Multi-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling by Walid Mottawea, Basit Yousuf, Salma Sultan, Tamer Ahmed, JuDong Yeo, Nico Hüttmann, Yingxi Li, Nour Elhouda Bouhlel, Hebatoallah Hassan, Xu Zhang, Zoran Minic, Riadh Hammami

“…Our results highlight the ability of MEVs to cross the intestinal and blood-brain barriers to deliver their cargoes to distant organs, with potential implication for the gut-brain axis.IMPORTANCEMicrobiota-released extracellular vesicles (MEVs) have emerged as a key player in intercellular signaling. …”
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Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interacti... by Francesco Verona, Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Matilde Todaro, Giuseppe Giannini, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi

“…TAMs have demonstrated the ability to communicate with CSCs via direct ligand/receptor (such as CD90/CD11b, LSECtin/BTN3A3, EPHA4/Ephrin) interaction. …”
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Development of a one-step multiplex RT-qPCR method for rapid detection of bovine diarrhea viruses by Dequan Yang, Li Ma, Zhongping Yang, Xianchao Yang, Jian Wang, Houbin Ju, Chunguang Lu, Yonggang Weng, Heping Zhao, Haixiao Shen, Xin Li, Feifei Ge, Xiaoxu Wang, Xiujuan Wu, Meng Xiang, Guidan Feng, Congsheng Tang, Shixin Huang, Hongjin Zhao

“…The sensitivity, specificity, and reproducibility ability were evaluated for the mRT-qPCR. Further, 80 bovine fecal samples were subjected to the mRT-qPCR, and the results were verified using conventional reverse-transcription PCR (RT-PCR) or PCR methods and sequencing methods.ResultsThis novel method demonstrated high sensitivity and specificity,achieving a detection limit of 24 copies/mL for each pathogen. …”
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Benefits, limits, and risks of ChatGPT in medicine by Jonathan A. Tangsrivimol, Jonathan A. Tangsrivimol, Erfan Darzidehkalani, Hafeez Ul Hassan Virk, Zhen Wang, Zhen Wang, Jan Egger, Michelle Wang, Sean Hacking, Benjamin S. Glicksberg, Markus Strauss, Markus Strauss, Chayakrit Krittanawong, Chayakrit Krittanawong

“…Additionally, ChatGPT facilitates remote monitoring and chronic disease management, providing personalized advice, medication reminders, and emotional support, thus bridging gaps between clinical visits. Its ability to process and synthesize vast amounts of data accelerates research workflows, aiding in literature reviews, hypothesis generation, and clinical trial designs. …”
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Deciphering the functional roles of PE18 and PPE26 proteins in modulating Mycobacterium tuberculosis pathogenesis and immune response by Aquib Ehtram, Mohd Shariq, Neha Quadir, Neha Quadir, Salma Jamal, Manjunath Pichipalli, Sheeba Zarin, Sheeba Zarin, Javaid Ahmad Sheikh, Nasreen Z. Ehtesham, Seyed E. Hasnain, Seyed E. Hasnain

“…The observed disruption of actin dynamics and endosome-phagosome maturation underscores a novel mechanism by which Mtb evades host defenses. The ability of PE18 and PPE26 to induce effector T-cell responses highlights their potential as targets for host-directed therapies or vaccine development against TB. …”
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Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway by Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu, Yuanyuan Ji

“…This is attributed to its ability to regulate the LIMS1/ILK signaling pathway, which represents a common molecular mechanism in both heart and kidney tissues.…”
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Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb in acute and subacute Stroke (RHOMBUS II): results of a feasibility randomised controlle... by Cherry Kilbride, Tom Butcher, Meriel Norris, Nana Anokye, Alyson Warland, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais, Jennifer Ryan, Francesca Gowing, Elmar Kal, Carole Pound, Victoria Stewart, Basaam Aweid, Arul Samiyappan

“…Objective To investigate the safety, feasibility and acceptability of the Neurofenix platform for upper-limb rehabilitation in acute and subacute stroke.Design A feasibility randomised controlled trial with a parallel process evaluation.Setting Acute Stroke Unit and participants’ homes (London, UK).Participants 24 adults (>18 years), acute and subacute poststroke, new unilateral weakness, scoring 9–25 on the Motricity Index (elbow and shoulder), with sufficient cognitive and communicative abilities to participate.Interventions Participants randomised to the intervention or control group on a 2:1 ratio. …”
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Effect of Midsole Compliance on Oxygen Consumption and Perception of Effort and Comfort during running by Kai Biedermann, Gian-Andri Baumann, Christina M. Spengler, Fernando G. Beltrami

“… Introduction Advanced Footwear Technology (AFT) enhances running economy, which is partly attributed to midsole foam properties such as high resilience (the ability of a material to absorb and recover energy under elastic deformation) and high compliance (the tolerance of a material to deformation). …”
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Soviet Researchers on the Middle East: Ahead of Their Time by I. D. Zvyagelskaya

“…Nevertheless, the Soviet leadership passed the first test for the ability to reassess their ideological stereotypes in the early 1950s, when the leaders of the Egyptian revolution turned to the USSR for military assistance. …”
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Non-formal encounters between Israeli families and African immigrant families foster lifelong learning competence by Michal Ganz Meishar

