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12501
Association of Immune Nutrition Indices with the Risk of All-Cause Mortality and Cardiovascular Mortality in Patients with Heart Failure in the NHANES (1999–2018)
Published 2025-01-01“…A time-dependent receiver operating characteristic curve analysis was conducted to assess the predictive ability. …”
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12502
Staphylococcus aureus nt5 gene mutation through CRISPR RNA-guided base editing weakens bacterial virulence and immune evasion
Published 2025-12-01“…Herein, to reveal nt5 gene role in drug resistance and infection ability of S. aureus, we performed nt5C166T gene mutation using a clustered regulatory interspaced short palindromic repeat ribonucleic acid (RNA)-guided base editing system to investigate the lose-of-function of NT5 protein. …”
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12503
Role of YAP/TAZ in bone diseases: A transductor from mechanics to biology
Published 2025-03-01“…Emerging research highlights bone cells' ability to sense various mechanical stimuli and relay these signals intracellularly. …”
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12504
Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells
Published 2025-01-01“…It enables endocrine therapy resistance by superceding intrinsic structural-energetic gatekeepers of ER hormone-dependence, it enhances metastatic burden by enabling neomorphic ER-dependent transcriptional programs, and it resists SERM and SERD inhibiton by reducing their binding affinities and abilities to antagonize transcriptional coregulator binding. …”
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12505
Enhancement of Cognitive Benefits and Anti-Anxiety Effects of <i>Phytolacca americana</i> Fruits in a Zebrafish (<i>Danio rerio</i>) Model of Scopolamine-Induced Memory Impairment
Published 2025-01-01“…Furthermore, these extracts demonstrated the ability to mitigate cholinergic deficits by inhibiting AChE activity and supporting antioxidant defense mechanisms through increased activity of antioxidant enzymes and reduced lipid and protein peroxidation. …”
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12506
Wetland elevation change following beneficial use of dredged material nourishment
Published 2025-02-01“…This investigation allowed for a comprehensive examination of geotechnical modeling methods for planning wetland nourishments, including predicting the ability to keep pace with sea level rise. Ultimately, the two BUDM nourishments offset the effects of SLR by approximately 18-28 years.…”
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12507
Predictive biomarkers for cardiometabolic risk in postmenopausal women: insights into visfatin, adropin, and adiponectin
Published 2025-02-01“…Visfatin is known for its pro-inflammatory properties and its ability to modulate insulin resistance. Adropin is involved in energy homeostasis and metabolic health, while adiponectin has anti-inflammatory and insulin-sensitizing effects. …”
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12508
A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor
Published 2025-02-01“…Here, using BRET2-based biosensors, we demonstrated the ability of ARIP to inhibit agonist-induced β-arrestin recruitment on a series of 7TMRs that includes both stable and transient β-arrestin binders, with efficiencies that depend on receptor type. …”
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12509
Breeding for Heat Tolerant Aromatic Rice Varieties and Identification of Novel QTL Regions Associated with Heat Tolerance During Reproductive Phase by QTL-Seq
Published 2025-01-01“…Therefore, our objective was to develop heat-tolerant aromatic rice varieties using the pedigree method, focusing on selecting for seed-setting ability under extremely high temperatures along with the use of single nucleotide polymorphism/insertion and deletion (SNP/InDel) markers to improve aromatic properties and grain quality. …”
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12510
Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance
Published 2025-01-01“…In aHUS, FHAAs target the C-terminus, thereby impacting FH ability to recognize cell surfaces. In C3G, in contrast, FHAAs often target the N-terminus, generating an acquired functional FH deficiency. …”
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12511
Understanding the exodus: a 15-year retrospective cohort study on the pattern and determinants of migration among Nigerian doctors and dentists
