Insights from UKCTOCS for design, conduct and analyses of large randomised controlled trials by Usha Menon, Aleksandra Gentry-Maharaj, Matthew Burnell, Sophia Apostolidou, Andy Ryan, Jatinderpal K Kalsi, Naveena Singh, Lesley Fallowfield, Alistair J McGuire, Stuart Campbell, Steven J Skates, Anne Dawnay, Mahesh Parmar, Ian J Jacobs

“…This included online forms that the teams completed in real time (resulting in an almost paperless trial) and systems to check and manage trial processes and track blood samples. We automated key steps such as checking whether participants were eligible, assigning correct action based on results of screening tests, scheduling appointments and printing letters. …”
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Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts by Seyma Katrinli, Agaz H. Wani, Adam X. Maihofer, Andrew Ratanatharathorn, Nikolaos P. Daskalakis, Janitza Montalvo-Ortiz, Diana L. Núñez-Ríos, Anthony S. Zannas, Xiang Zhao, Allison E. Aiello, Allison E. Ashley-Koch, Diana Avetyan, Dewleen G. Baker, Jean C. Beckham, Marco P. Boks, Leslie A. Brick, Evelyn Bromet, Frances A. Champagne, Chia-Yen Chen, Shareefa Dalvie, Michelle F. Dennis, Segun Fatumo, Catherine Fortier, Sandro Galea, Melanie E. Garrett, Elbert Geuze, Gerald Grant, Michael A. Hauser, Jasmeet P. Hayes, Sian M. J. Hemmings, Bertrand Russel Huber, Aarti Jajoo, Stefan Jansen, Ronald C. Kessler, Nathan A. Kimbrel, Anthony P. King, Joel E. Kleinman, Nastassja Koen, Karestan C. Koenen, Pei-Fen Kuan, Israel Liberzon, Sarah D. Linnstaedt, Adriana Lori, Benjamin J. Luft, Jurjen J. Luykx, Christine E. Marx, Samuel A. McLean, Divya Mehta, William Milberg, Mark W. Miller, Mary S. Mufford, Clarisse Musanabaganwa, Jean Mutabaruka, Leon Mutesa, Charles B. Nemeroff, Nicole R. Nugent, Holly K. Orcutt, Xue-Jun Qin, Sheila A. M. Rauch, Kerry J. Ressler, Victoria B. Risbrough, Eugène Rutembesa, Bart P. F. Rutten, Soraya Seedat, Dan J. Stein, Murray B. Stein, Sylvanus Toikumo, Robert J. Ursano, Annette Uwineza, Mieke H. Verfaellie, Eric Vermetten, Christiaan H. Vinkers, Erin B. Ware, Derek E. Wildman, Erika J. Wolf, Ross McD Young, Ying Zhao, Leigh L. van den Heuvel, PGC-PTSD Epigenetics Workgroup, PsychENCODE PTSD Brainomics Project, Traumatic Stress Brain Research Group, Monica Uddin, Caroline M. Nievergelt, Alicia K. Smith, Mark W. Logue

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Sport participation as an educational tool and a means of promoting physical, mental, and social well-being by Francesco Sgrò

“…Monacis (2024) presented a Dual Career model based on the results of an orientation and tutoring project developed in Puglia, involving a sample of over 100 students from the province of Lecce. …”
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COVID-19 – if the cure is worse than the disease. The Italian chaos by Giuseppe FERRARI

“…However, the active cases curve is based on an unreliable sample of people tested positive to the COVID-19. …”

