A New Four‐Component L*‐Dependent Model for Radial Diffusion Based on Solar Wind and Magnetospheric Drivers of ULF Waves by Kyle R. Murphy, Jasmine Sandhu, I. Jonathan Rae, Thomas Daggitt, Sarah Glauert, Richard B. Horne, Clare E. J. Watt, Sarah Bentley, Adam Kellerman, Louis Ozeke, Alexa J. Halford, Sheng Tian, Aaron Breneman, Leonid Olifer, Ian R. Mann, Vassilis Angelopoulos, John Wygant

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Implementation of model-informed precision dosing for tamoxifen therapy in patients with breast cancer: A prospective intervention study by Ruben Y.M. van Nijnatten, Sanne M. Buijs, Bram C. Agema, Raphaël M.J. Fischer, Inge Ghobadi Moghaddam-Helmantel, Caroline M.E. Contant, Felix E. de Jongh, Auke M.T. Huijben, Manon Kop, Annemieke van der Padt-Pruijsten, Hanneke J.M. Zuetenhorst, Ron H.N. van Schaik, Birgit C.P. Koch, A. Jager, Stijn L.W. Koolen, Ron H.J. Mathijssen

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Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult... by Stuart I. Hodgetts, Jun Han Yoon, Alysia Fogliani, Emmanuel A. Akinpelu, Danii Baron-Heeris, Imke G. J. Houwers, Lachlan P. G. Wheeler, Bernadette T. Majda, Sreya Santhakumar, Sarah J. Lovett, Emma Duce, Margaret A. Pollett, Tylie M. Wiseman, Brooke Fehily, Alan R. Harvey

“…Ciliary neurotrophic factor (CNTF) promotes survival and enhances long-distance regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene therapy targeting corticospinal neurons (CSN) in motor-related regions of the cerebral cortex promotes plasticity and regrowth of axons projecting into the female adult F344 rat spinal cord after moderate thoracic (T10) contusion injury (SCI). …”
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Piloting an automated query and scoring system to facilitate APDS patient identification from health systems by Amy M. FitzPatrick, Aaron T. Chin, Sharon Nirenberg, Charlotte Cunningham-Rundles, Keith Sacco, Jesse Perlmutter, Joseph F. Dasso, Athanasios Tsalatsanis, Jay Maru, Jessica Creech, Jolan E. Walter, Nicholas Hartog, Neema Izadi, Mandy Palmucci, Manish J. Butte, Klaus Loewy, Anurag Relan, Nicholas L. Rider

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Tailored topotactic chemistry unlocks heterostructures of magnetic intercalation compounds by Samra Husremović, Oscar Gonzalez, Berit H. Goodge, Lilia S. Xie, Zhizhi Kong, Wanlin Zhang, Sae Hee Ryu, Stephanie M. Ribet, Shannon S. Fender, Karen C. Bustillo, Chengyu Song, Jim Ciston, Takashi Taniguchi, Kenji Watanabe, Colin Ophus, Chris Jozwiak, Aaron Bostwick, Eli Rotenberg, D. Kwabena Bediako

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Review of Interventional Therapies for Refractory Pediatric Migraine by Jacquelin Peck, Justin Zeien, Megha Patel, Elyse M. Cornett, Amnon A. Berger, Jamal Hasoon, Hisham Kassem, Jai Won Jung, Giovanni F. Ramírez, Paola Colon Fugueroa, Neil R. Singhal, Jaehong Song, Adam M. Kaye, Alan D. Kaye, Sarang S. Koushik, Natalie H. Strand, Latha Ganti

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Heterogeneity of Intermediate Care Organization Within a Single Healthcare System by Aaron S. Case, MD, MHS, Chad H. Hochberg, MD, MHS, Binu Koirala, PhD, MGS, BSN, RN, Eleni Flanagan, DNP, MBA, Souvik Chatterjee, MD, William N. Checkley, MD, PhD, Ayse P. Gurses, PhD, MS, MPH, David N. Hager, MD, PhD

