. 0.1 ± 0.50). At 9 weeks, social ability on the CBCL scale increased by 3.2 ± 6.26 from baseline in the probiotics group and by 0.6 ± 4.07 in the clonidine group, with a significant difference between the two (p = 0.049). …”
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The Human Milk-derived Peptide Drives Rapid Regulation of Macrophage Inflammation Responses in the Neonatal IntestineSummary by Fuqiang Yuan, Xu Han, Masha Huang, Yinglin Su, Yiting Zhang, Mengyuan Hu, Xiang Yu, Weilai Jin, Yun Li, Le Zhang

“…Mutation of key amino acids in CASB135-150 disrupted its interaction with FHL2 and abolished its ability to inhibit NF-κB signaling, which also prevented its protective effect in vivo. …”
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DESAIN PANTI SOSIAL TRESNA WERDHA DI MAKASSAR by Burhanuddin Burhanuddin, Ratriana Said, Wahdaniar Wahdaniar

“… Abstrak_ Jumlah lansia di kota Makassar baik yang tergolong terlantar dan hampir terlantar berdasarkan data pemerintah setempat saat ini semakin meningkat. …”
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Application of a new highly multiplexed amplicon sequencing tool to evaluate Plasmodium falciparum antimalarial resistance and relatedness in individual and pooled samples from Dsc... by Jacob M. Sadler, Alfred Simkin, Valery P. K. Tchuenkam, Isabela Gerdes Gyuricza, Isabela Gerdes Gyuricza, Abebe A. Fola, Kevin Wamae, Ashenafi Assefa, Ashenafi Assefa, Karamoko Niaré, Kyaw Thwai, Samuel J. White, William J. Moss, Rhoel R. Dinglasan, Sandrine Eveline Nsango, Christopher B. Tume, Jonathan B. Parr, Jonathan B. Parr, Jonathan B. Parr, Innocent Mbulli Ali, Jeffrey A. Bailey, Jeffrey A. Bailey, Jonathan J. Juliano, Jonathan J. Juliano, Jonathan J. Juliano, Jonathan J. Juliano

“…This assay uses oligonucleotide primers in two pools and a non-proprietary library and barcoding approach.ResultsWe evaluated Pf-SMARRT using control mocked dried blood spots (DBS) at varying levels of parasitemia and a mixture of 3D7 and Dd2 strains at known frequencies, showing the ability to genotype at low parasite density and recall within-sample allele frequencies. …”
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AAV2 serotype demonstrates the highest transduction efficiency in porcine lung-derived cells by Won Seok Ju, Seokho Kim, Areum Choi, Jae-Yeong Lee, Haesun Lee, Jingu No, Seunghoon Lee, Keonbong Oh, Jae Gyu Yoo

“…Background: The ability of adeno-associated viruses (AAVs) to transduce various cell types with minimal immune responses renders them prominent vectors for gene editing (GE), with different AAV serotypes exhibiting distinct transduction efficiencies due to their specific cellular tropism. …”
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Penentuan bobot kayu apu Pistia stratiotes L. sebagai fitoremediator dalam pendederan ikan gurami Lac. ukuran 3 cm by Kukuh Nirmala, Sulistia Wardani, Yuni Puji Hastuti, Wildan Nurusallam

“…Hasil penelitian menunjukkan bahwa perlakuan kayu apu 45 g/33 L air menunjukkan hasil tingkat kelangsungan hidup, pertumbuhan panjang mutlak, laju pertumbuhan bobot harian, efisiensi pakan yang paling baik, serta lebih menguntungkan dibandingkan dengan perlakuan kontrol (kayu apu 0 g).   …”
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Improving daily reference evapotranspiration forecasts: Designing AI-enabled recurrent neural networks based long short-term memory by Mumtaz Ali, Jesu Vedha Nayahi, Erfan Abdi, Mohammad Ali Ghorbani, Farzan Mohajeri, Aitazaz Ahsan Farooque, Salman Alamery

“…By combining RNNs with LSTM units, models can leverage the strengths of both approaches to improve their ability to process sequential data effectively. This integration allows for better capturing of both short-term and long-term dependencies in the input sequences. …”
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Subchronic cyanuric acid treatment impairs spatial flexible behavior in female adolescent rats through depressing GluN2B-dependent neuronal and synaptic function by Wei Sun, Haiyang Yu, Xiaoliang Li, Yiwen Wan, Yazi Mei, Yang Yang, Lei An

“…We found that subchronic CA exposure impairs reversal learning ability with dose-dependent effects but did not affect spatial learning and memory, or learning strategy. …”
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Antioxidant, Anti-Tyrosinase, and Wound-Healing Capacities of Soy Protein Hydrolysates Obtained by Hydrolysis with Papaya and Cantaloupe Juices Showing Proteolytic Activity by Thi-Phuong Nguyen, Quang Thai Le, Mai Linh Thi Tran, Kim Nhung Ta, Khoa Thi Nguyen

“…The present study attempted to investigate the ability of papaya ( Carica papaya ) and cantaloupe ( Cucumis melo ) juices in the hydrolysis of SPI and assess the antioxidant, anti-tyrosinase, and wound-healing activities of obtained hydrolysates. …”
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Design of a Wearable Exoskeleton Piano Practice Aid Based on Multi-Domain Mapping and Top-Down Process Model by Qiujian Xu, Meihui Li, Guoqiang Chen, Xiubo Ren, Dan Yang, Junrui Li, Xinran Yuan, Siqi Liu, Miaomiao Yang, Mufan Chen, Bo Wang, Peng Zhang, Huiguo Ma

