Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway by Sun Kening, Chen Ping, Zhang Liang, Lu Zhidong, Jin Qunhua

“…Multiple myeloma cells when treated with deguelin exhibited remarkably lower viability and colony-forming ability. Multiple myeloma cells treated with deguelin produced more SOD and had higher GSH levels. …”
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Transparent memory tests with even repeating addresses for storage devices by V. N. Yarmolik, I. M. Mrozek, V. A. Levantsevich, D. V. Demenkovets

“…The maximum diagnostic ability of new tests is shown for the case of the simplest faults, such as constant (SAF) and transition faults (TF), as well as for complex pattern sensitive faults (PNPSFk). …”
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SOCIO-CULTURAL AND PHILOSOPHICAL-LEGAL DIMENSIONS OF THE GENDER IDENTITY PROBLEM by V. S. Blikhar, I. M. Zharovska, I. O. Lychenko

“…It is characterized in the legal plane, first of all, by the equality of the social roles of men and women, and the overcoming of the gender hierarchy of social ties, in which men are perceived as higher beings by their mental and physical abilities, and their activities are more significant and of priority in comparison with the activities of women. …”
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Balancing Privacy and Utility in Split Learning: An Adversarial Channel Pruning-Based Approach by Afnan Alhindi, Saad Al-Ahmadi, Mohamed Maher Ben Ismail

“…The experiments demonstrated the superior defense ability, against data reconstruction attacks, of the proposed approach in comparison with relevant state-of-the-art approaches. …”
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Exercise-Intervened Circulating Extracellular Vesicles Alleviate Oxidative Stress in Cerebral Microvascular Endothelial Cells Under Hypertensive Plus Hypoxic Conditions by Smara Sigdel, Shuzhen Chen, Gideon Udoh, Jinju Wang

“…The functions of cEVs were assessed in an Angiotensin II (Ang II) plus hypoxia-injured cerebral microvascular endothelial cell (mBMEC) injury model. Cellular migration ability and oxidative stress were evaluated. We found that treadmill exercise stimulated cEV release, and ET-cEVs were more prone to be internalized by mBMECs. …”
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Enabling analytical precision in microplastic analysis: innovative solutions for precise method validation, evaluation and quality control by Jovan Badzoka, Christoph Kappacher, Jakob Lauß, Lisa Obwaller, Anna Pavun, Christian W. Huck

“…By incorporating a custom synthesized polymer with a thione functionality as an internal standard alongside conventional MP polymers, we demonstrate the ability of this approach for comprehensive method validation, evaluation and quality control on a particle-based approach.…”
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Long-Term Environmental Enrichment Relieves Dysfunctional Cognition and Synaptic Protein Levels Induced by Prenatal Inflammation in Older CD-1 Mice by Zhe-Zhe Zhang, Li-Ping Zeng, Jing Chen, Yong-Fang Wu, Ya-Tao Wang, Lan Xia, Qi-Gang Yang, Fang Wang, Gui-Hai Chen

“…Analysis revealed that at 15 months of age, the control mice experienced a reduction in cognitive ability and elevated expression levels of Arc and Syt1 genes when compared to control mice at 3 months of age. …”
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The Effect of a 12-Week Plyometric and Tabata Training Program with Three Weekly Sessions on Cardiovascular Efficiency in Elite Soccer Players by Nidhin Muthrathiparambil Narayanan, Kayambu Sundar, Nirmal Michael Salvi, Yashpal, Debajit Karmakar, Sohom Saha, Bekir Erhan Orhan, Farjana Akter Boby, Yuni Astuti

“…In conclusion, the implementation of a plyometric and Tabata training program has been found to produce significant improvements in cardiovascular efficiency in elite soccer players, making them valuable preseason conditioning strategies to enhance endurance, performance, and overall athletic abilities. …”
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Conjunctival scarring in trachoma is associated with the HLA-C ligand of KIR and is exacerbated by heterozygosity at KIR2DL2/KIR2DL3. by Chrissy H Roberts, Sandra Molina, Pateh Makalo, Hassan Joof, Emma M Harding-Esch, Sarah E Burr, David C W Mabey, Robin L Bailey, Matthew J Burton, Martin J Holland

“…<h4>Conclusions</h4>To explain the observations in the context of chlamydial infection and trachoma we propose a two-stage model of response and disease that balances the cytolytic response of KIR expressing NK cells with the ability to secrete interferon gamma, a combination that may cause pathology. …”
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Spatiotemporal air quality prediction using stochastic advection–diffusion model for multimodal data fusion by Byeongseong Choi, Michelle A Hummel

“…The model captures 78% of observed data within a 75% confidence interval across both scenarios, demonstrating its ability to accurately represent uncertainty. Our findings demonstrate that the proposed SAD model can effectively integrate multimodal data to provide improved prediction of particulate matter concentrations at high spatial resolution. …”
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SRADHO: statistical reduction approach with deep hyper optimization for disease classification using artificial intelligence by G. Sathish Kumar, E. Suganya, S. Sountharrajan, Balamurugan Balusamy, Adil O. Khadidos, Alaa O. Khadidos, Shitharth Selvarajan

