A Theoretical Study on the Efficacy and Mechanism of Combined YAP-1 and PARP-1 Inhibitors in the Treatment of Glioblastoma Multiforme Using Peruvian Maca <i>Lepidium meyenii</i> by Albert Gabriel Turpo-Peqqueña, Sebastian Luna-Prado, Renato Javier Valencia-Arce, Fabio Leonardo Del-Carpio-Carrazco, Badhin Gómez

“…Current therapeutic strategies, including surgery, chemotherapy, and radiotherapy, often fail due to the tumor’s ability to develop resistance. The proteins YAP-1 (Yes-associated protein 1) and PARP-1 (Poly-(ADP-ribose)–polymerase-1) have been implicated in this resistance, playing crucial roles in cell proliferation and DNA repair mechanisms, respectively. …”
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Improving P-Doped DBRs Operation at Cryogenic Temperatures: Investigating Different Mirror Geometry by Behzad Namvar, Topi Uusitalo, Heikki Virtanen, Mircea Guina, Jukka Viheriala

“…The use of vertical-cavity-surface-emitting lasers with ability to operate at cryogenic temperatures (Cryo-VCSELs) is a promising path to implement optical data links between superconducting processors maintained in cryogenic environments (4 K range) and room temperature (RT) computing hardware. …”
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Characterization of visual cognition in pre-manifest, manifest and reduced penetrance Huntington’s disease by Rocio Del Pino, Maria Ángeles Acera, Amaia Ortiz de Echevarrría, Beatriz Tijero, Marta Ruiz-Lopez, Johanne Somme, Javier Ruiz-Martínez, Andrea Gabilondo, Ioana M. Croitoru, Lara Pardina, Naia Ayo-Mentxakatorre, Ane Murueta-Goyena, Iñigo Gabilondo, Rosario Sanchez-Pernaute, Tamara Fernández-Valle, Juan Carlos Gómez Esteban

“…ROC analyses showed that especially visuospatial abilities, visual memory, and visual attention (AUC = 0.927, 0.878, 0.874, respectively) effectively differentiated HC and pre-manifest from early and manifest HD. …”
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Effects of Periodic Task-Specific Test Feedback on Physical Performance in Older Adults Undertaking Band-Based Resistance Exercise by Ryuichi Hasegawa, Mohammod Monirul Islam, Ryuji Watanabe, Naoki Tomiyama, Dennis R. Taaffe

“…Results from this nonrandomized study suggest that periodic test feedback during resistance training may enhance task-specific physical performance in older persons, thereby augmenting reserve capacity or potentially reducing the time required to recover functional abilities.…”
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PMA Induces Vaccine Adjuvant Activity by the Modulation of TLR Signaling Pathway by Dool-Ri Oh, Hu Won Kang, Jong-Ro Kim, Sunoh Kim, In-Kyu Park, Joon Haeng Rhee, Won Keun Oh, Young Ran Kim

“…Toll-like receptor (TLR) ligands are being developed for use as vaccine adjuvants and as immunomodulators because of their ability to stimulate innate and adaptive immune responses. …”
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Time series predictions in unmonitored sites: a survey of machine learning techniques in water resources by Jared D. Willard, Charuleka Varadharajan, Xiaowei Jia, Vipin Kumar

“…Modern machine learning methods increasingly outperform their process-based and empirical model counterparts for hydrologic time series prediction with their ability to extract information from large, diverse data sets. …”
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Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment by Fatih Ciftci, Ali Can Özarslan, İmran Cagri Kantarci, Aslihan Yelkenci, Ozlem Tavukcuoglu, Mansour Ghorbanpour

“…Drug targeting aims to ensure that the drug acts only in the pathological area; it is defined as the ability to accumulate selectively and quantitatively in the target tissue or organ, regardless of the chemical structure of the active drug substance and the method of administration. …”
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Study on the structure characterization and moisturizing effect of Tremella polysaccharide fermented from GCMCC5.39 by Meng Yang, Zilong Zhang, Yan He, Chengliang Li, Jinmei Wang, Xia Ma

“…The molecular weights of FTPS-1 and FTPS-2 were 25 722 and 177 263 Da. FTPS-2 had a better ability to prevent moisture loss, and the optimal moisture retention period was 0–4 h. …”
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Unified Quantile Regression Deep Neural Network with Time-Cognition for Probabilistic Residential Load Forecasting by Zhuofu Deng, Binbin Wang, Heng Guo, Chengwei Chai, Yanze Wang, Zhiliang Zhu

“…In addition, a novel periodical coding method marks the model to enhance its ability of capturing regular load pattern. Then, features generated from both subnetworks are fused and fed into the forecasting model with an end-to-end manner. …”
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BWFER-YOLOv8: An Enhanced Cascaded Framework for Concealed Object Detection by Khalid Ijaz, Ikramullah Khosa, Ejaz A. Ansari, Syed Farooq Ali, Asif Hussain, Faran Awais Butt

“…The nonuniform illumination also generates a higher false positive rate due to the limited ability to differentiate small hidden objects from the background of images. …”
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Effect of non-starch polysaccharides and butterfly pea flower on the in vitro digestibility of glutinous rice by Jamie Xiu Qing Siah, Teck Ann Ong, Oni Yuliarti, Joshua Ding Wei Teo