“…This study designs and develops a wearable exoskeleton piano assistance system for individuals recovering from neurological injuries, aiming to help users regain the ability to perform complex tasks such as playing the piano. …”
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Multivalent Neuroprotective Activity of <i>Elettaria cardamomum</i> (Cardamom) and <i>Foeniculum vulgare</i> (Fennel) in H₂O₂-Induced Oxidative Stress in SH-S... by Himadri Sharma, Hyewon Yang, Niti Sharma, Seong Soo A. An

“…This study was performed to evaluate their neuroprotective ability based on certain acellular and cellular assays. …”
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miR-129-5p Promotes Osteogenic Differentiation of BMSCs and Bone Regeneration via Repressing Dkk3 by Changming Zhao, Yulin Gu, Yan Wang, Qiaozhen Qin, Ting Wang, Meng Huang, Heyang Zhang, Yannv Qu, Jingwen Zhang, Zhangzhen Du, Xiao-Xia Jiang, Lulu Xu

“…BMSCs were transduced by miR-129-5p mimic, miR-129-5p inhibitor, and negative control lentivirus. The ability of BMSC differentiation to osteoblast was tested by alkaline phosphatase (ALP) and alizarin red staining (ARS). …”
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Effect of colchicine on physiological and biochemical properties of <i>Rhodococcus qingshengii</i> by Yu. A. Markova, L. A. Belovezhets, V. N. Nurminsky, I. S. Kapustina, N. V. Ozolina, V. V. Gurina, A. L. Rakevich, A. V. Sidorov

“…Due to their relatively high growth rate and ability to form biof ilms, Rhodococcus are a convenient model for studying the effect of biologically active compounds on pathogenic Mycolata. …”
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Study on the Key Influential Factors on Water Huff-n-Puff in Ultralow-Permeability Reservoir by Xiaoyan Wang, Kun Xie, Jie Zhang, Yong Zhang, Yang Zhang, Wei Wang, Xi Yan, Fengxiang Zhao

“…The results show that imbibition and energy supplement are main mechanisms of water huff-n-puff; imbibition oil recovery is influenced by rock wettability, permeability, boundary condition, fracture length, water injection speed, and imbibition solution type; the stronger the water-wet reservoir rock is, the bigger the core permeability is, the longer the fracture length is, the larger the contacting area between imbibition solution and rock is, the stronger the ability of imbibition solution to change wettability, and to reduce the interfacial tension force between oil and water is, the better effect of water huff-n-puff is. …”
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Blood biomarkers to identify patients with different intracranial lesion combinations after traumatic brain injury by Pia Koivikko, Ari J. Katila, Riikka SK. Takala, Iftakher Hossain, Teemu M. Luoto, Rahul Raj, Mari Koivisto, Olli Tenovuo, Kaj Blennow, Peter Hutchinson, Henna-Riikka Maanpää, Mehrbod Mohammadian, Virginia F. Newcombe, Jean-Charles Sanchez, Jussi Tallus, Mark van Gils, Henrik Zetterberg, Jussi P. Posti

“…The results may reflect the severity of TBI but also show that biomarkers have a variable ability to identify patients with combinations of intracranial traumatic lesions in the examined time window.…”
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Comparison of Gensini score and SYNTAX score for predicting in-stent restenosis in patients with coronary artery disease and drug-eluting stent implantation by Min-Tao Gai, Shi-Qi Yan, Ming-yuan Wang, Amanguli Ruze, Ling Zhao, Qiu-Lin Li, Bang-Hao Zhao, An-Xia Deng, Su Hu, Xiao-Ming Gao

“…Furthermore, Gensini score [AUC 95%CI: 0.81 (0.78–0.84)] and SYNTAX score [AUC 95%CI: 0.76 (0.72–0.79)] showed a moderate ability to predict ISR. The predictors were further verified in a cohort validation study, which confirmed that the Gensini score was a better predictor for ISR than SYNTAX score, with an AUC and 95%CI of 0.67 (0.60–0.73) and 0.53 (0.46–0.60), respectively. …”
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Mesenchymal stem cell-mediated adipogenic transformation: a key driver of oral squamous cell carcinoma progression by Yiting Shao, Yu Du, Zheng Chen, Lei Xiang, Shaoqin Tu, Yi Feng, Yuluan Hou, Xiaoxing Kou, Hong Ai

“…Knockdown of FASN in OSCC-MSCs reduced their adipogenic potential and inhibited their ability to promote OSCC cell proliferation and migration. …”
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Importin subunit beta‐1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation by Zoe Lombardi, Lucia Gardini, Anatolii V. Kashchuk, Alessio Menconi, Matteo Lulli, Ignazia Tusa, Alessandro Tubita, Luisa Maresca, Barbara Stecca, Marco Capitanio, Elisabetta Rovida

“…The combination of ivermectin and the ERK5 inhibitor AX15836 synergistically reduced cell viability and colony formation ability in A375 and HeLa cells and was more effective than single treatments in preventing the growth of A375 and HeLa spheroids. …”
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Bi-level data-driven enterprise-wide optimization with mixed-integer nonlinear scheduling problems by Hasan Nikkhah, Zahir Aghayev, Amir Shahbazi, Vassilis M. Charitopoulos, Styliani Avraamidou, Burcu Beykal

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Mechanisms of L-citrulline on phosphodiesterase 5 in erectile dysfunction intervention by Abdulhakeem Olarewaju Sulyman, Olawale Moshood Aliyu, Emmanuel Oladipo Ajani, Yusuf Folohunsho Abdulkareem, Isaac Ade Afe, Fathia Oluwakemi Abdulyakeen, Halimat Yusuf Lukman, Saheed Sabiu, Karishma Singh, Kuben Naidoo

“…Its therapeutic potential in erectile dysfunction lies in its ability to boost NO production, improving penile blood flow and erection quality. …”
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