Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients by Karla R. Castro, Nádia E. Aikawa, Carla Gonçalves Saad, Júlio C. B. Moraes, Ana C. Medeiros, Licia Maria H. Mota, Clovis A. A. Silva, Eloísa Bonfá, Jozélio F. Carvalho

“…Analysis of the frequencies of each lipid alteration at baseline and at 3M were alike (P>0.05). Positive correlations were found between VLDL-c and CRP (r=0.647, P=0.009) and between triglycerides and CRP (r=0.604, P=0.017) levels at 3M. …”
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Evaluation of 16s Long Read Metabarcoding for Characterizing the Microbiome and Salmonella Contamination of Retail Poultry Meat by Zachary Tobar, Katie Y. Lee, Megan E. Gaa, Bryshal P. Moore, Xunde Li, Maurice E. Pitesky

“…However, due to greater taxonomic resolution afforded by using 16s long reads, the assay allowed alpha diversity assessment of the microbiome of raw poultry meat with the ability to assign taxonomy to the species and strain level for some amplicon sequence variants (ASV). …”
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Enhanced brightness and photostability of dye-sensitized Nd-doped rare earth nanocomposite for in vivo NIR-IIb vascular and orthotopic tumor imaging by Syue-Liang Lin, Shih-Po Su, Yuan-Zhen Yang, Cheng-Yu Chiang, Hsin-Yu Chi, Cheng Allen Chang, Tse-Ying Liu, Huihua Kenny Chiang

“…The dye-sensitized onion-like Nd-RENP nanocomposite presents a significant advancement in NIR-IIb imaging, providing enhanced brightness and photostability. Its ability to maintain clear and stable imaging over extended periods suggests potential applications in dynamic vascular and tumor-targeted imaging. …”
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Leveraging Single-Cell Multi-Omics to Decode Tumor Microenvironment Diversity and Therapeutic Resistance by Hussein Sabit, Borros Arneth, Timothy M. Pawlik, Shaimaa Abdel-Ghany, Aysha Ghazy, Rawan M. Abdelazeem, Amany Alqosaibi, Ibtesam S. Al-Dhuayan, Jawaher Almulhim, Noof A. Alrabiah, Ahmed Hashash

“…Recent developments in single-cell multi-omics technologies have provided the ability to identify diverse cell types and decipher key components of the tumor microenvironment (TME), leading to important advancements toward a much deeper understanding of how tumor microenvironment heterogeneity contributes to cancer progression and therapeutic resistance. …”
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Palmitic Acid Induces Production of Proinflammatory Cytokines Interleukin-6, Interleukin-1β, and Tumor Necrosis Factor-α via a NF-κB-Dependent Mechanism in HaCaT Keratinocytes by Bing-rong Zhou, Jia-an Zhang, Qian Zhang, Felicia Permatasari, Yang Xu, Di Wu, Zhi-qiang Yin, Dan Luo

“…Secretion levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), NF-κB nuclear translocation, NF-κB activation, Stat3 phosphorylation, and peroxisome proliferator-activated receptor alpha (PPARα) mRNA and protein levels, as well as the cell proliferation ability were measured at the end of the treatment and after 24 hours of recovery. …”
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Inhibitory properties of a latent inhibitor after its compound preexposure with several novel stimuli: evidence from human conditioning by Unai Liberal, Gabriel Rodríguez, Paula Nogueiras, James Byron Nelson, Geoffrey Hall, Geoffrey Hall

“…The inhibitory properties of latent inhibitors have been the subject of controversy, as standard latent inhibition training—consisting of pre-exposure to the target stimulus alone—does not provide the latent inhibitor with the ability to pass a summation test, a key criterion for demonstrating genuine inhibition. …”
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A ROS-responsive hydrogel encapsulated with matrix metalloproteinase-13 siRNA nanocarriers to attenuate osteoarthritis progression by Qiuyang Wang, Kai Feng, Guangsheng Wan, Wei Liao, Jing Jin, Peng Wang, Xiaolian Sun, Weijun Wang, Qing Jiang

