LncRNA GAS5 inhibits glioma progression through miR-135b-5p/APC axis by ZHANG Jidong, WANG Yutao, JI Jianwen

“…The results of CCK-8, Transwell and wound healing assays revealed that overexpression of GAS5 significantly inhibited the viability, invasion and migration abilities in T98 cells when compared with the cells of the vector group (P<0.01). …”
Get full text

Clinical Holistic Medicine: Metastatic Cancer by Søren Ventegodt, Elin Solheim, Mads E. Saunte, Mohammed Morad, Isack Kandel, Joav Merrick

“…The patient went through the following phases: (1) finding the purpose of life and hidden resources; (2) confronting denial; (3) taking responsibility for being very ill; (4) severe existential crises with no wish to live while still fighting; (5) integration of many repressed feelings and negative decisions thus rehabilitating character; (6) confronting lack of intimacy and trust in others and this way rehabilitating the ability to love; (7) rehabilitating the will to live, breaking through and falling in love with life; (8) assuming responsibility for the social relations; and sometimes (9) quality of life is improved radically with indications of spontaneous remission of the liver tumors.…”
Get full text

CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation by Yan-Yan Xue, Zhe-Sheng Zhang, Rong-Rong Lin, Hui-Fen Huang, Ke-Qing Zhu, Dian-Fu Chen, Zhi-Ying Wu, Qing-Qing Tao

“…Abstract Background Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder, which is characterized by a decline in cognitive abilities. Genome-wide association and clinicopathological studies have demonstrated that the CD2-associated protein (CD2AP) gene is one of the most important genetic risk factors for AD. …”
Get full text

Mechanism of melanoma suppression by Prosopis juliflora derived alkaloids: Apoptosis induction and signaling pathway inhibition by Jasoda Choudhari, Snehal K. Nimal, Shridhar Chougule, Trupti Shinde, N.R. Dhatrak, Gopal C. Kundu, Rajesh N. Gacche

“…In-vitro spheroid assay was performed to explored the PJLME-AF cytotoxic effects on tumour spheroid forming ability of melanoma cells. Additionally, the anti-tumor efficacy of PJLME-AF was tested in an in-vivo C57BL/6 mouse model. …”
Get full text

&beta;-Caryophyllene and Statins in Bone Fracture Healing &ndash; A Narrative Review by Marom H, Khan MA, Darvish N, Tornetta III P, Khoury A, Weil YA, Skelley NW, Allison DC, Meiron S, Ehrmann Barr T

“…It highlights the complementary mechanisms of these agents: BCP’s anti-inflammatory and osteogenic properties and statins’ ability to inhibit osteoclast activity and promote angiogenesis. …”
Get full text

Rematuration Periods and Sperm Characteristics of Litopenaeus vannamei by L. Okmawati Anwar, K. Sumantadinata, O. Carman

“… The reproduction ability of male has an important role in seeds production of Litopenaeus vannamei. …”
Get full text

Computational insights into Sitahe (Leuconotis eugenifolia) bioactive compounds: A promising approach for radioprotection through p53 inhibition by Dian Pribadi Perkasa, Iin Kurnia, Taufik Muhammad Fakih, Teja Kisnanto, Dwi Ramadhani, Harry Nugroho Eko Surniyantoro, Boky Jeanne Tuasikal, Alfian Mahardika Forentin, Mukh Syaifudin

“…In this study, in silico docking simulations were conducted to systematically assess the ability of key phytochemicals from Sitahe to modulate p53 activity, a critical gene in DNA repair and cancer therapy. …”
Get full text

Development and Validation of a Predictive Model Based on Serum Silent Information Regulator 6 Levels in Chinese Older Adult Patients: Cross-Sectional Descriptive Study by Yuzi You, Wei Liang, Yajie Zhao

“…ConclusionsSIRT6 shows promise in predicting CAD, with enhanced predictive abilities when combined with the TyG index. In clinical settings, monitoring fluctuations in SIRT6 and TyG may offer valuable insights for early CAD detection. …”
Get full text

Anti-Inflammatory and Anti-Migratory Effects of Morin on Non-Small-Cell Lung Cancer Metastasis via Inhibition of NLRP3/MAPK Signaling Pathway by Punnida Arjsri, Kamonwan Srisawad, Sonthaya Umsumarng, Pilaiporn Thippraphan, Songyot Anuchapreeda, Pornngarm Dejkriengkraikul

“…Our findings demonstrated the significant ability of morin to decrease the production of IL-1β, IL-18, and IL-6 in a dose-dependent manner (<i>p</i> < 0.05), as well as suppress NSCLC cell migration and invasion. …”
Get full text

Correlation Analysis of Twig and Leaf Characteristics and Leaf Thermal Dissipation of <i>Hippophae rhamnoides</i> in the Riparian Zone of the Taohe River in Gansu Province, China by Qun Li, Min Ma, Yurui Tang, Tingting Zhao, Chengzhang Zhao, Bo Li

“…<b>Aims</b>: The functional traits of twigs and leaves are closely related to the ability of plants to cope with heterogeneous environments. …”
Get full text

