Design of a humanized CD40 agonist antibody with specific properties using AlphaFold2 and development of an anti-PD-L1/CD40 bispecific antibody for cancer immunotherapy by Kun Du, He Huang

“…BA4415 demonstrated the ability to enhance T-cell cytokine release in vitro assays, exhibiting superior functional attributes compared to the anti-PD-L1 antibody. …”
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An Approach for Detecting Parkinson’s Disease by Integrating Optimal Feature Selection Strategies with Dense Multiscale Sample Entropy by Minh Tai Pham Nguyen, Minh Khue Phan Tran, Tadashi Nakano, Thi Hong Tran, Quoc Duy Nam Nguyen

“…As a result, the model demonstrated a significant ability to differentiate between PD patients and healthy controls, with classification accuracy reported as ACC [CI 95%: 97.82–98.5%] for disease identification and ACC [CI 95%: 96.3–97.3%] for severity assessment. …”
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Cell stress response to combined ionizing and non-ionizing radiation and magnetic fields: a review based on human buccal epithelium cells by К. А. Кузнецов, Г. М. Онищенко, О. Т. Ніколов

“…Conclusions: Vague effect of ultra-low doses of IR with modifying abilities of EHF-microwaves and MF was shown on the example of HGQ. …”
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High Doses of Halotolerant Gut-Indigenous Lactobacillus plantarum Reduce Cultivable Lactobacilli in Newborn Calves without Increasing Its Species Abundance by Alexander Rodriguez-Palacios, Henry R. Staempfli, J. Scott Weese

“…For the first time, a halotolerant strain of L. plantarum with inhibitory activity against a human pathogen has the ability to inhibit other lactobacilli in vivo without changing its species abundance, causing transintestinal translocation, or inducing clinical disease. …”
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Exploring community stakeholder perspectives of partnership development in community-engaged undergraduate Global Health Education in the UK: a qualitative study by Shyam Sundar Budhathoki, Helen Ward, Dorota Chapko, Christine Pettitt, Keitumetse-Kabelo Murray

“…Relationships built were maintained via a service evaluation report, and participants discussed how attitudes of academic institutions towards collaboration influence communities’ ability to participate in medical education.Conclusions The perspectives of CBOs reported in this study demonstrate that factors important to partnership development in community-engaged medical education are consistent with the key principles of co-production. …”
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Effects of Algal-Derived β-Glucan on the Growth Performance, Intestinal Health, and Aeromonas veronii Resistance of Ricefield Eel (Monopterus albus) by Yu Guo, Zijing Yuan, Yueyun Han, Daiqin Yang, Hanwen Yuan, Fuxian Zhang

“…In summary, the addition of 0.1%–0.2% β-glucan can promote eel growth, improve intestinal digestion and antioxidant capacity, regulate intestinal flora, and enhance intestinal physical function and anti-infection ability.…”
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The effectiveness of the combined PBL and Tencent Conference online teaching mode in the clinical internship teaching of cardiac surgery. by Xiuwen Chen, Yao Xiao, Yunhui You, Jianxi Zhu, Shiqing Liu, Huiqiong Chen, Hong Zhu

“…The PBL teaching method can stimulate students' interest in learning and cultivate their comprehensive ability to a certain extent. Future educators should flexibly adapt the teaching method to the learning situation, develop a reasonable teaching mode of clinical internship, and ensure quality.…”
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Cost-effective adsorption of cationic dyes using ZnO nanorods supported by orange peel-derived carbon by Eman J. E. Abdelrazek, Ahmed A. Gahlan, Gamal A. Gouda, Abdelaal S. A. Ahmed

“…The results indicated the potential ability of OP-derived porous carbons as adsorbents for cationic dyes from aqueous media.…”
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Baduanjin Training to Improve Parkinson's Disease Gait and Balance Function by DONG Shuangshuang, YAN Hongjie, DONG Qing, CAI Zenglin