“…Research questions are as follows: In what way do non-formal encounters lead to the development of lifelong learning ability? What are the challenges and consequences of non-formal activity for research participants, families and educators from the pedagogical, social and personal perspectives? …”
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Artemisinin supplementation in concentrated cottonseed protein basal diets enhances growth, antioxidant capacity, intestinal immunity and microbiota in hybrid grouper (Epinephelus... by Ling Pan, Qi Wang, Weikang Li, Xiaohui Dong, Shiwei Xie, Beiping Tan, Hongyu Liu, Yan Wang

“…Artemisinin supplementation significantly enhanced the activities of SOD, GSH-Px, CAT, and T-AOC in the liver and hindgut (P < 0.05),while also reducing MDA levels, thereby demonstrating its protective effect against oxidative stress and its ability to strengthen antioxidant defense system. …”
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Research progress of auricular point therapy to relieve preoperative period anxiety before elective surgery in adults (耳穴压豆缓解成年人择期手术术前焦虑的研究进展)... by GAO Yuan (高原), XU Lingzhi (徐凌志), LI Suxia (李素霞)

“…In particular, the traditional Chinese medicine technique of auricular acupressure offers a novel approach to managing preoperative anxiety through its ability to promote circulation, relieve pain, calm the mind, and induce tranquility. …”
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Validation Indicator Identification and Customer Ranking in Microloans: A Study at Middle East Bank in Iran by Azadeh Ahmadi Kousha, Faegh Ahmadi, Mohammad Hossein Ranjbar, Hamidreza Kordlouie

“…ResultsThe findings indicate that when assessing a loan application, the following indicators should be considered to determine the applicant's ability to repay the loan or provide suitable collateral. …”
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Analysis of the long-range transport of the volcanic plume from the 2021 Tajogaite/Cumbre Vieja eruption to Europe using TROPOMI and ground-based measurements by P. Hedelt, J. Reichardt, F. Lauermann, B. Weiß, N. Theys, A. Redondas, A. Barreto, O. Garcia, D. Loyola

“…Transport and dispersion of the volcanic emissions were monitored by ground-based stations and satellite instruments alike. In particular, the spectrometric fluorescence and Raman lidar for atmospheric moisture sensing (RAMSES) at the Lindenberg Meteorological Observatory measured the plume of the strongest Tajogaite eruption of 22–23 September 2021 over northeastern Germany 4 d later. …”
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Results of propagation of Fagus silvatica L. plants in vitro by Mykola Lisovyi, Andrii Ivaniuk

“…A 4-fold decrease in the concentration of mineral salts in the nutrient medium makes the ability of Fagus silvatica L. clones to rhizogenesis virtually impossible. …”
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Vision impairment and associated daily activity limitation: A systematic review and meta-analysis. by Masoud Rahmati, Lee Smith, Laurent Boyer, Guillaume Fond, Dong Keon Yon, Hayeon Lee, Tarnjit Sehmbi, Mapa Prabhath Piyasena, Shahina Pardhan

“…<h4>Background</h4>Vision impairment is a common disability that poses significant challenges to individuals' ability to perform activities essential for independent living, including activities of daily living (ADL) and instrumental activities of daily living (IADL). …”
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High-fat diet-induced liver injury in Channa argus through lipid metabolism, anti-oxidative status, apoptosis, and inflammation by Jiaxin Tian, Ying Li, Jiwu Wan, Zhinan Yang, Guiqin Wang

“…Anti-oxidative status-related biochemical parameters were determined; the malondialdehyde level was increased, and anti-oxidative indices (including catalase, superoxide dismutase, glutathione, glutathione-S-transferase, and total antioxidant capacity) were decreased in the L22 group, which also induced DNA damage and inhibited the expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) pathway-related antioxidant genes to suppress antioxidant ability. At 90 days, the L22 group exhibited a significant upregulation of mRNA expression levels for liver inflammatory factors, including interleukin-1β (IL-1β), IL-8, IL-10, and tumor necrosis factor-α (TNF-α). …”
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Preparation of Tragopogon graminifolius-loaded electrospun nanofibers and evaluating its wound healing activity in a rat model of skin scar by Leila Almasi, Elham Arkan, Mohammad Hosein Farzaei, Amin Iranpanah, Cyrus Jalili, Fatemeh Abbaszadeh, Faranak Aghaz, Sajad Fakhri, Javier Echeverría

“…The efficacy of nanofibers composed of polyvinyl alcohol (PVA)/polyethylene oxide (PEO)/chitosan (CS) in promoting wound healing can be attributed to their ability to stimulate collagen production. Among the herbal agents with fewer adverse effects, Tragopogon graminifolius DC. …”
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Comprehensive Analysis of m5C RNA Methylation Regulator Genes in Clear Cell Renal Cell Carcinoma by Jiajin Wu, Chao Hou, Yuhao Wang, Zhongyuan Wang, Pu Li, Zengjun Wang

“…Then, the predictive ability of survival of this m5C-related risk signature was analyzed by Cox regression analysis and nomogram. …”
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Effect of the season on blood changes of oxidative stress index (OSi) in the Italian Mediterranean Buffalo (Bubalis bubalis by Giovanna De Matteis, Emanuela Rossi, Maria Chiara La Mantia, Roberto Steri, Vittoria Lucia Barile, David Meo Zilio

“…Previous studies in cattle showed that high temperatures increase the production of reactive oxygen species (ROS), causing an imbalance between ROS and the ability of antioxidant systems to detoxify and remove the reactive intermediates. …”
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