“…This study reveals that si-Fe-HPP, with its ROS-responsive and RNAi abilities, can significantly protect chondrocytes and attenuate OA progression, providing novel insights and directions for the development of therapeutic materials for OA treatment. …”
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Rationale and design of the HOVON 170 DLBCL-ANTICIPATE trial: preventing anthracycline-induced cardiac dysfunction with dexrazoxane by Marijke Linschoten, Jesse Geels, Erik van Werkhoven, Heleen Visser-Wisselaar, Martine E. D. Chamuleau, Arco J. Teske, Lourens Robbers, Simone Oerlemans, Heleen Crommelin, Marleen Breems-de Ridder, Astrid Schut, Folkert W. Asselbergs, Anna van Rhenen, on behalf of the HOVON 170 DLBCL – ANTICIPATE consortium

“…Abstract Background Dexrazoxane has been studied for its ability to prevent anthracycline-induced cardiac dysfunction (AICD) in several trials but its use in clinical practice remains limited. …”
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Glutathione reductase plays a role in the metabolism of methylmercury degradation in Rhodotorula mucilaginosa by Yi Guo, Wenlong Deng, Qigui Mo, You Yu, Zhenwang Zhang, Mingjie Wei, Ruiling Tang, Surui Lu, Yanting Su

“…Metabolic indicator tests of engineered strains overexpressing the glutathione reductase encoding gene also support this notion.IMPORTANCEThe remediation of methylmercury pollution is crucial for environmental health. The ability of Rhodotorula mucilaginosa to resist and degrade methylmercury offers a new avenue for bioremediation efforts. …”
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Advanced sleep disorder detection using multi-layered ensemble learning and advanced data balancing techniques by Muhammad Mostafa Monowar, S. M. Nuruzzaman Nobel, Maharin Afroj, Md Abdul Hamid, Md Zia Uddin, Md Mohsin Kabir, M. F. Mridha

“…The combination of models not only enhanced accuracy but also improved the system's ability to handle unbalanced data, a common limitation in traditional methods. …”
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Tannic acid-loaded inorganic-organic coating on magnesium bone nails for enhanced antibacterial, anti-inflammatory and corrosion resistance by Sirui Xu, Chuanyao Dong, Xiaolin Yu, Tianshu Lv, Dapeng Zeng, Ruiyan Li, Xingfu Bao, Kan Zhang

“…Magnesium alloy is a promising material due to its high mechanical strength, strong osteoinductive ability, superior biodegradability, and density comparable to that of natural bone. …”
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Adipose Tissue-Derived Stem Cells Differentiate into Carcinoma-Associated Fibroblast-Like Cells under the Influence of Tumor-Derived Factors by Constantin Jotzu, Eckhard Alt, Gabriel Welte, Jie Li, Bryan T. Hennessy, Eswaran Devarajan, Srinivasalu Krishnappa, Severin Pinilla, Lilly Droll, Yao-Hua Song

“…Additionally, we found that these hASC-derived CAF-like cells exhibit functional properties of CAFs, including the ability to promote tumor cell invasion in an in vitro invasion assay, as well as increased expression of stromal-cell-derived factor 1 (SDF-1) and CCL5. …”
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Strategies to Improve the Quality and Freshness of Human Bone Marrow-Derived Mesenchymal Stem Cells for Neurological Diseases by Da Yeon Lee, Sung Eun Lee, Do Hyeon Kwon, Saraswathy Nithiyanandam, Mi Ha Lee, Ji Su Hwang, Shaherin Basith, Jung Hwan Ahn, Tae Hwan Shin, Gwang Lee

“…Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) have been studied for their application to manage various neurological diseases, owing to their anti-inflammatory, immunomodulatory, paracrine, and antiapoptotic ability, as well as their homing capacity to specific regions of brain injury. …”
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Study on the performance and mechanism of graphene oxide / polyurethane composite modified asphalt by Tengteng Guo, Zhenxia Li, Yuanzhao Chen, Qingyu Xu, Jing Wang, Lihui Jin