Knowledge, attitudes, and beliefs regarding acute coronary syndrome in patients with type 2 diabetes: a cross-sectional study by Mohammad Amerzadeh, Mahdie Bahrami, Mojtaba Senmar, Zahra Hosseinkhani, Zahra Shafiei Kisomi

“…Patients had a low attitude towards heart disease, with approximately 36.4% being somewhat or completely confident in their ability to assist others with a heart attack. Regarding performance, 45.7% of individuals believed that they should promptly go to the hospital during a heart attack. …”
Get full text

External validation and revision of the Lafontaine criteria for unstable distal radius fractures: a retrospective study by Pornpanit Dissaneewate, Phatklao Thanavirun, Yanin Tangjaroenpaisan, Kantapon Dissaneewate

“…Therefore, we aimed to evaluate the Lafontaine criteria as a diagnostic prediction rule for distal radius fractures, assess the inter-rater reliability and predictive ability of various parameters for distal radius instability, and develop new criteria for fracture instability using reliable and highly predictive factors. …”
Get full text

Les effets paradoxaux du transfert des forces de sécurité en Tunisie (juin 1955-mars 1956) by Khansa Ben Tarjem

“…The outcome of this competition depended not only on the number of supporters, but also on the ability to mobilise coercive resources and foreign support, particularly colonial and regional. …”
Get full text

Patient-Generated Collections for Organizing Electronic Health Record Data to Elevate Personal Meaning, Improve Actionability, and Support Patient–Health Care Provider Communicatio... by Drashko Nakikj, David Kreda, Karan Luthria, Nils Gehlenborg

“…The lack of personalized organization and important connections can limit patients’ ability to use their data and make informed health decisions. …”
Get full text

Development and validation of the Information Literacy Measurement Scale (ILMS-34) in Chinese public health practitioners by Hui Li, Ke-Ying Li, Xia-Rong Hu, Xuan Hong, Yan-Ting He, Hua-Wei Xiong, Yi-Li Zhang

“…Results EFA yielded four dimensions for the ILMS-34: information consciousness, information knowledge, information ability, and information ethics. Subsequent CFA showed a good model fit of the four-factor structure (χ2/df = 1.485, RMSEA = 0.043, SRMR = 0.038, TLI = 0.977, CFI = 0.979). …”
Get full text

Molecular Docking Appraisal of Phytochemicals as Potential Inhibitors of PI3K/Akt Pathway for Breast Cancer Treatment by Magdalene Eno Effiong, Mercy Bella-Omunagbe, Israel Sunmola Afolabi, Shalom Nwodo Chinedu

“…Conclusion: Ellagic acid, apigenin, luteolin, quercetin, chlorogenic acid, chrysin, and naringenin phytochemicals are seen as the better lead molecules due to their ability to strongly bind to the proteins under study in this pathway. …”
Get full text

Comparing the Accuracy and Reliability of Detecting the Intensity of Spinal Inflammation on STIR Sequence with Apparent Diffusion Coefficient Values in Axial Spondyloarthritis by Ho Yin Chung, Tommy Tsang Cheung, Vince Wing Hang Lau, Kam Ho Lee, Florence King Pui Chan

“…Conclusion: Reading of STIR MRI is limited by the lack of ability in differentiating subtle differences of spinal inflammation. …”
Get full text

Constructing the constitutively active ribosomal protein S6 kinase 2 from <i>Arabidopsis thaliana</i> (AtRPS6K2) and testing its activity <i>in vitro</i> by A. V. Zhigailov, G. E. Stanbekova, D. K. Beisenov, A. S. Nizkorodova, N. S. Polimbetova, B. K. Iskakov

“…TaRPS6 as part of 40S ribosomal subunits isolated from wheat embryos, though the non-mutated variant had less activity than phosphomimetic one. The ability of recombinant non-mutated kinase to phosphorylate TaRPS6 can be explained by its phosphorylation by bacterial kinases during the expression and isolation steps. …”
Get full text

Measurement report: The ice-nucleating activity of lichen sampled in a northern European boreal forest by U. Proske, U. Proske, U. Proske, M. P. Adams, G. C. E. Porter, M. A. Holden, M. A. Holden, J. Bäck, B. J. Murray

“…The great terrestrial abundance of lichens in Hyytiälä, and around the world, calls for further research to combine their ice-nucleating ability with dispersal studies to evaluate the flux of lichenous INPs into the atmosphere, as well as to what extent these particles reach heights and locations where they might influence cloud properties.…”
Get full text

Adaptive potential of winter rye cultivars developed at VIR in the context of their grain protein content in the environments of Leningrad province by N. I. Aniskov, I. V. Safonova, V. I. Horeva

“…The sum of their ranks according to the coefficients of variation (V), environmental plasticity (O), relative trait stability (St²) and homeostasis (Hom), as well as each cultivar’s adaptability coefficient (AC), stress resistance level (Y min – Y max) and compensatory ability (Y min + Y max/2), was 13–31 units.Conclusion. …”
Get full text