Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy by Xiangrui Zhang, Lihan Zhang, Beibei Li, Qingchao Wang, Peixin Chen, Ranran Shi, Xiuman Zhou, Xiaoshuang Niu, Wenjie Zhai, Yahong Wu, Wenhui Shen, Xiaowen Zhou, Wenshan Zhao

“…In vitro co-culture experiments further revealed that Epinastine effectively restored the ability of Jurkat cells to secrete IL-2. In the MC38 tumor-bearing model, Epinastine significantly enhanced the infiltration of T cells and NK cells into the tumor site and augmented their secretion of IFN-γ, leading to effective suppression of tumor growth. …”
Get full text

Goal-Oriented Respiratory Management for Critically Ill Patients with Acute Respiratory Distress Syndrome by Carmen Sílvia Valente Barbas, Gustavo Faissol Janot Matos, Marcelo Britto Passos Amato, Carlos Roberto Ribeiro Carvalho

“…This paper, based on relevant literature articles and the authors' clinical experience, presents a goal-oriented respiratory management for critically ill patients with acute respiratory distress syndrome (ARDS) that can help improve clinicians' ability to care for these patients. Early recognition of ARDS modified risk factors and avoidance of aggravating factors during hospital stay such as nonprotective mechanical ventilation, multiple blood products transfusions, positive fluid balance, ventilator-associated pneumonia, and gastric aspiration can help decrease its incidence. …”
Get full text

Salivary Glands Proteins Expression of Anopheles dirus A Fed on Plasmodium vivax- and Plasmodium falciparum-Infected Human Blood by Saowanee Cotama, Paron Dekumyoy, Yudthana Samung, Usa Lek-Uthai

“…The study shows that salivary glands proteins expression of An. dirus may affect the malaria parasite life cycle and the ability of mosquitoes to transmit malaria parasites in post-24-hour disappearance observation.…”
Get full text

On-demand prediction of low-frequency average sound absorption coefficient of underwater coating using machine learning by Nansha Gao, Mou Wang, Xiao Liang, Guang Pan

“…This study proposes an underwater coating with sound absorption ability in the middle-to-low frequency range and establishes an acoustic theoretical model combining the equivalent medium theory and the transfer matrix method. …”
Get full text

Following Spinal Cord Injury Transected Reticulospinal Tract Axons Develop New Collateral Inputs to Spinal Interneurons in Parallel with Locomotor Recovery by Zacnicte May, Keith K. Fenrich, Julia Dahlby, Nicholas J. Batty, Abel Torres-Espín, Karim Fouad

“…This difference suggests that activity in neuronal networks below the first SCI may contribute to enhanced recovery, because dSTAG rats recovered locomotor ability before the second hemisection. In conclusion, our findings support the hypothesis that the injured RtST forms new connections and is a key player in the recovery of locomotion post-SCI.…”
Get full text

White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner by Lanyun Feng, Shihui Gu, Peng Wang, Hao Chen, Zhen Chen, Zhiqiang Meng, Luming Liu

“…Pretreatment values of WBC and granulocyte count were independent factors with poor prognosis ability with respect to pancreatic cancer.…”
Get full text

Strain-Dependence of the Structure and Ferroic Properties of Epitaxial NiTiO3 Thin Films Grown on Different Substrates by Tamas Varga, Timothy C. Droubay, Mark E. Bowden, Libor Kovarik, Dehong Hu, Scott A. Chambers

“…Physical property measurements reveal a dependence of the weak ferromagnetism and lattice polarization on strain and highlight our ability to control the ferroic properties in NiTiO3 thin films by the choice of substrate. …”
Get full text

Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice by Jie Li, Yuanjie Guo, Liyuan Ma, Yixiang Liu, Chao Zou, Huiying Kuang, Bing Han, Yingliang Xiao, Yanbo Wang

“…The results show that, in comparison to their individual applications, the combination of AOS and C3G (mass ratio, 3:1) displayed a stronger ability to up-regulate the expression of tight junction proteins, while enhanced intestinal epithelial barrier was also observed and levels of mucin-2 and β-defensins were simultaneously increased in the intestinal mucus. …”
Get full text

Update on the Progress of Musashi-2 in Malignant Tumors by Yiting Niu, Tao Zhou, Yanjun Li

“…Since the discovery of the Musashi (MSI) protein, its ability to affect the mitosis of Drosophila progenitor cells has garnered significant interest among scientists. …”
Get full text

The Influence of Self-Perception on Manipulative Dexterity in Adults with Multiple Sclerosis by Rosa M. Martínez-Piédrola, Cristina García-Bravo, Elisabet Huertas-Hoyas, Patricia Sánchez-Herrera Baeza, Jorge Pérez-Corrales, Carlos Sánchez-Camarero, Marta Pérez-de-Heredia-Torres

“…Multiple sclerosis is a disorder which causes a loss of functionality, affecting the person’s ability to perform activities of daily living, such as interpersonal interactions and relationship, dressing, self-care, or bathing, as well as having a negative impact on work and leisure activities. …”
Get full text