“…Gait indicators and balance indicators were used to evaluate, analyze and compare the two groups of patients before the test and 3 weeks after the test.Results1) IDEEA gait indicators: there was no statistically significant difference in gait indicators between the two groups before the test (<italic>P</italic>&gt;0.05); after 3 weeks, compared with those before the test, the two gait indexes of cycle time and stride duration in the treatment group were improved, and the differences were statistically significant (<italic>P</italic>&lt;0.05), while the comparison of the gait index of the control group before and after the test, the difference was not statistically significant (<italic>P</italic>&gt;0.05); the cycle time and stride duration of the treatment group were respectively (1.30±0.32) s and (645.90±156.65) ms, which were better than those of the control group (1.56±0.38) s and (765.05±158.93) ms, and the differences were statistically significant (<italic>P</italic>&lt;0.05). 2) Balance index: there was no statistically significant difference in the balance index between the two groups before the test (<italic>P</italic>&gt;0.05); the scores and grades of balance test in the treatment group were improved after 3 weeks of the test compared with those before the test (<italic>P</italic>&lt;0.05), while there was no significant difference in the balance index of the control group before and after the test (<italic>P</italic>&gt;0.05); the balance test level of the treatment group was 1.00 (1.00, 2.20), which was better than the control group's 2.15 (1.00, 3.83), the difference was statistically significant (<italic>P</italic>&lt;0.05).ConclusionBaduanjin training can significantly improve the gait and balance ability of patients with mild to moderate PD.…”
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Sensitivity analysis on natural convective trapezoidal cavity containing hybrid nanofluid with magnetic effect: Numerical and statistical approach by Sweety Khatun, Rupa Kundu, Saiful Islam, Ritu Aktary, Dipankar Kumar

“…In the event of a growing magnetic impact, reverse behaviors should be noted. The water's ability to transmit heat increases to 11.29 % when the Ag-SiO2-H2O hybrid nanofluid is used. …”
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Association of serum neurofilament light chain with cognitive impairment: findings from the National Health and Nutrition Examination Survey by Tianjiao Meng, Qinwen Fei, Tian Lv, Shiqin Chen

“…The nomogram model based on NfL identified by LASSO regression displayed a considerable predicative value for low total-CF, with an area under the curve [AUC = 85.6% (81.6–89.3%)].ConclusionThere is a strong correlation between serum NfL levels and cognitive function, especially DSST, which reflects attention and information processing abilities, as well as overall cognitive function, but not memory and language fluency. …”
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Understanding how, for whom and under what circumstances telecare can support independence in community-dwelling older adults: a realist review by Lauren Fothergill, Niall Hayes, Yvonne Latham, Jenny Hamilton, Saiqa Ahmed, Carol Holland

“…Telecare that supports autonomy by enabling choice over technological resources may support self-reliance and control over one’s life, including choosing the level of monitoring, freedom to call for help if needed, and the ability to customise technology to suit needs (3). …”
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Yield, plasticity, stability and homeostasis of spring barley cultivars in the Non-Black Earth Region by L. M. Eroshenko, M. M. Romakhin, N. A. Eroshenko, I. A. Dedushev, V. V. Romakhina, M. A. Boldyrev

“…‘Luboyar’, ‘Nadezhny’ and ‘Rafael’ showed the highest adaptability to the worst growing conditions (4.65–5.04 t/ha) as well as high adaptive and compensatory ability. Cvs. ‘Sudar’, ‘Nur’ and ‘Zlatoyar’ were identified for high environmental plasticity (Cvi = 24.1–25.9%; bi = 1.02–1.16; σ = 1.52–1.59), while ‘Lyuboyar’, ‘Znatny’ and ‘Vladimir’ for their stability parameters (S2di = 0.05–0.19; σ2CACi = 1.60–1.78; σ2(G×E)gi = 0.05–0.15). …”
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circHUWE1 Exerts an Oncogenic Role in Inducing DDP-Resistant NSCLC Progression Depending on the Regulation of miR-34a-5p/TNFAIP8 by Xueliang Yang, Quan Sun, Yongming Song, Wenli Li

“…Colony forming assay was performed to assess colony forming ability. Cell apoptosis and cell cycle distribution were determined by flow cytometry. …”
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Gaussian Process Regression Total Nitrogen Prediction Based on Data Decomposition Technology and Several Intelligent Algorithms by WANG Yongshun, CUI Dongwen

