Machine learning and molecular dynamics simulations predict potential TGR5 agonists for type 2 diabetes treatment by Ojochenemi A. Enejoh, Chinelo H. Okonkwo, Hector Nortey, Olalekan A. Kemiki, Ainembabazi Moses, Ainembabazi Moses, Florence N. Mbaoji, Abdulrazak S. Yusuf, Olaitan I. Awe

“…TGR5 agonists are attractive candidates for T2D therapy because of their ability to improve glycemic control. This study used machine learning-based models (ML), molecular docking (MD), and molecular dynamics simulations (MDS) to explore novel small molecules as potential TGR5 agonists.MethodsBioactivity data for known TGR5 agonists were obtained from the ChEMBL database. …”
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Propionate metabolism in a human pathogenic fungus: proteomic and biochemical analyses by Luiz Paulo Araújo Santos, Leandro do Prado Assunção, Patrícia de Souza Lima, Gabriel Brum Tristão, Matthias Brock, Clayton Luiz Borges, Mirelle Garcia Silva-Bailão, Célia Maria de Almeida Soares, Alexandre Melo Bailão

“…Therefore, fungi require a functional MCC for full virulence and the ability to metabolize propionyl-CoA is related to the virulence traits in Paracoccidioides spp. …”
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PENGEMBANGAN PEMBELAJARAN BERBASIS RISET DI JURUSAN TADRIS BAHASA INDONESIA FITK IAIN SYEKH NURJATI CIREBON by Indrya Mulyaningsih, Nina Nurfiana, Mohammad Ali Zahidin

“…Validitas data menggunakan teknik triangulasi, baik sumber data maupun metode pengumpulan data. …”
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Comparative response mechanisms of two cultivars of Musa paradisiaca L. to Fusarium oxysporum f.sp. cubense infection by Yajie Duan, Yajie Duan, Zhiwei Jia, Zhiwei Lu, Huigang Hu, Rulin Zhan

“…With the aim of enhancing plants’ ability to respond to pathogenic fungi, this study focuses on disease resistance genes. …”
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Anti-invasion activities of heat-killed lactic acid bacteria isolates against Salmonella enterica serovar Typhimurium by Anis Syahirah Saifor Adzuan, Sharifah Aminah Syed Mohamad, Rashidah Iberahim, Noor Nadia Syahira Mohd Kamal, Nurliana Abd Mutalib, Nur Intan Hasbullah, Muneer Alsaydi, Nor'aishah Hasan, Low Kheng Oon, Olaide Olawunmi Ajibola, Rozila Alias, Maimunah Mustakim, Azlin Sham Rambely, Emida Mohamed, Mohammad Reza Pourmand

“…Tairu and R isolates were tested for their antibacterial ability against S. Typhimurium. Both R and Tairu isolates displayed strong inhibition zones (27 ± 0.06 mm, 23 ± 0.06 mm) respectively. …”
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Effects of Gestational Inflammation with Postpartum Enriched Environment on Age-Related Changes in Cognition and Hippocampal Synaptic Plasticity-Related Proteins by Shi-Yu Sun, Xue-Yan Li, He-Hua Ge, Yu-Xin Zhang, Zhe-Zhe Zhang, Zhan-Qiang Zhuang, Chong-Yang Ren, Fang Wang, Gui-Hai Chen

“…At the age of 6 and 18 months, Morris water maze (MWM) and western blotting were, respectively, used to evaluate or measure the ability of spatial learning and memory and the levels of postsynaptic plasticity-related proteins in the hippocampus, including postsynaptic density protein 95 (PSD-95), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) GluA1 subunit, and Homer-1b/c. …”
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Prognostic correlation analysis of multiple myeloma based on HALP score of peripheral blood before chemotherapy by CHEN Min, AN Liying, LIN Xiaojing, ZHAO Pan, ZOU Xingli, WEI Jin, NI Xun