“…The improvement of rutting factor and frequency scanning master curve shows its better anti-rutting deformation ability. The strain recovery R-value for the composite modified bitumen increased by 20.7% at a stress level of 0.1 kPa, and the unrecoverable creep compliance Jnr decreased by 76.0%, showing excellent viscoelastic properties. …”
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Impact of sodium alginate hydrogel containing bacteriophage peptides that specifically bind to the EtCab protein on the inhibition of Eimeria tenella infection by Hang Chen, Wenjing Zhi, Bingrong Bai, Faisal R. Anjum, Zhipeng Jia, Rui Kong, Qiuju Liu, Biao Wang, Chunli Ma, Dexing Ma

“…The recombinant EtCab protein served as the ligand in this selection process. The binding ability of target phages to the EtCab protein or E. tenella sporozoites was evaluated. …”
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Isoforsythiaside confers neuroprotection against Alzheimer’s disease by attenuating ferroptosis and neuroinflammation in vivo and in vitro by Chunyue Wang, Hongbo Jiang, Honghan Liu, Shanshan Chen, Hangyu Guo, Shuoshuo Ma, Weiwei Han, Yu Li, Di Wang

“…Vahl that has been confirmed to improve the memory and cognitive abilities of APP/PS1 mice in our previous study. The purpose of this study was to explore the anti-ferroptosis and anti-neuroinflammatory properties of IFY-mediated neuroprotection. …”
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Repurposing of phosphodiesterase-5 inhibitor sildenafil as a therapeutic agent to prevent gastric cancer growth through suppressing c-MYC stability for IL-6 transcription by Zhenzhan Zhang, Wuqing Huang, Donghua Huang, Zhou Xu, Qingfeng Xie, Xin Tan, Wenjun He, Weihao Yang, Guoxin Li, Jianguang Ji, Hao Liu

“…Functionally, the PDE5 inhibitor sildenafil exhibited the suppressive ability to prevent oncogenic growth in GC. Mechanistically, sildenafil restrained GC growth by directly activating PKG through PDE5 inhibition for regulating c-MYC expression via its phosphorylation and ubiquitination degradation, thereby suppressing c-MYC stability for IL-6 transcription within the downstream IL-6/JAK/STAT3 signalling pathway. …”
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Adolescent girls’ explanations of high rates of low mood and anxiety in their population: a co-produced qualitative study by Ola Demkowicz, Rebecca Jefferson, Pratyasha Nanda, Lucy Foulkes, Jo Lam, Steven Pryjmachuk, Rhiannon Evans, Bernadka Dubicka, Liz Neill, Laura Anne Winter, Georgina Nnamani

“…There is a paucity of mental health research that meaningfully progresses understanding of these gender disparities, including that engages adolescent girls’ own perspectives, limiting our ability to direct further research and enhance intervention approaches. …”
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The impact of family members on aging persons’ technology use intentions by Freek Van Baelen, Melissa De Regge, Bart Larivière, Katrien Verleye, Kristof Eeckloo

“…It was investigated how the level of fit (when both the aging person and his or her family caregiver hold similar beliefs about the technological capabilities of the aging person) and the direction of misfit (whether the abilities of the aging person are greater or worse than the family caregiver thinks) shape the aging person's intention to use healthcare technologies. …”
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Melanin-like nanoparticles slow cyst growth in ADPKD by dual inhibition of oxidative stress and CREB by Yongzhan Sun, Quan Zou, Huizheng Yu, Xiaoping Yi, Xudan Dou, Yu Yang, Zhiheng Liu, Hong Yang, Junya Jia, Yupeng Chen, Shao-Kai Sun, Lirong Zhang

“…Mechanistically, we observed that MMPP directly binds to the bZIP DNA-binding domain of CREB, leading to competitive inhibition of CREB’s DNA binding ability and subsequent reduction in CREB target gene expression. …”
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