“…The findings suggest that C5 and BPF influenced the digestibility and textural properties of GR through their interactions with starch molecules and ability to form a protective layer around the rice grains. …”
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Bioconversion of Airborne Methylamine by Immobilized Recombinant Amine Oxidase from the Thermotolerant Yeast Hansenula polymorpha by Sasi Sigawi, Marina Nisnevitch, Oksana Zakalska, Andriy Zakalskiy, Yeshayahu Nitzan, Mykhailo Gonchar

“…The primary amine oxidase (primary amine : oxygen oxidoreductase (deaminating) or amine oxidase, AMO; EC 1.4.3.21), a copper-containing enzyme from the thermotolerant yeast Hansenula polymorpha which was overexpressed in baker’s yeast Saccharomyces cerevisiae, was tested for its ability to oxidize airborne methylamine. A continuous fluidized bed bioreactor (CFBR) was designed to enable bioconversion of airborne methylamine by AMO immobilized in calcium alginate (CA) beads. …”
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Using Generative Adversarial Networks for the synthesis of emotional facial expressions in virtual educational environments by William Villegas-Ch, Alexandra Maldonado Navarro, Araceli Mera-Navarrete

“…This tuning optimizes the discriminator’s ability to identify the minor details in facial expressions by using perceptual losses, allowing for better differentiation between the generated emotions, reducing classification errors, and improving precision in difficult-to-represent emotions. …”
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In Vitro Differentiation of First Trimester Human Umbilical Cord Perivascular Cells into Contracting Cardiomyocyte-Like Cells by Peter Szaraz, Matthew Librach, Leila Maghen, Farwah Iqbal, Tanya A. Barretto, Shlomit Kenigsberg, Andrée Gauthier-Fisher, Clifford L. Librach

“…When applying aggregate-based differentiation, FTM HUCPVCs showed increased aggregate formation potential and generated contracting cells within 1 week of coculture, making them the first MSC type with this ability. Our results indicate that young FTM HUCPVCs have superior cardiomyogenic potential coupled with beneficial immunogenic properties when compared to MSCs of older tissue sources, suggesting that in vitro predifferentiation could be a potential strategy to increase their effectiveness in vivo.…”
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Oilpalm-RTMDet: An lightweight oil palm detector base on RTMDet by Jirong Ding, Runlian Huang, Yehua Liang, Xin Weng, Jianjun Chen, Haotian You

“…Finally, the SGEAttention mechanism is introduced to enhance the extraction ability of oil palm tree features. The experimental results show that Oilpalm-RTMDET model has higher target detection accuracy, with AP50 and AP75 achieving 94.1 % and 58 % respectively, and FPS of 48.4 img/s, which is better than that of RTMDET model. …”
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Feature Fusion Model Using Transfer Learning and Bidirectional Attention Mechanism for Plant Pipeline Leak Detection by Yujin Han, Yourak Choi, Jonghyuk Lee, Ji-Hoon Bae

“…An attention mechanism is incorporated within the LSTM to prioritize critical features, enhancing the ability of the model to distinguish leak signals from noise. …”
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Clinical Management of Children and Adolescents with Neurofibromatosis Type 1 Like Phenotypes and Complex Behavioural Manifestations: A Multidisciplinary and Dimensional Approach by Ana Moscoso, Aurélie Julien, Antoine Tanet, Angèle Consoli, Martine Pagnard, France Trevisan, Isabelle Kemlin, Diana Rodriguez, David Cohen

“…For the selected cases, we performed a psychiatric assessment, a tailored neuropsychological evaluation based on clinical demands and history, broad speech and motor skills evaluations if there were concerns regarding language, motor abilities and/or learning difficulties and autism specific evaluations, if clinically relevant. …”
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Activation of Human Neutrophils by the Anti-Inflammatory Mediator Esenbeckia leiocarpa Leads to Atypical Apoptosis by Rafael de Liz, Heros Horst, Moacir Geraldo Pizzolatti, Tânia Silvia Fröde, Denis Girard

“…Since the resolution of inflammation occurs by elimination of apoptotic neutrophils, the ability of CHE to induce neutrophil apoptosis correlates well with its anti-inflammatory properties, as previously reported.…”
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Amphiphiles Self-Assembly: Basic Concepts and Future Perspectives of Supramolecular Approaches by Domenico Lombardo, Mikhail A. Kiselev, Salvatore Magazù, Pietro Calandra

“…Amphiphiles are synthetic or natural molecules with the ability to self-assemble into a wide variety of structures including micelles, vesicles, nanotubes, nanofibers, and lamellae. …”
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Psychologic Resilience and Related Factors in the Euthymic Bipolar Patients by Ersin Uygun, Aylin Koseoglu, Suat Kucukgoncu, Sahap N. Erkoc

“…This fact attracted the attention onto the psychological resilience, which is the ability of dealing with stressful life-events and overcoming the traumatic experiences, and it has become a phenomenon that is taken into consideration to empower the protective factors for the disorder. …”
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