Exenatide Is an Effective Antihyperglycaemic Agent in a Mouse Model of Wolfram Syndrome 1 by Tuuli Sedman, Kertu Rünkorg, Maarja Krass, Hendrik Luuk, Mario Plaas, Eero Vasar, Vallo Volke

“…Exenatide increased the insulin-to-glucose ratio irrespective of genotype, demonstrating the ability to correct the impaired insulin secretion caused by wolframin deficiency. …”
Get full text

Damaged Flexibility Matrix Method for Damage Detection of Frame Buildings by Luis S. Vaca Oyola, Mónica R. Jaime Fonseca, Ramsés Rodríguez Rocha

“…The combined effects of incomplete modal information and noise were studied in a ten-story four-bay building model taken from the literature. The ability of the DFM to assess structural damage was corroborated. …”
Get full text

Clinical Holistic Medicine: Holistic Rehabilitation by Søren Ventegodt, Mark Gringols, Joav Merrick

“…Quality of life, health, and ability are often lost at the same time and most often in one decaying existential movement over 5 or 10 years. …”
Get full text

Influence of Electrostatic Interactions on the Self-Assembly of Charged Peptides by Xue Sun, Bolan Wu, Na Li, Bo Liu, Shijun Li, Liang Ma, Hangyu Zhang

“…It is noteworthy that the Z5 hydrogel in normal saline (NS) shows exceptional self-healing properties, demonstrating the ability to recover its initial strength in seconds after the removal of shear force, thus rendering it an acceptable material for printing. …”
Get full text

Application of Artificial Intelligence Models for Evapotranspiration Prediction along the Southern Coast of Turkey by Mohammed Majeed Hameed, Mohamed Khalid AlOmar, Siti Fatin Mohd Razali, Mohammed Abd Kareem Khalaf, Wajdi Jaber Baniya, Ahmad Sharafati, Mohammed Abdulhakim AlSaadi

“…Moreover, among the 10 statistical measures, the uncertainty at 95% U95 indicator showed an excellent ability to select the best and most efficient forecast model. …”
Get full text

Carbon Nanofiber-Reinforced Carbon Black Support for Enhancing the Durability of Catalysts Used in Proton Exchange Membrane Fuel Cells Against Carbon Corrosion by Minki Sung, Hyeonseok Yi, Jimin Han, Jong Beom Lee, Seong-Ho Yoon, Joo-Il Park

“…The improved performance of the MEAs with the hybrid carbon support is attributed to the ability of the CNF to act as a structural backbone, facilitate water removal, and provide abundant edge plane sites for anchoring the platinum catalyst, which promoted the oxygen reduction reaction and improved catalyst utilization. …”
Get full text

Reprogramming of Melanoma Tumor-Infiltrating Lymphocytes to Induced Pluripotent Stem Cells by Hidehito Saito, Keisuke Okita, Noemi Fusaki, Michael S. Sabel, Alfred E. Chang, Fumito Ito

“…A wide variety of T cell receptor gene rearrangement patterns in TIL-derived iPSCs confirmed the heterogeneity of T cells infiltrating melanomas. The ability to reprogram TILs containing patient-specific tumor-reactive repertoire might allow the generation of patient- and tumor-specific polyclonal T cells for cancer immunotherapy.…”
Get full text

Antrodia cinnamomea ameliorates neointimal formation by inhibiting inflammatory cell infiltration through downregulation of adhesion molecule expression in vitro and in vivo by Yan Zhang, Aijin Ma, Hao Xi, Ning Chen, Rong Wang, Chenhui Yang, Jinbang Chen, Pin Lv, Fuping Zheng, Wenyi Kang

“…Mechanistically, EEAC suppressed expression levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule (VCAM-1) in VSMCs, which attenuates the ability of monocytes/macrophages adhesion to VSMCs. …”
Get full text

Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells by Marta Buzzetti, Sonia Morlando, Dimitrios Solomos, Ammara Mehmood, Alexander W. I. Cox, Mattia Chiesa, Yuri D’Alessandra, Michela Garofalo, Caroline H. Topham, Gianpiero Di Leva

“…We present evidence supporting dinaciclib’s ability to inhibit MB cells in vitro proliferation at considerably lower doses than palbociclib. …”
Get full text

Physicochemical properties and drug likeness of hydroxycinnamic acids and their molecular docking with caffeine and amoxicillin: Potential anticancer drugs by Umer Sherefedin, Abebe Belay, Kusse Gudishe, Alemu Kebede, Alemayehu Getahun Kumela, Tesfaye Feyisa, Jebel Haji Mahamud, Shallo Fekadu

“…FA and p-CA also showed favorable pharmacokinetic properties, including high gastrointestinal absorption, low drug–drug interaction risks, and a predicted ability to permeate the blood–brain barrier. These findings support the therapeutic potential of HCAs, particularly p-CA, as promising anticancer agents, warranting further experimental and clinical investigations to optimize their efficacy and safety.…”
Get full text