Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy respo... by Benjamin H. Jenkins, Ian Tracy, Maria Fernanda S. D. Rodrigues, Melanie J. L. Smith, Begoña R. Martinez, Mark Edmond, Sangeetha Mahadevan, Anjali Rao, Hailing Zong, Kai Liu, Abhishek Aggarwal, Li Li, Lauri Diehl, Emma V. King, Jamie G. Bates, Christopher J. Hanley, Gareth J. Thomas

“…IL-11 + iCAF were spatially associated with inflammatory monocytes and regulated in vitro through synergistic activation of canonical NF-κB signalling by IL-1β and TNF-α. FRC-like were enriched in immune-hot HPV+ve tumours, associated with CD4 + T-cells and B-cells in tertiary lymphoid structures and regulated through non-canonical NF-κB signalling via lymphotoxin. …”
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CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models by Felipe Saceanu Leser, Flavio de Souza Júnyor, Iohanna Bianca Pagnoncelli, Anna Beatriz Delgado, Isabelle Medeiros, Ana Clara Campanelli Nóbrega, Brenda da Silva Andrade, Maiara Nascimento de Lima, Nícolas Emanoel da Silva, Laurent Jacob, Kevin Boyé, Luiz Henrique Medeiros Geraldo, Alessandra Mendonça Teles de Souza, Tatiana Maron-Gutierrez, Hugo Castro-Faria-Neto, Cristian Follmer, Carolina Braga, Gilda Angela Neves, Anne Eichmann, Luciana Ferreira Romão, Flavia Regina Souza Lima

“…Mechanistically, neuronal CCL21 was shown to regulate microglial cell migration, proliferation, and activation in a CCR7-dependent manner through both canonical (PI3K/AKT) and non-canonical (ERK1/2/JNK) signaling pathways. …”
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Nietzsche y la razón poética (Reflexión sobre la postura nietzscheana en torno a la cuestión de la razón moderna) (Artículo) by Luis Antonio Velasco Guzmán

“…This paper analyses the possibility that opens up Nietzsche's claim about the poetic reason as an independent and different knowledge against the one that is characterized with the canonical characteristics of the strong rationality (such as "system", "method", "clarity", etc.), and try to scrutinize its epistemological thesis. …”
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Robust High-Gain Observers Based Liquid Levels and Leakage Flow Rate Estimation by Feten Smida, Salim Hadj Saïd, Faouzi M’sahli

“…We have proposed a state repartition that allows putting the model of the quadruple tank system to the canonical form for which the design of the observer is more easier. …”
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Three-loop ladder diagrams with two off-shell legs by Ming-Ming Long

“…We provide solutions to the canonical differential equations of two integral families in both Euclidean and physical regions. …”
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Behavior of a Free Dual-Spin Gyrostat with Different Ratios of Inertia Moments by Vladimir Aslanov

“…The dimensionless nonlinear equations of the gyrostat are written in Serret-Andoyer canonical variables. The previously known exact solutions are complemented by new several solutions in terms of Jacobi elliptic functions. …”
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A New Solution to the Matrix Equation X−AX¯B=C by Caiqin Song

“…The proposed approach does not require the coefficient matrices to be in arbitrary canonical form. At the end of this paper, the numerical example is shown to illustrate the effectiveness of the proposed method.…”
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'Woorde in die mond gelê'? Psalmomdigting en die proses van kanonvorming by E. Kloppers

“…In this article the origin and history of these views are investigated and are evaluated against the background of the formation of canons on various levels. Some canonised views and traditions that need critical rethinking are indicated at the end of the article. …”
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Crevicular Alkaline Phosphatase Activity and Rate of Tooth Movement of Female Orthodontic Subjects under Different Continuous Force Applications by Rohaya Megat Abdul Wahab, Maryati Md Dasor, Sahidan Senafi, Asma Alhusna Abang Abdullah, Zulham Yamamoto, Abdul Aziz Jemain, Shahrul Hisham Zainal Ariffin