“…Six IC settings (50%) were embedded within acute care wards, four (33%) were stand-alone units, and two (17%) were embedded within an ICU. …”
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CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair by Luc Provencher, Wilson Nartey, Peter M. Brownlee, Austin W. Atkins, Jean-Philippe Gagné, Lou Baudrier, Nicholas S. Y. Ting, Cortt G. Piett, Shujuan Fang, Dustin D. Pearson, Shaun Moore, Pierre Billon, Zachary D. Nagel, Guy G. Poirier, Gareth J. Williams, Aaron A. Goodarzi

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The inflammasome adaptor protein ASC promotes amyloid deposition in cryopyrin-associated periodic syndromes by Cristina Alarcón-Vila, Laura Hurtado-Navarro, Sandra V Mateo, Alejandro Peñín-Franch, Carlos M Martínez, Cristina Molina-López, María C Baños, Ana I Gómez, Javier Gómez-Román, Alberto Baroja-Mazo, Juan I Arostegui, Natalia Palmou-Fontana, Juan J Martínez-García, Pablo Pelegrin

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Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

“…The problems found in the current healthcare model were grouped into ten main areas: (1) the healthcare model for RDs; (2) coordination with primary healthcare providers and other tertiary and secondary hospitals; (3) access to and coordination with non-medical services; (4) the role of case manager in the XUEC; (5) genetic diagnosis; (6) undiagnosed patients; (7) treatments; (8) referring process, continuous follow-up, and transition from pediatric to adult centers; (9) research and education for professionals; and (10) associations of PLWRD and their families (patients’ advocacy). …”
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Open-label dose-extending placebos for opioid use disorder: a protocol for a randomised controlled clinical trial with methadone treatment by Annabelle M Belcher, Thomas O Cole, Aaron D Greenblatt, Stephen W Hoag, David H Epstein, Michael Wagner, Amy S Billing, Ebonie Massey, Kristen R Hamilton, Zofia K Kozak, Christopher J Welsh, Eric Weintraub, Emerson M Wickwire, Eric D Wish, Ted J Kaptchuk, Luana Colloca

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Enhancing lung transplantation with ECMO: a comprehensive review of mechanisms, outcomes, and future considerations by Pervaiz Butt Salman, Kakar Vivek, Abdulaziz Salman, Razzaq Nabeel, Saleem Yasir, Kumar Arun, Ashiq Fazil, Ghisulal Praveen, Thrush Aaron, Malik Sadaf, Griffin Mairead, Amir Mahanoor, Khan Umar, Salim Ashal, Zoumot Zaid, Mydin Izanee, Aljabery Yazan, Bhatnagar Gopal, Bayrak Yusuf, Obeso Andres, Ahmed Usman

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Challenges with achieving and maintaining oral cholera vaccine coverage: insights from serial cross-sectional representative surveys in a cholera-endemic community in the Democrati... by Oliver Cumming, Andrew S Azman, Espoir Bwenge Malembaka, Jackie Knee, Placide Okitayemba Welo, Aimé Cikomola, Aybüke Koyuncu, Patrick Musole Bugeme, Juan Dent, Chloe Hutchins, Hanmeng Xu, Karin Gallandat, Joseph Matundanya, Delphin Rukakiza, Merveille Nkombo, Jaime Saidi Mufitini, Baron Bashige Rumedeka, Laurent Akilimali, Elizabeth C Lee

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X-ray phase contrast imaging and diffraction in the laser-heated diamond anvil cell: A case study on the high-pressure melting of Pt by Emma Ehrenreich-Petersen, Bernhard Massani, Thea Engler, Olivia S. Pardo, Konstantin Glazyrin, Nico Giordano, Johannes Hagemann, Daniel Sneed, Timofey Fedotenko, Daniel J. Campbell, Mario Wendt, Sergej Wenz, Christian G. Schroer, Mathias Trabs, R.Stewart McWilliams, Hanns-Peter Liermann, Zsolt Jenei, Earl F. O’Bannon