“…Total nitrogen (TN) is one of the important indicators to reflect the degree of water pollution and measure the eutrophication status of lakes and reservoirs.To improve the accuracy of TN prediction,based on the empirical wavelet transform (EWT) and wavelet packet transform (WPT) decomposition technology,this paper proposes a Gaussian process regression (GPR) prediction model optimized by osprey optimization algorithm (OOA),rime optimization algorithm (ROA),bald eagle search (BES) and black widow optimization algorithm (BWOA) respectively.Firstly,the TN time series is decomposed into several more regular subsequence components by EWT and WPT respectively.Then,the paper briefly introduces the principles of OOA,ROA,BES,and BWOA algorithms and applies OOA,ROA,BES,and BWOA to optimize GPR hyperparameters.Finally,EWT-OOA-GPR,EWT-ROA-GPR,EWT-BES-GPR,EWT-BWOA-GPR,WPT-OOA-GPR,WPT-ROA-GPR,WPT-BES-GPR,WPT-BWOA-GPR models (EWT-OOA-GPR and other eight models for short) are established to predict the components of TN by the optimized super-parameters.The final prediction results are obtained after reconstruction,and WT-OOA-GPR,WT-ROA-GPR,WT-BES-GPR and WT-BWOA-GPR models based on wavelet transform (WT) are built.Eight models,including EWT-OOA-SVM based on support vector machine (SVM),the paper compares the unoptimized EWT-GPR,WPT-GPR models,and the uncomposed OOA-GPR,ROA-GPR,BES-GPR,and BWOA-GPR models.The models were verified by the monitoring TN concentration time series data of Mudihe Reservoir,an important drinking water source in China,from 2008 to 2022.The results are as follows.① The average absolute percentage error of eight models such as EWT-OOA-GPR for TN prediction is between 0.161% and 0.219%,and the coefficient of determination is 0.999 9,which is superior to other comparison models,with higher prediction accuracy and better generalization ability.② EWT takes into account the advantages of WT and EMD.WPT can decompose low-frequency and high-frequency signals at the same time.Both of them can decompose TN time series data into more regular modal components,significantly improving the accuracy of model prediction,and the decomposition effect is better than that of the WT method.③ OOA,ROA,BES,and BWOA can effectively optimize GPR hyperparameters and improve GPR prediction performance.…”
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Barriers and Facilitators in Accessing HIV Prevention Services for Men Having Sex with Men (MSM): A Comprehensive Analysis by Felix Sanni, Roger Abang, Godwin Emmanuel, Abiye Kalaiwo, Olugbemi Motilewa, Paul Amechi, Paul Umoh, Bartholomew Boniface Ochonye

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Co-design for stroke intervention development: Results of a scoping review. by Hardeep Singh, Natasha Benn, Agnes Fung, Kristina M Kokorelias, Julia Martyniuk, Michelle L A Nelson, Heather Colquhoun, Jill I Cameron, Sarah Munce, Marianne Saragosa, Kian Godhwani, Aleena Khan, Paul Yejong Yoo, Kerry Kuluski

“…It is increasingly used to design stroke interventions; however, limited guidance exists, particularly with/for individuals with stroke who have diverse cognitive, physical and functional abilities. Thus, we describe 1) the extent of existing research that has used co-design for stroke intervention development and 2) how co-design has been used to develop stroke interventions among studies that explicitly used co-design, including the rationale, types of co-designed stroke interventions, participants involved, research methodologies/approaches, methods of incorporating end-users in the research, co-design limitations, challenges and potential strategies reported by researchers.…”
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Nomogram for prognosis prediction in metastatic pancreatic cancer patients undergoing intra-arterial infusion chemotherapy: incorporating immune-inflammation scores and coagulation... by Yifan Yang, Shaoqi Zong, Yongqiang Hua

“…The model demonstrated good discriminative ability, with a C-index of 0.722, and the AUC values at 6- and 12-month OS predictions were 0.828 and 0.851 in the training cohort, while in the validation cohort, the corresponding AUC values were 0.754 and 0.791, respectively. …”
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Lipid-Derived Mediators in Endogenous Anti-Inflammation and Resolution: Lipoxins and Aspirin-Triggered 15-epi-Lipoxins by Charles N. Serhan, Nan Chiang

“…Its aspirin-triggered 15R epimer (15-epi-LXA4) and their bioactive stable analogs act in the subnanomolar to nanomolar range in human cellular systems and murine models of acute inflammation and reperfusion. ALXR also has the ability to interact with a wide panel of small peptides that give different signaling responses in vitro than LXA4 or its analogs, suggesting that ALXR is capable of serving as a multirecognition receptor in immune responses. …”
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Perspectives on AI-based recommendations for mask-wearing and COVID-19 vaccination for transplant recipients in the post-COVID-19 era by Oscar A. Garcia Valencia, Charat Thongprayoon, Jing Miao, Jackrapong Bruminhent, Iasmina M. Craici, Wisit Cheungpasitporn

“…However, it recommends a personalized consultation with healthcare providers in cases where patients express concerns about vaccine-related side effects, demonstrating an ability to adapt recommendations based on individual health considerations. …”
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