Molecular feature-based classification of retroperitoneal liposarcoma: a prospective cohort study by Mengmeng Xiao, Xiangji Li, Fanqin Bu, Shixiang Ma, Xiaohan Yang, Jun Chen, Yu Zhao, Ferdinando Cananzi, Chenghua Luo, Li Min

“…The GSVA algorithm was utilized to assess signaling pathway levels in each sample, and unsupervised clustering was employed to distinguish RPLS subtypes. …”
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A surveillance study to determine the accuracy of mild traumatic brain injury diagnosis in an emergency department: protocol for a retrospective cohort study by Ian D Cameron, Ilaria Pozzato, Ashley Craig, Bamini Gopinath, Mark Gillett, Annette Kifley, Kim Van Vu, Susanne Meares, Anthony Liang

“…We estimate that 30 000 ED attendances will be screened and that a sample size of 500 cases with mTBI will be identified during this 1-year period, which will provide reliable estimates of mTBI occurrence in the ED setting.Ethics and dissemination The study was approved by the Northern Sydney Local Health District Ethics Committee. …”
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Improvement of Nanopore sequencing provides access to high quality genomic data for multi-component CRESS-DNA plant viruses by Daniel H. Otron, Denis Filloux, Andy Brousse, Murielle Hoareau, Babbitha Fenelon, Cécile Hoareau, Emmanuel Fernandez, Fidèle Tiendrébéogo, Jean-Michel Lett, Justin S. Pita, Philippe Roumagnac, Pierre Lefeuvre

“…Whereas alternatives have proved effective in some applications, there is a strong need for next-generation sequencing methods suitable for small-scale projects that can routinely produce high quality sequences comparable to the gold standard Sanger sequencing. …”
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Coproducing a culturally sensitive storytelling video intervention to improve psychosocial well-being: a multimethods participatory study with Nepalese migrant workers by Jackie Cassell, Daniel Michelson, Padam Simkhada, Priyamvada Paudyal, Kavian Kulasabanathan, Anjum Memon, Sharada Prasad Wasti, Ram Silwal, Edwin R van Teijlingen, Pimala Neupane, Jib Lal Sapkota, Carol Watts, Prajaya Shukla, Ram Sharan Pathak, Clio Berry, Alice Moult

“…Despite these limitations, the project is testament to the value of participatory methods in the development of culturally sensitive public health interventions for marginalised groups, and points to the utility of coproduced storytelling formats in migrant health contexts. …”
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Hospital Stage of Myocardial Infarction Treatment in 13 Regions of Russian Federation by Results of the International Research by A. V. Kontsevaya, K. Bates, E. A. Goryachkin, N. Bobrova, L. I. Syromiatnikova, Yu. V. Popova, D. Yu. Platonov, I. V. Osipova, A. M. Nedbaikin, T. N. Malorodova, O. A. Mirolyubova, D. V. Kryuchkov, L. A. Khaisheva, A. S. Galyavich, M. V. Franz, A. Yu. Efanov, D. V. Duplyakov, O. M. Drapkina, D. Leon, M. McKee

“…This study is observational and the part of big international project. It includes a representative sample of patients with MI admitted to 16 clinics in 13 regions of Russian Federation (Arkhangelsk region, Belgorod region, Bryansk region, Tver region, Saratov region, Rostov region, Samara region, the Republic of Tatarstan, Perm region, Tyumen region, Khanty-Mansiysk Autonomous district, Kemerovo region, Altai region). …”
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A short pragmatic tool for evaluating community engagement: Partnering for Health Improvement and Research Equity by John G. Oetzel, Blake Boursaw, Lenora Littledeer, Sarah Kastelic, Page Castro-Reyes, Juan M. Peña, Patricia Rodriguez Espinosa, Shannon Sanchez-Youngman, Lorenda Belone, Nina Wallerstein

“…The PHIRE is a straightforward and easy-to-use tool, for a range of CBPR/CEnR projects, that can provide benefit to partnerships by identifying actionable changes to their partnering practices to reach their desired research and practical outcomes.…”
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The needs of family caregivers providing palliative home care in Portugal: a multi-stage mixed methods study protocol by Carlos Laranjeira, Carlos Laranjeira, Carlos Laranjeira, Maria dos Anjos Dixe, Maria dos Anjos Dixe, Alexandra Coelho, Carla Reigada, Carla Reigada, Rui Carneiro, Ana Querido, Ana Querido, Ana Querido