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Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: a multicentre, prospective study by Rina Triasih, Yan Mardian, Dewi Lokida, Helmia Farida, Herman Kosasih, Adhella Menur Naysilla, Arif Budiman, Chakrawati Hayuningsih, Moh Syarofil Anam, Dwi Wastoro, Mujahidah Mujahidah, Setya Dipayana, Amalia Setyati, Abu Tholib Aman, Nurhayati Lukman, Muhammad Karyana, Ahnika Kline, Aaron Neal, Chuen-Yen Lau, Clifford Lane

“…The five most common causative pathogens identified were Haemophilus influenzae non-type B (N=73, 38.8%), respiratory syncytial virus (RSV) (N=51, 27.1%), Klebsiella pneumoniae (N=43, 22.9%), Streptococcus pneumoniae (N=29, 15.4%) and Influenza virus (N=25, 13.3%). …”
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Usefulness of Adalimumab in the Treatment of Refractory Uveitis Associated with Juvenile Idiopathic Arthritis by Carmen García-De-Vicuña, Manuel Díaz-Llopis, David Salom, Rosa Bou, Jesus Díaz-Cascajosa, Miguel Cordero-Coma, Gabriela Ortega, Norberto Ortego-Centeno, Marta Suarez-De-Figueroa, Juan Cruz-Martínez, Alex Fonollosa, Ricardo Blanco, Ángel María García-Aparicio, Jose M. Benítez-Del-Castillo, Jordi Antón

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PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma by Valentin Van den bossche, Julie Vignau, Engy Vigneron, Isabella Rizzi, Hannah Zaryouh, An Wouters, Jérôme Ambroise, Steven Van Laere, Simon Beyaert, Raphaël Helaers, Cédric van Marcke, Lionel Mignion, Elise Y. Lepicard, Bénédicte F. Jordan, Céline Guilbaud, Olivier Lowyck, Hajar Dahou, Antonella Mendola, Manon Desgres, Léo Aubert, Isabelle Gerin, Guido T. Bommer, Romain Boidot, Perrine Vermonden, Aurélien Warnant, Yvan Larondelle, Jean-Pascal Machiels, Olivier Feron, Sandra Schmitz, Cyril Corbet

“…This study points out lipid metabolism rewiring as a non-genetic resistance-causing mechanism in HNSCC that may be therapeutically targeted to overcome acquired resistance to anti-EGFR therapy.…”
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Limited Effect of Future Land‐Use Changes on Human Heat Stress and Labor Capacity by Steven J. DeHertog, Anton Orlov, Felix Havermann, Suqi Guo, Iris Manola, Julia Pongratz, Quentin Lejeune, Carl‐Friedrich Schleussner, Inga Menke, Florian Humpenöder, Alexander Popp, Peter Lawrence, George C. Hurtt, Louise Chini, Inne Vanderkelen, Edouard L. Davin, Thomas Reerink, Sonia I. Seneviratne, Hans Verbeeck, Wim Thiery

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Intensified monsoonal rainstorm events over westerly-dominated Asian interior during the warm mid-Holocene by Peixian Shu, Weijian Zhou, Aaron E. Putnam, Baosheng Li, Shugang Kang, Yingying Sha, Zhengguo Shi, Guodong Ming, Hong Wang, Youbin Sun, David K. Wright, Weiguo Liu, Xiaodong Liu, Peng Cheng, Yougui Song, Dongfeng Niu, John R. Dodson, Hua Du, Jiaju Zhao, Zeke Zhang, Yahui Qiu, Zhisheng An

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Tungsten Diselenide Nanoparticles Produced via Femtosecond Ablation for SERS and Theranostics Applications by Andrei Ushkov, Dmitriy Dyubo, Nadezhda Belozerova, Ivan Kazantsev, Dmitry Yakubovsky, Alexander Syuy, Gleb V. Tikhonowski, Daniil Tselikov, Ilya Martynov, Georgy Ermolaev, Dmitriy Grudinin, Alexander Melentev, Anton A. Popov, Alexander Chernov, Alexey D. Bolshakov, Andrey A. Vyshnevyy, Aleksey Arsenin, Andrei V. Kabashin, Gleb I. Tselikov, Valentyn Volkov

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