Adropin expression reflects circadian, lipoprotein, and mitochondrial processes in human tissues by Joseph R. Stevens, Clemence Girardet, Mingqi Zhou, Farah Gamie, Geetika Aggarwal, Ryan P. McMillan, Matthew W. Hulver, Laurent O. Martinez, Marcel van der Brug, Bruno Vellas, Andrew D. Nguyen, Marcus M. Seldin, Andrew A. Butler, MAPT Study Group, Principal investigator, Bruno Vellas, Coordination, Sophie Guyonnet, Project leader, Isabelle Carrié, CRA, Lauréane Brigitte, Investigators, Catherine Faisant, Françoise Lala, Julien Delrieu, Hélène Villars, Psychologists, Emeline Combrouze, Carole Badufle, Audrey Zueras, Methodology, statistical analysis and data management, Sandrine Andrieu, Christelle Cantet, Christophe Morin, Multidomain group, Gabor Abellan Van Kan, Charlotte Dupuy, Yves Rolland, Céline Caillaud, Pierre-Jean Ousset, Françoise Lala, Co-Investigators in associated centres, Jean-François Dartigues, Isabelle Marcet, Fleur Delva, Alexandra Foubert, Sandrine Cerda, Marie-Noëlle Cuffi, Corinne Costes, Olivier Rouaud, Patrick Manckoundia, Valérie Quipourt, Sophie Marilier, Evelyne Franon, Lawrence Bories, Marie-Laure Pader, Marie-France Basset, Bruno Lapoujade, Valérie Faure, Michael Li Yung Tong, Christine Malick-Loiseau, Evelyne Cazaban-Campistron, Françoise Desclaux, Colette Blatge, Thierry Dantoine, Cécile Laubarie-Mouret, Isabelle Saulnier, Jean-Pierre Clément, Marie-Agnès Picat, Laurence Bernard-Bourzeix, Stéphanie Willebois, Iléana Désormais, Noëlle Cardinaud, Marc Bonnefoy, Pierre Livet, Pascale Rebaudet, Claire Gédéon, Catherine Burdet, Flavien Terracol, Alain Pesce, Stéphanie Roth, Sylvie Chaillou, Sandrine Louchart, Kristel Sudres, Nicolas Lebrun, Nadège Barro-Belaygues, Jacques Touchon, Karim Bennys, Audrey Gabelle, Aurélia Romano, Lynda Touati, Cécilia Marelli, Cécile Pays, Philippe Robert, Franck Le Duff, Claire Gervais, Sébastien Gonfrier, Yannick Gasnier, Serge Bordes, Danièle Begorre, Christian Carpuat, Khaled Khales, Jean-François Lefebvre, Samira Misbah El Idrissi, Pierre Skolil, Jean-Pierre Salles, MRI group, Carole Dufouil, Stéphane Lehéricy, Marie Chupin, Jean-François Mangin, Ali Bouhayia, Michèle Allard, Frédéric Ricolfi, Dominique Dubois, Marie Paule Bonceour Martel, François Cotton, Alain Bonafé, Stéphane Chanalet, Françoise Hugon, Fabrice Bonneville, Christophe Cognard, François Chollet, PET scans group, Pierre Payoux, Thierry Voisin, Julien Delrieu, Sophie Peiffer, Anne Hitzel, Michèle Allard, Michel Zanca, Jacques Monteil, Jacques Darcourt, Medico-economics group, Laurent Molinier, Hélène Derumeaux, Nadège Costa, Biological sample collection, Bertrand Perret, Claire Vinel, Sylvie Caspar-Bauguil, Safety management, Pascale Olivier-Abbal, IHU Open Science Group, Nicola Coley, Sandrine Andrieu, Christelle Cantet, Sophie Guyonnet

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Increasing uptake of self-management education programmes for type 2 diabetes in primary care: the Embedding research programme including an RCT by Melanie J Davies, Shona Agarwal, Danielle H Bodicoat, Alan Brennan, Simon Dixon, Helen Eborall, Agnieszka Glab, Laura J Gray, Michelle Hadjiconstantinou, Lisa Huddlestone, Nicky Hudson, Anju Keetharuth, Kamlesh Khunti, Caroline Kristunas, Graham Martin, Alison Northern, Mike Patterson, Daniel Pollard, Rebecca Pritchard, Sally Schreder, Jane Speight, Bernie Stribling, Jackie Sturt, Jess Turner, Christina Weis

“…Contributors provided governance and oversight of the project, offered advice on recruitment, publicity, local culture and dissemination, and acted as a critical friend giving feedback on project delivery in the local context. …”
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Cervical ripening at home or in hospital during induction of labour: the CHOICE prospective cohort study, process evaluation and economic analysis by Mairead Black, Cassandra Yuill, Mairi Harkness, Sayem Ahmed, Linda Williams, Kathleen A Boyd, Maggie Reid, Amar Bhide, Neelam Heera, Jane Huddleston, Neena Modi, John Norrie, Dharmintra Pasupathy, Julia Sanders, Gordon C S Smith, Rosemary Townsend, Helen Cheyne, Christine McCourt, Sarah Stock

“…The sample included geographically and socially diverse populations. …”
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Vergence Eye Movements: From Basic Science to Clinical Application by Wolfgang Jaschinski, Rudolf Groner

“…The mean point of vergence is biased under projection. Journal of Eye Movement Research, 12(4). https://doi.org/10.16910/jemr.12.4.2. …”
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Organizational Culture and Stock Price Crash Risk by Gholamreza Kordestani, Ramin Eskandari, Mahdi Shams

“…In other words, managers tend to strategically withhold negative news about the organization and loss-making projects during such times. This can lead to the accumulation of bad news regarding the fundamental status and performance of the organization. …”
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Understanding the effectiveness and underlying mechanisms of lifestyle modification interventions in adults with learning disabilities: a mixed-methods systematic review by Dikshyanta Rana, Sophie Westrop, Nishant Jaiswal, Evi Germeni, Arlene McGarty, Louisa Ells, Phillippa Lally, Michael McEwan, Craig Melville, Leanne Harris, Olivia Wu