“…Lastly, phase IV will synthesize the results and produce a white book for FC advocacy in PC.DiscussionThe project will enrich community PC while optimizing social welfare activities. …”
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HOMESIDE: home-based family caregiver-delivered music and reading interventions for people living with dementia: protocol of a randomised controlled trial by Sabine Braat, Felicity Anne Baker, Imogen Clark, Young-Eun Claire Lee, Thomas Wosch, Helen Odell-Miller, Nicola Lautenschlager, Jodie Bloska, Anna Bukowska, Ming H Hsu, Tone Kvamme, Agnieszka Smrokowska-Reichmann, Karette A Stensaeth

“…However, no randomised study has examined the effects on BPSD of music interventions delivered by informal caregivers (CGs) in the home setting. Our project aims to address the need for improved informal care by training cohabiting family CGs to implement music interventions that target BPSD, and the quality of life (QoL) and well-being of people with dementia (PwD) and CGs.Methods and analysis A large international three-arm parallel-group randomised controlled trial will recruit a sample of 495 dyads from Australia, Germany, UK, Poland and Norway. …”
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Impact of digital health on Type 2 diabetes management: a randomised controlled trial of the ‘TreC Diabete’ platform (TELEMECHRON Study) by Alexia Giovanazzi, Lorenzo Gios, Maria Adalgisa Gentilini, Marina Mastellaro, Patrizia Bartolotta, Lucrezia Nicolussi Giacomaz, Claudio Eccher, Sandro Inchiostro

“…Within the context of a broader project funded by the Italian Ministry of Health (TELEMECHRON study), a randomised controlled trial (RCT) has been conducted in the Autonomous Province of Trento on type 2 diabetes individuals with an untargeted glycated haemoglobin (HbA1c) level.MethodsThe overall aim was to evaluate the impact of the “TreC Diabete” digital platform, including a smartphone application (app) and a dashboard. …”
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Stigma-directed services (Stig2Health) to improve ‘linkage to care’ for people living with HIV in rural Tanzania: study protocol for a nested pre-post implementation study within t... by Raphael Magnolini, Aneth Vedastus Kalinjuma, Elizabeth Senkoro, Bernard Kivuma, Olivia Kitau, Anna Eichenberger, Leila Samson, Eileen Krinke, Getrud Joseph Mollel, Robert Ndege, James Okuma, Herry Mapesi, Tracy Glass, Manuel Battegay, Fiona Vanobberghen, Maja Weisser

“…Self-reported stigma and depression are assessed using the Berger Stigma scale and the PHQ-9 questionnaire, respectively. The sample size calculation was based on cohort data from 2018. …”
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Arthroscopic meniscectomy versus non-surgical or sham treatment in patients with MRI confirmed degenerative meniscus lesions: a protocol for an individual participant data meta-ana... by Ewa M Roos, Martin Englund, Victor A van de Graaf, Rudolf W Poolman, Maroeska M Rovers, Stan R W Wijn, Jan J Rongen, Håvard Østerås, May A Risberg, Kristoffer B Hare, Gerjon Hannink

“…The common perception by most orthopaedic surgeons is that there are subgroups of patients that do need APM to improve, and they argue that each study sample of the existing trials is not representative for the day-to-day patients in the clinic. …”
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The role of protein-phenolic interactions in the formation of red wine colloidal particles by Matteo Marangon, Valentina Marassi, Fulvio Mattivi, Christine Mayr Marangon, Luigi Moio, Barbara Roda, Luca Rolle, Maurizio Ugliano, Andrea Versari, Sara Zanella, Andrea Curioni

“…Recent studies from the D-Wines (Diversity of the Italian Wines) project aimed to elucidate the structure, composition, and formation mechanisms of red wine colloids by analysing monovarietal wines from 10 Italian red grape varieties. …”
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Development and validation of the Global Adolescent and Child Physical Activity Questionnaire (GAC-PAQ) in 14 countries: study protocol by Tom Loney, Yang Liu, Justin Richards, Mark S Tremblay, Adewale L Oyeyemi, John J Reilly, Dale W Esliger, Karen Roberts, Melody Smith, Valerie Carson, Anuradha Khadilkar, Marie Löf, S H Wong, Diego Augusto Santos Silva, Jasmin Bhawra, Narayan Subedi, Javier Brazo-Sayavera, Alejandra Jauregui, Piyawat Katewongsa, Dyah Anantalia Widyastari, Leigh M Vanderloo, Olga Lucia Sarmiento, Taru Manyanga, Richard Larouche, Mahdi Rostami Haji Abadi, Salomé Aubert, Rachel C Colley, Christine Delisle Nyström, Ryan Harper-Brown, Silvia Alejandra Gonzalez Cifuentes, Geoff Kira, Nicholas Kuzik, Tawonga W Mwase-Vuma, Oliver W A Wilson