“…Univariate and multivariate analyses were conducted using the Cox regression model, and a forest plot was generated using Graphpad Prism to illustrate factors that may impact patient prognosis. The predictive ability of HALP score combined with β2-microglobulin and ECOG score for prognosis in MM patients was evaluated using receiver operating characteristic curve (ROC) analysis. …”
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Preoperative carcinoembryonic antigen to lymphocyte ratio serves as a prognostic predictor in elderly patients with colorectal cancer: a multicentre retrospective study by Lei Jiang, Ning Tan, Xiaonan Zhang, Jiayi Jiang, Xinyi Li, Gang Deng, Tao Liang, Haohan Ma, Weiping Deng, Lichang Guan, Kaijun Zhang, Xujie Cai, Lishu Xu

“…In the two validation cohorts, CLR also presented a strong discriminatory ability in predicting postoperative all-cause death, with the area under the curve (AUC) of 0.68 in the external cohort and 0.78 in the localised cohort. …”
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Evaluation of Some Quality Parameters of Pumpkin Seeds and Oil After Roasting with Marjoram by Mariola Kozłowska, Małgorzata Ziarno, Katarzyna Zawada, Hanna Kowalska, Dorota Derewiaka, Małgorzata Chobot, Iwona Ścibisz

“…In addition, all the oils showed the ability to scavenge DPPH^· radicals and were characterized by a higher proportion of yellow (positive value of the b* parameter) and green (negative value of the a* parameter) color. …”
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Kelayakan dan Keefektifan Sistem Konseling Behavioral Teknik Modeling dalam LMS Schoology untuk Meningkatkan Motivasi Belajar Siswa by Putu Deby Oktariani, Kadek Suranata, Kadek Ari Dwiarwati

“…Panduan ini sebagai pedoman bagi guru BK dalam melaksanakan layanan bimbingan konseling secara online. …”
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Design of INSPIRE: Evaluation of the effectiveness of practice facilitation on implementation of screening, brief interventions, referral to treatment and medication for unhealthy... by Jennifer Bannon, Justin D. Smith, Mark J. Van Ryzin, Megan McHugh, Jennifer Heinrich, Theresa L. Walunas, Abel N. Kho

“…Conclusion: The INSPIRE study will evaluate the ability of primary care clinicians in small practices to participate in practice education programs and implement standard screening and treatment protocols, adapted for documentation in the electronic health record (EHR). …”
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Nomogram model using serum Club cell secretory protein 16 to predict prognosis and acute exacerbation in patients with idiopathic pulmonary fibrosis by Yaqiong Tian, Xuan Zhou, Mi Tian, Lijun Ren, Ruyi Zou, Hanyi Jiang, Miaomiao Xie, Mei Huang, Jingjing Ding, Yin Liu, Jingyu Chen, Min Cao, Hourong Cai

“…Conclusions The nomogram model based on CC16 performed good predictive ability for prognosis and acute exacerbation of IPF.…”
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Executive function, limbic circuit dynamics and repetitive and restricted behaviors in children with autism spectrum disorder by Xiangyu Zheng, Xinyue Wang, Ruochen Song, Junbin Tian, Li Yang

“…Since the orbitofrontal cortex (OFC) plays a role in both EF and RRBs, its functional connectivity dynamics could offer valuable insights into this relationship.MethodsThis study analyzed data from the Autism Brain Imaging Data Exchange (ABIDE) II database to explore brain function in 93 boys with ASD and 110 typically developing (TD) boys. …”
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Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach by Genbao Zhu, Genbao Zhu, Genbao Zhu, Zhiming Jiang, Niuping Zhu, Niuping Zhu, Donghui Wang, Donghui Wang, Tianpeng Guo, Tianpeng Guo, Yiqing Meng, Yiqing Meng, Yi Zhu, Yi Zhu, Kemeng Tan, Mengxue Hu, Heng Tang, Xuannian Wang, Xuannian Wang

“…Moreover, the results of in vitro experiments revealed that SSA significantly inhibited the proliferative and migratory abilities of PC3 cells in a dose-dependent manner. …”
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Kemampuan representasi matematis peserta didik pada pembelajaran Think Pair Share berbantuan media Canva by Ida Setiani, Putriaji Hendikawati