Published 2024-12-01“…This alarming trend threatens the country’s ability to provide equitable healthcare. Objective This study investigated the patterns and determinants of migration among doctors and dentists who graduated from the University of Benin, Nigeria, 15 years ago. …”
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12512
Intracranial aneurysm instability prediction model based on 4D-Flow MRI and HR-MRI
Published 2025-01-01“…We introduce a specialized ensemble learning framework, termed the Hybrid Model, which synergistically combines two heterogeneous base learning algorithms: 4D-Flow logistic regression (4D-Flow-LR) and Multi-crop Attention Branch Network (MicroAB-Net). The ability of the hybrid model to predict aneurysm instability was compared with baseline models: PHASES (population, hypertension, age, size, earlier rupture, and site) LR, ELAPSS (earlier subarachnoid hemorrhage, location, age, population, size, and shape) LR, aneurysm wall enhancement (AWE) LR, and Radiomics using the area under the curve (AUC) with Delong's test. …”
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12513
Predictive method for poultry carcass visceral dimensions using 3D point cloud and Genetic Algorithm-based wavelet neural network
Published 2025-01-01“…Finally, in order to verify the generalizability of the method, generalizability experiments were conducted on different breeds of poultry, which proved that the method of this study had superior generalizability ability. In the comparative analysis of the six models, the MAPE and RMSE of the GA-WNN model for the prediction of the three visceral dimensions were the lowest except for the RMSE for the prediction of visceral length. …”
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12514
Hybrid Prophet-NAR Model for Short-Term Electricity Load Forecasting
Published 2025-01-01“…The proposed PropNAR integrated the strengths of the Prophet model in capturing deterministic structures, such as trends, seasonality, and holiday effects with the NAR model’s ability to handle nonlinear stochastic relationships. …”
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12515
Host-symbiont-gene phylogenetic reconciliation
Published 2023-05-01“…We evaluate the capacity of our method on simulated data, notably its capacity to infer horizontal gene transfers, and its ability to detect hostsymbiont co-evolution by comparing host/symbiont/gene and symbiont/gene models based on their estimated likelihoods. …”
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12516
Use of Relay Method for Enhancing Comb Construction by <i>Apis cerana cerana</i> Utilizing <i>Apis mellifera ligustica</i>
Published 2025-01-01“…Italian honey bees (IHBs, <i>Apis mellifera ligustica</i>) exhibit superior comb-building abilities compared with Chinese honey bees (CHBs, <i>Apis cerana cerana</i>), which often fail to fully utilize wax foundations, resulting in incomplete comb structures. …”
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12517
Comprehensive phenotypic analysis of multiple gene deletions of α-glucan synthase and Crh-transglycosylase gene families in Aspergillus niger highlighting the versatility of the fu...
Published 2025-06-01“…These observations underscore the ability of fungal cells to adapt and secure cell wall integrity, even when two entire cell wall protein-encoding gene families are missing.…”
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12518
Development of Attenuated Total Reflectance Mid-Infrared (ATR-MIR) and Near-Infrared (NIR) Spectroscopy for the Determination of Resistant Starch Content in Wheat Grains
Published 2021-01-01“…The validation of the developed best NIR and ATR-MIR calibration models showed that the ATR-MIR best calibration model has a better RS prediction ability than the NIR best calibration model. Two high grain RS content wheat mutants were screened out by the ATR-MIR best calibration model from the wheat mutant library. …”
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12519
A Prospective Randomized Study for Comparison of Modified Proximal Femoral Plate with Dynamic Hip Screw System
Published 2024-06-01“…It is an angular stable construct with the ability to achieve compression across the fracture site. …”
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12520
Highly Sensitive Non-Dispersive Infrared Gas Sensor with Innovative Application for Monitoring Carbon Dioxide Emissions from Lithium-Ion Battery Thermal Runaway
Published 2024-12-01“…Notably, carbon dioxide (CO<sub>2</sub>) gas sensors are emphasized for their ability to enhance early-warning systems, facilitating the timely detection of potential issues and, in turn, improving the overall safety standards of electric vehicles. …”
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