“…We anticipate that the GAC-PAQ will facilitate global surveillance of PA in children/adolescents. Our project includes a robust knowledge translation strategy sensitive to social determinants of health to inform inclusive surveillance and PA interventions globally.…”
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Wet-radome attenuation in ARM cloud radars and its utilization in radar calibration using disdrometer measurements by M. Deng, S. E. Giangrande, M. P. Jensen, K. Johnson, C. R. Williams, J. M. Comstock, Y.-C. Feng, A. Matthews, I. A. Lindenmaier, T. G. Wendler, M. Rocque, A. Zhou, Z. Zhu, E. Luke, D. Wang

“…This increase is linked to a drop of about 1 dB in transmitter power toward the end of the project.</p>…”
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Impact of digital antenatal care intervention on paper-based antenatal care recordkeeping: a before-and-after study in primary healthcare facilities in Nepal by Biraj Man Karmacharya, Emma Radovich, Loveday Penn-Kekana, Clara Calvert, Ona L McCarthy, Abha Shrestha, Oona M R Campbell, Seema Das, Sulata Karki, Rajani Shakya

“…However, the study’s small sample size limited the ability to examine variation in effects.…”
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Introducing the MESMER-M-TPv0.1.0 module: spatially explicit Earth system model emulation for monthly precipitation and temperature by S. Schöngart, S. Schöngart, L. Gudmundsson, M. Hauser, P. Pfleiderer, Q. Lejeune, S. Nath, S. I. Seneviratne, C.-F. Schleussner, C.-F. Schleussner, C.-F. Schleussner

“…Therefore, the monthly residual field is decomposed into independent principal components and subsequently approximated and sampled using a kernel density estimation with a Gaussian kernel. …”
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A computational DNA methylation method to remove contaminated DNA from spent embryo culture medium for noninvasive preimplantation genetic testingResearch in context by Yidong Chen, Jin Huang, Fuchou Tang, Lu Wen, Jie Qiao

“…In real clinical SECM samples, the method improved aneuploidy detection sensitivity at a cumulus cell contamination ratio of 50%. …”
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Differential expression of plasma extracellular vesicles microRNAs and exploration of their association with bone metabolism in childhood trauma participants treated in a psychosom... by Yangyang He, Yangyang He, Karin Wuertz-Kozak, Karin Wuertz-Kozak, Petra Cazzanelli, Sanne Houtenbos, Sanne Houtenbos, Francisco Garcia-Carrizo, Francisco Garcia-Carrizo, Tim J. Schulz, Tim J. Schulz, Tim J. Schulz, Pia-Maria Wippert, Pia-Maria Wippert

“…MiRNA target gene network prediction revealed highly associated target genes of dysregulated miRNAs, such as Trinucleotide Repeat Containing Adaptor 6B (TNRC6B), and enrichment analysis highlighted pathways including the forkhead box protein O (FoxO) signaling pathway.DiscussionsThis study explored the potential associations between childhood trauma and bone metabolism, due to the sample size and experimental group limitations, these associations should be validated in future experiments with larger sample sizes and different control group settings.…”
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Associations of social network use and social network addictive behaviors with self-esteem in adolescents: the EHDLA study by Estefanía Martínez-Iniesta, José Adrián Montenegro-Espinosa, Bruno Bizzozero-Peroni, Bruno Bizzozero-Peroni, Jorge Olivares-Arancibia, Rodrigo Yáñez-Sepúlveda, Daniel Duclos-Bastías, Daniel Duclos-Bastías, Josefa María Panisello Royo, Arthur Eumann Mesas, José Francisco López-Gil, Estela Jiménez-López, Estela Jiménez-López

“…The use of specific social media platforms and their associated addictive behaviors related to self-esteem were also evaluated.MethodsThis cross-sectional study used secondary data from the Eating Healthy and Daily Life Activities (EHDLA) project, which included a representative sample of adolescents aged 12–17 years from the Valle de Ricote in the Region of Murcia, Spain. …”
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Associations between contextual and compositional characteristics of early childcare facilities with health, health behaviours and well-being among young children aged 0 to 6 years... by Jennifer Hilger-Kolb, Sven Schneider, Raphael Herr, Nina Osenbruegge, Stephanie Hoffmann, Max Herke, Claudia Pischke, Leonie Sundmacher, Katharina Diehl

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