“…A patient and public involvement group provided input and insights throughout the project. Results A total of 80 studies with 4805 participants were included in the systematic review. …”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…External validation was conducted to assess model performance in another sample from a similar population as the development cohort. …”
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Characterizing the marine iodine cycle and its relationship to ocean deoxygenation in an Earth system model by K. Cheng, A. Ridgwell, D. S. Hardisty

“…However, although I <span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M4" display="inline" overflow="scroll" dspmath="mathml"><mo>/</mo></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="8pt" height="14pt" class="svg-formula" dspmath="mathimg" md5hash="57ee8123d9c9aefcf23d9c7f6463c158"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="bg-21-4927-2024-ie00003.svg" width="8pt" height="14pt" src="bg-21-4927-2024-ie00003.png"/></svg:svg></span></span> Ca ratios are increasingly commonly being measured in ancient carbonate samples, a fully quantitative interpretation of this proxy requires the availability of a mechanistic interpretative framework for the marine iodine cycle that can account for the extent and intensity of ocean deoxygenation in the past. …”
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The implementation of Safety Management Systems in healthcare: a systematic review and international comparison by Zhivko Zhelev, Sian de Bell, Alison Bethel, Maria Clarke, Rob Anderson, Jo Thompson Coon

“…Stakeholder and public and patient involvement Experts from patient safety organisations in each country and public collaborators provided feedback throughout the project. How up to date is this review? The review was based on documents published between 2007 and 2023. …”
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Integrating Palliative Care and Heart Failure: the PalliatHeartSynthesis realist synthesis by Tracey McConnell, Carolyn Blair, Geoff Wong, Claire Duddy, Clare Howie, Loreena Hill, Joanne Reid

“…Consistency checks Consistency checks were carried out by a second reviewer Tracey McConnell (TM) on a 10% random sample of the screening (title, abstract and full text) and the coding process for the main search. …”
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Emotional literacy programme in special schools for children with a learning disability in England: the ZF-SEND feasibility RCT by Biza Stenfert Kroese, Gemma Unwin, Richard Hastings, Andrew Jahoda, Rachel McNamara, David Gillespie, Jeremy Segrott, Kate Ingarfield, Myrsini Gianatsi, Elizabeth Randell, Zoe Mather, Barbara Barrett, Poushali Ganguli, John Rose, Mariam Sahle, Emily Warren, Nathan Da Cruz

“…Conclusions The findings of this study indicate that a large-scale randomised controlled trial is feasible provided that a number of amendments to the study design are made to improve: (1) the timing of the project to suit the demands of special schools’ yearly timetable; (2) recruitment and (3) outcome and service use data collection. …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…Data on health service utilisation, productivity loss and patient out-of-pocket expenses were collected at baseline and 12 months using a modified online version of the Client Service Receipt Inventory. Sample size An a priori sample size calculation of n = 380 dyads was computed as being sufficient to detect a standardised effect size of Cohen’s d = 0.4 for patient DASS-21 at 12 months post randomisation. …”
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Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…Objectives The overall objectives of this project are to examine the clinical effectiveness and cost-effectiveness of HCL systems for managing glucose levels in people who have type 1 diabetes. …”
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Glycaemic control in labour with diabetes: GILD, a scoping study by Nia Wyn Jones, Eleanor J Mitchell, Kate F Walker, Susan Ayers, Lucy Bradshaw, Georgina Constantinou, Tasso Gazis, Shalini Ojha, Phoebe Pallotti, Stavros Petrou, Rachel Plachcinski, Michael Rimmer, Liz Schroeder, Jim G Thornton, Natalie Wakefield

“…Limitations Glucose levels may be poorly recorded in maternity notes and in practice tested more frequently than the study suggests. Sample sizes in some of the work packages were smaller than our pre-specified target, attrition in the Delphi survey was greater than anticipated and the study was conducted during the COVID-19 pandemic impacting results. …”
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Optimising neonatal services for very preterm births between 27+0 and 31+6 weeks gestation in England: the OPTI-PREM mixed-methods study by Thillagavathie Pillay, Oliver Rivero-Arias, Natalie Armstrong, Sarah E Seaton, Miaoqing Yang, Victor L Banda, Kelvin Dawson, Abdul QT Ismail, Vasiliki Bountziouka, Caroline Cupit, Alexis Paton, Bradley N Manktelow, Elizabeth S Draper, Neena Modi, Helen E Campbell, Elaine M Boyle

“…Key stakeholders engaged, supported the OPTI-PREM project, and participated in discussions on potential implications of our findings. …”
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The Ethical Significance of Brain-Computer Interfaces as Enablers of Communication by Toma Gruica

“…Fall 2021, Spectrum. https://voices.uchicago.edu/triplehelix/2025/01/02/the-future-of-medicine-or-an-ethical-nightmare-elon-musks-neuralink-and-the-advent-of-brain-machine-interfaces/ [4] Burwell, S., Sample, M., & Racine, E. (2017). Ethical aspects of brain-computer interfaces: A scoping review. …”
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