“…Canine retraction was performed using nickel titanium coil spring that delivered forces of 100 gm or 150 gm to either side. …”
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VARIOUS LABIAL BOW MODIFICATION IN REMOVABLE ORTHODONTIC APPLIANCE by Ajeng Firliana Dewi, Elly Rusdiana, Sianiwati Goenharto

“…The variations include labial arch with M-loop, labial arch with canine retraction loop, labial arch with loop on canine, and labial arch with Andresen loop. …”
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Cutaneous Disease as Sole Clinical Manifestation of Protothecosis in a Boxer Dog by Emmanouil I. Papadogiannakis, Emmanouil N. Velonakis, Gregory K. Spanakos, Alexander F. Koutinas

“…Systemic therapy seems to be ineffective for skin nodules, at least in chronic cases of canine cutaneous protothecosis. Although canine protothecosis usually presents with the disseminated form, cutaneous disease as sole clinical manifestation of the infection may also be witnessed.…”
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Parameter and State Estimator for State Space Models by Ruifeng Ding, Linfan Zhuang

“…This paper proposes a parameter and state estimator for canonical state space systems from measured input-output data. …”
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Urban Leisure and the Rise of Commercial Entertainment in 19th-Century Vilnius: The Role of Ivan Shuman in a Modernizing City by Juozapas Paškauskas

“… The article explores the evolution of the entertainment scene in Vilnius during the second half of the 19th century, focusing on its marginal position outside national canons and mainstream theatre. Through the work of Ivan Antonovich Shuman, the city’s first entertainment entrepreneur, the study situates Vilnius’ post-serfdom and post-uprising entertainment culture within a broader regional context. …”
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Classical Theory of Linear Multistep Methods for Volterra Functional Differential Equations by Yunfei Li, Shoufu Li

“…Based on the linear multistep methods for ordinary differential equations (ODEs) and the canonical interpolation theory that was presented by Shoufu Li who is exactly the second author of this paper, we propose the linear multistep methods for general Volterra functional differential equations (VFDEs) and build the classical stability, consistency, and convergence theories of the methods. …”
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The decoupling of moduli about the standard embedding by Beatrice Chisamanga, Jock McOrist, Sebastien Picard, Eirik Eik Svanes

“…Given a stable gauge bundle over a complex threefold with trivial canonical bundle and no holomorphic vector fields, we also show that the Euler characteristic of this differential complex is zero. …”
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Novel First-Order Current-Mode All-Pass Sections Using CCIII by Sudhanshu Maheshwari, Iqbal A. Khan

“…Two new configurations realizing canonical first-order current-mode all-pass sections (APSs) using a single third generation current conveyor (CCIII) are given. …”
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Marketing strategy of the new product introduction on the market by Zdenka Kádeková, Lubica Kubicova

“…The important sources of innovation include basic and applied research, which can afford mostly the strong and large companies such as Danone Group that is the largest producer of fresh dairy products in the world and the world´s second largest supplier of the mineral water.…”
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Algebraic Verification Method for SEREs Properties via Groebner Bases Approaches by Ning Zhou, Jinzhao Wu, Xinyan Gao

“…A mechanism for constructing canonical polynomial set based symbolic representations for both circuit descriptions and assertions is studied. …”
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Jean Rhys et Shani Mootoo ou la fragmentation de l’être by Freddy Marcin

“…Feminine identity crisis will be analyzed in correlation with narrative strategies used in post-colonial and queer literatures as well as deconstruction and subversion of literary canons.…”
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Memory, Jesus, and Mary Magdalene: Whose memory matters? by N.E. Müller van Velden

“… This article explores how the collective memory of the Christian tradition draws on the characterisation of Mary Magdalene in two sets of writings: the canonical Gospels, and the Gnostic Christian writing, Gospel of Mary. …”
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