“…Hasil penelitian menunjukkan bahwa pembelajaran TPS berbantuan media Canva efektif terhadap kemampuan representasi matematis karena memenuhi kriteria yaitu: 1) Kemampuan representasi matematis peserta didik pada pembelajaran TPS berbantuan media Canva mencapai ketuntasan belajar secara klasikal; 2) Rata-rata kemampuan representasi matematis peserta didik pada pembelajaran TPS berbantuan media Canva lebih baik daripada rata-rata kemampuan representasi matematis peserta didik pada pembelajaran Problem Based Learning; dan 3) Proporsi ketuntasan hasil tes kemampuan representasi matematis peserta didik pada pembelajaran TPS berbantuan media Canva lebih tinggi daripada ketuntasan hasil tes kemampuan representasi matematis peserta didik pada pembelajaran Problem Based Learning.…”
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Implementasi kebijakan pembelajaran daring di kota Pontianak by Sri Haryaningsih, Ira Patriani, Farah Devi Andriani

“…Hasil penelitian menjukkan bahwa Komunikasi yang terjadi di jajaran Pemerintah Kota Pontianak dan Dinas Pendidikan dan Kebudayaan Kota Pontianak sudah cukup baik, terlihat dalam penerbitan surat edaran yang dikeluarkan oleh Kota Pontianak dalam upaya pencegahan covid-19, selanjutnya di respon oleh Dinas Pendidikan Kota Pontianak dengan mengeluar-kan surat edaran perihal pencegahan covid-19 dengan meliburkan sementara kegiatan belajar mengajar di sekolah dan mengintruksikan untuk belajar di dalam rumah. …”
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Advancing Radiobiology: Investigating the Effects of Photon, Proton, and Carbon-Ion Irradiation on PANC-1 Cells in 2D and 3D Tumor Models by Alexandra Charalampopoulou, Amelia Barcellini, Giuseppe Magro, Anna Bellini, Sara Sevan Borgna, Giorgia Fulgini, Giovanni Battista Ivaldi, Alessio Mereghetti, Ester Orlandi, Marco Giuseppe Pullia, Simone Savazzi, Paola Tabarelli De Fatis, Gaia Volpi, Angelica Facoetti

“…Carbon-ion radiotherapy (CIRT) has emerged as a promising approach due to its ability to deliver highly localized doses and unique radiobiological properties compared to X-rays. …”
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Unveiling Silent Atherosclerosis in Type 1 Diabetes: The Role of Glycoprotein and Lipoprotein Lipidomics, and Cardiac Autonomic Neuropathy by Sara de Lope Quiñones, Manuel Luque-Ramírez, Antonio Carlos Michael Fernández, Alejandra Quintero Tobar, Jhonatan Quiñones-Silva, María Ángeles Martínez García, María Insenser Nieto, Beatriz Dorado Avendaño, Héctor F. Escobar-Morreale, Lía Nattero-Chávez

“…Stratification by the presence of CAN revealed no impact on the model’s ability to predict subclinical atherosclerosis, underscoring its robustness across different risk subgroups. …”
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Dinamika Internet, Media Sosial, dan Politik di Era Kontemporer: Tinjauan Relasi Negara-Masyarakat by Faisal Fadilla Noorikhsan, Hilal Ramdhani, Budi Chrismanto Sirait, Nisa Khoerunisa

“…Kandidat yang berpartisipasi dalam pemilihan umum, baik itu pemilihan legislatif, presiden, maupun kepala daerah, tidak dapat mengandalkan saluran komunikasi politik konvensional saja. …”
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Archeohandi: protocol for a national disabilities database in archaeology in France by Rozenn Colleter, Valérie Delattre, Cyrille Le Forestier, Alex Baiet, Philippe Blanchard, Fanny Chenal, Anne-Sophie Coupey, Stéphanie Desbrosse-Degobertière, Sylvie Duchesne, Cécile Durin, Jean-Luc Gisclon, Noémie Gryspeirt, Fanny La Rocca, Raphaëlle Lefebvre, Jérôme Livet, Cécile Paresys, Mikaël Rouzic, Isabelle Souquet, Florence Tane, Aminte Thomann, Ivy Thomson, Émilie Trébuchet, Marie-Cécile Truc, Jean-Baptiste Barreau

“…Our database is hosted on the Huma-Num platform, with a management interface and quick access based on multiple tabs. The data includes information about archaeological operations, subjects, and pathologies; it is complemented by pictorial data stored on the Nakala platform. …”
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