“…Artificial neural networks have been extensively used for disease prediction and diagnosis due to their ability to learn complex patterns and relationships from large datasets. …”
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How health literacy relates to venous leg ulcer healing: A scoping review. by Ayoub Bouguettaya, Georgina Gethin, Sebastian Probst, Jane Sixsmith, Victoria Team, Carolina Weller

“…<h4>Background</h4>The level of personal health literacy of patients with venous leg ulcers is likely to affect their ability to self-manage their condition impacting on their adherence to treatment and influences healing and recovery outcomes.…”
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Phenotypic Definition of the Progenitor Cells with Erythroid Differentiation Potential Present in Human Adult Blood by Valentina Tirelli, Barbara Ghinassi, Anna Rita Migliaccio, Carolyn Whitsett, Francesca Masiello, Massimo Sanchez, Giovanni Migliaccio

“…To clarify the phenotype of AB HPC which generate EBs in these cultures, flow cytometric profiling for CD34/CD36 expression, followed by isolation and functional characterization (colony-forming-ability in semisolid-media and fold-increase in HEMA) were performed. …”
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Development of Predictive Models for Progression from Diabetic Kidney Disease to End-Stage Renal Disease in Type 2 Diabetes Mellitus: A Retrospective Cohort Study by Hu H, Mu X, Zhao S, Yang M, Zhou H

“…Among 85 patients with biopsy-proven diabetic DKD, the combined prognostic model integrating KFRE, interstitial fibrosis and tubular atrophy (IFTA), SII and BMI demonstrated enhanced predictive ability at 5 years. The developed models offer improved accuracy over existing methods by incorporating renal pathology and novel inflammatory indices, making them more applicable in clinical settings.Conclusion: The predictive model proved to be effective in assessing the progression of DKD to ESRD. …”
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Exploring a Chemotactic Role for EVs from Progenitor Cell Populations of Human Exfoliated Deciduous Teeth for Promoting Migration of Naïve BMSCs in Bone Repair Process by Lin Luo, Steven J. Avery, Rachel J. Waddington

“…Extracellular vesicles (EVs) are a functional membranous structure which could participate in multiple cell interactions and imitate the biological functions of their parenting cells largely. To assess their ability to mobilize naïve BMSCs in the bone repair process, Nanosight Tracking Analysis (NTA) and Enzyme-Linked Immunosorbent Assays (ELISA) were performed to illustrate the composition and functional contents of EV samples derived from SHEDs with different culturing time (24 h, 48 h, and 72 h). …”
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Senescence-related circRNA circHIF-1α is associated with pancreatic cancer progression by Hao Hua, Yazu Deng, Dijie Zheng, Changhao Wu, Liwen Chen, Binbin Shi, Zhiwei He, Chao Yu

“…CircHIF-1α knockdown induces cellular senescence and suppresses PC proliferation in vitro experiments. The ability of circHIF-1α knockdown to suppress the progression of PC cells was further confirmed in vivo experiments. …”
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Key wound healing genes as diagnostic biomarkers and therapeutic targets in uterine corpus endometrial carcinoma: an integrated in silico and in vitro study by Fuchuan Jiang, Sajjad Ahmad, Sadia kanwal, Yasir Hameed, Qian Tang

“…Overexpression studies in UCEC cell lines demonstrated that CD44 and MMP2 reduce proliferative ability while enhancing migration and wound healing. …”
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Confidence in the efficacy of routine vaccines after the COVID-19 pandemic: a cross-sectional web-based study by Areej M. Zubaid, Maha T. Alhamdi, Noor I. Al-Harthi, Khulood M. Al-Harthi, Razan A. AlQarni, Yassmin M. Shebany, Ahmed Ibrahim Fathelrahman, Sayed F. Abdelwahab

“…The most common reason for the change in participants’ confidence (68%, n = 743) in routine vaccination after the COVID-19 pandemic was the fear of the impact of COVID-19 vaccine on the immune system or the body’s ability to respond correctly to routine vaccines. …”
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Predicting breast cancer recurrence using deep learning by Deepa Kumari, Mutyala Venkata Sai Subhash Naidu, Subhrakanta Panda, Jabez Christopher

“…The BCR-HDL framework’s unique contributions include its ability to predict not only diagnostic outcomes but also prognostic and recurrence timing, offering a comprehensive solution for breast cancer management. …”
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Lebanese Cannabis sativa L. extract protects from cisplatin-induced nephrotoxicity in mice by inhibiting podocytes apoptosis by Alia Khalil, Sahar Al Toufaily, Wassim Shebaby, Marissa El Hage, Dima Mroue, Wissam Faour, Mohamad Mroueh

“…In addition, in vitro scratch assay demonstrated the ability of COE to promote and restore the migratory capacity of podocytes in cisplatin-treated cells. …”
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